Toe1 promotes proliferation and differentiation of neural progenitor cells

Tingting Deng; Xingxing Wu; Yujie Wang; Xiaoqin Fan; Bing Hu

doi:10.1016/j.heliyon.2024.e39535

. 2024 Oct 18;10(20):e39535. doi: 10.1016/j.heliyon.2024.e39535

Toe1 promotes proliferation and differentiation of neural progenitor cells

Tingting Deng ^a,¹, Xingxing Wu ^a,¹, Yujie Wang ^a, Xiaoqin Fan ^a, Bing Hu ^a,^⁎

PMCID: PMC11535345 PMID: 39502232

Abstract

Toe1 (target of EGR1, member 1) is a 3′- exonuclease in the deadenylase family, essential for the maturation of small nuclear RNAs. Mutations in Toe1 are linked to pontocerebellar hypoplasia 7 (PCH7), a severe neurodegenerative syndrome affecting infants, characterized by progressive neurodegeneration, developmental delay, and genital abnormalities. The pathogenic mechanisms of PCH7 are unclear but are thought to involve abnormal neural stem cell (NSC) development during embryogenesis. This study investigates Toe1's role in NSC development using the C17.2 NSC line. Colony formation, EdU incorporation, and CFSE staining assays showed that Toe1 knockout inhibited C17.2 cell proliferation. Upon inducing differentiation, Toe1 knockout significantly reduced cell dendrites. Immunofluorescence, qPCR, and Western blot analyses indicated that Toe1 knockout suppressed the expression of neuronal marker βIII-tubulin and glial cell marker Gfap, thereby inhibiting C17.2 cell differentiation. Additionally, Toe1 knockout reduced the expression of Dll1 and Jag1, suggesting an inhibition of Notch signaling. High-throughput transcriptome sequencing revealed that Toe1 influenced calcium ion binding, ECM, and amino acid catabolism in undifferentiated C17.2 cells, and peptidase activity, chemotactic factors, ECM, and TNF signaling in differentiated cells. These findings underscore Toe1's critical regulatory role in NSC proliferation and differentiation, with significant implications for developing therapeutic targets for neurodegenerative diseases such as PCH7.

1. Introduction

Stem cells are a unique category of cells with self-renewal and multilineage differentiation abilities [1,2]. Stem cells can be categorized into embryonic and adult stem cells, based on their developmental stages. Adult stem cells are undifferentiated cells that exist in differentiated tissues, capable of self-renewal and differentiation into specialized cells that constitute of the respective tissue. Examples include neural stem cells (NSCs), hematopoietic stem cells, bone marrow mesenchymal stem cells, and epidermal stem cells. NSCs in this study belong to a class of cells that can self-renew and generate a large number of brain tissue cells. These cells have the capacity to differentiate into neurons, astrocytes, and oligodendrocytes [3,4]. The precise regulation of NSCs is essential during brain development, ensuring production of a specific number of neurons at distinct stages and maintaining normal brain development and function [5]. Dysregulation of NSC control can lead to various brain disorders including cerebellar hypoplasia, lissencephaly, and autism.

Pontocerebellar hypoplasia (PCH) is a rare congenital neurodegenerative disorder characterized by abnormal development of the cerebellum, particularly the pons [6]. In addition to impaired brain development, individuals with PCH often exhibit clinical features including microcephaly, delayed motor development, and mild to severe intellectual disabilities [7]. PCH has multiple subtypes with broad-ranging effects and thus far, 13 PCH subtypes have been identified based on their clinical features [6,8]. Among these, PCH7 is a subtype characterized by more severe symptoms, primarily affecting infants. In addition to poor brain development, PCH7 expression is also associated with respiratory abnormalities, muscle tone abnormalities, and gonadal dysfunction [[9], [10], [11]]. In 2017, Gleeson et al. identified the TOE1 gene mutations in 12 PCH7 families using genomic sequencing. Mutations A103T, F148Y, V173G, and E220K did not affect TOE1 mRNA levels; however, they significantly reduced TOE1 protein expression. By generating homozygous Toe1 knockout mice, they observed that the knockout mice died before embryonic day 11.5. Furthermore, zebrafish lacking Toe1 exhibited structural brain defects resembling the pathology in human PCH7 [12]. This highlights the crucial role of TOE1 in neurodevelopment. Given that defects in small nuclear RNA (snRNA) processing are common causes of early-onset neurodegenerative diseases [13], Gleeson et al. speculated that mutations in TOE1 leading to abnormal snRNA processing could represent a potential pathogenic factors for PCH7. However, whether TOE1 affects NSC development has not yet been reported. Recent sequencing of additional PCH7 patients has identified new TOE1 mutations [[14], [15], [16]], further demonstrating a close correlation between TOE1 and neurodevelopment.

The aim of the study was to investigate the impact of Toe1 on the development of NSC, by focusing on the C17.2 NSC line. Our research highlights the importance of Toe1 in the development of NSCs and provides novel potential targets and insights into the diagnosis and treatment of PCH7.

2. Materials and methods

2.1. The C17.2 cell line and culture conditions

The C17.2 cell line is derived from multipotent NSCs isolated from the neonatal mouse cerebellum and immortalized via v-myc transfection. The cell line was purchased C17.2 from FuHeng Cell Center, Shanghai, China (FH1164). C17.2 cells were cultured in Dulbecco's modified Eagle's medium (DMEM, SH30243.01, Hyclone) containing 10 % fetal bovine serum (10099141, Gibco), 5 % horse serum (SH30074.03, Hyclone), 2 mM L-glutamine (25030081, Life Technologies), and 1 % penicillin/streptomycin (15070063, Gibco). These cells were incubated in standard humidified incubators (37 °C and 5 % CO₂).

For differentiation studies, the C17.2 cells were seeded in a routine culture medium. Twenty-four hours after seeding, the medium was replaced with DMEM/F-12 medium (11330032, Thermo Fisher Scientific) supplemented with 1 mM L-glutamine, 1 % penicillin/streptomycin, modified N2 supplements (17502048, Thermo Fisher Scientific), 10 ng/mL NGF (1156-NG-100, R&D Systems), and 10 ng/mL BDNF (248-BDB-010, R&D Systems). The differentiation medium was changed every third day for the duration of differentiation.

2.2. Colony formation and 5-ethynyl-2′-deoxyuridine incorporation assays

C17.2 cells were seeded in 12-well plates at a density of 800 cells/well. The cells were subsequently cultured for 10 d, fixed with 4 % paraformaldehyde (DF0135, LEAGENE) for 30 min at room temperature (RT), and stained with 0.5 % crystal violet solution (G1065, Solarbio) for 20 min. The plate was washed thrice with 1 × phosphate-buffered saline (PBS) and air-dried at RT. Colonies were imaged and counted.

To conduct the 5-ethynyl-2′-deoxyuridine (EdU) incorporation assay, cells were seeded in 96-well plates. The Click-iT EdU Lagging Kit (C10340, Invitrogen) was used to evaluate cell proliferation according to the manufacturer's instructions. DNA staining was performed using Hoechst 33342 solution.

2.3. Cell cycle analysis using flow cytometry

For cell cycle studies, collected cells were fixed with 75 % ethanol at 4 °C overnight, washed once with 1 × PBS, digested with 50 μg/mL RNase A (EN0531, Fermentas) at 37 °C for 10 min, and stained with propidium iodide. After staining, the cell cycle was analyzed using a BD Accuri C6 Plus flow cytometer. The data were analyzed using the FlowJo v10 software.

2.4. Reverse transcription and real-time quantitative PCR

RNA was extracted using TRIzol reagent (15596-018, Invitrogen), and cDNA was obtained via reverse transcription using an RT reagent Kit (T04897030001; Roche). qPCR was performed using the Universal SYBR Green Master Kit (04913850001; Roche) and conducted on Applied Biosystems StepOne™ Real-Time PCR Systems. The primer sequences are listed in Table 1.

Table 1.

The sequence of qPCR primers in the experiments.

Gapdh-FP	AGGTCGGTGTGAACGGATTTG
Gapdh-RP	GGGGTCGTTGATGGCAACA
Gfap-FP	ACCAGCTTACGGCCAACAG
Gfap-RP	CCAGCGATTCAACCTTTCTCT
βIII-tubulin-FP	AGGCCCGACAACTTTATCT
βIII-tubulin-RP	CTCTTTCCGCACGACATCTA
Nestin-FP	AGAGTCAGATCGCTCAGATCC
Nestin -RP	GCAGAGTCCTGTATGTAGCCAC
Dll1-FP	GCAGGACCTTCTTTCGCGTAT
Dll1-RP	AAGGGGAATCGGATGGGGTT
Jagged1-FP	CCTCGGGTCAGTTTGAGCTG
Jagged1-RP	CCTTGAGGCACACTTTGAAGTA
Notch1-FP	GATGGCCTCAATGGGTACAAG
Notch1-RP	TCGTTGTTGTTGATGTCACAGT
Notch2-FP	ATGTGGACGAGTGTCTGTTGC
Notch2-RP	GGAAGCATAGGCACAGTCATC
Ucma-FP	GAATCTGATGCCTCCAATTTCCT
Ucma-RP	C TCGTTCCTTTGCTCCTCGTAATA
Cdkn1a-FP	CCTGGTGATGTCCGACCTG
Cdkn1a-RP	CCATGAGCGCATCGCAATC
Tnfsf18-FP	ATGGAGGAAATGCCTTTGAGAG
Tnfsf18-RP	GATGGCAGTTGGCTTGAGTGA
Cd74-FP	CCGCCTAGACAAGCTGACC
Cd74-RP	ACAGGTTTGGCAGATTTCGGA
Btn2a2-FP	TTGCCCGATAGCCTCCCTT
Btn2a2-RP	GGCAGTGTAGTGTGGTATTCTCT
Vnn1-FP	CTTTCCTCGCGGCTGTTTAC
Vnn1-RP	CCTCCAGGTATGGGTAGATCGT

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2.5. Protein expression detected using Western blot (WB) analysis

Total protein was extracted using Beyotime RIPA buffer (P0013) supplemented with protease (Roche) and phosphatase inhibitor cocktails (Roche). Twenty micrograms of total protein were subjected to electrophoresis. Electrophoresis products were transferred onto polyvinylidene difluoride membranes (Millipore) using the wet transfer method. The membranes were blocked with 5 % skim milk for 1 h at RT and subsequently incubated with primary antibodies at 4° for overnight. The primary antibodies were washed with 1 × TBST and the membranes were incubated with the secondary antibody. Images were acquired using the Amersham Imager 680 system. The following antibodies were used: Gapdh (P30008M; Abmart); Nestin (MAB353; Merck millipore); βIII -Tubulin (TU-20) (4466S; CST); Gfap (MAB360; Merck millipore); goat anti-mouse IgG H&L (HRP) (ab6789; Abcam); goat anti-rabbit IgG H&L (HRP) (ab6721; Abcam). For immunofluorescence (IF), Nestin, βIII-tubulin, and GFAP were the same as WB, and the secondary antibodies of IF were Alexa Fluor 555-labeled donkey anti-mouse antibody (AB_2762848; Invitrogen) and Alexa Fluor 488-labeled donkey anti-mouse antibody (AB_2762823; Invitrogen).

2.6. RNA sequencing analysis

The total RNA from each group was extracted and sequenced on an Illumina HiSeq/MiSeq platform (Novogene Co., Ltd.) RNA-seq results were read in FASTA format following fastp data-quality evaluation and filtering. The DESeq2 R package (1.20.0) was used to analyze differentially expressed genes (DEGs) with a threshold of padj <0.05 and |log2(foldchange)| >1. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of DEGs were implemented using the clusterProfiler R package (3.8.1).

2.7. Statistical analyses

Data are represented as the mean ± SEM. Statistically significant differences between two groups were analyzed using a standard two-tailed Student's t-test in Prism (GraphPad software 8.0). Statistical significance was set at p < 0.05.

3. Results

3.1. Toe1 knockout inhibited the proliferation of neural stem cells

Primary NSCs were isolated from the brains of neonatal mice (within the first 3 d post-birth) and cultured in vitro. Subsequently, we designed single-guide RNA (sgRNA) targeting Toe1 or GFP (as a negative control) and introduced the sgRNA into primary cells via lentiviral infection. The sgRNA sequences were Toe1-sgRNA1 CTGTGTGAGATGTTCCCAGC, Toe1-sgRNA2 GTGCATTGAGGAACGTTACA, GFP-sgRNA1 GAGCTGGACGGCGACGTAAA, and GFP-sgRNA2, CAAGTTCAGCGTGTCCGGCG.

Western blotting verified that the knockout effect of the Toe1 gene was good (Fig. 1-A), and we observed that, in comparison to the control group (KO-NC), NSCs with Toe1 knockout (KO-Toe1) exhibited slower growth, characterized by smaller and fewer neurospheres (Fig. 1-B/C). However, with prolonged culture time, the proliferation rates of both groups decreased, the cells gradually died, and the KO-Toe1 group showed a faster cell death rate than the control group.

Owing to the inability of primary cells to be cultured long-term in vitro (presumably due to the gradual loss of cell stemness during the culture process, leading to the inability of cells to continuously divide), subsequent experiments could not be conducted using primary cells. Isolating primary NSCs was cumbersome, posing challenges in maintaining consistent cell activity and stemness across each batch. Additionally, infecting of primary NSCs with the virus yields low efficiency, presenting challenges in achieving the desired knockout efficiency. Consequently, we adjusted our experimental approach and opted to use the mouse neural stem cell line C17.2 for further experiments.

Similar to the previous step, we constructed a C17.2 knockout cell line via lentiviral transfection, and WB confirmed a successful gene knockout effect (Fig. 2-A). To explore the regulatory role of Toe1 in C17.2 cells, we performed a colony formation assay. The results revealed a reduced number of clones formed by Toe1 knockout cells compared to the that of the control group, with thinner clone shapes (Fig. 2-B). This indicated that Toe1 knockout resulted in slower proliferation of C17.2 cells, consistent with observations in primary stem cells. To further validate the phenotypic effects of Toe1 on C17.2 cell growth, EdU and CFSE experiments were conducted. Both experiments confirmed that Toe1 knockout inhibited the growth of NSCs (Fig. 2-C/D/E). Cell cycle analysis demonstrated that Toe1 knockout led to a decrease in the number of cells arrested in the G1 phase and an increase in the number of cells arrested in the S and G2-M phases (Fig. 2-F/G).

Fig. 2 — Depletion of Toe1 Suppresses the Proliferation of C17.2 Cell Line

(A) Western blot analysis, quantitatively evaluating the efficacy of Toe1 depletion at the protein level.

(B) Images from the colony formation assay, offering a visual representation of the impact of Toe1 knockout on clonogenic potential.

(C) Fluorescence microscopy images capturing EdU-positive cells, indicative of active DNA synthesis. Scale bars indicate 60 μm.

(D) Statistical analysis of EdU-positive cells, ∗∗p < 0.01.

(E) Flow cytometry detection of CFSE dye signal intensity, offering a quantitative assessment of cell proliferation kinetics.

(F) Flow cytometry analysis of the cell cycle, providing insights into alterations in cell cycle progression induced by Toe1 depletion.

(G) Statistical analysis of cell cycle phases, ∗p < 0.05.

3.2. Transcriptome analysis of undifferentiated C17.2 cells

We extracted RNA from KO-NC and KO-Toe1 C17.2 cells for high-throughput transcriptome sequencing. A total of 979 DEGs were identified, of which 767 were upregulated and 212 were downregulated (Fig. 3-A/B). GO functional enrichment analysis was conducted to further understand the functions and features of DEGs.

GO results revealed that the most representative Molecular Function category among the upregulated DEGs is “calcium ion binding” (Fig. 3-C), involving 35 genes (Table 2). Calcium ions are common and widely present in living organisms. Calcium ion signaling is a crucial regulatory factor in cell growth and development. Calcium ion signaling can modulate cell proliferation, differentiation, and survival. Elevated intracellular calcium ion concentrations activate numerous calcium-binding proteins and calcium sensors, triggering a cascade of cell growth- and development-related signaling pathways and biological responses.

Table 2.

GO categories significantly enriched for differentially expressed genes (DEGs) in undifferentiated C17.2 cells.

upregulated DEGsupregulated DEGs
Category	GOID	Description	GeneRatio	BgRatio	pvalue	padj	geneID	geneName	Count
CC	GO:0031012	extracellular matrix	30/548	363/15676	1.21E-05	0.0047945679401624	ENSMUSG00000019997/ENSMUSG00000031790/ENSMUSG00000072941/ENSMUSG00000025650/ENSMUSG00000026574/ENSMUSG00000022382/ENSMUSG00000060459/ENSMUSG00000026249/ENSMUSG00000031391/ENSMUSG00000055632/ENSMUSG00000030606/ENSMUSG00000020758/ENSMUSG00000022483/ENSMUSG00000041445/ENSMUSG00000026697/ENSMUSG00000048126/ENSMUSG00000004894/ENSMUSG00000026069/ENSMUSG00000033327/ENSMUSG00000043822/ENSMUSG00000064080/ENSMUSG00000041559/ENSMUSG00000035270/ENSMUSG00000005397/ENSMUSG00000038156/ENSMUSG00000044006/ENSMUSG00000029307/ENSMUSG00000030116/ENSMUSG00000025020/ENSMUSG00000030849	Ctgf/Mmp15/Sod3/Col7a1/Dpt/Wnt7b/Kng2/Serpine2/L1cam/Hmcn2/Hapln3/Itgb4/Col2a1/Mmrn2/Myoc/Col6a3/Hapln2/Il1rl1/Tnxb/Adamtsl5/Fbln2/Fmod/Impg2/Nid1/Spon1/Cilp2/Dmp1/Mfap5/Slit1/Fgfr2	30
CC	GO:0005578	proteinaceous extracellular matrix	24/548	292/15676	9.71E-05	0.0192247939442793	ENSMUSG00000019997/ENSMUSG00000025650/ENSMUSG00000026574/ENSMUSG00000022382/ENSMUSG00000055632/ENSMUSG00000030606/ENSMUSG00000020758/ENSMUSG00000022483/ENSMUSG00000041445/ENSMUSG00000026697/ENSMUSG00000048126/ENSMUSG00000004894/ENSMUSG00000026069/ENSMUSG00000033327/ENSMUSG00000043822/ENSMUSG00000064080/ENSMUSG00000041559/ENSMUSG00000035270/ENSMUSG00000005397/ENSMUSG00000038156/ENSMUSG00000044006/ENSMUSG00000029307/ENSMUSG00000030116/ENSMUSG00000025020	Ctgf/Col7a1/Dpt/Wnt7b/Hmcn2/Hapln3/Itgb4/Col2a1/Mmrn2/Myoc/Col6a3/Hapln2/Il1rl1/Tnxb/Adamtsl5/Fbln2/Fmod/Impg2/Nid1/Spon1/Cilp2/Dmp1/Mfap5/Slit1	24
MF	GO:0005509	calcium ion binding	35/544	483/15421	4.66E-05	0.0302625472019761	ENSMUSG00000016995/ENSMUSG00000068923/ENSMUSG00000047428/ENSMUSG00000062591/ENSMUSG00000027171/ENSMUSG00000021950/ENSMUSG00000026414/ENSMUSG00000027861/ENSMUSG00000074264/ENSMUSG00000063767/ENSMUSG00000055632/ENSMUSG00000029055/ENSMUSG00000023000/ENSMUSG00000048895/ENSMUSG00000047216/ENSMUSG00000036862/ENSMUSG00000029608/ENSMUSG00000026175/ENSMUSG00000029544/ENSMUSG00000001021/ENSMUSG00000078144/ENSMUSG00000025473/ENSMUSG00000032776/ENSMUSG00000064080/ENSMUSG00000024430/ENSMUSG00000005397/ENSMUSG00000035860/ENSMUSG00000027435/ENSMUSG00000043789/ENSMUSG00000061723/ENSMUSG00000048827/ENSMUSG00000074486/ENSMUSG00000068452/ENSMUSG00000025020/ENSMUSG00000035183	Matn4/Syt11/Dlk2/Tubb4a/Prrg4/Anxa8/Tnnt2/Casq2/Amy1/S100a7a/Hmcn2/Plch2/Dhh/Cdk5r1/Cdh19/Dchs1/Rph3a/Vil1/Cabp1/S100a3/Capns2/Adam8/Mctp2/Fbln2/Cabyr/Nid1/Cdhr3/Cd93/Vwce/Tnnt3/Pkd1l3/Bglap2/Duox2/Slit1/Slc24a5	35

downregulated DEGs
Category	GOID	Description	GeneRatio	BgRatio	pvalue	padj	geneID	geneName	Count
BP	GO:1901606	alpha-amino acid catabolic process	7/161	66/15663	4.98E-06	0.00516906308729224	ENSMUSG00000021238/ENSMUSG00000020840/ENSMUSG00000025911/ENSMUSG00000007039/ENSMUSG00000021033/ENSMUSG00000021646/ENSMUSG00000028011	Aldh6a1/Blmh/Adhfe1/Ddah2/Gstz1/Mccc2/Tdo2	7
BP	GO:0051186	cofactor metabolic process	16/161	414/15663	5.78E-06	0.00516906308729224	ENSMUSG00000017390/ENSMUSG00000025150/ENSMUSG00000020150/ENSMUSG00000028070/ENSMUSG00000025911/ENSMUSG00000021033/ENSMUSG00000021646/ENSMUSG00000001663/ENSMUSG00000004035/ENSMUSG00000040181/ENSMUSG00000062729/ENSMUSG00000029864/ENSMUSG00000026489/ENSMUSG00000029162/ENSMUSG00000028011/ENSMUSG00000004267	Aldoc/Cbr2/Gamt/Naxe/Adhfe1/Gstz1/Mccc2/Gstt1/Gstm7/Fmo1/Ppox/Gstk1/Coq8a/Khk/Tdo2/Eno2	16
BP	GO:0009063	cellular amino acid catabolic process	7/161	76/15663	1.28E-05	0.00764680373208239	ENSMUSG00000021238/ENSMUSG00000020840/ENSMUSG00000025911/ENSMUSG00000007039/ENSMUSG00000021033/ENSMUSG00000021646/ENSMUSG00000028011	Aldh6a1/Blmh/Adhfe1/Ddah2/Gstz1/Mccc2/Tdo2	7
BP	GO:0016054	organic acid catabolic process	10/161	189/15663	2.59E-05	0.00925931069791845	ENSMUSG00000036138/ENSMUSG00000021238/ENSMUSG00000020840/ENSMUSG00000025911/ENSMUSG00000007039/ENSMUSG00000021033/ENSMUSG00000021646/ENSMUSG00000031387/ENSMUSG00000021884/ENSMUSG00000028011	Acaa1a/Aldh6a1/Blmh/Adhfe1/Ddah2/Gstz1/Mccc2/Renbp/Hacl1/Tdo2	10
BP	GO:0046395	carboxylic acid catabolic process	10/161	189/15663	2.59E-05	0.00925931069791845	ENSMUSG00000036138/ENSMUSG00000021238/ENSMUSG00000020840/ENSMUSG00000025911/ENSMUSG00000007039/ENSMUSG00000021033/ENSMUSG00000021646/ENSMUSG00000031387/ENSMUSG00000021884/ENSMUSG00000028011	Acaa1a/Aldh6a1/Blmh/Adhfe1/Ddah2/Gstz1/Mccc2/Renbp/Hacl1/Tdo2	10
BP	GO:1901605	alpha-amino acid metabolic process	9/161	173/15663	7.54E-05	0.0224649221494001	ENSMUSG00000020150/ENSMUSG00000000958/ENSMUSG00000021238/ENSMUSG00000020840/ENSMUSG00000025911/ENSMUSG00000007039/ENSMUSG00000021033/ENSMUSG00000021646/ENSMUSG00000028011	Gamt/Slc7a7/Aldh6a1/Blmh/Adhfe1/Ddah2/Gstz1/Mccc2/Tdo2	9
BP	GO:0044282	small molecule catabolic process	11/161	266/15663	9.71E-05	0.0247915380253325	ENSMUSG00000036138/ENSMUSG00000021238/ENSMUSG00000020840/ENSMUSG00000025911/ENSMUSG00000007039/ENSMUSG00000021033/ENSMUSG00000021646/ENSMUSG00000031387/ENSMUSG00000029162/ENSMUSG00000021884/ENSMUSG00000028011	Acaa1a/Aldh6a1/Blmh/Adhfe1/Ddah2/Gstz1/Mccc2/Renbp/Khk/Hacl1/Tdo2	11

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In the Cellular Component category, upregulated DEGs were predominantly involved in the “extracellular matrix” (Fig. 3-C). The ECM constitutes a three-dimensional network outside the cells, providing structural and biochemical support to the surrounding cells. The ECM is a critical environment for cell growth and development, with components such as collagen and fibronectin that significantly influence cell adhesion, proliferation, morphology, and migration. Growth factors and signaling molecules within the ECM also play a role in directing cell behavior. In our study, upregulated ECM genes (Table 2), including dermatopontin (Dpt), fibroblast growth factor receptor 2 (Fgfr2), interleukin 1 receptor-like 1 (Il1rl1), multimerin 2 (Mmrn2), and the serine (or cysteine) peptidase inhibitor clade E member 2 (Serpine2), were enriched in negative regulation of cell population proliferation (GO:0008285). Therefore, elevated expression of these genes may contribute to the observed deceleration in C17.2 cell proliferation.

