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. 2001 Dec;21(6):783–797. doi: 10.1023/A:1015112407079

Genomic Dissection Reveals Locus Response to Stress for Mammalian Acetylcholinesterase

Alastair D Grant 1, Michael Shapira 1, Hermona Soreq 1
PMCID: PMC11533849  PMID: 12043848

Abstract

The mammalian acetylcholinesterase (ACHE) locus was investigated using computational predictive methods and experiments of reverse transcription polymerase chain reaction (RT-PCR). Computational analysis identified two genes downstream to ACHE, an inversely oriented arsenite resistance gene homologue (ARS), and a novel previously unidentified gene (PIX), co-oriented with ACHE. Experimental evidence shows coregulation of murine ACHE and ARS following confined swim, indicating coordinated locus response to stress, that is possibly mediated by altered cholinergic neurotransmission.

Keywords: acetylcholinesterase, ARS, PIX, stress response, locus response

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