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. 1984 Apr 1;219(1):337–339. doi: 10.1042/bj2190337

Altered sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA in ketotic diabetic rats.

G A Cook, T W Stephens, R A Harris
PMCID: PMC1153484  PMID: 6426472

Abstract

Carnitine palmitoyltransferase of liver mitochondria prepared from ketotic diabetic rats has a diminished sensitivity to inhibition by malonyl-CoA compared with carnitine palmitoyltransferase of mitochondria prepared from normal fed rats.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brashear A., Cook G. A. A spectrophotometric, enzymatic assay for D-3-hydroxybutyrate that is not dependent on hydrazine. Anal Biochem. 1983 Jun;131(2):478–482. doi: 10.1016/0003-2697(83)90201-4. [DOI] [PubMed] [Google Scholar]
  2. Bremer J. The effect of fasting on the activity of liver carnitine palmitoyltransferase and its inhibition by malonyl-CoA. Biochim Biophys Acta. 1981 Sep 24;665(3):628–631. doi: 10.1016/0005-2760(81)90282-4. [DOI] [PubMed] [Google Scholar]
  3. Cook G. A., King M. T., Veech R. L. Ketogenesis and malonyl coenzyme A content of isolated rat hepatocytes. J Biol Chem. 1978 Apr 25;253(8):2529–2531. [PubMed] [Google Scholar]
  4. Cook G. A., Otto D. A., Cornell N. W. Differential inhibition of ketogenesis by malonyl-CoA in mitochondria from fed and starved rats. Biochem J. 1980 Dec 15;192(3):955–958. doi: 10.1042/bj1920955. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Förster O., Rudas B. Ketosis in rats with streptozotocin-induced diabetes. Lancet. 1969 Jun 28;1(7609):1321–1322. doi: 10.1016/s0140-6736(69)92263-6. [DOI] [PubMed] [Google Scholar]
  6. Gillim S. E., Paxton R., Cook G. A., Harris R. A. Activity state of the branched chain alpha-ketoacid dehydrogenase complex in heart, liver, and kidney of normal, fasted, diabetic, and protein-starved rats. Biochem Biophys Res Commun. 1983 Feb 28;111(1):74–81. doi: 10.1016/s0006-291x(83)80119-3. [DOI] [PubMed] [Google Scholar]
  7. Harano Y., Kosugi K., Kashiwagi A., Nakano T., Hidaka H., Shigeta Y. Regulatory mechanism of ketogenesis by glucagon and insulin in isolated and cultured hepatocytes. J Biochem. 1982 May;91(5):1739–1748. doi: 10.1093/oxfordjournals.jbchem.a133866. [DOI] [PubMed] [Google Scholar]
  8. Junod A., Lambert A. E., Stauffacher W., Renold A. E. Diabetogenic action of streptozotocin: relationship of dose to metabolic response. J Clin Invest. 1969 Nov;48(11):2129–2139. doi: 10.1172/JCI106180. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Mansford K. R., Opie L. Comparison of metabolic abnormalities in diabetes mellitus induced by streptozotocin or by alloxan. Lancet. 1968 Mar 30;1(7544):670–671. doi: 10.1016/s0140-6736(68)92103-x. [DOI] [PubMed] [Google Scholar]
  10. McGarry J. D., Leatherman G. F., Foster D. W. Carnitine palmitoyltransferase I. The site of inhibition of hepatic fatty acid oxidation by malonyl-CoA. J Biol Chem. 1978 Jun 25;253(12):4128–4136. [PubMed] [Google Scholar]
  11. McGarry J. D., Mannaerts G. P., Foster D. W. A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis. J Clin Invest. 1977 Jul;60(1):265–270. doi: 10.1172/JCI108764. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Ontko J. A., Johns M. L. Evaluation of malonyl-CoA in the regulation of long-chain fatty acid oxidation in the liver. Evidence for an unidentified regulatory component of the system. Biochem J. 1980 Dec 15;192(3):959–962. doi: 10.1042/bj1920959. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Saggerson E. D., Carpenter C. A. Effects of fasting, adrenalectomy and streptozotocin-diabetes on sensitivity of hepatic carnitine acyltransferase to malonyl CoA. FEBS Lett. 1981 Jul 6;129(2):225–228. doi: 10.1016/0014-5793(81)80170-6. [DOI] [PubMed] [Google Scholar]
  14. Schein P. S., Alberti K. G., Williamson D. H. Effects of streptozotocin on carbohydrate and lipid metabolism in the rat. Endocrinology. 1971 Sep;89(3):827–834. doi: 10.1210/endo-89-3-827. [DOI] [PubMed] [Google Scholar]
  15. Stephens T. W., Cook G. A., Harris R. A. Effect of pH on malonyl-CoA inhibition of carnitine palmitoyltransferase I. Biochem J. 1983 May 15;212(2):521–524. doi: 10.1042/bj2120521. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Topping D. L., Targ M. E. Time-course of changes in blood glucose and ketone bodies, plasma lipids and liver fatty acid composition in streptozotocin-diabetic male rats. Horm Res. 1975;6(3):129–137. doi: 10.1159/000178670. [DOI] [PubMed] [Google Scholar]
  17. WILLIAMSON D. H., MELLANBY J., KREBS H. A. Enzymic determination of D(-)-beta-hydroxybutyric acid and acetoacetic acid in blood. Biochem J. 1962 Jan;82:90–96. doi: 10.1042/bj0820090. [DOI] [PMC free article] [PubMed] [Google Scholar]

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