The biological processes associated with downregulated DEGs were primarily related to metabolism (Fig. 3-D), including small-molecule catabolic processes, alpha-amino acid metabolic processes, carboxylic acid catabolic processes, organic acid catabolic processes, cellular amino acid catabolic processes, cofactor metabolic processes, and alpha-amino acid catabolic processes. The potential associations between these metabolic pathways were investigated. Thus, we selected the top five significantly enriched metabolic processes as the primary nodes for constructing a Directed Acyclic Graph displaying the associated GO terms (Supplementary Fig. 1). The bottommost branch node in the graph corresponds to the alpha-amino acid catabolic process, suggesting that this metabolic pathway is most significantly influenced by Toe1.

Amino acid metabolic pathways include protein degradation and amino acid synthesis. During protein degradation, proteins undergo breakdown into amino acids, subsequently entering amino acid synthesis pathways. These amino acids can further synthesize proteins or can be metabolized into other metabolic products for cellular growth. Abnormal expression of genes related to amino acid degradation can disrupt normal amino acid metabolism, leading to downstream product synthesis and potentially impeding cell growth. Decreased expression of genes (Table 2), such as Ddah2 [17], Mcc2 [18], and Tdo2 [19], can result in a decrease in cell proliferation.

3.3. Toe1 knockout inhibited the C17.2 cell differentiation

NSCs C17.2 possess the potential to differentiate into neuronal and glial cells. Therefore, we investigated the impact of Toe1 on the differentiation process of C17.2 cells. We induced differentiation of KO-NC and KO-Toe1 C17.2 cells using a differentiation medium. After 6 d of induction, we initially observed changes in cell morphology, where the majority of cells in the control group extended to one or more dendrites, whereas the KO-Toe1 group exhibited fewer cells with dendrites (Fig. 4-A/B). Morphological alterations provide preliminary evidence for the regulation of neural cell differentiation of Toe1. Next, we used Nestin (a marker of NSCs), βIII-tubulin (a marker of neurons), and Gfap (a marker of astrocytes) to determine the differentiation of C17.2 (Fig. 4-C). We also detected mRNA levels of these marker genes by qPCR. qPCR results showed that the expression levels of Nestin and βIII-tubulin were reduced in the KO-Toe1 group, whereas Gfap showed no significant change (Fig. 4-D). However, in WB experiments, the protein expression levels of Nestin, βIII-tubulin, and Gfap in the KO-Toe1 group were significantly lower than those in the control group (Fig. 4-E), aligning with the IF results. These findings suggested that the deletion of Toe1 inhibits the differentiation of NSCs C17.2.

Fig. 4 — Toe1 knockout inhibited the C17.2 cell differentiation

(A) Microscopic bright-field images capturing C17.2 cells after induction of differentiation. Enlarged images are presented in the upper right corner. Scale bars indicate 100 μm

(B) Quantitative analysis of cells with dendrites length >35 μm ∗∗∗p < 0.001.

(C) Immunofluorescence staining of Nestin, Gfap and βIII-tubulin in differentiated C17.2 cells. Scale bars indicate 60 μm.

(D) qPCR analysis of mRNA levels for Nestin, βIII-tubulin, and Gfap, ∗p < 0.05, ∗∗p < 0.01.

(E) Western blot analysis of protein levels for Nestin, βIII-tubulin, and Gfap.

(F) qPCR analysis of the impact of Toe1 depletion on Notch pathway-related genes, ∗∗p < 0.01.

The Notch signaling pathway is an evolutionarily conserved signaling cascade primarily composed of Notch receptors, Notch ligands, CSL/DNA-binding proteins, and downstream target genes [20]. Mammals have four Notch receptors (Notch1-4) and five transmembrane Notch ligands (Jag1, Jag2, Dll1, Dll3, and Dll4). Given the crucial role of the Notch signaling pathway in nervous system development [21], we aimed to investigate whether the deletion of Toe1 affects this pathway. qPCR results indicated that the deletion of Toe1 suppressed the expression of Notch ligands Dll1 and Jag1, while having no significant effect on the Notch receptors Notch1 and Notch2 (Fig. 4-F). These results suggest that Toe1 may regulate Notch pathway by regulating Notch ligand expression, thereby promoting the differentiation of NSCs.

3.4. Transcriptome analysis of differentiated C17.2 cells

To further elucidate the mechanisms by which Toe1 regulates the differentiation of NSCs, we performed RNA high-throughput sequencing on KO-NC and KO-Toe1 differentiated cells. A total of 1281 DEGs were obtained, of which 1035 were upregulated and 246 were downregulated genes (Fig. 5-A/B).

GO analysis revealed that the 1035 upregulated DEGs were primarily associated with 439 functional groups, including 359 biological processes (BP), 27 cellular components (CC), and 53 molecular functions (MF). The top 10 most statistically significant terms from each of the BP, CC, and MF subcategories were systematically selected for subsequent visualization.

In the BP category, the top 10 significantly enriched terms were delineated as follows (Fig. 5-C): regulation of endopeptidase activity (46 genes), regulation of peptidase activity (49 genes), defense response to other organisms (51 genes), response to interferon-gamma (25 genes), icosanoid metabolic process (18 genes), fatty acid derivative metabolic process (19 genes), response to interferon-beta (14 genes), cytokine-mediated signaling pathway (40 genes), negative regulation of endopeptidase activity (26 genes), and cell chemotaxis (32 genes), as depicted in Table 3.

Table 3.

GO categories significantly enriched for differentially expressed genes (DEGs) in differentiated C17.2 cells.

