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. 1984 Apr 1;219(1):165–171. doi: 10.1042/bj2190165

Mechanism of enhanced RNA synthesis in acute-phase rat liver and its relationship to chromatin structure.

L Schiaffonati, L Bardella, G Cairo, V Giancotti, A Bernelli-Zazzera
PMCID: PMC1153461  PMID: 6202295

Abstract

Nuclei isolated from the liver of rats undergoing an acute inflammatory reaction induced by turpentine treatment show increased RNA synthesis. This increase is essentially determined by a faster polyribonucleotide-elongation rate while the number of transcribing polymerase molecules is unchanged. The sensitivity of chromatin to micrococcal-nuclease digestion and the composition of chromosomal proteins are not affected by the acute-phase process. Therefore the increased RNA synthesis by liver nuclei from acutely inflamed rats does not seem to correlate with major changes in chromatin structure.

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Selected References

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