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. 1984 Apr 1;219(1):333–336. doi: 10.1042/bj2190333

Changes in content and secretion of pancreatic enzymes in the obese Zucker rat.

R Bruzzone, E R Trimble, A Gjinovci, A E Renold
PMCID: PMC1153483  PMID: 6202297

Abstract

The contents of three major digestive enzymes (amylase, lipase and chymotrypsinogen) were measured in the obese Zucker rat. Only minimal changes were found in 7-week-old rats, but in adult obese rats (14-16 weeks) the amylase content was decreased by 50%, whereas the lipase and chymotrypsinogen contents were increased by 45% and 20%, respectively, compared with lean controls. Abnormalities of enzyme secretion were also found. Since the changes observed in enzyme proportions in adult obese Zucker rats are qualitatively similar to those observed in insulinopenic diabetes and other states associated with decreased glucose metabolism, it is speculated that the abnormalities found in the obese Zucker rat may be due to decreased glucose metabolism in the exocrine tissue consequent to insulin resistance.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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