upregulated DEGs
Category	GOID	Description	GeneRatio	BgRatio	pvalue	padj	geneID	geneName	Count
BP	GO:0052548	regulation of endopeptidase activity	45/858	286/15881	8.74E-11	2.13E-07	ENSMUSG00000023030/ENSMUSG00000000753/ENSMUSG00000024778/ENSMUSG00000024066/ENSMUSG00000044303/ENSMUSG00000017737/ENSMUSG00000028039/ENSMUSG00000035873/ENSMUSG00000033538/ENSMUSG00000078945/ENSMUSG00000042842/ENSMUSG00000096472/ENSMUSG00000019997/ENSMUSG00000028128/ENSMUSG00000025507/ENSMUSG00000019823/ENSMUSG00000028599/ENSMUSG00000022510/ENSMUSG00000096727/ENSMUSG00000041481/ENSMUSG00000046223/ENSMUSG00000078942/ENSMUSG00000031387/ENSMUSG00000027985/ENSMUSG00000079017/ENSMUSG00000021403/ENSMUSG00000024338/ENSMUSG00000079014/ENSMUSG00000025889/ENSMUSG00000020340/ENSMUSG00000060459/ENSMUSG00000026315/ENSMUSG00000026249/ENSMUSG00000037860/ENSMUSG00000027834/ENSMUSG00000000120/ENSMUSG00000020178/ENSMUSG00000020787/ENSMUSG00000071203/ENSMUSG00000051029/ENSMUSG00000019278/ENSMUSG00000028864/ENSMUSG00000004231/ENSMUSG00000025888/ENSMUSG00000079012	Slc11a2/Serpinf1/Fas/Xdh/Cdkn2a/Mmp9/Efna3/Pawr/Casp4/Naip2/Serpinb6b/Cdkn2d/Ctgf/F3/Pidd1/Mical1/Tnfrsf1b/Trp63/Psmb9/Serpina3g/Plaur/Naip6/Renbp/Lef1/Ifi27l2a/Serpinb9b/Psmb8/Serpina3i/Snca/Cyfip2/Kng2/Serpinb8/Serpine2/Aim2/Serpini1/Ngfr/Adora2a/P2rx1/Naip5/Serpinb1b/Dpep1/Hgf/Pax2/Casp1/Serpina3m	45
BP	GO:0052547	regulation of peptidase activity	49/858	329/15881	9.29E-11	2.13E-07	ENSMUSG00000017002/ENSMUSG00000023030/ENSMUSG00000000753/ENSMUSG00000024778/ENSMUSG00000024066/ENSMUSG00000044303/ENSMUSG00000017737/ENSMUSG00000028039/ENSMUSG00000035873/ENSMUSG00000033538/ENSMUSG00000078945/ENSMUSG00000042842/ENSMUSG00000096472/ENSMUSG00000027082/ENSMUSG00000019997/ENSMUSG00000028128/ENSMUSG00000025507/ENSMUSG00000019823/ENSMUSG00000028599/ENSMUSG00000022510/ENSMUSG00000096727/ENSMUSG00000041481/ENSMUSG00000046223/ENSMUSG00000078942/ENSMUSG00000031387/ENSMUSG00000027985/ENSMUSG00000032359/ENSMUSG00000079017/ENSMUSG00000021403/ENSMUSG00000024338/ENSMUSG00000079014/ENSMUSG00000025889/ENSMUSG00000020340/ENSMUSG00000060459/ENSMUSG00000078949/ENSMUSG00000026315/ENSMUSG00000026249/ENSMUSG00000037860/ENSMUSG00000027834/ENSMUSG00000000120/ENSMUSG00000020178/ENSMUSG00000020787/ENSMUSG00000071203/ENSMUSG00000051029/ENSMUSG00000019278/ENSMUSG00000028864/ENSMUSG00000004231/ENSMUSG00000025888/ENSMUSG00000079012	Slpi/Slc11a2/Serpinf1/Fas/Xdh/Cdkn2a/Mmp9/Efna3/Pawr/Casp4/Naip2/Serpinb6b/Cdkn2d/Tfpi/Ctgf/F3/Pidd1/Mical1/Tnfrsf1b/Trp63/Psmb9/Serpina3g/Plaur/Naip6/Renbp/Lef1/Ctsh/Ifi27l2a/Serpinb9b/Psmb8/Serpina3i/Snca/Cyfip2/Kng2/R3hdml/Serpinb8/Serpine2/Aim2/Serpini1/Ngfr/Adora2a/P2rx1/Naip5/Serpinb1b/Dpep1/Hgf/Pax2/Casp1/Serpina3m	49
BP	GO:0098542	defense response to other organism	51/858	363/15881	3.25E-10	4.96E-07	ENSMUSG00000029380/ENSMUSG00000017002/ENSMUSG00000061232/ENSMUSG00000046718/ENSMUSG00000016024/ENSMUSG00000030921/ENSMUSG00000042677/ENSMUSG00000035208/ENSMUSG00000066800/ENSMUSG00000020826/ENSMUSG00000078945/ENSMUSG00000069516/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000040253/ENSMUSG00000053175/ENSMUSG00000079363/ENSMUSG00000029373/ENSMUSG00000001166/ENSMUSG00000078942/ENSMUSG00000055994/ENSMUSG00000029298/ENSMUSG00000054072/ENSMUSG00000035692/ENSMUSG00000026177/ENSMUSG00000028268/ENSMUSG00000017830/ENSMUSG00000032690/ENSMUSG00000020641/ENSMUSG00000000386/ENSMUSG00000002944/ENSMUSG00000104713/ENSMUSG00000059108/ENSMUSG00000029605/ENSMUSG00000029371/ENSMUSG00000034459/ENSMUSG00000032661/ENSMUSG00000037860/ENSMUSG00000034855/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000041515/ENSMUSG00000071203/ENSMUSG00000079164/ENSMUSG00000075370/ENSMUSG00000079339/ENSMUSG00000053318/ENSMUSG00000062157/ENSMUSG00000021948/ENSMUSG00000034266/ENSMUSG00000067773	Cxcl1/Slpi/H2-K1/Bst2/Lbp/Trim30a/Zc3h12a/Slfn8/Rnasel/Nos2/Naip2/Lyz2/Tlr2/Syk/Gbp7/Bcl3/Gbp4/Pf4/Oas1c/Naip6/Nod2/Gbp9/Iigp1/Isg15/Slc11a1/Gbp3/Dhx58/Oas2/Rsad2/Mx1/Cd36/Gbp6/Ifitm6/Oas1b/Cxcl5/Ifit1/Oas3/Aim2/Cxcl10/Il12rb1/Il15/Irf8/Naip5/Tlr5/Igll1/Ifit1bl1/Slamf8/Ifnlr1/Prkcd/Batf/Defb41	51
BP	GO:0034341	response to interferon-gamma	25/858	110/15881	6.60E-10	7.56E-07	ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000046718/ENSMUSG00000035373/ENSMUSG00000074151/ENSMUSG00000037580/ENSMUSG00000020826/ENSMUSG00000026166/ENSMUSG00000040253/ENSMUSG00000019122/ENSMUSG00000079363/ENSMUSG00000029298/ENSMUSG00000034438/ENSMUSG00000026177/ENSMUSG00000025889/ENSMUSG00000028268/ENSMUSG00000031504/ENSMUSG00000035186/ENSMUSG00000104713/ENSMUSG00000059108/ENSMUSG00000000791/ENSMUSG00000041515/ENSMUSG00000031780/ENSMUSG00000078922/ENSMUSG00000025888	Ccl2/Cx3cl1/Bst2/Ccl7/Nlrc5/Gch1/Nos2/Ccl20/Gbp7/Ccl9/Gbp4/Gbp9/Gbp8/Slc11a1/Snca/Gbp3/Rab20/Ubd/Gbp6/Ifitm6/Il12rb1/Irf8/Ccl17/Tgtp1/Casp1	25
BP	GO:0006690	icosanoid metabolic process	18/858	69/15881	1.63E-08	1.50E-05	ENSMUSG00000024610/ENSMUSG00000047250/ENSMUSG00000006344/ENSMUSG00000050737/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000026688/ENSMUSG00000025002/ENSMUSG00000033715/ENSMUSG00000003484/ENSMUSG00000074604/ENSMUSG00000017969/ENSMUSG00000041193/ENSMUSG00000052974/ENSMUSG00000020892/ENSMUSG00000060063/ENSMUSG00000025955/ENSMUSG00000025197	Cd74/Ptgs1/Ggt5/Ptges/Tlr2/Syk/Mgst3/Cyp2c55/Akr1c14/Cyp4f18/Mgst2/Ptgis/Pla2g5/Cyp2f2/Aloxe3/Alox5ap/Akr1cl/Cyp2c23	18
BP	GO:1901568	fatty acid derivative metabolic process	19/858	84/15881	8.03E-08	5.49E-05	ENSMUSG00000024610/ENSMUSG00000047250/ENSMUSG00000006344/ENSMUSG00000050737/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000026688/ENSMUSG00000025002/ENSMUSG00000033715/ENSMUSG00000003484/ENSMUSG00000074604/ENSMUSG00000017969/ENSMUSG00000041193/ENSMUSG00000052974/ENSMUSG00000020892/ENSMUSG00000060063/ENSMUSG00000025955/ENSMUSG00000007908/ENSMUSG00000025197	Cd74/Ptgs1/Ggt5/Ptges/Tlr2/Syk/Mgst3/Cyp2c55/Akr1c14/Cyp4f18/Mgst2/Ptgis/Pla2g5/Cyp2f2/Aloxe3/Alox5ap/Akr1cl/Hmgcll1/Cyp2c23	19
BP	GO:0035456	response to interferon-beta	14/858	47/15881	1.04E-07	5.49E-05	ENSMUSG00000046718/ENSMUSG00000069893/ENSMUSG00000054072/ENSMUSG00000028268/ENSMUSG00000048852/ENSMUSG00000104713/ENSMUSG00000059108/ENSMUSG00000034459/ENSMUSG00000037860/ENSMUSG00000068606/ENSMUSG00000054203/ENSMUSG00000078922/ENSMUSG00000058163/ENSMUSG00000078921	Bst2/9930111J21Rik1/Iigp1/Gbp3/Gm12185/Gbp6/Ifitm6/Ifit1/Aim2/Gm4841/Ifi205/Tgtp1/Gm5431/Tgtp2	14
BP	GO:0019221	cytokine-mediated signaling pathway	40/858	299/15881	1.05E-07	5.49E-05	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000024778/ENSMUSG00000035373/ENSMUSG00000028965/ENSMUSG00000074151/ENSMUSG00000033538/ENSMUSG00000022514/ENSMUSG00000028128/ENSMUSG00000026166/ENSMUSG00000028599/ENSMUSG00000021457/ENSMUSG00000012889/ENSMUSG00000019122/ENSMUSG00000026068/ENSMUSG00000029373/ENSMUSG00000066755/ENSMUSG00000005057/ENSMUSG00000054072/ENSMUSG00000008318/ENSMUSG00000055003/ENSMUSG00000074272/ENSMUSG00000068227/ENSMUSG00000032690/ENSMUSG00000059108/ENSMUSG00000029371/ENSMUSG00000025494/ENSMUSG00000037860/ENSMUSG00000034855/ENSMUSG00000031712/ENSMUSG00000000120/ENSMUSG00000040329/ENSMUSG00000062157/ENSMUSG00000028602/ENSMUSG00000051379/ENSMUSG00000031780/ENSMUSG00000025888/ENSMUSG00000004266	Cd74/Cxcl1/Ccl2/Cx3cl1/Fas/Ccl7/Tnfrsf9/Nlrc5/Casp4/Il1rap/F3/Ccl20/Tnfrsf1b/Syk/Podnl1/Ccl9/Il18rap/Pf4/Tnfsf18/Sh2b2/Iigp1/Relt/Lrtm2/Ceacam1/Il2rb/Oas2/Ifitm6/Cxcl5/Sigirr/Aim2/Cxcl10/Il15/Ngfr/Il7/Ifnlr1/Tnfrsf8/Flrt3/Ccl17/Casp1/Ptpn6	40
BP	GO:0010951	negative regulation of endopeptidase activity	26/858	150/15881	1.19E-07	5.49E-05	ENSMUSG00000000753/ENSMUSG00000017737/ENSMUSG00000078945/ENSMUSG00000042842/ENSMUSG00000096472/ENSMUSG00000019823/ENSMUSG00000028599/ENSMUSG00000041481/ENSMUSG00000046223/ENSMUSG00000078942/ENSMUSG00000031387/ENSMUSG00000027985/ENSMUSG00000021403/ENSMUSG00000079014/ENSMUSG00000025889/ENSMUSG00000060459/ENSMUSG00000026315/ENSMUSG00000026249/ENSMUSG00000027834/ENSMUSG00000020178/ENSMUSG00000071203/ENSMUSG00000051029/ENSMUSG00000019278/ENSMUSG00000028864/ENSMUSG00000004231/ENSMUSG00000079012	Serpinf1/Mmp9/Naip2/Serpinb6b/Cdkn2d/Mical1/Tnfrsf1b/Serpina3g/Plaur/Naip6/Renbp/Lef1/Serpinb9b/Serpina3i/Snca/Kng2/Serpinb8/Serpine2/Serpini1/Adora2a/Naip5/Serpinb1b/Dpep1/Hgf/Pax2/Serpina3m	26
BP	GO:0060326	cell chemotaxis	32/858	212/15881	1.26E-07	5.49E-05	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000016024/ENSMUSG00000035373/ENSMUSG00000029082/ENSMUSG00000050335/ENSMUSG00000023913/ENSMUSG00000039621/ENSMUSG00000022676/ENSMUSG00000026166/ENSMUSG00000021457/ENSMUSG00000019122/ENSMUSG00000036585/ENSMUSG00000029373/ENSMUSG00000055994/ENSMUSG00000027985/ENSMUSG00000066755/ENSMUSG00000031520/ENSMUSG00000040026/ENSMUSG00000074715/ENSMUSG00000029371/ENSMUSG00000034855/ENSMUSG00000002489/ENSMUSG00000037362/ENSMUSG00000074115/ENSMUSG00000053318/ENSMUSG00000028864/ENSMUSG00000031780/ENSMUSG00000021948/ENSMUSG00000030707	Cd74/Cxcl1/Ccl2/Cx3cl1/Lbp/Ccl7/Bst1/Lgals3/Pla2g7/Prex1/Snai2/Ccl20/Syk/Ccl9/Fgf1/Pf4/Nod2/Lef1/Tnfsf18/Vegfc/Saa3/Ccl28/Cxcl5/Cxcl10/Tiam1/Nov/Saa1/Slamf8/Hgf/Ccl17/Prkcd/Coro1a	32
BP	GO:0007162	negative regulation of cell adhesion	34/858	234/15881	1.32E-07	5.49E-05	ENSMUSG00000024610/ENSMUSG00000027750/ENSMUSG00000029816/ENSMUSG00000044303/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000054855/ENSMUSG00000053965/ENSMUSG00000019850/ENSMUSG00000022676/ENSMUSG00000048826/ENSMUSG00000027985/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000076441/ENSMUSG00000032020/ENSMUSG00000039981/ENSMUSG00000074715/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000030004/ENSMUSG00000026249/ENSMUSG00000051262/ENSMUSG00000020178/ENSMUSG00000000706/ENSMUSG00000052013/ENSMUSG00000079494/ENSMUSG00000021948/ENSMUSG00000028519/ENSMUSG00000024696/ENSMUSG00000004266/ENSMUSG00000068748/ENSMUSG00000034652	Cd74/Postn/Gpnmb/Cdkn2a/Lgals3/Pawr/Rnd1/Pde5a/Tnfaip3/Snai2/Dact2/Lef1/Cd80/Tnfsf18/Btn2a2/Ass1/Ubash3b/Zc3h12d/Ccl28/Ceacam1/Lrrc32/Nat8/Serpine2/Nat8f3/Adora2a/Btn1a1/Btla/Nat8f5/Prkcd/Dab1/Lpxn/Ptpn6/Ptprz1/Cd300a	34
BP	GO:1990266	neutrophil migration	18/858	80/15881	1.92E-07	7.03E-05	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000016024/ENSMUSG00000035373/ENSMUSG00000029082/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000039621/ENSMUSG00000026166/ENSMUSG00000021457/ENSMUSG00000019122/ENSMUSG00000029373/ENSMUSG00000055994/ENSMUSG00000029371/ENSMUSG00000053318/ENSMUSG00000031780	Cd74/Cxcl1/Ccl2/Cx3cl1/Lbp/Ccl7/Bst1/Lgals3/Pawr/Prex1/Ccl20/Syk/Ccl9/Pf4/Nod2/Cxcl5/Slamf8/Ccl17	18
BP	GO:0010466	negative regulation of peptidase activity	29/858	185/15881	2.15E-07	7.03E-05	ENSMUSG00000017002/ENSMUSG00000000753/ENSMUSG00000017737/ENSMUSG00000078945/ENSMUSG00000042842/ENSMUSG00000096472/ENSMUSG00000027082/ENSMUSG00000019823/ENSMUSG00000028599/ENSMUSG00000041481/ENSMUSG00000046223/ENSMUSG00000078942/ENSMUSG00000031387/ENSMUSG00000027985/ENSMUSG00000021403/ENSMUSG00000079014/ENSMUSG00000025889/ENSMUSG00000060459/ENSMUSG00000078949/ENSMUSG00000026315/ENSMUSG00000026249/ENSMUSG00000027834/ENSMUSG00000020178/ENSMUSG00000071203/ENSMUSG00000051029/ENSMUSG00000019278/ENSMUSG00000028864/ENSMUSG00000004231/ENSMUSG00000079012	Slpi/Serpinf1/Mmp9/Naip2/Serpinb6b/Cdkn2d/Tfpi/Mical1/Tnfrsf1b/Serpina3g/Plaur/Naip6/Renbp/Lef1/Serpinb9b/Serpina3i/Snca/Kng2/R3hdml/Serpinb8/Serpine2/Serpini1/Adora2a/Naip5/Serpinb1b/Dpep1/Hgf/Pax2/Serpina3m	29
BP	GO:0050878	regulation of body fluid levels	35/858	250/15881	2.18E-07	7.03E-05	ENSMUSG00000024164/ENSMUSG00000031778/ENSMUSG00000024066/ENSMUSG00000042429/ENSMUSG00000057123/ENSMUSG00000032860/ENSMUSG00000021822/ENSMUSG00000027082/ENSMUSG00000028128/ENSMUSG00000021457/ENSMUSG00000022510/ENSMUSG00000032839/ENSMUSG00000006435/ENSMUSG00000022512/ENSMUSG00000029373/ENSMUSG00000082361/ENSMUSG00000032020/ENSMUSG00000074272/ENSMUSG00000032690/ENSMUSG00000002944/ENSMUSG00000060459/ENSMUSG00000026580/ENSMUSG00000041245/ENSMUSG00000020892/ENSMUSG00000027611/ENSMUSG00000026249/ENSMUSG00000068323/ENSMUSG00000020178/ENSMUSG00000063415/ENSMUSG00000020787/ENSMUSG00000006488/ENSMUSG00000050578/ENSMUSG00000021948/ENSMUSG00000004266/ENSMUSG00000044338	C3/Cx3cl1/Xdh/Adora1/Gja5/P2ry2/Plau/Tfpi/F3/Syk/Trp63/Trpc1/Neurl1a/Cldn1/Pf4/Btc/Ubash3b/Ceacam1/Oas2/Cd36/Kng2/Selp/Wnk3/Aloxe3/Procr/Serpine2/Slc4a5/Adora2a/Cyp26b1/P2rx1/Prl7a1/Mmp13/Prkcd/Ptpn6/Aplnr	35
BP	GO:2000116	regulation of cysteine-type endopeptidase activity	31/858	207/15881	2.37E-07	7.03E-05	ENSMUSG00000023030/ENSMUSG00000024778/ENSMUSG00000024066/ENSMUSG00000044303/ENSMUSG00000017737/ENSMUSG00000035873/ENSMUSG00000033538/ENSMUSG00000078945/ENSMUSG00000096472/ENSMUSG00000019997/ENSMUSG00000028128/ENSMUSG00000025507/ENSMUSG00000019823/ENSMUSG00000028599/ENSMUSG00000022510/ENSMUSG00000096727/ENSMUSG00000046223/ENSMUSG00000078942/ENSMUSG00000027985/ENSMUSG00000079017/ENSMUSG00000025889/ENSMUSG00000020340/ENSMUSG00000037860/ENSMUSG00000000120/ENSMUSG00000020178/ENSMUSG00000020787/ENSMUSG00000071203/ENSMUSG00000019278/ENSMUSG00000028864/ENSMUSG00000004231/ENSMUSG00000025888	Slc11a2/Fas/Xdh/Cdkn2a/Mmp9/Pawr/Casp4/Naip2/Cdkn2d/Ctgf/F3/Pidd1/Mical1/Tnfrsf1b/Trp63/Psmb9/Plaur/Naip6/Lef1/Ifi27l2a/Snca/Cyfip2/Aim2/Ngfr/Adora2a/P2rx1/Naip5/Dpep1/Hgf/Pax2/Casp1	31
BP	GO:0022408	negative regulation of cell-cell adhesion	25/858	146/15881	2.65E-07	7.03E-05	ENSMUSG00000024610/ENSMUSG00000029816/ENSMUSG00000044303/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000019850/ENSMUSG00000022676/ENSMUSG00000027985/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000076441/ENSMUSG00000032020/ENSMUSG00000039981/ENSMUSG00000074715/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000026249/ENSMUSG00000020178/ENSMUSG00000000706/ENSMUSG00000052013/ENSMUSG00000021948/ENSMUSG00000004266/ENSMUSG00000034652	Cd74/Gpnmb/Cdkn2a/Lgals3/Pawr/Pde5a/Tnfaip3/Snai2/Lef1/Cd80/Tnfsf18/Btn2a2/Ass1/Ubash3b/Zc3h12d/Ccl28/Ceacam1/Lrrc32/Serpine2/Adora2a/Btn1a1/Btla/Prkcd/Ptpn6/Cd300a	25
BP	GO:0042742	defense response to bacterium	27/858	167/15881	2.97E-07	7.03E-05	ENSMUSG00000017002/ENSMUSG00000061232/ENSMUSG00000016024/ENSMUSG00000020826/ENSMUSG00000078945/ENSMUSG00000069516/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000040253/ENSMUSG00000053175/ENSMUSG00000078942/ENSMUSG00000055994/ENSMUSG00000029298/ENSMUSG00000054072/ENSMUSG00000035692/ENSMUSG00000026177/ENSMUSG00000028268/ENSMUSG00000002944/ENSMUSG00000104713/ENSMUSG00000029371/ENSMUSG00000041515/ENSMUSG00000071203/ENSMUSG00000079164/ENSMUSG00000075370/ENSMUSG00000053318/ENSMUSG00000021948/ENSMUSG00000067773	Slpi/H2-K1/Lbp/Nos2/Naip2/Lyz2/Tlr2/Syk/Gbp7/Bcl3/Naip6/Nod2/Gbp9/Iigp1/Isg15/Slc11a1/Gbp3/Cd36/Gbp6/Cxcl5/Irf8/Naip5/Tlr5/Igll1/Slamf8/Prkcd/Defb41	27
BP	GO:0002548	monocyte chemotaxis	12/858	37/15881	3.03E-07	7.03E-05	ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000035373/ENSMUSG00000050335/ENSMUSG00000023913/ENSMUSG00000026166/ENSMUSG00000019122/ENSMUSG00000066755/ENSMUSG00000034855/ENSMUSG00000037362/ENSMUSG00000053318/ENSMUSG00000031780	Ccl2/Cx3cl1/Ccl7/Lgals3/Pla2g7/Ccl20/Ccl9/Tnfsf18/Cxcl10/Nov/Slamf8/Ccl17	12
BP	GO:0035458	cellular response to interferon-beta	12/858	37/15881	3.03E-07	7.03E-05	ENSMUSG00000069893/ENSMUSG00000054072/ENSMUSG00000028268/ENSMUSG00000048852/ENSMUSG00000104713/ENSMUSG00000034459/ENSMUSG00000037860/ENSMUSG00000068606/ENSMUSG00000054203/ENSMUSG00000078922/ENSMUSG00000058163/ENSMUSG00000078921	9930111J21Rik1/Iigp1/Gbp3/Gm12185/Gbp6/Ifit1/Aim2/Gm4841/Ifi205/Tgtp1/Gm5431/Tgtp2	12
BP	GO:0030593	neutrophil chemotaxis	16/858	66/15881	3.07E-07	7.03E-05	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000016024/ENSMUSG00000035373/ENSMUSG00000029082/ENSMUSG00000050335/ENSMUSG00000039621/ENSMUSG00000026166/ENSMUSG00000021457/ENSMUSG00000019122/ENSMUSG00000029373/ENSMUSG00000055994/ENSMUSG00000029371/ENSMUSG00000031780	Cd74/Cxcl1/Ccl2/Cx3cl1/Lbp/Ccl7/Bst1/Lgals3/Prex1/Ccl20/Syk/Ccl9/Pf4/Nod2/Cxcl5/Ccl17	16
BP	GO:0006691	leukotriene metabolic process	8/858	15/15881	3.22E-07	7.03E-05	ENSMUSG00000006344/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000026688/ENSMUSG00000003484/ENSMUSG00000074604/ENSMUSG00000041193/ENSMUSG00000060063	Ggt5/Tlr2/Syk/Mgst3/Cyp4f18/Mgst2/Pla2g5/Alox5ap	8
BP	GO:0097530	granulocyte migration	20/858	102/15881	4.44E-07	8.93E-05	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000016024/ENSMUSG00000035373/ENSMUSG00000029082/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000039621/ENSMUSG00000026166/ENSMUSG00000021457/ENSMUSG00000019122/ENSMUSG00000029373/ENSMUSG00000055994/ENSMUSG00000066755/ENSMUSG00000029371/ENSMUSG00000053318/ENSMUSG00000031780/ENSMUSG00000034652	Cd74/Cxcl1/Ccl2/Cx3cl1/Lbp/Ccl7/Bst1/Lgals3/Pawr/Prex1/Ccl20/Syk/Ccl9/Pf4/Nod2/Tnfsf18/Cxcl5/Slamf8/Ccl17/Cd300a	20
BP	GO:0097529	myeloid leukocyte migration	24/858	140/15881	4.48E-07	8.93E-05	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000016024/ENSMUSG00000035373/ENSMUSG00000029082/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000023913/ENSMUSG00000039621/ENSMUSG00000026166/ENSMUSG00000021457/ENSMUSG00000019122/ENSMUSG00000029373/ENSMUSG00000055994/ENSMUSG00000066755/ENSMUSG00000031520/ENSMUSG00000029371/ENSMUSG00000034855/ENSMUSG00000037362/ENSMUSG00000053318/ENSMUSG00000031780/ENSMUSG00000034652	Cd74/Cxcl1/Ccl2/Cx3cl1/Lbp/Ccl7/Bst1/Lgals3/Pawr/Pla2g7/Prex1/Ccl20/Syk/Ccl9/Pf4/Nod2/Tnfsf18/Vegfc/Cxcl5/Cxcl10/Nov/Slamf8/Ccl17/Cd300a	24
BP	GO:0031347	regulation of defense response	52/858	469/15881	6.51E-07	0.000124324454186619	ENSMUSG00000024164/ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000016024/ENSMUSG00000000753/ENSMUSG00000030921/ENSMUSG00000042677/ENSMUSG00000029082/ENSMUSG00000074151/ENSMUSG00000003541/ENSMUSG00000042429/ENSMUSG00000033538/ENSMUSG00000053965/ENSMUSG00000020826/ENSMUSG00000019850/ENSMUSG00000062300/ENSMUSG00000079685/ENSMUSG00000027995/ENSMUSG00000028599/ENSMUSG00000034023/ENSMUSG00000053475/ENSMUSG00000019122/ENSMUSG00000079363/ENSMUSG00000026068/ENSMUSG00000055994/ENSMUSG00000066755/ENSMUSG00000025889/ENSMUSG00000017969/ENSMUSG00000041193/ENSMUSG00000017830/ENSMUSG00000074272/ENSMUSG00000020641/ENSMUSG00000002944/ENSMUSG00000029371/ENSMUSG00000037860/ENSMUSG00000030468/ENSMUSG00000000791/ENSMUSG00000037362/ENSMUSG00000031712/ENSMUSG00000060063/ENSMUSG00000020178/ENSMUSG00000030107/ENSMUSG00000044258/ENSMUSG00000079164/ENSMUSG00000021322/ENSMUSG00000053318/ENSMUSG00000062157/ENSMUSG00000059588/ENSMUSG00000028864/ENSMUSG00000025888/ENSMUSG00000034652/ENSMUSG00000025279	C3/Cd74/Cxcl1/Lbp/Serpinf1/Trim30a/Zc3h12a/Bst1/Nlrc5/Ier3/Adora1/Casp4/Pde5a/Nos2/Tnfaip3/Nectin2/Ulbp1/Tlr2/Tnfrsf1b/Fancd2/Tnfaip6/Ccl9/Gbp4/Il18rap/Nod2/Tnfsf18/Snca/Ptgis/Pla2g5/Dhx58/Ceacam1/Rsad2/Cd36/Cxcl5/Aim2/Siglecg/Il12rb1/Nov/Il15/Alox5ap/Adora2a/Usp18/Ctla2a/Tlr5/Aoah/Slamf8/Ifnlr1/Calcrl/Hgf/Casp1/Cd300a/Dnase1l3	52
BP	GO:0001562	response to protozoan	11/858	33/15881	6.94E-07	0.000127320561383514	ENSMUSG00000003541/ENSMUSG00000040253/ENSMUSG00000053175/ENSMUSG00000029373/ENSMUSG00000029298/ENSMUSG00000054072/ENSMUSG00000026177/ENSMUSG00000028268/ENSMUSG00000104713/ENSMUSG00000041515/ENSMUSG00000034266	Ier3/Gbp7/Bcl3/Pf4/Gbp9/Iigp1/Slc11a1/Gbp3/Gbp6/Irf8/Batf	11
BP	GO:0006935	chemotaxis	50/858	446/15881	7.70E-07	0.000135903313202798	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000016024/ENSMUSG00000022995/ENSMUSG00000096188/ENSMUSG00000022636/ENSMUSG00000035373/ENSMUSG00000029082/ENSMUSG00000050335/ENSMUSG00000028039/ENSMUSG00000023913/ENSMUSG00000039621/ENSMUSG00000062991/ENSMUSG00000025207/ENSMUSG00000022676/ENSMUSG00000026166/ENSMUSG00000021457/ENSMUSG00000019122/ENSMUSG00000036585/ENSMUSG00000029373/ENSMUSG00000055994/ENSMUSG00000004151/ENSMUSG00000027985/ENSMUSG00000066755/ENSMUSG00000056486/ENSMUSG00000031520/ENSMUSG00000040026/ENSMUSG00000074715/ENSMUSG00000020340/ENSMUSG00000017724/ENSMUSG00000029371/ENSMUSG00000026442/ENSMUSG00000052516/ENSMUSG00000025427/ENSMUSG00000034855/ENSMUSG00000002489/ENSMUSG00000037362/ENSMUSG00000000120/ENSMUSG00000074115/ENSMUSG00000053318/ENSMUSG00000028602/ENSMUSG00000028864/ENSMUSG00000051379/ENSMUSG00000031780/ENSMUSG00000043953/ENSMUSG00000021948/ENSMUSG00000048251/ENSMUSG00000030707	Cd74/Cxcl1/Ccl2/Cx3cl1/Lbp/Enah/Cmtm4/Alcam/Ccl7/Bst1/Lgals3/Efna3/Pla2g7/Prex1/Nrg1/Sema4g/Snai2/Ccl20/Syk/Ccl9/Fgf1/Pf4/Nod2/Etv1/Lef1/Tnfsf18/Chn1/Vegfc/Saa3/Ccl28/Cyfip2/Etv4/Cxcl5/Nfasc/Robo2/Rnf165/Cxcl10/Tiam1/Nov/Ngfr/Saa1/Slamf8/Tnfrsf8/Hgf/Flrt3/Ccl17/Ccrl2/Prkcd/Bcl11b/Coro1a	50
BP	GO:0042330	taxis	50/858	448/15881	8.80E-07	0.000149504937037632	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000016024/ENSMUSG00000022995/ENSMUSG00000096188/ENSMUSG00000022636/ENSMUSG00000035373/ENSMUSG00000029082/ENSMUSG00000050335/ENSMUSG00000028039/ENSMUSG00000023913/ENSMUSG00000039621/ENSMUSG00000062991/ENSMUSG00000025207/ENSMUSG00000022676/ENSMUSG00000026166/ENSMUSG00000021457/ENSMUSG00000019122/ENSMUSG00000036585/ENSMUSG00000029373/ENSMUSG00000055994/ENSMUSG00000004151/ENSMUSG00000027985/ENSMUSG00000066755/ENSMUSG00000056486/ENSMUSG00000031520/ENSMUSG00000040026/ENSMUSG00000074715/ENSMUSG00000020340/ENSMUSG00000017724/ENSMUSG00000029371/ENSMUSG00000026442/ENSMUSG00000052516/ENSMUSG00000025427/ENSMUSG00000034855/ENSMUSG00000002489/ENSMUSG00000037362/ENSMUSG00000000120/ENSMUSG00000074115/ENSMUSG00000053318/ENSMUSG00000028602/ENSMUSG00000028864/ENSMUSG00000051379/ENSMUSG00000031780/ENSMUSG00000043953/ENSMUSG00000021948/ENSMUSG00000048251/ENSMUSG00000030707	Cd74/Cxcl1/Ccl2/Cx3cl1/Lbp/Enah/Cmtm4/Alcam/Ccl7/Bst1/Lgals3/Efna3/Pla2g7/Prex1/Nrg1/Sema4g/Snai2/Ccl20/Syk/Ccl9/Fgf1/Pf4/Nod2/Etv1/Lef1/Tnfsf18/Chn1/Vegfc/Saa3/Ccl28/Cyfip2/Etv4/Cxcl5/Nfasc/Robo2/Rnf165/Cxcl10/Tiam1/Nov/Ngfr/Saa1/Slamf8/Tnfrsf8/Hgf/Flrt3/Ccl17/Ccrl2/Prkcd/Bcl11b/Coro1a	50
BP	GO:0071346	cellular response to interferon-gamma	18/858	89/15881	1.03E-06	0.000169109125338634	ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000035373/ENSMUSG00000074151/ENSMUSG00000020826/ENSMUSG00000026166/ENSMUSG00000040253/ENSMUSG00000019122/ENSMUSG00000079363/ENSMUSG00000029298/ENSMUSG00000034438/ENSMUSG00000028268/ENSMUSG00000031504/ENSMUSG00000104713/ENSMUSG00000000791/ENSMUSG00000041515/ENSMUSG00000031780/ENSMUSG00000025888	Ccl2/Cx3cl1/Ccl7/Nlrc5/Nos2/Ccl20/Gbp7/Ccl9/Gbp4/Gbp9/Gbp8/Gbp3/Rab20/Gbp6/Il12rb1/Irf8/Ccl17/Casp1	18
BP	GO:0006942	regulation of striated muscle contraction	15/858	64/15881	1.14E-06	0.000173364212662983	ENSMUSG00000042677/ENSMUSG00000006457/ENSMUSG00000042429/ENSMUSG00000053965/ENSMUSG00000057123/ENSMUSG00000026576/ENSMUSG00000019997/ENSMUSG00000050541/ENSMUSG00000061603/ENSMUSG00000024065/ENSMUSG00000041695/ENSMUSG00000036570/ENSMUSG00000027470/ENSMUSG00000035458/ENSMUSG00000038239	Zc3h12a/Actn3/Adora1/Pde5a/Gja5/Atp1b1/Ctgf/Adra1b/Akap6/Ehd3/Kcnj2/Fxyd1/Mylk2/Tnni3/Hrc	15
BP	GO:1903038	negative regulation of leukocyte cell-cell adhesion	19/858	99/15881	1.21E-06	0.000173364212662983	ENSMUSG00000024610/ENSMUSG00000029816/ENSMUSG00000044303/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000076441/ENSMUSG00000039981/ENSMUSG00000074715/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000020178/ENSMUSG00000000706/ENSMUSG00000052013/ENSMUSG00000004266/ENSMUSG00000034652	Cd74/Gpnmb/Cdkn2a/Lgals3/Pawr/Pde5a/Cd80/Tnfsf18/Btn2a2/Ass1/Zc3h12d/Ccl28/Ceacam1/Lrrc32/Adora2a/Btn1a1/Btla/Ptpn6/Cd300a	19
BP	GO:0022407	regulation of cell-cell adhesion	38/858	304/15881	1.23E-06	0.000173364212662983	ENSMUSG00000024610/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000029816/ENSMUSG00000044303/ENSMUSG00000037440/ENSMUSG00000000732/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000019850/ENSMUSG00000022676/ENSMUSG00000021457/ENSMUSG00000027985/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000076441/ENSMUSG00000032020/ENSMUSG00000039981/ENSMUSG00000041351/ENSMUSG00000074715/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000026249/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000020178/ENSMUSG00000040329/ENSMUSG00000000706/ENSMUSG00000039323/ENSMUSG00000052013/ENSMUSG00000021948/ENSMUSG00000004266/ENSMUSG00000020325/ENSMUSG00000034652/ENSMUSG00000030707/ENSMUSG00000026117	Cd74/Ccl2/Cx3cl1/Gpnmb/Cdkn2a/Vnn1/Icosl/Lgals3/Pawr/Pde5a/Tnfaip3/Snai2/Syk/Lef1/Cd80/Tnfsf18/Btn2a2/Ass1/Ubash3b/Zc3h12d/Rap1gap/Ccl28/Ceacam1/Lrrc32/Serpine2/Il12rb1/Il15/Adora2a/Il7/Btn1a1/Igfbp2/Btla/Prkcd/Ptpn6/Fstl3/Cd300a/Coro1a/Zap70	38
BP	GO:0006936	muscle contraction	31/858	223/15881	1.24E-06	0.000173364212662983	ENSMUSG00000042677/ENSMUSG00000006457/ENSMUSG00000047250/ENSMUSG00000035873/ENSMUSG00000042429/ENSMUSG00000053965/ENSMUSG00000057123/ENSMUSG00000026576/ENSMUSG00000022144/ENSMUSG00000019997/ENSMUSG00000040907/ENSMUSG00000050541/ENSMUSG00000026251/ENSMUSG00000026253/ENSMUSG00000061603/ENSMUSG00000021070/ENSMUSG00000028834/ENSMUSG00000055632/ENSMUSG00000042451/ENSMUSG00000064329/ENSMUSG00000024065/ENSMUSG00000020787/ENSMUSG00000026418/ENSMUSG00000041695/ENSMUSG00000059588/ENSMUSG00000027071/ENSMUSG00000036570/ENSMUSG00000027470/ENSMUSG00000035458/ENSMUSG00000038239/ENSMUSG00000020081	Zc3h12a/Actn3/Ptgs1/Pawr/Adora1/Pde5a/Gja5/Atp1b1/Gdnf/Ctgf/Atp1a3/Adra1b/Chrnd/Chrng/Akap6/Bdkrb2/Trim63/Hmcn2/Mybph/Scn1a/Ehd3/P2rx1/Tnni1/Kcnj2/Calcrl/P2rx3/Fxyd1/Mylk2/Tnni3/Hrc/Tacr2	31
BP	GO:0003013	circulatory system process	43/858	365/15881	1.25E-06	0.000173364212662983	ENSMUSG00000031778/ENSMUSG00000059895/ENSMUSG00000027750/ENSMUSG00000042677/ENSMUSG00000026463/ENSMUSG00000038235/ENSMUSG00000028024/ENSMUSG00000003541/ENSMUSG00000047250/ENSMUSG00000042429/ENSMUSG00000037580/ENSMUSG00000053965/ENSMUSG00000057123/ENSMUSG00000020826/ENSMUSG00000032860/ENSMUSG00000026576/ENSMUSG00000029084/ENSMUSG00000019997/ENSMUSG00000024039/ENSMUSG00000040907/ENSMUSG00000050541/ENSMUSG00000003484/ENSMUSG00000061603/ENSMUSG00000031520/ENSMUSG00000074272/ENSMUSG00000002944/ENSMUSG00000024481/ENSMUSG00000021070/ENSMUSG00000041046/ENSMUSG00000064329/ENSMUSG00000068323/ENSMUSG00000024065/ENSMUSG00000028978/ENSMUSG00000020178/ENSMUSG00000020787/ENSMUSG00000035296/ENSMUSG00000026418/ENSMUSG00000041695/ENSMUSG00000036570/ENSMUSG00000031489/ENSMUSG00000035458/ENSMUSG00000038239/ENSMUSG00000020081	Cx3cl1/Ptp4a3/Postn/Zc3h12a/Atp2b4/F11r/Enpep/Ier3/Ptgs1/Adora1/Gch1/Pde5a/Gja5/Nos2/P2ry2/Atp1b1/Cd38/Ctgf/Cbs/Atp1a3/Adra1b/Cyp4f18/Akap6/Vegfc/Ceacam1/Cd36/Lvrn/Bdkrb2/Ramp3/Scn1a/Slc4a5/Ehd3/Nos3/Adora2a/P2rx1/Sgcg/Tnni1/Kcnj2/Fxyd1/Adrb3/Tnni3/Hrc/Tacr2	43
BP	GO:0009617	response to bacterium	47/858	416/15881	1.33E-06	0.00017943813373397	ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000017002/ENSMUSG00000061232/ENSMUSG00000016024/ENSMUSG00000024778/ENSMUSG00000042677/ENSMUSG00000028965/ENSMUSG00000037580/ENSMUSG00000020826/ENSMUSG00000078945/ENSMUSG00000019850/ENSMUSG00000032501/ENSMUSG00000069516/ENSMUSG00000027995/ENSMUSG00000028599/ENSMUSG00000021457/ENSMUSG00000040253/ENSMUSG00000053175/ENSMUSG00000029373/ENSMUSG00000078942/ENSMUSG00000055994/ENSMUSG00000029298/ENSMUSG00000075122/ENSMUSG00000054072/ENSMUSG00000035692/ENSMUSG00000008318/ENSMUSG00000026177/ENSMUSG00000025889/ENSMUSG00000028268/ENSMUSG00000015243/ENSMUSG00000002944/ENSMUSG00000104713/ENSMUSG00000070034/ENSMUSG00000029371/ENSMUSG00000034855/ENSMUSG00000028978/ENSMUSG00000000120/ENSMUSG00000041515/ENSMUSG00000071203/ENSMUSG00000079164/ENSMUSG00000075370/ENSMUSG00000053318/ENSMUSG00000028602/ENSMUSG00000021948/ENSMUSG00000025888/ENSMUSG00000067773	Cxcl1/Ccl2/Slpi/H2-K1/Lbp/Fas/Zc3h12a/Tnfrsf9/Gch1/Nos2/Naip2/Tnfaip3/Trib1/Lyz2/Tlr2/Tnfrsf1b/Syk/Gbp7/Bcl3/Pf4/Naip6/Nod2/Gbp9/Cd80/Iigp1/Isg15/Relt/Slc11a1/Snca/Gbp3/Abca1/Cd36/Gbp6/Sp110/Cxcl5/Cxcl10/Nos3/Ngfr/Irf8/Naip5/Tlr5/Igll1/Slamf8/Tnfrsf8/Prkcd/Casp1/Defb41	47
BP	GO:0050670	regulation of lymphocyte proliferation	27/858	182/15881	1.69E-06	0.00022198362143384	ENSMUSG00000024610/ENSMUSG00000029816/ENSMUSG00000023067/ENSMUSG00000044303/ENSMUSG00000000732/ENSMUSG00000029082/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000029084/ENSMUSG00000021457/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000039981/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000040329/ENSMUSG00000000706/ENSMUSG00000039323/ENSMUSG00000052013/ENSMUSG00000004266/ENSMUSG00000034652/ENSMUSG00000030707/ENSMUSG00000026117	Cd74/Gpnmb/Cdkn1a/Cdkn2a/Icosl/Bst1/Lgals3/Pawr/Pde5a/Cd38/Syk/Cd80/Tnfsf18/Btn2a2/Zc3h12d/Ceacam1/Lrrc32/Il12rb1/Il15/Il7/Btn1a1/Igfbp2/Btla/Ptpn6/Cd300a/Coro1a/Zap70	27
BP	GO:0006937	regulation of muscle contraction	21/858	121/15881	1.89E-06	0.000240633636531606	ENSMUSG00000042677/ENSMUSG00000006457/ENSMUSG00000047250/ENSMUSG00000035873/ENSMUSG00000042429/ENSMUSG00000053965/ENSMUSG00000057123/ENSMUSG00000026576/ENSMUSG00000019997/ENSMUSG00000050541/ENSMUSG00000061603/ENSMUSG00000024065/ENSMUSG00000020787/ENSMUSG00000026418/ENSMUSG00000041695/ENSMUSG00000059588/ENSMUSG00000036570/ENSMUSG00000027470/ENSMUSG00000035458/ENSMUSG00000038239/ENSMUSG00000020081	Zc3h12a/Actn3/Ptgs1/Pawr/Adora1/Pde5a/Gja5/Atp1b1/Ctgf/Adra1b/Akap6/Ehd3/P2rx1/Tnni1/Kcnj2/Calcrl/Fxyd1/Mylk2/Tnni3/Hrc/Tacr2	21
BP	GO:0032944	regulation of mononuclear cell proliferation	27/858	184/15881	2.10E-06	0.000260386556786972	ENSMUSG00000024610/ENSMUSG00000029816/ENSMUSG00000023067/ENSMUSG00000044303/ENSMUSG00000000732/ENSMUSG00000029082/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000029084/ENSMUSG00000021457/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000039981/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000040329/ENSMUSG00000000706/ENSMUSG00000039323/ENSMUSG00000052013/ENSMUSG00000004266/ENSMUSG00000034652/ENSMUSG00000030707/ENSMUSG00000026117	Cd74/Gpnmb/Cdkn1a/Cdkn2a/Icosl/Bst1/Lgals3/Pawr/Pde5a/Cd38/Syk/Cd80/Tnfsf18/Btn2a2/Zc3h12d/Ceacam1/Lrrc32/Il12rb1/Il15/Il7/Btn1a1/Igfbp2/Btla/Ptpn6/Cd300a/Coro1a/Zap70	27
BP	GO:0042832	defense response to protozoan	10/858	30/15881	2.25E-06	0.000269734057898988	ENSMUSG00000040253/ENSMUSG00000053175/ENSMUSG00000029373/ENSMUSG00000029298/ENSMUSG00000054072/ENSMUSG00000026177/ENSMUSG00000028268/ENSMUSG00000104713/ENSMUSG00000041515/ENSMUSG00000034266	Gbp7/Bcl3/Pf4/Gbp9/Iigp1/Slc11a1/Gbp3/Gbp6/Irf8/Batf	10
BP	GO:0008015	blood circulation	42/858	361/15881	2.29E-06	0.000269734057898988	ENSMUSG00000031778/ENSMUSG00000059895/ENSMUSG00000027750/ENSMUSG00000042677/ENSMUSG00000026463/ENSMUSG00000038235/ENSMUSG00000028024/ENSMUSG00000003541/ENSMUSG00000047250/ENSMUSG00000042429/ENSMUSG00000037580/ENSMUSG00000053965/ENSMUSG00000057123/ENSMUSG00000020826/ENSMUSG00000032860/ENSMUSG00000026576/ENSMUSG00000029084/ENSMUSG00000019997/ENSMUSG00000024039/ENSMUSG00000040907/ENSMUSG00000050541/ENSMUSG00000003484/ENSMUSG00000061603/ENSMUSG00000031520/ENSMUSG00000074272/ENSMUSG00000002944/ENSMUSG00000024481/ENSMUSG00000021070/ENSMUSG00000064329/ENSMUSG00000068323/ENSMUSG00000024065/ENSMUSG00000028978/ENSMUSG00000020178/ENSMUSG00000020787/ENSMUSG00000035296/ENSMUSG00000026418/ENSMUSG00000041695/ENSMUSG00000036570/ENSMUSG00000031489/ENSMUSG00000035458/ENSMUSG00000038239/ENSMUSG00000020081	Cx3cl1/Ptp4a3/Postn/Zc3h12a/Atp2b4/F11r/Enpep/Ier3/Ptgs1/Adora1/Gch1/Pde5a/Gja5/Nos2/P2ry2/Atp1b1/Cd38/Ctgf/Cbs/Atp1a3/Adra1b/Cyp4f18/Akap6/Vegfc/Ceacam1/Cd36/Lvrn/Bdkrb2/Scn1a/Slc4a5/Ehd3/Nos3/Adora2a/P2rx1/Sgcg/Tnni1/Kcnj2/Fxyd1/Adrb3/Tnni3/Hrc/Tacr2	42
BP	GO:0050865	regulation of cell activation	48/858	439/15881	2.60E-06	0.000298397855416916	ENSMUSG00000024610/ENSMUSG00000035385/ENSMUSG00000029816/ENSMUSG00000016024/ENSMUSG00000023067/ENSMUSG00000024778/ENSMUSG00000044303/ENSMUSG00000037440/ENSMUSG00000000732/ENSMUSG00000029082/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000019850/ENSMUSG00000029084/ENSMUSG00000062300/ENSMUSG00000019997/ENSMUSG00000079685/ENSMUSG00000034023/ENSMUSG00000021457/ENSMUSG00000055994/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000025889/ENSMUSG00000041193/ENSMUSG00000032020/ENSMUSG00000039981/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000026580/ENSMUSG00000026249/ENSMUSG00000031548/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000020178/ENSMUSG00000040329/ENSMUSG00000063415/ENSMUSG00000044258/ENSMUSG00000000706/ENSMUSG00000039323/ENSMUSG00000075370/ENSMUSG00000052013/ENSMUSG00000021948/ENSMUSG00000004266/ENSMUSG00000034652/ENSMUSG00000030707/ENSMUSG00000026117	Cd74/Ccl2/Gpnmb/Lbp/Cdkn1a/Fas/Cdkn2a/Vnn1/Icosl/Bst1/Lgals3/Pawr/Pde5a/Tnfaip3/Cd38/Nectin2/Ctgf/Ulbp1/Fancd2/Syk/Nod2/Cd80/Tnfsf18/Btn2a2/Snca/Pla2g5/Ubash3b/Zc3h12d/Ceacam1/Lrrc32/Selp/Serpine2/Sfrp1/Il12rb1/Il15/Adora2a/Il7/Cyp26b1/Ctla2a/Btn1a1/Igfbp2/Igll1/Btla/Prkcd/Ptpn6/Cd300a/Coro1a/Zap70	48
BP	GO:0071621	granulocyte chemotaxis	17/858	86/15881	2.86E-06	0.000314568211123084	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000016024/ENSMUSG00000035373/ENSMUSG00000029082/ENSMUSG00000050335/ENSMUSG00000039621/ENSMUSG00000026166/ENSMUSG00000021457/ENSMUSG00000019122/ENSMUSG00000029373/ENSMUSG00000055994/ENSMUSG00000066755/ENSMUSG00000029371/ENSMUSG00000031780	Cd74/Cxcl1/Ccl2/Cx3cl1/Lbp/Ccl7/Bst1/Lgals3/Prex1/Ccl20/Syk/Ccl9/Pf4/Nod2/Tnfsf18/Cxcl5/Ccl17	17
BP	GO:0070663	regulation of leukocyte proliferation	27/858	187/15881	2.88E-06	0.000314568211123084	ENSMUSG00000024610/ENSMUSG00000029816/ENSMUSG00000023067/ENSMUSG00000044303/ENSMUSG00000000732/ENSMUSG00000029082/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000029084/ENSMUSG00000021457/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000039981/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000040329/ENSMUSG00000000706/ENSMUSG00000039323/ENSMUSG00000052013/ENSMUSG00000004266/ENSMUSG00000034652/ENSMUSG00000030707/ENSMUSG00000026117	Cd74/Gpnmb/Cdkn1a/Cdkn2a/Icosl/Bst1/Lgals3/Pawr/Pde5a/Cd38/Syk/Cd80/Tnfsf18/Btn2a2/Zc3h12d/Ceacam1/Lrrc32/Il12rb1/Il15/Il7/Btn1a1/Igfbp2/Btla/Ptpn6/Cd300a/Coro1a/Zap70	27
BP	GO:0042110	T cell activation	43/858	378/15881	3.14E-06	0.000332999720706009	ENSMUSG00000024610/ENSMUSG00000035385/ENSMUSG00000029816/ENSMUSG00000024778/ENSMUSG00000029570/ENSMUSG00000023927/ENSMUSG00000044303/ENSMUSG00000037440/ENSMUSG00000000732/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000039621/ENSMUSG00000034023/ENSMUSG00000021457/ENSMUSG00000053175/ENSMUSG00000027985/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000026177/ENSMUSG00000049109/ENSMUSG00000039981/ENSMUSG00000074272/ENSMUSG00000020641/ENSMUSG00000090958/ENSMUSG00000036587/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000020178/ENSMUSG00000040329/ENSMUSG00000063415/ENSMUSG00000044258/ENSMUSG00000000706/ENSMUSG00000039323/ENSMUSG00000052013/ENSMUSG00000048251/ENSMUSG00000004266/ENSMUSG00000021998/ENSMUSG00000034652/ENSMUSG00000030707/ENSMUSG00000034266/ENSMUSG00000026117	Cd74/Ccl2/Gpnmb/Fas/Lfng/Satb1/Cdkn2a/Vnn1/Icosl/Lgals3/Pawr/Pde5a/Prex1/Fancd2/Syk/Bcl3/Lef1/Cd80/Tnfsf18/Btn2a2/Slc11a1/Themis/Zc3h12d/Ceacam1/Rsad2/Lrrc32/Fut7/Il12rb1/Il15/Adora2a/Il7/Cyp26b1/Ctla2a/Btn1a1/Igfbp2/Btla/Bcl11b/Ptpn6/Lcp1/Cd300a/Coro1a/Batf/Zap70	43
BP	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	27/858	188/15881	3.19E-06	0.000332999720706009	ENSMUSG00000023030/ENSMUSG00000024778/ENSMUSG00000024066/ENSMUSG00000044303/ENSMUSG00000017737/ENSMUSG00000033538/ENSMUSG00000078945/ENSMUSG00000096472/ENSMUSG00000019997/ENSMUSG00000028128/ENSMUSG00000025507/ENSMUSG00000019823/ENSMUSG00000028599/ENSMUSG00000022510/ENSMUSG00000046223/ENSMUSG00000078942/ENSMUSG00000027985/ENSMUSG00000079017/ENSMUSG00000025889/ENSMUSG00000000120/ENSMUSG00000020178/ENSMUSG00000020787/ENSMUSG00000071203/ENSMUSG00000019278/ENSMUSG00000028864/ENSMUSG00000004231/ENSMUSG00000025888	Slc11a2/Fas/Xdh/Cdkn2a/Mmp9/Casp4/Naip2/Cdkn2d/Ctgf/F3/Pidd1/Mical1/Tnfrsf1b/Trp63/Plaur/Naip6/Lef1/Ifi27l2a/Snca/Ngfr/Adora2a/P2rx1/Naip5/Dpep1/Hgf/Pax2/Casp1	27
BP	GO:0002685	regulation of leukocyte migration	24/858	156/15881	3.31E-06	0.000337249425959055	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000016024/ENSMUSG00000029082/ENSMUSG00000017737/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000042429/ENSMUSG00000023913/ENSMUSG00000026166/ENSMUSG00000027995/ENSMUSG00000029373/ENSMUSG00000055994/ENSMUSG00000066755/ENSMUSG00000031520/ENSMUSG00000074715/ENSMUSG00000026580/ENSMUSG00000029371/ENSMUSG00000034855/ENSMUSG00000037362/ENSMUSG00000053318/ENSMUSG00000034652	Cd74/Cxcl1/Ccl2/Cx3cl1/Lbp/Bst1/Mmp9/Lgals3/Pawr/Adora1/Pla2g7/Ccl20/Tlr2/Pf4/Nod2/Tnfsf18/Vegfc/Ccl28/Selp/Cxcl5/Cxcl10/Nov/Slamf8/Cd300a	24
BP	GO:0055117	regulation of cardiac muscle contraction	13/858	53/15881	3.42E-06	0.000341319570521802	ENSMUSG00000042677/ENSMUSG00000042429/ENSMUSG00000053965/ENSMUSG00000057123/ENSMUSG00000026576/ENSMUSG00000019997/ENSMUSG00000050541/ENSMUSG00000061603/ENSMUSG00000024065/ENSMUSG00000041695/ENSMUSG00000036570/ENSMUSG00000035458/ENSMUSG00000038239	Zc3h12a/Adora1/Pde5a/Gja5/Atp1b1/Ctgf/Adra1b/Akap6/Ehd3/Kcnj2/Fxyd1/Tnni3/Hrc	13
BP	GO:0050727	regulation of inflammatory response	33/858	258/15881	3.71E-06	0.000361653508798864	ENSMUSG00000024164/ENSMUSG00000016024/ENSMUSG00000000753/ENSMUSG00000042677/ENSMUSG00000029082/ENSMUSG00000003541/ENSMUSG00000042429/ENSMUSG00000033538/ENSMUSG00000053965/ENSMUSG00000020826/ENSMUSG00000019850/ENSMUSG00000027995/ENSMUSG00000028599/ENSMUSG00000034023/ENSMUSG00000053475/ENSMUSG00000019122/ENSMUSG00000055994/ENSMUSG00000066755/ENSMUSG00000025889/ENSMUSG00000017969/ENSMUSG00000041193/ENSMUSG00000030468/ENSMUSG00000037362/ENSMUSG00000060063/ENSMUSG00000020178/ENSMUSG00000030107/ENSMUSG00000044258/ENSMUSG00000021322/ENSMUSG00000053318/ENSMUSG00000059588/ENSMUSG00000028864/ENSMUSG00000025888/ENSMUSG00000025279	C3/Lbp/Serpinf1/Zc3h12a/Bst1/Ier3/Adora1/Casp4/Pde5a/Nos2/Tnfaip3/Tlr2/Tnfrsf1b/Fancd2/Tnfaip6/Ccl9/Nod2/Tnfsf18/Snca/Ptgis/Pla2g5/Siglecg/Nov/Alox5ap/Adora2a/Usp18/Ctla2a/Aoah/Slamf8/Calcrl/Hgf/Casp1/Dnase1l3	33
BP	GO:0019370	leukotriene biosynthetic process	6/858	10/15881	4.26E-06	0.000406611537396964	ENSMUSG00000006344/ENSMUSG00000021457/ENSMUSG00000026688/ENSMUSG00000074604/ENSMUSG00000041193/ENSMUSG00000060063	Ggt5/Syk/Mgst3/Mgst2/Pla2g5/Alox5ap	6
BP	GO:0006941	striated muscle contraction	21/858	128/15881	4.78E-06	0.000447693376838909	ENSMUSG00000042677/ENSMUSG00000006457/ENSMUSG00000042429/ENSMUSG00000053965/ENSMUSG00000057123/ENSMUSG00000026576/ENSMUSG00000019997/ENSMUSG00000040907/ENSMUSG00000050541/ENSMUSG00000026251/ENSMUSG00000026253/ENSMUSG00000061603/ENSMUSG00000042451/ENSMUSG00000064329/ENSMUSG00000024065/ENSMUSG00000026418/ENSMUSG00000041695/ENSMUSG00000036570/ENSMUSG00000027470/ENSMUSG00000035458/ENSMUSG00000038239	Zc3h12a/Actn3/Adora1/Pde5a/Gja5/Atp1b1/Ctgf/Atp1a3/Adra1b/Chrnd/Chrng/Akap6/Mybph/Scn1a/Ehd3/Tnni1/Kcnj2/Fxyd1/Mylk2/Tnni3/Hrc	21
BP	GO:0046651	lymphocyte proliferation	31/858	238/15881	4.98E-06	0.00045658805184466	ENSMUSG00000024610/ENSMUSG00000029816/ENSMUSG00000023067/ENSMUSG00000023927/ENSMUSG00000044303/ENSMUSG00000000732/ENSMUSG00000029082/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000029084/ENSMUSG00000021457/ENSMUSG00000027985/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000026177/ENSMUSG00000039981/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000040329/ENSMUSG00000000706/ENSMUSG00000039323/ENSMUSG00000052013/ENSMUSG00000021948/ENSMUSG00000004266/ENSMUSG00000034652/ENSMUSG00000030707/ENSMUSG00000026117	Cd74/Gpnmb/Cdkn1a/Satb1/Cdkn2a/Icosl/Bst1/Lgals3/Pawr/Pde5a/Cd38/Syk/Lef1/Cd80/Tnfsf18/Btn2a2/Slc11a1/Zc3h12d/Ceacam1/Lrrc32/Il12rb1/Il15/Il7/Btn1a1/Igfbp2/Btla/Prkcd/Ptpn6/Cd300a/Coro1a/Zap70	31
BP	GO:0051249	regulation of lymphocyte activation	39/858	335/15881	5.17E-06	0.000464882194057896	ENSMUSG00000024610/ENSMUSG00000035385/ENSMUSG00000029816/ENSMUSG00000023067/ENSMUSG00000024778/ENSMUSG00000044303/ENSMUSG00000037440/ENSMUSG00000000732/ENSMUSG00000029082/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000019850/ENSMUSG00000029084/ENSMUSG00000079685/ENSMUSG00000034023/ENSMUSG00000021457/ENSMUSG00000055994/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000039981/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000031548/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000020178/ENSMUSG00000040329/ENSMUSG00000063415/ENSMUSG00000044258/ENSMUSG00000000706/ENSMUSG00000039323/ENSMUSG00000075370/ENSMUSG00000052013/ENSMUSG00000004266/ENSMUSG00000034652/ENSMUSG00000030707/ENSMUSG00000026117	Cd74/Ccl2/Gpnmb/Cdkn1a/Fas/Cdkn2a/Vnn1/Icosl/Bst1/Lgals3/Pawr/Pde5a/Tnfaip3/Cd38/Ulbp1/Fancd2/Syk/Nod2/Cd80/Tnfsf18/Btn2a2/Zc3h12d/Ceacam1/Lrrc32/Sfrp1/Il12rb1/Il15/Adora2a/Il7/Cyp26b1/Ctla2a/Btn1a1/Igfbp2/Igll1/Btla/Ptpn6/Cd300a/Coro1a/Zap70	39
BP	GO:0051250	negative regulation of lymphocyte activation	20/858	119/15881	5.49E-06	0.000484555701703014	ENSMUSG00000024610/ENSMUSG00000029816/ENSMUSG00000024778/ENSMUSG00000044303/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000019850/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000039981/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000031548/ENSMUSG00000020178/ENSMUSG00000000706/ENSMUSG00000052013/ENSMUSG00000004266/ENSMUSG00000034652	Cd74/Gpnmb/Fas/Cdkn2a/Lgals3/Pawr/Pde5a/Tnfaip3/Cd80/Tnfsf18/Btn2a2/Zc3h12d/Ceacam1/Lrrc32/Sfrp1/Adora2a/Btn1a1/Btla/Ptpn6/Cd300a	20
BP	GO:0032943	mononuclear cell proliferation	31/858	240/15881	5.92E-06	0.00051253118978055	ENSMUSG00000024610/ENSMUSG00000029816/ENSMUSG00000023067/ENSMUSG00000023927/ENSMUSG00000044303/ENSMUSG00000000732/ENSMUSG00000029082/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000029084/ENSMUSG00000021457/ENSMUSG00000027985/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000026177/ENSMUSG00000039981/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000040329/ENSMUSG00000000706/ENSMUSG00000039323/ENSMUSG00000052013/ENSMUSG00000021948/ENSMUSG00000004266/ENSMUSG00000034652/ENSMUSG00000030707/ENSMUSG00000026117	Cd74/Gpnmb/Cdkn1a/Satb1/Cdkn2a/Icosl/Bst1/Lgals3/Pawr/Pde5a/Cd38/Syk/Lef1/Cd80/Tnfsf18/Btn2a2/Slc11a1/Zc3h12d/Ceacam1/Lrrc32/Il12rb1/Il15/Il7/Btn1a1/Igfbp2/Btla/Prkcd/Ptpn6/Cd300a/Coro1a/Zap70	31
BP	GO:0050868	negative regulation of T cell activation	17/858	91/15881	6.40E-06	0.000543617089267539	ENSMUSG00000024610/ENSMUSG00000029816/ENSMUSG00000044303/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000039981/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000020178/ENSMUSG00000000706/ENSMUSG00000052013/ENSMUSG00000004266/ENSMUSG00000034652	Cd74/Gpnmb/Cdkn2a/Lgals3/Pawr/Pde5a/Cd80/Tnfsf18/Btn2a2/Zc3h12d/Ceacam1/Lrrc32/Adora2a/Btn1a1/Btla/Ptpn6/Cd300a	17
BP	GO:0045071	negative regulation of viral genome replication	12/858	48/15881	6.57E-06	0.000547761946633226	ENSMUSG00000017002/ENSMUSG00000046718/ENSMUSG00000042677/ENSMUSG00000066800/ENSMUSG00000001166/ENSMUSG00000035692/ENSMUSG00000074272/ENSMUSG00000032690/ENSMUSG00000020641/ENSMUSG00000059108/ENSMUSG00000029605/ENSMUSG00000032661	Slpi/Bst2/Zc3h12a/Rnasel/Oas1c/Isg15/Ceacam1/Oas2/Rsad2/Ifitm6/Oas1b/Oas3	12
BP	GO:1903037	regulation of leukocyte cell-cell adhesion	29/858	219/15881	7.22E-06	0.000591013280582534	ENSMUSG00000024610/ENSMUSG00000035385/ENSMUSG00000029816/ENSMUSG00000044303/ENSMUSG00000037440/ENSMUSG00000000732/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000021457/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000076441/ENSMUSG00000039981/ENSMUSG00000074715/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000020178/ENSMUSG00000040329/ENSMUSG00000000706/ENSMUSG00000039323/ENSMUSG00000052013/ENSMUSG00000004266/ENSMUSG00000034652/ENSMUSG00000030707/ENSMUSG00000026117	Cd74/Ccl2/Gpnmb/Cdkn2a/Vnn1/Icosl/Lgals3/Pawr/Pde5a/Syk/Cd80/Tnfsf18/Btn2a2/Ass1/Zc3h12d/Ccl28/Ceacam1/Lrrc32/Il12rb1/Il15/Adora2a/Il7/Btn1a1/Igfbp2/Btla/Ptpn6/Cd300a/Coro1a/Zap70	29
BP	GO:0046456	icosanoid biosynthetic process	10/858	34/15881	8.05E-06	0.000647325607203432	ENSMUSG00000024610/ENSMUSG00000047250/ENSMUSG00000006344/ENSMUSG00000050737/ENSMUSG00000021457/ENSMUSG00000026688/ENSMUSG00000074604/ENSMUSG00000017969/ENSMUSG00000041193/ENSMUSG00000060063	Cd74/Ptgs1/Ggt5/Ptges/Syk/Mgst3/Mgst2/Ptgis/Pla2g5/Alox5ap	10
BP	GO:0003012	muscle system process	36/858	305/15881	8.70E-06	0.000688133234172638	ENSMUSG00000026185/ENSMUSG00000042677/ENSMUSG00000026463/ENSMUSG00000006457/ENSMUSG00000047250/ENSMUSG00000035873/ENSMUSG00000031626/ENSMUSG00000042429/ENSMUSG00000053965/ENSMUSG00000057123/ENSMUSG00000026576/ENSMUSG00000022144/ENSMUSG00000019997/ENSMUSG00000040907/ENSMUSG00000050541/ENSMUSG00000026251/ENSMUSG00000026253/ENSMUSG00000061603/ENSMUSG00000021070/ENSMUSG00000028834/ENSMUSG00000055632/ENSMUSG00000042451/ENSMUSG00000064329/ENSMUSG00000024065/ENSMUSG00000002489/ENSMUSG00000028978/ENSMUSG00000020787/ENSMUSG00000026418/ENSMUSG00000041695/ENSMUSG00000059588/ENSMUSG00000027071/ENSMUSG00000036570/ENSMUSG00000027470/ENSMUSG00000035458/ENSMUSG00000038239/ENSMUSG00000020081	Igfbp5/Zc3h12a/Atp2b4/Actn3/Ptgs1/Pawr/Sorbs2/Adora1/Pde5a/Gja5/Atp1b1/Gdnf/Ctgf/Atp1a3/Adra1b/Chrnd/Chrng/Akap6/Bdkrb2/Trim63/Hmcn2/Mybph/Scn1a/Ehd3/Tiam1/Nos3/P2rx1/Tnni1/Kcnj2/Calcrl/P2rx3/Fxyd1/Mylk2/Tnni3/Hrc/Tacr2	36
BP	GO:0030595	leukocyte chemotaxis	23/858	155/15881	9.75E-06	0.000750098118624512	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000016024/ENSMUSG00000035373/ENSMUSG00000029082/ENSMUSG00000050335/ENSMUSG00000023913/ENSMUSG00000039621/ENSMUSG00000026166/ENSMUSG00000021457/ENSMUSG00000019122/ENSMUSG00000029373/ENSMUSG00000055994/ENSMUSG00000066755/ENSMUSG00000031520/ENSMUSG00000029371/ENSMUSG00000034855/ENSMUSG00000037362/ENSMUSG00000053318/ENSMUSG00000031780/ENSMUSG00000030707	Cd74/Cxcl1/Ccl2/Cx3cl1/Lbp/Ccl7/Bst1/Lgals3/Pla2g7/Prex1/Ccl20/Syk/Ccl9/Pf4/Nod2/Tnfsf18/Vegfc/Cxcl5/Cxcl10/Nov/Slamf8/Ccl17/Coro1a	23
BP	GO:1901570	fatty acid derivative biosynthetic process	11/858	42/15881	9.81E-06	0.000750098118624512	ENSMUSG00000024610/ENSMUSG00000047250/ENSMUSG00000006344/ENSMUSG00000050737/ENSMUSG00000021457/ENSMUSG00000026688/ENSMUSG00000074604/ENSMUSG00000017969/ENSMUSG00000041193/ENSMUSG00000060063/ENSMUSG00000007908	Cd74/Ptgs1/Ggt5/Ptges/Syk/Mgst3/Mgst2/Ptgis/Pla2g5/Alox5ap/Hmgcll1	11
BP	GO:0070661	leukocyte proliferation	31/858	247/15881	1.07E-05	0.000802908155121352	ENSMUSG00000024610/ENSMUSG00000029816/ENSMUSG00000023067/ENSMUSG00000023927/ENSMUSG00000044303/ENSMUSG00000000732/ENSMUSG00000029082/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000029084/ENSMUSG00000021457/ENSMUSG00000027985/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000026177/ENSMUSG00000039981/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000040329/ENSMUSG00000000706/ENSMUSG00000039323/ENSMUSG00000052013/ENSMUSG00000021948/ENSMUSG00000004266/ENSMUSG00000034652/ENSMUSG00000030707/ENSMUSG00000026117	Cd74/Gpnmb/Cdkn1a/Satb1/Cdkn2a/Icosl/Bst1/Lgals3/Pawr/Pde5a/Cd38/Syk/Lef1/Cd80/Tnfsf18/Btn2a2/Slc11a1/Zc3h12d/Ceacam1/Lrrc32/Il12rb1/Il15/Il7/Btn1a1/Igfbp2/Btla/Prkcd/Ptpn6/Cd300a/Coro1a/Zap70	31
BP	GO:0050866	negative regulation of cell activation	23/858	157/15881	1.21E-05	0.000894677453366934	ENSMUSG00000024610/ENSMUSG00000029816/ENSMUSG00000024778/ENSMUSG00000044303/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000019850/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000032020/ENSMUSG00000039981/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000026249/ENSMUSG00000031548/ENSMUSG00000020178/ENSMUSG00000000706/ENSMUSG00000052013/ENSMUSG00000021948/ENSMUSG00000004266/ENSMUSG00000034652	Cd74/Gpnmb/Fas/Cdkn2a/Lgals3/Pawr/Pde5a/Tnfaip3/Cd80/Tnfsf18/Btn2a2/Ubash3b/Zc3h12d/Ceacam1/Lrrc32/Serpine2/Sfrp1/Adora2a/Btn1a1/Btla/Prkcd/Ptpn6/Cd300a	23
BP	GO:0050863	regulation of T cell activation	30/858	237/15881	1.25E-05	0.000905445009573326	ENSMUSG00000024610/ENSMUSG00000035385/ENSMUSG00000029816/ENSMUSG00000044303/ENSMUSG00000037440/ENSMUSG00000000732/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000034023/ENSMUSG00000021457/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000039981/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000020178/ENSMUSG00000040329/ENSMUSG00000063415/ENSMUSG00000044258/ENSMUSG00000000706/ENSMUSG00000039323/ENSMUSG00000052013/ENSMUSG00000004266/ENSMUSG00000034652/ENSMUSG00000030707/ENSMUSG00000026117	Cd74/Ccl2/Gpnmb/Cdkn2a/Vnn1/Icosl/Lgals3/Pawr/Pde5a/Fancd2/Syk/Cd80/Tnfsf18/Btn2a2/Zc3h12d/Ceacam1/Lrrc32/Il12rb1/Il15/Adora2a/Il7/Cyp26b1/Ctla2a/Btn1a1/Igfbp2/Btla/Ptpn6/Cd300a/Coro1a/Zap70	30
BP	GO:0042129	regulation of T cell proliferation	21/858	136/15881	1.26E-05	0.000905445009573326	ENSMUSG00000029816/ENSMUSG00000044303/ENSMUSG00000000732/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000021457/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000039981/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000000706/ENSMUSG00000039323/ENSMUSG00000052013/ENSMUSG00000004266/ENSMUSG00000030707/ENSMUSG00000026117	Gpnmb/Cdkn2a/Icosl/Lgals3/Pawr/Pde5a/Syk/Cd80/Tnfsf18/Btn2a2/Zc3h12d/Ceacam1/Lrrc32/Il12rb1/Il15/Btn1a1/Igfbp2/Btla/Ptpn6/Coro1a/Zap70	21
BP	GO:0070098	chemokine-mediated signaling pathway	10/858	36/15881	1.41E-05	0.000997089774295324	ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000035373/ENSMUSG00000026166/ENSMUSG00000019122/ENSMUSG00000029373/ENSMUSG00000029371/ENSMUSG00000034855/ENSMUSG00000031780	Cxcl1/Ccl2/Cx3cl1/Ccl7/Ccl20/Ccl9/Pf4/Cxcl5/Cxcl10/Ccl17	10
BP	GO:0050900	leukocyte migration	31/858	252/15881	1.60E-05	0.00111112566403895	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000016024/ENSMUSG00000035373/ENSMUSG00000029082/ENSMUSG00000017737/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000042429/ENSMUSG00000023913/ENSMUSG00000039621/ENSMUSG00000026166/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000019122/ENSMUSG00000029373/ENSMUSG00000055994/ENSMUSG00000066755/ENSMUSG00000031520/ENSMUSG00000074715/ENSMUSG00000026580/ENSMUSG00000029371/ENSMUSG00000036587/ENSMUSG00000034855/ENSMUSG00000037362/ENSMUSG00000053318/ENSMUSG00000031780/ENSMUSG00000034652/ENSMUSG00000030707	Cd74/Cxcl1/Ccl2/Cx3cl1/Lbp/Ccl7/Bst1/Mmp9/Lgals3/Pawr/Adora1/Pla2g7/Prex1/Ccl20/Tlr2/Syk/Ccl9/Pf4/Nod2/Tnfsf18/Vegfc/Ccl28/Selp/Cxcl5/Fut7/Cxcl10/Nov/Slamf8/Ccl17/Cd300a/Coro1a	31
BP	GO:0002694	regulation of leukocyte activation	43/858	404/15881	1.68E-05	0.00113843736732177	ENSMUSG00000024610/ENSMUSG00000035385/ENSMUSG00000029816/ENSMUSG00000016024/ENSMUSG00000023067/ENSMUSG00000024778/ENSMUSG00000044303/ENSMUSG00000037440/ENSMUSG00000000732/ENSMUSG00000029082/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000019850/ENSMUSG00000029084/ENSMUSG00000062300/ENSMUSG00000079685/ENSMUSG00000034023/ENSMUSG00000021457/ENSMUSG00000055994/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000025889/ENSMUSG00000041193/ENSMUSG00000039981/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000031548/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000020178/ENSMUSG00000040329/ENSMUSG00000063415/ENSMUSG00000044258/ENSMUSG00000000706/ENSMUSG00000039323/ENSMUSG00000075370/ENSMUSG00000052013/ENSMUSG00000004266/ENSMUSG00000034652/ENSMUSG00000030707/ENSMUSG00000026117	Cd74/Ccl2/Gpnmb/Lbp/Cdkn1a/Fas/Cdkn2a/Vnn1/Icosl/Bst1/Lgals3/Pawr/Pde5a/Tnfaip3/Cd38/Nectin2/Ulbp1/Fancd2/Syk/Nod2/Cd80/Tnfsf18/Btn2a2/Snca/Pla2g5/Zc3h12d/Ceacam1/Lrrc32/Sfrp1/Il12rb1/Il15/Adora2a/Il7/Cyp26b1/Ctla2a/Btn1a1/Igfbp2/Igll1/Btla/Ptpn6/Cd300a/Coro1a/Zap70	43
BP	GO:0032787	monocarboxylic acid metabolic process	47/858	457/15881	1.69E-05	0.00113843736732177	ENSMUSG00000024164/ENSMUSG00000024610/ENSMUSG00000060600/ENSMUSG00000053279/ENSMUSG00000037440/ENSMUSG00000006457/ENSMUSG00000021196/ENSMUSG00000003541/ENSMUSG00000047250/ENSMUSG00000006344/ENSMUSG00000027332/ENSMUSG00000019577/ENSMUSG00000056973/ENSMUSG00000020333/ENSMUSG00000050737/ENSMUSG00000042010/ENSMUSG00000020010/ENSMUSG00000023963/ENSMUSG00000028497/ENSMUSG00000019806/ENSMUSG00000029167/ENSMUSG00000025002/ENSMUSG00000033327/ENSMUSG00000033715/ENSMUSG00000027068/ENSMUSG00000003484/ENSMUSG00000021947/ENSMUSG00000025889/ENSMUSG00000017969/ENSMUSG00000031725/ENSMUSG00000055782/ENSMUSG00000002944/ENSMUSG00000052974/ENSMUSG00000020892/ENSMUSG00000032262/ENSMUSG00000027412/ENSMUSG00000026435/ENSMUSG00000090145/ENSMUSG00000090700/ENSMUSG00000060063/ENSMUSG00000032066/ENSMUSG00000063415/ENSMUSG00000025955/ENSMUSG00000010651/ENSMUSG00000002475/ENSMUSG00000054545/ENSMUSG00000025197	C3/Cd74/Eno3/Aldh1a1/Vnn1/Actn3/Pfkp/Ier3/Ptgs1/Ggt5/Ivd/Pdk4/Ces1d/Acsl6/Ptges/Acacb/Vnn3/Cyp39a1/Hacd4/Aig1/Ppargc1a/Cyp2c55/Tnxb/Akr1c14/Dhrs9/Cyp4f18/Cryl1/Snca/Ptgis/Ces1f/Abcd2/Cd36/Cyp2f2/Aloxe3/Elovl4/Lpin3/Slc45a3/Ugt1a6b/Cyp4f40/Alox5ap/Bco2/Cyp26b1/Akr1cl/Acaa1b/Abhd3/Ugt1a6a/Cyp2c23	47
BP	GO:0050851	antigen receptor-mediated signaling pathway	19/858	118/15881	1.77E-05	0.0011733303986913	ENSMUSG00000042677/ENSMUSG00000000732/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000029084/ENSMUSG00000062300/ENSMUSG00000021457/ENSMUSG00000005057/ENSMUSG00000053216/ENSMUSG00000049109/ENSMUSG00000000706/ENSMUSG00000075370/ENSMUSG00000109713/ENSMUSG00000021108/ENSMUSG00000002699/ENSMUSG00000024696/ENSMUSG00000004266/ENSMUSG00000034652/ENSMUSG00000026117	Zc3h12a/Icosl/Lgals3/Pawr/Cd38/Nectin2/Syk/Sh2b2/Btn2a2/Themis/Btn1a1/Igll1/Pvrig/Prkch/Lcp2/Lpxn/Ptpn6/Cd300a/Zap70	19
BP	GO:0007159	leukocyte cell-cell adhesion	30/858	243/15881	2.03E-05	0.0013331880123945	ENSMUSG00000024610/ENSMUSG00000035385/ENSMUSG00000029816/ENSMUSG00000044303/ENSMUSG00000037440/ENSMUSG00000000732/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000021457/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000076441/ENSMUSG00000039981/ENSMUSG00000074715/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000026580/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000020178/ENSMUSG00000040329/ENSMUSG00000000706/ENSMUSG00000039323/ENSMUSG00000052013/ENSMUSG00000004266/ENSMUSG00000034652/ENSMUSG00000030707/ENSMUSG00000026117	Cd74/Ccl2/Gpnmb/Cdkn2a/Vnn1/Icosl/Lgals3/Pawr/Pde5a/Syk/Cd80/Tnfsf18/Btn2a2/Ass1/Zc3h12d/Ccl28/Ceacam1/Lrrc32/Selp/Il12rb1/Il15/Adora2a/Il7/Btn1a1/Igfbp2/Btla/Ptpn6/Cd300a/Coro1a/Zap70	30
BP	GO:0043900	regulation of multi-organism process	38/858	343/15881	2.12E-05	0.00137015496136892	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000017002/ENSMUSG00000046718/ENSMUSG00000016024/ENSMUSG00000030921/ENSMUSG00000042677/ENSMUSG00000053965/ENSMUSG00000066800/ENSMUSG00000020826/ENSMUSG00000032860/ENSMUSG00000019850/ENSMUSG00000021822/ENSMUSG00000032501/ENSMUSG00000030220/ENSMUSG00000062300/ENSMUSG00000027995/ENSMUSG00000079363/ENSMUSG00000001166/ENSMUSG00000055994/ENSMUSG00000027985/ENSMUSG00000035692/ENSMUSG00000017830/ENSMUSG00000074272/ENSMUSG00000032690/ENSMUSG00000020641/ENSMUSG00000002944/ENSMUSG00000059108/ENSMUSG00000029605/ENSMUSG00000029371/ENSMUSG00000079173/ENSMUSG00000032661/ENSMUSG00000037860/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000041515/ENSMUSG00000000266/ENSMUSG00000062157	Cd74/Cxcl1/Slpi/Bst2/Lbp/Trim30a/Zc3h12a/Pde5a/Rnasel/Nos2/P2ry2/Tnfaip3/Plau/Trib1/Arhgdib/Nectin2/Tlr2/Gbp4/Oas1c/Nod2/Lef1/Isg15/Dhx58/Ceacam1/Oas2/Rsad2/Cd36/Ifitm6/Oas1b/Cxcl5/Zan/Oas3/Aim2/Il12rb1/Il15/Irf8/Mid2/Ifnlr1	38
BP	GO:0044057	regulation of system process	42/858	395/15881	2.15E-05	0.00137015496136892	ENSMUSG00000031778/ENSMUSG00000032561/ENSMUSG00000026185/ENSMUSG00000042677/ENSMUSG00000022150/ENSMUSG00000026463/ENSMUSG00000006457/ENSMUSG00000047250/ENSMUSG00000035873/ENSMUSG00000042429/ENSMUSG00000037580/ENSMUSG00000053965/ENSMUSG00000057123/ENSMUSG00000062991/ENSMUSG00000026576/ENSMUSG00000029084/ENSMUSG00000034394/ENSMUSG00000019997/ENSMUSG00000050541/ENSMUSG00000061603/ENSMUSG00000028834/ENSMUSG00000041245/ENSMUSG00000027674/ENSMUSG00000024065/ENSMUSG00000037362/ENSMUSG00000028978/ENSMUSG00000000120/ENSMUSG00000020178/ENSMUSG00000020787/ENSMUSG00000049044/ENSMUSG00000026418/ENSMUSG00000041695/ENSMUSG00000028602/ENSMUSG00000059588/ENSMUSG00000027071/ENSMUSG00000028864/ENSMUSG00000050578/ENSMUSG00000036570/ENSMUSG00000027470/ENSMUSG00000035458/ENSMUSG00000038239/ENSMUSG00000020081	Cx3cl1/Acpp/Igfbp5/Zc3h12a/Dab2/Atp2b4/Actn3/Ptgs1/Pawr/Adora1/Gch1/Pde5a/Gja5/Nrg1/Atp1b1/Cd38/Lif/Ctgf/Adra1b/Akap6/Trim63/Wnk3/Pex5l/Ehd3/Nov/Nos3/Ngfr/Adora2a/P2rx1/Rapgef4/Tnni1/Kcnj2/Tnfrsf8/Calcrl/P2rx3/Hgf/Mmp13/Fxyd1/Mylk2/Tnni3/Hrc/Tacr2	42
BP	GO:0043901	negative regulation of multi-organism process	22/858	152/15881	2.26E-05	0.00141679455304625	ENSMUSG00000017002/ENSMUSG00000046718/ENSMUSG00000016024/ENSMUSG00000042677/ENSMUSG00000066800/ENSMUSG00000019850/ENSMUSG00000032501/ENSMUSG00000030220/ENSMUSG00000027995/ENSMUSG00000001166/ENSMUSG00000055994/ENSMUSG00000035692/ENSMUSG00000017830/ENSMUSG00000074272/ENSMUSG00000032690/ENSMUSG00000020641/ENSMUSG00000002944/ENSMUSG00000059108/ENSMUSG00000029605/ENSMUSG00000032661/ENSMUSG00000041515/ENSMUSG00000000266	Slpi/Bst2/Lbp/Zc3h12a/Rnasel/Tnfaip3/Trib1/Arhgdib/Tlr2/Oas1c/Nod2/Isg15/Dhx58/Ceacam1/Oas2/Rsad2/Cd36/Ifitm6/Oas1b/Oas3/Irf8/Mid2	22
BP	GO:0042136	neurotransmitter biosynthetic process	15/858	81/15881	2.47E-05	0.00153312538579441	ENSMUSG00000042677/ENSMUSG00000026463/ENSMUSG00000006764/ENSMUSG00000037580/ENSMUSG00000020826/ENSMUSG00000079685/ENSMUSG00000027995/ENSMUSG00000017969/ENSMUSG00000076441/ENSMUSG00000002944/ENSMUSG00000006235/ENSMUSG00000040046/ENSMUSG00000028978/ENSMUSG00000079164/ENSMUSG00000007034	Zc3h12a/Atp2b4/Tph2/Gch1/Nos2/Ulbp1/Tlr2/Ptgis/Ass1/Cd36/Epor/Tph1/Nos3/Tlr5/Slc44a4	15
BP	GO:0055065	metal ion homeostasis	49/858	492/15881	2.62E-05	0.00160205833694635	ENSMUSG00000012428/ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000003617/ENSMUSG00000023030/ENSMUSG00000066152/ENSMUSG00000022032/ENSMUSG00000026463/ENSMUSG00000035873/ENSMUSG00000021831/ENSMUSG00000042429/ENSMUSG00000032860/ENSMUSG00000026576/ENSMUSG00000029084/ENSMUSG00000040907/ENSMUSG00000032839/ENSMUSG00000050541/ENSMUSG00000035694/ENSMUSG00000044026/ENSMUSG00000038403/ENSMUSG00000036019/ENSMUSG00000022416/ENSMUSG00000027994/ENSMUSG00000026177/ENSMUSG00000061603/ENSMUSG00000025889/ENSMUSG00000041329/ENSMUSG00000032020/ENSMUSG00000026822/ENSMUSG00000074715/ENSMUSG00000028825/ENSMUSG00000002944/ENSMUSG00000060459/ENSMUSG00000021070/ENSMUSG00000063354/ENSMUSG00000041046/ENSMUSG00000006235/ENSMUSG00000034855/ENSMUSG00000020178/ENSMUSG00000029716/ENSMUSG00000030523/ENSMUSG00000004266/ENSMUSG00000036570/ENSMUSG00000035458/ENSMUSG00000030707/ENSMUSG00000044338/ENSMUSG00000038239/ENSMUSG00000021337/ENSMUSG00000043051	Steap4/Cxcl1/Ccl2/Cp/Slc11a2/Slc31a2/Scara5/Atp2b4/Pawr/Ero1l/Adora1/P2ry2/Atp1b1/Cd38/Atp1a3/Trpc1/Adra1b/Caps2/Slc35g1/Hfe2/Tmtc2/Cacna1i/Mcub/Slc11a1/Akap6/Snca/Atp1b2/Ubash3b/Lcn2/Ccl28/Rhd/Cd36/Kng2/Bdkrb2/Slc39a4/Ramp3/Epor/Cxcl10/Adora2a/Tfr2/Trpm1/Ptpn6/Fxyd1/Tnni3/Coro1a/Aplnr/Hrc/Scgn/Disc1	49
BP	GO:0002768	immune response-regulating cell surface receptor signaling pathway	21/858	143/15881	2.76E-05	0.00166064117495872	ENSMUSG00000042677/ENSMUSG00000000732/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000029084/ENSMUSG00000062300/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000005057/ENSMUSG00000053216/ENSMUSG00000049109/ENSMUSG00000000706/ENSMUSG00000075370/ENSMUSG00000052013/ENSMUSG00000109713/ENSMUSG00000021108/ENSMUSG00000002699/ENSMUSG00000024696/ENSMUSG00000004266/ENSMUSG00000034652/ENSMUSG00000026117	Zc3h12a/Icosl/Lgals3/Pawr/Cd38/Nectin2/Tlr2/Syk/Sh2b2/Btn2a2/Themis/Btn1a1/Igll1/Btla/Pvrig/Prkch/Lcp2/Lpxn/Ptpn6/Cd300a/Zap70	21
BP	GO:0002764	immune response-regulating signaling pathway	30/858	247/15881	2.79E-05	0.00166064117495872	ENSMUSG00000016024/ENSMUSG00000030921/ENSMUSG00000042677/ENSMUSG00000000732/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000019850/ENSMUSG00000029084/ENSMUSG00000062300/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000055994/ENSMUSG00000032359/ENSMUSG00000005057/ENSMUSG00000053216/ENSMUSG00000049109/ENSMUSG00000017830/ENSMUSG00000020641/ENSMUSG00000002944/ENSMUSG00000000706/ENSMUSG00000079164/ENSMUSG00000075370/ENSMUSG00000052013/ENSMUSG00000109713/ENSMUSG00000021108/ENSMUSG00000002699/ENSMUSG00000024696/ENSMUSG00000004266/ENSMUSG00000034652/ENSMUSG00000026117	Lbp/Trim30a/Zc3h12a/Icosl/Lgals3/Pawr/Tnfaip3/Cd38/Nectin2/Tlr2/Syk/Nod2/Ctsh/Sh2b2/Btn2a2/Themis/Dhx58/Rsad2/Cd36/Btn1a1/Tlr5/Igll1/Btla/Pvrig/Prkch/Lcp2/Lpxn/Ptpn6/Cd300a/Zap70	30
BP	GO:0032102	negative regulation of response to external stimulus	31/858	260/15881	2.97E-05	0.00174327104677398	ENSMUSG00000000753/ENSMUSG00000042677/ENSMUSG00000003541/ENSMUSG00000042429/ENSMUSG00000019850/ENSMUSG00000025207/ENSMUSG00000021822/ENSMUSG00000032501/ENSMUSG00000027082/ENSMUSG00000022676/ENSMUSG00000028599/ENSMUSG00000053475/ENSMUSG00000055994/ENSMUSG00000115388/ENSMUSG00000017969/ENSMUSG00000041193/ENSMUSG00000032020/ENSMUSG00000017830/ENSMUSG00000074272/ENSMUSG00000060459/ENSMUSG00000026249/ENSMUSG00000052516/ENSMUSG00000030468/ENSMUSG00000037362/ENSMUSG00000020178/ENSMUSG00000044258/ENSMUSG00000021322/ENSMUSG00000053318/ENSMUSG00000059588/ENSMUSG00000028864/ENSMUSG00000021948	Serpinf1/Zc3h12a/Ier3/Adora1/Tnfaip3/Sema4g/Plau/Trib1/Tfpi/Snai2/Tnfrsf1b/Tnfaip6/Nod2/Eppk1/Ptgis/Pla2g5/Ubash3b/Dhx58/Ceacam1/Kng2/Serpine2/Robo2/Siglecg/Nov/Adora2a/Ctla2a/Aoah/Slamf8/Calcrl/Hgf/Prkcd	31
BP	GO:0090257	regulation of muscle system process	25/858	189/15881	3.09E-05	0.00179395859923885	ENSMUSG00000026185/ENSMUSG00000042677/ENSMUSG00000026463/ENSMUSG00000006457/ENSMUSG00000047250/ENSMUSG00000035873/ENSMUSG00000042429/ENSMUSG00000053965/ENSMUSG00000057123/ENSMUSG00000026576/ENSMUSG00000019997/ENSMUSG00000050541/ENSMUSG00000061603/ENSMUSG00000028834/ENSMUSG00000024065/ENSMUSG00000028978/ENSMUSG00000020787/ENSMUSG00000026418/ENSMUSG00000041695/ENSMUSG00000059588/ENSMUSG00000036570/ENSMUSG00000027470/ENSMUSG00000035458/ENSMUSG00000038239/ENSMUSG00000020081	Igfbp5/Zc3h12a/Atp2b4/Actn3/Ptgs1/Pawr/Adora1/Pde5a/Gja5/Atp1b1/Ctgf/Adra1b/Akap6/Trim63/Ehd3/Nos3/P2rx1/Tnni1/Kcnj2/Calcrl/Fxyd1/Mylk2/Tnni3/Hrc/Tacr2	25
BP	GO:0060048	cardiac muscle contraction	16/858	93/15881	3.48E-05	0.00199330800472934	ENSMUSG00000042677/ENSMUSG00000042429/ENSMUSG00000053965/ENSMUSG00000057123/ENSMUSG00000026576/ENSMUSG00000019997/ENSMUSG00000040907/ENSMUSG00000050541/ENSMUSG00000061603/ENSMUSG00000064329/ENSMUSG00000024065/ENSMUSG00000026418/ENSMUSG00000041695/ENSMUSG00000036570/ENSMUSG00000035458/ENSMUSG00000038239	Zc3h12a/Adora1/Pde5a/Gja5/Atp1b1/Ctgf/Atp1a3/Adra1b/Akap6/Scn1a/Ehd3/Tnni1/Kcnj2/Fxyd1/Tnni3/Hrc	16
BP	GO:0042098	T cell proliferation	23/858	168/15881	3.67E-05	0.00205844052277085	ENSMUSG00000029816/ENSMUSG00000023927/ENSMUSG00000044303/ENSMUSG00000000732/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000021457/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000026177/ENSMUSG00000039981/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000000706/ENSMUSG00000039323/ENSMUSG00000052013/ENSMUSG00000004266/ENSMUSG00000030707/ENSMUSG00000026117	Gpnmb/Satb1/Cdkn2a/Icosl/Lgals3/Pawr/Pde5a/Syk/Cd80/Tnfsf18/Btn2a2/Slc11a1/Zc3h12d/Ceacam1/Lrrc32/Il12rb1/Il15/Btn1a1/Igfbp2/Btla/Ptpn6/Coro1a/Zap70	23
BP	GO:0030003	cellular cation homeostasis	48/858	485/15881	3.71E-05	0.00205844052277085	ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000003617/ENSMUSG00000023030/ENSMUSG00000066152/ENSMUSG00000022032/ENSMUSG00000026463/ENSMUSG00000035873/ENSMUSG00000021831/ENSMUSG00000032860/ENSMUSG00000026576/ENSMUSG00000029084/ENSMUSG00000040907/ENSMUSG00000032839/ENSMUSG00000050541/ENSMUSG00000044026/ENSMUSG00000038403/ENSMUSG00000060961/ENSMUSG00000022416/ENSMUSG00000027994/ENSMUSG00000026177/ENSMUSG00000061603/ENSMUSG00000025889/ENSMUSG00000041329/ENSMUSG00000032020/ENSMUSG00000031504/ENSMUSG00000074715/ENSMUSG00000002944/ENSMUSG00000060459/ENSMUSG00000023032/ENSMUSG00000021070/ENSMUSG00000063354/ENSMUSG00000041046/ENSMUSG00000006235/ENSMUSG00000068323/ENSMUSG00000034855/ENSMUSG00000029716/ENSMUSG00000038600/ENSMUSG00000030523/ENSMUSG00000053318/ENSMUSG00000004266/ENSMUSG00000036570/ENSMUSG00000035458/ENSMUSG00000030707/ENSMUSG00000044338/ENSMUSG00000038239/ENSMUSG00000021337/ENSMUSG00000043051	Cxcl1/Ccl2/Cp/Slc11a2/Slc31a2/Scara5/Atp2b4/Pawr/Ero1l/P2ry2/Atp1b1/Cd38/Atp1a3/Trpc1/Adra1b/Slc35g1/Hfe2/Slc4a4/Cacna1i/Mcub/Slc11a1/Akap6/Snca/Atp1b2/Ubash3b/Rab20/Ccl28/Cd36/Kng2/Slc4a8/Bdkrb2/Slc39a4/Ramp3/Epor/Slc4a5/Cxcl10/Tfr2/Atp6v0a4/Trpm1/Slamf8/Ptpn6/Fxyd1/Tnni3/Coro1a/Aplnr/Hrc/Scgn/Disc1	48
BP	GO:0050858	negative regulation of antigen receptor-mediated signaling pathway	7/858	19/15881	3.73E-05	0.00205844052277085	ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000053216/ENSMUSG00000109713/ENSMUSG00000024696/ENSMUSG00000004266/ENSMUSG00000034652	Lgals3/Pawr/Btn2a2/Pvrig/Lpxn/Ptpn6/Cd300a	7
BP	GO:0042130	negative regulation of T cell proliferation	12/858	57/15881	4.26E-05	0.00229737713698819	ENSMUSG00000029816/ENSMUSG00000044303/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000075122/ENSMUSG00000053216/ENSMUSG00000039981/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000000706/ENSMUSG00000052013/ENSMUSG00000004266	Gpnmb/Cdkn2a/Pawr/Pde5a/Cd80/Btn2a2/Zc3h12d/Ceacam1/Lrrc32/Btn1a1/Btla/Ptpn6	12
BP	GO:0071674	mononuclear cell migration	12/858	57/15881	4.26E-05	0.00229737713698819	ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000035373/ENSMUSG00000050335/ENSMUSG00000023913/ENSMUSG00000026166/ENSMUSG00000019122/ENSMUSG00000066755/ENSMUSG00000034855/ENSMUSG00000037362/ENSMUSG00000053318/ENSMUSG00000031780	Ccl2/Cx3cl1/Ccl7/Lgals3/Pla2g7/Ccl20/Ccl9/Tnfsf18/Cxcl10/Nov/Slamf8/Ccl17	12
BP	GO:0045861	negative regulation of proteolysis	32/858	278/15881	4.46E-05	0.00237804532103481	ENSMUSG00000017002/ENSMUSG00000000753/ENSMUSG00000044303/ENSMUSG00000017737/ENSMUSG00000078945/ENSMUSG00000042842/ENSMUSG00000096472/ENSMUSG00000027082/ENSMUSG00000019823/ENSMUSG00000028599/ENSMUSG00000041481/ENSMUSG00000046223/ENSMUSG00000078942/ENSMUSG00000031387/ENSMUSG00000027985/ENSMUSG00000021403/ENSMUSG00000079014/ENSMUSG00000025889/ENSMUSG00000060459/ENSMUSG00000078949/ENSMUSG00000026315/ENSMUSG00000026249/ENSMUSG00000027834/ENSMUSG00000020178/ENSMUSG00000044258/ENSMUSG00000071203/ENSMUSG00000051029/ENSMUSG00000019278/ENSMUSG00000028864/ENSMUSG00000004231/ENSMUSG00000079012/ENSMUSG00000060579	Slpi/Serpinf1/Cdkn2a/Mmp9/Naip2/Serpinb6b/Cdkn2d/Tfpi/Mical1/Tnfrsf1b/Serpina3g/Plaur/Naip6/Renbp/Lef1/Serpinb9b/Serpina3i/Snca/Kng2/R3hdml/Serpinb8/Serpine2/Serpini1/Adora2a/Ctla2a/Naip5/Serpinb1b/Dpep1/Hgf/Pax2/Serpina3m/Fhit	32
BP	GO:0002429	immune response-activating cell surface receptor signaling pathway	20/858	137/15881	4.63E-05	0.0024417914537119	ENSMUSG00000042677/ENSMUSG00000000732/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000029084/ENSMUSG00000062300/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000005057/ENSMUSG00000053216/ENSMUSG00000049109/ENSMUSG00000000706/ENSMUSG00000075370/ENSMUSG00000109713/ENSMUSG00000021108/ENSMUSG00000002699/ENSMUSG00000024696/ENSMUSG00000004266/ENSMUSG00000034652/ENSMUSG00000026117	Zc3h12a/Icosl/Lgals3/Pawr/Cd38/Nectin2/Tlr2/Syk/Sh2b2/Btn2a2/Themis/Btn1a1/Igll1/Pvrig/Prkch/Lcp2/Lpxn/Ptpn6/Cd300a/Zap70	20
BP	GO:0050728	negative regulation of inflammatory response	18/858	116/15881	4.84E-05	0.00252352323242011	ENSMUSG00000000753/ENSMUSG00000042677/ENSMUSG00000003541/ENSMUSG00000042429/ENSMUSG00000019850/ENSMUSG00000028599/ENSMUSG00000053475/ENSMUSG00000055994/ENSMUSG00000017969/ENSMUSG00000041193/ENSMUSG00000030468/ENSMUSG00000037362/ENSMUSG00000020178/ENSMUSG00000044258/ENSMUSG00000021322/ENSMUSG00000053318/ENSMUSG00000059588/ENSMUSG00000028864	Serpinf1/Zc3h12a/Ier3/Adora1/Tnfaip3/Tnfrsf1b/Tnfaip6/Nod2/Ptgis/Pla2g5/Siglecg/Nov/Adora2a/Ctla2a/Aoah/Slamf8/Calcrl/Hgf	18
BP	GO:0072593	reactive oxygen species metabolic process	28/858	230/15881	4.90E-05	0.00252377207245588	ENSMUSG00000029380/ENSMUSG00000023067/ENSMUSG00000030921/ENSMUSG00000042677/ENSMUSG00000024066/ENSMUSG00000026463/ENSMUSG00000003541/ENSMUSG00000037580/ENSMUSG00000039621/ENSMUSG00000020826/ENSMUSG00000019577/ENSMUSG00000021822/ENSMUSG00000019997/ENSMUSG00000079685/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000024039/ENSMUSG00000025889/ENSMUSG00000017969/ENSMUSG00000076441/ENSMUSG00000002944/ENSMUSG00000006235/ENSMUSG00000028978/ENSMUSG00000032066/ENSMUSG00000000120/ENSMUSG00000079164/ENSMUSG00000004231/ENSMUSG00000021948	Cxcl1/Cdkn1a/Trim30a/Zc3h12a/Xdh/Atp2b4/Ier3/Gch1/Prex1/Nos2/Pdk4/Plau/Ctgf/Ulbp1/Tlr2/Syk/Cbs/Snca/Ptgis/Ass1/Cd36/Epor/Nos3/Bco2/Ngfr/Tlr5/Pax2/Prkcd	28
BP	GO:0016042	lipid catabolic process	29/858	244/15881	5.62E-05	0.0028641673164529	ENSMUSG00000031877/ENSMUSG00000016194/ENSMUSG00000031886/ENSMUSG00000057074/ENSMUSG00000042429/ENSMUSG00000023913/ENSMUSG00000027332/ENSMUSG00000056973/ENSMUSG00000042010/ENSMUSG00000023963/ENSMUSG00000002847/ENSMUSG00000019806/ENSMUSG00000071047/ENSMUSG00000003484/ENSMUSG00000074604/ENSMUSG00000041193/ENSMUSG00000062826/ENSMUSG00000031725/ENSMUSG00000055782/ENSMUSG00000061825/ENSMUSG00000027412/ENSMUSG00000030825/ENSMUSG00000032066/ENSMUSG00000063415/ENSMUSG00000010651/ENSMUSG00000050097/ENSMUSG00000036834/ENSMUSG00000002475/ENSMUSG00000021948	Ces2g/Hsd11b1/Ces2e/Ces1g/Adora1/Pla2g7/Ivd/Ces1d/Acacb/Cyp39a1/Pla1a/Aig1/Ces1a/Cyp4f18/Mgst2/Pla2g5/Ces2f/Ces1f/Abcd2/Ces2c/Lpin3/Hsd17b14/Bco2/Cyp26b1/Acaa1b/Ces2b/Plch1/Abhd3/Prkcd	29
BP	GO:0006631	fatty acid metabolic process	34/858	307/15881	5.73E-05	0.00288850487619805	ENSMUSG00000024164/ENSMUSG00000024610/ENSMUSG00000047250/ENSMUSG00000006344/ENSMUSG00000027332/ENSMUSG00000019577/ENSMUSG00000056973/ENSMUSG00000020333/ENSMUSG00000050737/ENSMUSG00000042010/ENSMUSG00000028497/ENSMUSG00000019806/ENSMUSG00000029167/ENSMUSG00000025002/ENSMUSG00000033327/ENSMUSG00000033715/ENSMUSG00000003484/ENSMUSG00000021947/ENSMUSG00000025889/ENSMUSG00000017969/ENSMUSG00000031725/ENSMUSG00000055782/ENSMUSG00000002944/ENSMUSG00000052974/ENSMUSG00000020892/ENSMUSG00000032262/ENSMUSG00000027412/ENSMUSG00000026435/ENSMUSG00000090700/ENSMUSG00000060063/ENSMUSG00000025955/ENSMUSG00000010651/ENSMUSG00000002475/ENSMUSG00000025197	C3/Cd74/Ptgs1/Ggt5/Ivd/Pdk4/Ces1d/Acsl6/Ptges/Acacb/Hacd4/Aig1/Ppargc1a/Cyp2c55/Tnxb/Akr1c14/Cyp4f18/Cryl1/Snca/Ptgis/Ces1f/Abcd2/Cd36/Cyp2f2/Aloxe3/Elovl4/Lpin3/Slc45a3/Cyp4f40/Alox5ap/Akr1cl/Acaa1b/Abhd3/Cyp2c23	34
BP	GO:0032945	negative regulation of mononuclear cell proliferation	13/858	68/15881	6.02E-05	0.00296571992427505	ENSMUSG00000029816/ENSMUSG00000044303/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000075122/ENSMUSG00000053216/ENSMUSG00000039981/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000000706/ENSMUSG00000052013/ENSMUSG00000004266/ENSMUSG00000034652	Gpnmb/Cdkn2a/Pawr/Pde5a/Cd80/Btn2a2/Zc3h12d/Ceacam1/Lrrc32/Btn1a1/Btla/Ptpn6/Cd300a	13
BP	GO:0050672	negative regulation of lymphocyte proliferation	13/858	68/15881	6.02E-05	0.00296571992427505	ENSMUSG00000029816/ENSMUSG00000044303/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000075122/ENSMUSG00000053216/ENSMUSG00000039981/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000000706/ENSMUSG00000052013/ENSMUSG00000004266/ENSMUSG00000034652	Gpnmb/Cdkn2a/Pawr/Pde5a/Cd80/Btn2a2/Zc3h12d/Ceacam1/Lrrc32/Btn1a1/Btla/Ptpn6/Cd300a	13
BP	GO:0002683	negative regulation of immune system process	39/858	373/15881	6.08E-05	0.00296571992427505	ENSMUSG00000023367/ENSMUSG00000024610/ENSMUSG00000029810/ENSMUSG00000029816/ENSMUSG00000030921/ENSMUSG00000024778/ENSMUSG00000044303/ENSMUSG00000074151/ENSMUSG00000050335/ENSMUSG00000049577/ENSMUSG00000035873/ENSMUSG00000042429/ENSMUSG00000053965/ENSMUSG00000019850/ENSMUSG00000032501/ENSMUSG00000007805/ENSMUSG00000029373/ENSMUSG00000055994/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000032020/ENSMUSG00000017830/ENSMUSG00000039981/ENSMUSG00000074715/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000031548/ENSMUSG00000037362/ENSMUSG00000020178/ENSMUSG00000000706/ENSMUSG00000052013/ENSMUSG00000109713/ENSMUSG00000053318/ENSMUSG00000024696/ENSMUSG00000004266/ENSMUSG00000020325/ENSMUSG00000034652/ENSMUSG00000070524	Tmem176a/Cd74/Tmem176b/Gpnmb/Trim30a/Fas/Cdkn2a/Nlrc5/Lgals3/Zfpm1/Pawr/Adora1/Pde5a/Tnfaip3/Trib1/Twist2/Pf4/Nod2/Cd80/Tnfsf18/Btn2a2/Ubash3b/Dhx58/Zc3h12d/Ccl28/Ceacam1/Lrrc32/Sfrp1/Nov/Adora2a/Btn1a1/Btla/Pvrig/Slamf8/Lpxn/Ptpn6/Fstl3/Cd300a/Fcrlb	39
BP	GO:0002695	negative regulation of leukocyte activation	20/858	140/15881	6.34E-05	0.0030265076324846	ENSMUSG00000024610/ENSMUSG00000029816/ENSMUSG00000024778/ENSMUSG00000044303/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000019850/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000039981/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000031548/ENSMUSG00000020178/ENSMUSG00000000706/ENSMUSG00000052013/ENSMUSG00000004266/ENSMUSG00000034652	Cd74/Gpnmb/Fas/Cdkn2a/Lgals3/Pawr/Pde5a/Tnfaip3/Cd80/Tnfsf18/Btn2a2/Zc3h12d/Ceacam1/Lrrc32/Sfrp1/Adora2a/Btn1a1/Btla/Ptpn6/Cd300a	20
BP	GO:0008217	regulation of blood pressure	20/858	140/15881	6.34E-05	0.0030265076324846	ENSMUSG00000027750/ENSMUSG00000038235/ENSMUSG00000028024/ENSMUSG00000003541/ENSMUSG00000047250/ENSMUSG00000042429/ENSMUSG00000037580/ENSMUSG00000057123/ENSMUSG00000020826/ENSMUSG00000050541/ENSMUSG00000003484/ENSMUSG00000031520/ENSMUSG00000002944/ENSMUSG00000024481/ENSMUSG00000021070/ENSMUSG00000068323/ENSMUSG00000028978/ENSMUSG00000020787/ENSMUSG00000031489/ENSMUSG00000035458	Postn/F11r/Enpep/Ier3/Ptgs1/Adora1/Gch1/Gja5/Nos2/Adra1b/Cyp4f18/Vegfc/Cd36/Lvrn/Bdkrb2/Slc4a5/Nos3/P2rx1/Adrb3/Tnni3	20
BP	GO:0006873	cellular ion homeostasis	48/858	496/15881	6.50E-05	0.0030732742201079	ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000003617/ENSMUSG00000023030/ENSMUSG00000066152/ENSMUSG00000022032/ENSMUSG00000026463/ENSMUSG00000035873/ENSMUSG00000021831/ENSMUSG00000032860/ENSMUSG00000026576/ENSMUSG00000029084/ENSMUSG00000040907/ENSMUSG00000032839/ENSMUSG00000050541/ENSMUSG00000044026/ENSMUSG00000038403/ENSMUSG00000060961/ENSMUSG00000022416/ENSMUSG00000027994/ENSMUSG00000026177/ENSMUSG00000061603/ENSMUSG00000025889/ENSMUSG00000041329/ENSMUSG00000032020/ENSMUSG00000031504/ENSMUSG00000074715/ENSMUSG00000002944/ENSMUSG00000060459/ENSMUSG00000023032/ENSMUSG00000021070/ENSMUSG00000063354/ENSMUSG00000041046/ENSMUSG00000006235/ENSMUSG00000068323/ENSMUSG00000034855/ENSMUSG00000029716/ENSMUSG00000038600/ENSMUSG00000030523/ENSMUSG00000053318/ENSMUSG00000004266/ENSMUSG00000036570/ENSMUSG00000035458/ENSMUSG00000030707/ENSMUSG00000044338/ENSMUSG00000038239/ENSMUSG00000021337/ENSMUSG00000043051	Cxcl1/Ccl2/Cp/Slc11a2/Slc31a2/Scara5/Atp2b4/Pawr/Ero1l/P2ry2/Atp1b1/Cd38/Atp1a3/Trpc1/Adra1b/Slc35g1/Hfe2/Slc4a4/Cacna1i/Mcub/Slc11a1/Akap6/Snca/Atp1b2/Ubash3b/Rab20/Ccl28/Cd36/Kng2/Slc4a8/Bdkrb2/Slc39a4/Ramp3/Epor/Slc4a5/Cxcl10/Tfr2/Atp6v0a4/Trpm1/Slamf8/Ptpn6/Fxyd1/Tnni3/Coro1a/Aplnr/Hrc/Scgn/Disc1	48
BP	GO:0070664	negative regulation of leukocyte proliferation	13/858	69/15881	7.06E-05	0.00330221028539629	ENSMUSG00000029816/ENSMUSG00000044303/ENSMUSG00000035873/ENSMUSG00000053965/ENSMUSG00000075122/ENSMUSG00000053216/ENSMUSG00000039981/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000000706/ENSMUSG00000052013/ENSMUSG00000004266/ENSMUSG00000034652	Gpnmb/Cdkn2a/Pawr/Pde5a/Cd80/Btn2a2/Zc3h12d/Ceacam1/Lrrc32/Btn1a1/Btla/Ptpn6/Cd300a	13
BP	GO:2000377	regulation of reactive oxygen species metabolic process	22/858	164/15881	7.34E-05	0.00340034638495104	ENSMUSG00000029380/ENSMUSG00000023067/ENSMUSG00000030921/ENSMUSG00000042677/ENSMUSG00000024066/ENSMUSG00000026463/ENSMUSG00000003541/ENSMUSG00000037580/ENSMUSG00000021822/ENSMUSG00000079685/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000025889/ENSMUSG00000017969/ENSMUSG00000076441/ENSMUSG00000002944/ENSMUSG00000006235/ENSMUSG00000032066/ENSMUSG00000000120/ENSMUSG00000079164/ENSMUSG00000004231/ENSMUSG00000021948	Cxcl1/Cdkn1a/Trim30a/Zc3h12a/Xdh/Atp2b4/Ier3/Gch1/Plau/Ulbp1/Tlr2/Syk/Snca/Ptgis/Ass1/Cd36/Epor/Bco2/Ngfr/Tlr5/Pax2/Prkcd	22
BP	GO:0002250	adaptive immune response	32/858	286/15881	7.72E-05	0.00354054418441462	ENSMUSG00000024164/ENSMUSG00000024610/ENSMUSG00000073411/ENSMUSG00000061232/ENSMUSG00000024778/ENSMUSG00000022636/ENSMUSG00000000732/ENSMUSG00000019850/ENSMUSG00000062300/ENSMUSG00000079685/ENSMUSG00000021457/ENSMUSG00000053175/ENSMUSG00000026068/ENSMUSG00000041481/ENSMUSG00000055994/ENSMUSG00000027985/ENSMUSG00000032359/ENSMUSG00000066755/ENSMUSG00000026177/ENSMUSG00000049109/ENSMUSG00000020641/ENSMUSG00000079343/ENSMUSG00000030468/ENSMUSG00000000791/ENSMUSG00000033107/ENSMUSG00000075370/ENSMUSG00000052013/ENSMUSG00000041439/ENSMUSG00000021948/ENSMUSG00000004266/ENSMUSG00000034266/ENSMUSG00000026117	C3/Cd74/H2-D1/H2-K1/Fas/Alcam/Icosl/Tnfaip3/Nectin2/Ulbp1/Syk/Bcl3/Il18rap/Serpina3g/Nod2/Lef1/Ctsh/Tnfsf18/Slc11a1/Themis/Rsad2/C1s2/Siglecg/Il12rb1/Rnf125/Igll1/Btla/Mfsd6/Prkcd/Ptpn6/Batf/Zap70	32
BP	GO:0051272	positive regulation of cellular component movement	46/858	473/15881	8.18E-05	0.00370646980177729	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000027750/ENSMUSG00000029816/ENSMUSG00000016024/ENSMUSG00000042677/ENSMUSG00000022150/ENSMUSG00000017737/ENSMUSG00000050335/ENSMUSG00000037685/ENSMUSG00000035873/ENSMUSG00000023913/ENSMUSG00000039621/ENSMUSG00000032860/ENSMUSG00000025207/ENSMUSG00000021822/ENSMUSG00000022676/ENSMUSG00000029851/ENSMUSG00000028128/ENSMUSG00000026166/ENSMUSG00000027995/ENSMUSG00000053475/ENSMUSG00000036585/ENSMUSG00000048779/ENSMUSG00000029373/ENSMUSG00000027985/ENSMUSG00000032359/ENSMUSG00000066755/ENSMUSG00000031520/ENSMUSG00000046761/ENSMUSG00000026580/ENSMUSG00000055632/ENSMUSG00000029371/ENSMUSG00000034855/ENSMUSG00000002489/ENSMUSG00000038756/ENSMUSG00000028978/ENSMUSG00000049044/ENSMUSG00000050315/ENSMUSG00000028864/ENSMUSG00000030170/ENSMUSG00000068748/ENSMUSG00000030707/ENSMUSG00000020081	Cd74/Cxcl1/Ccl2/Cx3cl1/Postn/Gpnmb/Lbp/Zc3h12a/Dab2/Mmp9/Lgals3/Atp8a1/Pawr/Pla2g7/Prex1/P2ry2/Sema4g/Plau/Snai2/Tcaf2/F3/Ccl20/Tlr2/Tnfaip6/Fgf1/P2ry6/Pf4/Lef1/Ctsh/Tnfsf18/Vegfc/Fam83h/Selp/Hmcn2/Cxcl5/Cxcl10/Tiam1/Ttll6/Nos3/Rapgef4/Synpo2/Hgf/Wnt5b/Ptprz1/Coro1a/Tacr2	46
BP	GO:1903901	negative regulation of viral life cycle	13/858	70/15881	8.24E-05	0.00370646980177729	ENSMUSG00000017002/ENSMUSG00000046718/ENSMUSG00000042677/ENSMUSG00000066800/ENSMUSG00000001166/ENSMUSG00000035692/ENSMUSG00000074272/ENSMUSG00000032690/ENSMUSG00000020641/ENSMUSG00000059108/ENSMUSG00000029605/ENSMUSG00000032661/ENSMUSG00000000266	Slpi/Bst2/Zc3h12a/Rnasel/Oas1c/Isg15/Ceacam1/Oas2/Rsad2/Ifitm6/Oas1b/Oas3/Mid2	13
BP	GO:0030335	positive regulation of cell migration	44/858	446/15881	8.36E-05	0.00372069810958262	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000027750/ENSMUSG00000029816/ENSMUSG00000016024/ENSMUSG00000042677/ENSMUSG00000022150/ENSMUSG00000017737/ENSMUSG00000050335/ENSMUSG00000037685/ENSMUSG00000035873/ENSMUSG00000023913/ENSMUSG00000039621/ENSMUSG00000032860/ENSMUSG00000025207/ENSMUSG00000021822/ENSMUSG00000022676/ENSMUSG00000029851/ENSMUSG00000028128/ENSMUSG00000026166/ENSMUSG00000027995/ENSMUSG00000053475/ENSMUSG00000036585/ENSMUSG00000048779/ENSMUSG00000029373/ENSMUSG00000027985/ENSMUSG00000032359/ENSMUSG00000066755/ENSMUSG00000031520/ENSMUSG00000046761/ENSMUSG00000026580/ENSMUSG00000055632/ENSMUSG00000029371/ENSMUSG00000034855/ENSMUSG00000002489/ENSMUSG00000028978/ENSMUSG00000049044/ENSMUSG00000050315/ENSMUSG00000028864/ENSMUSG00000030170/ENSMUSG00000068748/ENSMUSG00000030707	Cd74/Cxcl1/Ccl2/Cx3cl1/Postn/Gpnmb/Lbp/Zc3h12a/Dab2/Mmp9/Lgals3/Atp8a1/Pawr/Pla2g7/Prex1/P2ry2/Sema4g/Plau/Snai2/Tcaf2/F3/Ccl20/Tlr2/Tnfaip6/Fgf1/P2ry6/Pf4/Lef1/Ctsh/Tnfsf18/Vegfc/Fam83h/Selp/Hmcn2/Cxcl5/Cxcl10/Tiam1/Nos3/Rapgef4/Synpo2/Hgf/Wnt5b/Ptprz1/Coro1a	44
BP	GO:2000147	positive regulation of cell motility	45/858	460/15881	8.49E-05	0.00374401953504159	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000027750/ENSMUSG00000029816/ENSMUSG00000016024/ENSMUSG00000042677/ENSMUSG00000022150/ENSMUSG00000017737/ENSMUSG00000050335/ENSMUSG00000037685/ENSMUSG00000035873/ENSMUSG00000023913/ENSMUSG00000039621/ENSMUSG00000032860/ENSMUSG00000025207/ENSMUSG00000021822/ENSMUSG00000022676/ENSMUSG00000029851/ENSMUSG00000028128/ENSMUSG00000026166/ENSMUSG00000027995/ENSMUSG00000053475/ENSMUSG00000036585/ENSMUSG00000048779/ENSMUSG00000029373/ENSMUSG00000027985/ENSMUSG00000032359/ENSMUSG00000066755/ENSMUSG00000031520/ENSMUSG00000046761/ENSMUSG00000026580/ENSMUSG00000055632/ENSMUSG00000029371/ENSMUSG00000034855/ENSMUSG00000002489/ENSMUSG00000028978/ENSMUSG00000049044/ENSMUSG00000050315/ENSMUSG00000028864/ENSMUSG00000030170/ENSMUSG00000068748/ENSMUSG00000030707/ENSMUSG00000020081	Cd74/Cxcl1/Ccl2/Cx3cl1/Postn/Gpnmb/Lbp/Zc3h12a/Dab2/Mmp9/Lgals3/Atp8a1/Pawr/Pla2g7/Prex1/P2ry2/Sema4g/Plau/Snai2/Tcaf2/F3/Ccl20/Tlr2/Tnfaip6/Fgf1/P2ry6/Pf4/Lef1/Ctsh/Tnfsf18/Vegfc/Fam83h/Selp/Hmcn2/Cxcl5/Cxcl10/Tiam1/Nos3/Rapgef4/Synpo2/Hgf/Wnt5b/Ptprz1/Coro1a/Tacr2	45
BP	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	14/858	80/15881	8.74E-05	0.00381916224731035	ENSMUSG00000017737/ENSMUSG00000078945/ENSMUSG00000096472/ENSMUSG00000019823/ENSMUSG00000028599/ENSMUSG00000046223/ENSMUSG00000078942/ENSMUSG00000027985/ENSMUSG00000025889/ENSMUSG00000020178/ENSMUSG00000071203/ENSMUSG00000019278/ENSMUSG00000028864/ENSMUSG00000004231	Mmp9/Naip2/Cdkn2d/Mical1/Tnfrsf1b/Plaur/Naip6/Lef1/Snca/Adora2a/Naip5/Dpep1/Hgf/Pax2	14
BP	GO:0002688	regulation of leukocyte chemotaxis	15/858	90/15881	8.84E-05	0.00382446422924776	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000016024/ENSMUSG00000029082/ENSMUSG00000023913/ENSMUSG00000029373/ENSMUSG00000055994/ENSMUSG00000066755/ENSMUSG00000031520/ENSMUSG00000029371/ENSMUSG00000034855/ENSMUSG00000037362/ENSMUSG00000053318	Cd74/Cxcl1/Ccl2/Cx3cl1/Lbp/Bst1/Pla2g7/Pf4/Nod2/Tnfsf18/Vegfc/Cxcl5/Cxcl10/Nov/Slamf8	15
BP	GO:0006875	cellular metal ion homeostasis	42/858	421/15881	9.39E-05	0.00402631155299779	ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000003617/ENSMUSG00000023030/ENSMUSG00000066152/ENSMUSG00000022032/ENSMUSG00000026463/ENSMUSG00000035873/ENSMUSG00000021831/ENSMUSG00000032860/ENSMUSG00000026576/ENSMUSG00000029084/ENSMUSG00000040907/ENSMUSG00000032839/ENSMUSG00000050541/ENSMUSG00000044026/ENSMUSG00000038403/ENSMUSG00000022416/ENSMUSG00000027994/ENSMUSG00000026177/ENSMUSG00000061603/ENSMUSG00000025889/ENSMUSG00000041329/ENSMUSG00000032020/ENSMUSG00000074715/ENSMUSG00000002944/ENSMUSG00000060459/ENSMUSG00000021070/ENSMUSG00000063354/ENSMUSG00000041046/ENSMUSG00000006235/ENSMUSG00000034855/ENSMUSG00000029716/ENSMUSG00000030523/ENSMUSG00000004266/ENSMUSG00000036570/ENSMUSG00000035458/ENSMUSG00000030707/ENSMUSG00000044338/ENSMUSG00000038239/ENSMUSG00000021337/ENSMUSG00000043051	Cxcl1/Ccl2/Cp/Slc11a2/Slc31a2/Scara5/Atp2b4/Pawr/Ero1l/P2ry2/Atp1b1/Cd38/Atp1a3/Trpc1/Adra1b/Slc35g1/Hfe2/Cacna1i/Mcub/Slc11a1/Akap6/Snca/Atp1b2/Ubash3b/Ccl28/Cd36/Kng2/Bdkrb2/Slc39a4/Ramp3/Epor/Cxcl10/Tfr2/Trpm1/Ptpn6/Fxyd1/Tnni3/Coro1a/Aplnr/Hrc/Scgn/Disc1	42
BP	GO:1905954	positive regulation of lipid localization	13/858	71/15881	9.60E-05	0.00406232590811864	ENSMUSG00000024164/ENSMUSG00000042677/ENSMUSG00000022150/ENSMUSG00000037685/ENSMUSG00000032860/ENSMUSG00000020333/ENSMUSG00000042010/ENSMUSG00000003484/ENSMUSG00000015243/ENSMUSG00000002944/ENSMUSG00000024030/ENSMUSG00000025044/ENSMUSG00000021948	C3/Zc3h12a/Dab2/Atp8a1/P2ry2/Acsl6/Acacb/Cyp4f18/Abca1/Cd36/Abcg1/Msr1/Prkcd	13
BP	GO:0002757	immune response-activating signal transduction	28/858	239/15881	9.66E-05	0.00406232590811864	ENSMUSG00000016024/ENSMUSG00000030921/ENSMUSG00000042677/ENSMUSG00000000732/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000019850/ENSMUSG00000029084/ENSMUSG00000062300/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000055994/ENSMUSG00000005057/ENSMUSG00000053216/ENSMUSG00000049109/ENSMUSG00000017830/ENSMUSG00000020641/ENSMUSG00000002944/ENSMUSG00000000706/ENSMUSG00000079164/ENSMUSG00000075370/ENSMUSG00000109713/ENSMUSG00000021108/ENSMUSG00000002699/ENSMUSG00000024696/ENSMUSG00000004266/ENSMUSG00000034652/ENSMUSG00000026117	Lbp/Trim30a/Zc3h12a/Icosl/Lgals3/Pawr/Tnfaip3/Cd38/Nectin2/Tlr2/Syk/Nod2/Sh2b2/Btn2a2/Themis/Dhx58/Rsad2/Cd36/Btn1a1/Tlr5/Igll1/Pvrig/Prkch/Lcp2/Lpxn/Ptpn6/Cd300a/Zap70	28
BP	GO:0034612	response to tumor necrosis factor	21/858	156/15881	0.000100951848736192	0.00420877434821977	ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000024778/ENSMUSG00000042677/ENSMUSG00000035373/ENSMUSG00000028965/ENSMUSG00000033538/ENSMUSG00000037580/ENSMUSG00000026166/ENSMUSG00000028599/ENSMUSG00000021457/ENSMUSG00000019122/ENSMUSG00000066755/ENSMUSG00000008318/ENSMUSG00000035186/ENSMUSG00000037860/ENSMUSG00000031548/ENSMUSG00000000120/ENSMUSG00000028602/ENSMUSG00000031780/ENSMUSG00000025888	Ccl2/Cx3cl1/Fas/Zc3h12a/Ccl7/Tnfrsf9/Casp4/Gch1/Ccl20/Tnfrsf1b/Syk/Ccl9/Tnfsf18/Relt/Ubd/Aim2/Sfrp1/Ngfr/Tnfrsf8/Ccl17/Casp1	21
BP	GO:0043903	regulation of symbiosis, encompassing mutualism through parasitism	24/858	192/15881	0.000109655268381809	0.00453044198917997	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000017002/ENSMUSG00000046718/ENSMUSG00000016024/ENSMUSG00000030921/ENSMUSG00000042677/ENSMUSG00000066800/ENSMUSG00000062300/ENSMUSG00000027995/ENSMUSG00000001166/ENSMUSG00000055994/ENSMUSG00000027985/ENSMUSG00000035692/ENSMUSG00000074272/ENSMUSG00000032690/ENSMUSG00000020641/ENSMUSG00000002944/ENSMUSG00000059108/ENSMUSG00000029605/ENSMUSG00000029371/ENSMUSG00000032661/ENSMUSG00000041515/ENSMUSG00000000266	Cd74/Cxcl1/Slpi/Bst2/Lbp/Trim30a/Zc3h12a/Rnasel/Nectin2/Tlr2/Oas1c/Nod2/Lef1/Isg15/Ceacam1/Oas2/Rsad2/Cd36/Ifitm6/Oas1b/Cxcl5/Oas3/Irf8/Mid2	24
BP	GO:0071622	regulation of granulocyte chemotaxis	10/858	45/15881	0.000113960125000942	0.00466626011834212	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000016024/ENSMUSG00000029082/ENSMUSG00000029373/ENSMUSG00000055994/ENSMUSG00000066755/ENSMUSG00000029371	Cd74/Cxcl1/Ccl2/Cx3cl1/Lbp/Bst1/Pf4/Nod2/Tnfsf18/Cxcl5	10
BP	GO:0072511	divalent inorganic cation transport	38/858	371/15881	0.000116128420110225	0.00471296402323445	ENSMUSG00000023030/ENSMUSG00000020432/ENSMUSG00000026463/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000021831/ENSMUSG00000026576/ENSMUSG00000019997/ENSMUSG00000032839/ENSMUSG00000044026/ENSMUSG00000022416/ENSMUSG00000027994/ENSMUSG00000050777/ENSMUSG00000057897/ENSMUSG00000026177/ENSMUSG00000034353/ENSMUSG00000061603/ENSMUSG00000025889/ENSMUSG00000032020/ENSMUSG00000041245/ENSMUSG00000028214/ENSMUSG00000063354/ENSMUSG00000028255/ENSMUSG00000041046/ENSMUSG00000053395/ENSMUSG00000034855/ENSMUSG00000024065/ENSMUSG00000028978/ENSMUSG00000020178/ENSMUSG00000020787/ENSMUSG00000037418/ENSMUSG00000041695/ENSMUSG00000030523/ENSMUSG00000059588/ENSMUSG00000004266/ENSMUSG00000030707/ENSMUSG00000044338/ENSMUSG00000038239	Slc11a2/Tcn2/Atp2b4/Lgals3/Pawr/Ero1l/Atp1b1/Ctgf/Trpc1/Slc35g1/Cacna1i/Mcub/Tmem37/Camk2b/Slc11a1/Ramp1/Akap6/Snca/Ubash3b/Wnk3/Gem/Slc39a4/Clca1/Ramp3/Cacng8/Cxcl10/Ehd3/Nos3/Adora2a/P2rx1/Best1/Kcnj2/Trpm1/Calcrl/Ptpn6/Coro1a/Aplnr/Hrc	38
BP	GO:1902622	regulation of neutrophil migration	9/858	37/15881	0.000118882427709863	0.00478241064453887	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000016024/ENSMUSG00000029082/ENSMUSG00000035873/ENSMUSG00000029373/ENSMUSG00000055994/ENSMUSG00000029371/ENSMUSG00000053318	Cd74/Cxcl1/Lbp/Bst1/Pawr/Pf4/Nod2/Cxcl5/Slamf8	9
BP	GO:0070269	pyroptosis	6/858	16/15881	0.000122567148312901	0.00488776471446055	ENSMUSG00000033538/ENSMUSG00000078945/ENSMUSG00000078942/ENSMUSG00000037860/ENSMUSG00000071203/ENSMUSG00000025888	Casp4/Naip2/Naip6/Aim2/Naip5/Casp1	6
BP	GO:0002687	positive regulation of leukocyte migration	17/858	114/15881	0.000129025830779554	0.00510096948237099	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000016024/ENSMUSG00000017737/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000023913/ENSMUSG00000026166/ENSMUSG00000027995/ENSMUSG00000029373/ENSMUSG00000066755/ENSMUSG00000031520/ENSMUSG00000026580/ENSMUSG00000029371/ENSMUSG00000034855	Cd74/Cxcl1/Ccl2/Cx3cl1/Lbp/Mmp9/Lgals3/Pawr/Pla2g7/Ccl20/Tlr2/Pf4/Tnfsf18/Vegfc/Selp/Cxcl5/Cxcl10	17
BP	GO:0002521	leukocyte differentiation	42/858	429/15881	0.000142537425242417	0.00558697976206603	ENSMUSG00000023367/ENSMUSG00000024610/ENSMUSG00000029810/ENSMUSG00000024778/ENSMUSG00000029570/ENSMUSG00000023927/ENSMUSG00000044303/ENSMUSG00000037440/ENSMUSG00000049577/ENSMUSG00000038387/ENSMUSG00000039621/ENSMUSG00000019850/ENSMUSG00000032501/ENSMUSG00000034394/ENSMUSG00000027995/ENSMUSG00000034023/ENSMUSG00000021457/ENSMUSG00000053175/ENSMUSG00000029373/ENSMUSG00000027985/ENSMUSG00000027858/ENSMUSG00000066755/ENSMUSG00000018169/ENSMUSG00000035158/ENSMUSG00000053216/ENSMUSG00000049109/ENSMUSG00000032020/ENSMUSG00000035186/ENSMUSG00000074272/ENSMUSG00000020641/ENSMUSG00000032750/ENSMUSG00000036587/ENSMUSG00000031548/ENSMUSG00000031712/ENSMUSG00000040329/ENSMUSG00000063415/ENSMUSG00000044258/ENSMUSG00000048251/ENSMUSG00000004266/ENSMUSG00000020325/ENSMUSG00000034266/ENSMUSG00000026117	Tmem176a/Cd74/Tmem176b/Fas/Lfng/Satb1/Cdkn2a/Vnn1/Zfpm1/Rras/Prex1/Tnfaip3/Trib1/Lif/Tlr2/Fancd2/Syk/Bcl3/Pf4/Lef1/Tspan2/Tnfsf18/Mfng/Mitf/Btn2a2/Themis/Ubash3b/Ubd/Ceacam1/Rsad2/Gab3/Fut7/Sfrp1/Il15/Il7/Cyp26b1/Ctla2a/Bcl11b/Ptpn6/Fstl3/Batf/Zap70	42
BP	GO:0002253	activation of immune response	31/858	283/15881	0.00014664053773129	0.00569909750877709	ENSMUSG00000024164/ENSMUSG00000016024/ENSMUSG00000030921/ENSMUSG00000042677/ENSMUSG00000000732/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000019850/ENSMUSG00000029084/ENSMUSG00000062300/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000055994/ENSMUSG00000005057/ENSMUSG00000053216/ENSMUSG00000049109/ENSMUSG00000017830/ENSMUSG00000020641/ENSMUSG00000002944/ENSMUSG00000079343/ENSMUSG00000037860/ENSMUSG00000000706/ENSMUSG00000079164/ENSMUSG00000075370/ENSMUSG00000109713/ENSMUSG00000021108/ENSMUSG00000002699/ENSMUSG00000024696/ENSMUSG00000004266/ENSMUSG00000034652/ENSMUSG00000026117	C3/Lbp/Trim30a/Zc3h12a/Icosl/Lgals3/Pawr/Tnfaip3/Cd38/Nectin2/Tlr2/Syk/Nod2/Sh2b2/Btn2a2/Themis/Dhx58/Rsad2/Cd36/C1s2/Aim2/Btn1a1/Tlr5/Igll1/Pvrig/Prkch/Lcp2/Lpxn/Ptpn6/Cd300a/Zap70	31
BP	GO:1902105	regulation of leukocyte differentiation	26/858	221/15881	0.000158055893150143	0.00607074786034588	ENSMUSG00000023367/ENSMUSG00000024610/ENSMUSG00000029810/ENSMUSG00000024778/ENSMUSG00000044303/ENSMUSG00000037440/ENSMUSG00000049577/ENSMUSG00000032501/ENSMUSG00000034394/ENSMUSG00000034023/ENSMUSG00000021457/ENSMUSG00000029373/ENSMUSG00000027985/ENSMUSG00000066755/ENSMUSG00000035158/ENSMUSG00000053216/ENSMUSG00000032020/ENSMUSG00000074272/ENSMUSG00000031548/ENSMUSG00000031712/ENSMUSG00000040329/ENSMUSG00000063415/ENSMUSG00000044258/ENSMUSG00000004266/ENSMUSG00000020325/ENSMUSG00000026117	Tmem176a/Cd74/Tmem176b/Fas/Cdkn2a/Vnn1/Zfpm1/Trib1/Lif/Fancd2/Syk/Pf4/Lef1/Tnfsf18/Mitf/Btn2a2/Ubash3b/Ceacam1/Sfrp1/Il15/Il7/Cyp26b1/Ctla2a/Ptpn6/Fstl3/Zap70	26
BP	GO:0003015	heart process	21/858	161/15881	0.000158850794426844	0.00607074786034588	ENSMUSG00000042677/ENSMUSG00000026463/ENSMUSG00000042429/ENSMUSG00000037580/ENSMUSG00000053965/ENSMUSG00000057123/ENSMUSG00000026576/ENSMUSG00000019997/ENSMUSG00000040907/ENSMUSG00000050541/ENSMUSG00000061603/ENSMUSG00000041046/ENSMUSG00000064329/ENSMUSG00000024065/ENSMUSG00000028978/ENSMUSG00000035296/ENSMUSG00000026418/ENSMUSG00000041695/ENSMUSG00000036570/ENSMUSG00000035458/ENSMUSG00000038239	Zc3h12a/Atp2b4/Adora1/Gch1/Pde5a/Gja5/Atp1b1/Ctgf/Atp1a3/Adra1b/Akap6/Ramp3/Scn1a/Ehd3/Nos3/Sgcg/Tnni1/Kcnj2/Fxyd1/Tnni3/Hrc	21
BP	GO:0032496	response to lipopolysaccharide	28/858	248/15881	0.000182068558890856	0.00690054885184683	ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000017002/ENSMUSG00000016024/ENSMUSG00000024778/ENSMUSG00000042677/ENSMUSG00000028965/ENSMUSG00000037580/ENSMUSG00000020826/ENSMUSG00000019850/ENSMUSG00000032501/ENSMUSG00000028599/ENSMUSG00000029373/ENSMUSG00000055994/ENSMUSG00000075122/ENSMUSG00000008318/ENSMUSG00000026177/ENSMUSG00000025889/ENSMUSG00000015243/ENSMUSG00000002944/ENSMUSG00000104713/ENSMUSG00000029371/ENSMUSG00000034855/ENSMUSG00000028978/ENSMUSG00000000120/ENSMUSG00000041515/ENSMUSG00000028602/ENSMUSG00000025888	Cxcl1/Ccl2/Slpi/Lbp/Fas/Zc3h12a/Tnfrsf9/Gch1/Nos2/Tnfaip3/Trib1/Tnfrsf1b/Pf4/Nod2/Cd80/Relt/Slc11a1/Snca/Abca1/Cd36/Gbp6/Cxcl5/Cxcl10/Nos3/Ngfr/Irf8/Tnfrsf8/Casp1	28
BP	GO:0071356	cellular response to tumor necrosis factor	19/858	140/15881	0.000190997312605754	0.00717962029188513	ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000024778/ENSMUSG00000042677/ENSMUSG00000035373/ENSMUSG00000028965/ENSMUSG00000033538/ENSMUSG00000026166/ENSMUSG00000028599/ENSMUSG00000021457/ENSMUSG00000019122/ENSMUSG00000066755/ENSMUSG00000008318/ENSMUSG00000037860/ENSMUSG00000031548/ENSMUSG00000000120/ENSMUSG00000028602/ENSMUSG00000031780/ENSMUSG00000025888	Ccl2/Cx3cl1/Fas/Zc3h12a/Ccl7/Tnfrsf9/Casp4/Ccl20/Tnfrsf1b/Syk/Ccl9/Tnfsf18/Relt/Aim2/Sfrp1/Ngfr/Tnfrsf8/Ccl17/Casp1	19
BP	GO:0007271	synaptic transmission, cholinergic	7/858	24/15881	0.000201785211911171	0.00752347139694821	ENSMUSG00000026251/ENSMUSG00000057897/ENSMUSG00000026253/ENSMUSG00000002104/ENSMUSG00000000120/ENSMUSG00000020178/ENSMUSG00000020081	Chrnd/Camk2b/Chrng/Rapsn/Ngfr/Adora2a/Tacr2	7
BP	GO:0070838	divalent metal ion transport	37/858	368/15881	0.000206448244838139	0.00763525524861053	ENSMUSG00000023030/ENSMUSG00000026463/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000021831/ENSMUSG00000026576/ENSMUSG00000019997/ENSMUSG00000032839/ENSMUSG00000044026/ENSMUSG00000022416/ENSMUSG00000027994/ENSMUSG00000050777/ENSMUSG00000057897/ENSMUSG00000026177/ENSMUSG00000034353/ENSMUSG00000061603/ENSMUSG00000025889/ENSMUSG00000032020/ENSMUSG00000041245/ENSMUSG00000028214/ENSMUSG00000063354/ENSMUSG00000028255/ENSMUSG00000041046/ENSMUSG00000053395/ENSMUSG00000034855/ENSMUSG00000024065/ENSMUSG00000028978/ENSMUSG00000020178/ENSMUSG00000020787/ENSMUSG00000037418/ENSMUSG00000041695/ENSMUSG00000030523/ENSMUSG00000059588/ENSMUSG00000004266/ENSMUSG00000030707/ENSMUSG00000044338/ENSMUSG00000038239	Slc11a2/Atp2b4/Lgals3/Pawr/Ero1l/Atp1b1/Ctgf/Trpc1/Slc35g1/Cacna1i/Mcub/Tmem37/Camk2b/Slc11a1/Ramp1/Akap6/Snca/Ubash3b/Wnk3/Gem/Slc39a4/Clca1/Ramp3/Cacng8/Cxcl10/Ehd3/Nos3/Adora2a/P2rx1/Best1/Kcnj2/Trpm1/Calcrl/Ptpn6/Coro1a/Aplnr/Hrc	37
BP	GO:0048771	tissue remodeling	20/858	154/15881	0.000239306428798747	0.00873571316526715	ENSMUSG00000029816/ENSMUSG00000026185/ENSMUSG00000044303/ENSMUSG00000017737/ENSMUSG00000057123/ENSMUSG00000019577/ENSMUSG00000029084/ENSMUSG00000024743/ENSMUSG00000034394/ENSMUSG00000021457/ENSMUSG00000024039/ENSMUSG00000050541/ENSMUSG00000003051/ENSMUSG00000035158/ENSMUSG00000032020/ENSMUSG00000074272/ENSMUSG00000031548/ENSMUSG00000040046/ENSMUSG00000028978/ENSMUSG00000040329	Gpnmb/Igfbp5/Cdkn2a/Mmp9/Gja5/Pdk4/Cd38/Syt7/Lif/Syk/Cbs/Adra1b/Elf3/Mitf/Ubash3b/Ceacam1/Sfrp1/Tph1/Nos3/Il7	20
BP	GO:0045776	negative regulation of blood pressure	10/858	49/15881	0.00024131476200782	0.00873571316526715	ENSMUSG00000003541/ENSMUSG00000042429/ENSMUSG00000037580/ENSMUSG00000057123/ENSMUSG00000020826/ENSMUSG00000031520/ENSMUSG00000002944/ENSMUSG00000021070/ENSMUSG00000028978/ENSMUSG00000031489	Ier3/Adora1/Gch1/Gja5/Nos2/Vegfc/Cd36/Bdkrb2/Nos3/Adrb3	10
BP	GO:0002697	regulation of immune effector process	31/858	291/15881	0.000241917918008925	0.00873571316526715	ENSMUSG00000024164/ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000073411/ENSMUSG00000035385/ENSMUSG00000061232/ENSMUSG00000016024/ENSMUSG00000042677/ENSMUSG00000050335/ENSMUSG00000019850/ENSMUSG00000062300/ENSMUSG00000079685/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000079363/ENSMUSG00000026068/ENSMUSG00000055994/ENSMUSG00000066755/ENSMUSG00000017830/ENSMUSG00000074272/ENSMUSG00000020641/ENSMUSG00000002944/ENSMUSG00000029371/ENSMUSG00000037860/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000053318/ENSMUSG00000062157/ENSMUSG00000004266/ENSMUSG00000034652/ENSMUSG00000025279	C3/Cd74/Cxcl1/H2-D1/Ccl2/H2-K1/Lbp/Zc3h12a/Lgals3/Tnfaip3/Nectin2/Ulbp1/Tlr2/Syk/Gbp4/Il18rap/Nod2/Tnfsf18/Dhx58/Ceacam1/Rsad2/Cd36/Cxcl5/Aim2/Il12rb1/Il15/Slamf8/Ifnlr1/Ptpn6/Cd300a/Dnase1l3	31
BP	GO:2000117	negative regulation of cysteine-type endopeptidase activity	14/858	88/15881	0.000249819990082415	0.00879334040478286	ENSMUSG00000017737/ENSMUSG00000078945/ENSMUSG00000096472/ENSMUSG00000019823/ENSMUSG00000028599/ENSMUSG00000046223/ENSMUSG00000078942/ENSMUSG00000027985/ENSMUSG00000025889/ENSMUSG00000020178/ENSMUSG00000071203/ENSMUSG00000019278/ENSMUSG00000028864/ENSMUSG00000004231	Mmp9/Naip2/Cdkn2d/Mical1/Tnfrsf1b/Plaur/Naip6/Lef1/Snca/Adora2a/Naip5/Dpep1/Hgf/Pax2	14
BP	GO:0051346	negative regulation of hydrolase activity	33/858	318/15881	0.000251672221386859	0.00879334040478286	ENSMUSG00000017002/ENSMUSG00000000753/ENSMUSG00000017737/ENSMUSG00000038235/ENSMUSG00000078945/ENSMUSG00000019852/ENSMUSG00000042842/ENSMUSG00000096472/ENSMUSG00000027082/ENSMUSG00000019823/ENSMUSG00000028599/ENSMUSG00000041481/ENSMUSG00000046223/ENSMUSG00000078942/ENSMUSG00000031387/ENSMUSG00000027985/ENSMUSG00000021403/ENSMUSG00000079014/ENSMUSG00000025889/ENSMUSG00000060459/ENSMUSG00000078949/ENSMUSG00000026315/ENSMUSG00000026249/ENSMUSG00000027834/ENSMUSG00000028978/ENSMUSG00000020178/ENSMUSG00000071203/ENSMUSG00000051029/ENSMUSG00000019278/ENSMUSG00000028864/ENSMUSG00000004231/ENSMUSG00000079012/ENSMUSG00000035458	Slpi/Serpinf1/Mmp9/F11r/Naip2/Arfgef3/Serpinb6b/Cdkn2d/Tfpi/Mical1/Tnfrsf1b/Serpina3g/Plaur/Naip6/Renbp/Lef1/Serpinb9b/Serpina3i/Snca/Kng2/R3hdml/Serpinb8/Serpine2/Serpini1/Nos3/Adora2a/Naip5/Serpinb1b/Dpep1/Hgf/Pax2/Serpina3m/Tnni3	33
BP	GO:0032612	interleukin-1 production	12/858	68/15881	0.000253862078810326	0.00879334040478286	ENSMUSG00000042677/ENSMUSG00000033538/ENSMUSG00000019850/ENSMUSG00000026166/ENSMUSG00000027995/ENSMUSG00000055994/ENSMUSG00000015243/ENSMUSG00000074272/ENSMUSG00000002944/ENSMUSG00000037860/ENSMUSG00000071203/ENSMUSG00000025888	Zc3h12a/Casp4/Tnfaip3/Ccl20/Tlr2/Nod2/Abca1/Ceacam1/Cd36/Aim2/Naip5/Casp1	12
BP	GO:0001909	leukocyte mediated cytotoxicity	13/858	78/15881	0.000256961692737955	0.00879334040478286	ENSMUSG00000029380/ENSMUSG00000073411/ENSMUSG00000035385/ENSMUSG00000061232/ENSMUSG00000062300/ENSMUSG00000079685/ENSMUSG00000026068/ENSMUSG00000032359/ENSMUSG00000074272/ENSMUSG00000029371/ENSMUSG00000004266/ENSMUSG00000030707/ENSMUSG00000025279	Cxcl1/H2-D1/Ccl2/H2-K1/Nectin2/Ulbp1/Il18rap/Ctsh/Ceacam1/Cxcl5/Ptpn6/Coro1a/Dnase1l3	13
BP	GO:0002237	response to molecule of bacterial origin	29/858	266/15881	0.000256970018461393	0.00879334040478286	ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000017002/ENSMUSG00000016024/ENSMUSG00000024778/ENSMUSG00000042677/ENSMUSG00000028965/ENSMUSG00000037580/ENSMUSG00000020826/ENSMUSG00000019850/ENSMUSG00000032501/ENSMUSG00000027995/ENSMUSG00000028599/ENSMUSG00000029373/ENSMUSG00000055994/ENSMUSG00000075122/ENSMUSG00000008318/ENSMUSG00000026177/ENSMUSG00000025889/ENSMUSG00000015243/ENSMUSG00000002944/ENSMUSG00000104713/ENSMUSG00000029371/ENSMUSG00000034855/ENSMUSG00000028978/ENSMUSG00000000120/ENSMUSG00000041515/ENSMUSG00000028602/ENSMUSG00000025888	Cxcl1/Ccl2/Slpi/Lbp/Fas/Zc3h12a/Tnfrsf9/Gch1/Nos2/Tnfaip3/Trib1/Tlr2/Tnfrsf1b/Pf4/Nod2/Cd80/Relt/Slc11a1/Snca/Abca1/Cd36/Gbp6/Cxcl5/Cxcl10/Nos3/Ngfr/Irf8/Tnfrsf8/Casp1	29
BP	GO:0042113	B cell activation	24/858	203/15881	0.000258771964595043	0.00879334040478286	ENSMUSG00000024610/ENSMUSG00000023067/ENSMUSG00000024778/ENSMUSG00000029570/ENSMUSG00000044303/ENSMUSG00000061132/ENSMUSG00000000732/ENSMUSG00000029082/ENSMUSG00000035873/ENSMUSG00000019850/ENSMUSG00000029084/ENSMUSG00000021457/ENSMUSG00000053175/ENSMUSG00000055994/ENSMUSG00000027985/ENSMUSG00000018169/ENSMUSG00000031548/ENSMUSG00000040329/ENSMUSG00000075370/ENSMUSG00000052013/ENSMUSG00000021948/ENSMUSG00000004266/ENSMUSG00000034652/ENSMUSG00000034266	Cd74/Cdkn1a/Fas/Lfng/Cdkn2a/Blnk/Icosl/Bst1/Pawr/Tnfaip3/Cd38/Syk/Bcl3/Nod2/Lef1/Mfng/Sfrp1/Il7/Igll1/Btla/Prkcd/Ptpn6/Cd300a/Batf	24
BP	GO:0090025	regulation of monocyte chemotaxis	6/858	18/15881	0.00025885323912902	0.00879334040478286	ENSMUSG00000035385/ENSMUSG00000023913/ENSMUSG00000066755/ENSMUSG00000034855/ENSMUSG00000037362/ENSMUSG00000053318	Ccl2/Pla2g7/Tnfsf18/Cxcl10/Nov/Slamf8	6
BP	GO:0098581	detection of external biotic stimulus	6/858	18/15881	0.00025885323912902	0.00879334040478286	ENSMUSG00000016024/ENSMUSG00000078945/ENSMUSG00000027995/ENSMUSG00000078942/ENSMUSG00000055994/ENSMUSG00000071203	Lbp/Naip2/Tlr2/Naip6/Nod2/Naip5	6
BP	GO:0044406	adhesion of symbiont to host	5/858	12/15881	0.000261985176601372	0.00882472904169313	ENSMUSG00000062300/ENSMUSG00000040253/ENSMUSG00000029298/ENSMUSG00000028268/ENSMUSG00000104713	Nectin2/Gbp7/Gbp9/Gbp3/Gbp6	5
BP	GO:0001906	cell killing	15/858	99/15881	0.000264424934497735	0.00882472904169313	ENSMUSG00000029380/ENSMUSG00000073411/ENSMUSG00000035385/ENSMUSG00000061232/ENSMUSG00000020826/ENSMUSG00000062300/ENSMUSG00000079685/ENSMUSG00000026068/ENSMUSG00000029373/ENSMUSG00000032359/ENSMUSG00000074272/ENSMUSG00000029371/ENSMUSG00000004266/ENSMUSG00000030707/ENSMUSG00000025279	Cxcl1/H2-D1/Ccl2/H2-K1/Nos2/Nectin2/Ulbp1/Il18rap/Pf4/Ctsh/Ceacam1/Cxcl5/Ptpn6/Coro1a/Dnase1l3	15
BP	GO:0031348	negative regulation of defense response	21/858	167/15881	0.000265550067107207	0.00882472904169313	ENSMUSG00000000753/ENSMUSG00000042677/ENSMUSG00000074151/ENSMUSG00000003541/ENSMUSG00000042429/ENSMUSG00000019850/ENSMUSG00000028599/ENSMUSG00000053475/ENSMUSG00000055994/ENSMUSG00000017969/ENSMUSG00000041193/ENSMUSG00000017830/ENSMUSG00000074272/ENSMUSG00000030468/ENSMUSG00000037362/ENSMUSG00000020178/ENSMUSG00000044258/ENSMUSG00000021322/ENSMUSG00000053318/ENSMUSG00000059588/ENSMUSG00000028864	Serpinf1/Zc3h12a/Nlrc5/Ier3/Adora1/Tnfaip3/Tnfrsf1b/Tnfaip6/Nod2/Ptgis/Pla2g5/Dhx58/Ceacam1/Siglecg/Nov/Adora2a/Ctla2a/Aoah/Slamf8/Calcrl/Hgf	21
BP	GO:0006820	anion transport	41/858	428/15881	0.000270048169616867	0.00890964680476945	ENSMUSG00000023947/ENSMUSG00000037685/ENSMUSG00000029334/ENSMUSG00000042429/ENSMUSG00000005089/ENSMUSG00000020826/ENSMUSG00000032860/ENSMUSG00000020333/ENSMUSG00000054720/ENSMUSG00000029851/ENSMUSG00000021457/ENSMUSG00000003341/ENSMUSG00000046808/ENSMUSG00000037762/ENSMUSG00000048779/ENSMUSG00000060961/ENSMUSG00000026177/ENSMUSG00000003484/ENSMUSG00000025889/ENSMUSG00000041193/ENSMUSG00000015243/ENSMUSG00000027070/ENSMUSG00000002944/ENSMUSG00000070570/ENSMUSG00000023032/ENSMUSG00000021070/ENSMUSG00000070280/ENSMUSG00000028255/ENSMUSG00000068323/ENSMUSG00000020600/ENSMUSG00000020178/ENSMUSG00000054753/ENSMUSG00000025557/ENSMUSG00000037418/ENSMUSG00000038963/ENSMUSG00000028020/ENSMUSG00000024030/ENSMUSG00000007034/ENSMUSG00000025938/ENSMUSG00000021948/ENSMUSG00000036570	Nfkbie/Atp8a1/Prkg2/Adora1/Slc1a2/Nos2/P2ry2/Acsl6/Lrrc8c/Tcaf2/Syk/Atp8b3/Atp10d/Slc16a9/P2ry6/Slc4a4/Slc11a1/Cyp4f18/Snca/Pla2g5/Abca1/Lrp2/Cd36/Slc17a7/Slc4a8/Bdkrb2/Slc22a14/Clca1/Slc4a5/Slc7a15/Adora2a/AU018091/Slc15a1/Best1/Slco4a1/Glrb/Abcg1/Slc44a4/Slco5a1/Prkcd/Fxyd1	41
BP	GO:0019228	neuronal action potential	8/858	33/15881	0.000291339609061732	0.00954345319397931	ENSMUSG00000035873/ENSMUSG00000057182/ENSMUSG00000022416/ENSMUSG00000075318/ENSMUSG00000064329/ENSMUSG00000020787/ENSMUSG00000049044/ENSMUSG00000027071	Pawr/Scn3a/Cacna1i/Scn2a/Scn1a/P2rx1/Rapgef4/P2rx3	8
BP	GO:0015711	organic anion transport	33/858	321/15881	0.000298849721664433	0.00963241536880744	ENSMUSG00000023947/ENSMUSG00000037685/ENSMUSG00000042429/ENSMUSG00000005089/ENSMUSG00000020826/ENSMUSG00000032860/ENSMUSG00000020333/ENSMUSG00000021457/ENSMUSG00000003341/ENSMUSG00000046808/ENSMUSG00000037762/ENSMUSG00000060961/ENSMUSG00000026177/ENSMUSG00000003484/ENSMUSG00000025889/ENSMUSG00000041193/ENSMUSG00000015243/ENSMUSG00000027070/ENSMUSG00000002944/ENSMUSG00000070570/ENSMUSG00000023032/ENSMUSG00000021070/ENSMUSG00000070280/ENSMUSG00000068323/ENSMUSG00000020600/ENSMUSG00000020178/ENSMUSG00000054753/ENSMUSG00000025557/ENSMUSG00000038963/ENSMUSG00000024030/ENSMUSG00000007034/ENSMUSG00000025938/ENSMUSG00000021948	Nfkbie/Atp8a1/Adora1/Slc1a2/Nos2/P2ry2/Acsl6/Syk/Atp8b3/Atp10d/Slc16a9/Slc4a4/Slc11a1/Cyp4f18/Snca/Pla2g5/Abca1/Lrp2/Cd36/Slc17a7/Slc4a8/Bdkrb2/Slc22a14/Slc4a5/Slc7a15/Adora2a/AU018091/Slc15a1/Slco4a1/Abcg1/Slc44a4/Slco5a1/Prkcd	33
BP	GO:0046631	alpha-beta T cell activation	16/858	111/15881	0.000300356606572059	0.00963241536880744	ENSMUSG00000023927/ENSMUSG00000021457/ENSMUSG00000053175/ENSMUSG00000027985/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000074272/ENSMUSG00000020641/ENSMUSG00000036587/ENSMUSG00000031712/ENSMUSG00000020178/ENSMUSG00000052013/ENSMUSG00000048251/ENSMUSG00000034652/ENSMUSG00000034266/ENSMUSG00000026117	Satb1/Syk/Bcl3/Lef1/Cd80/Tnfsf18/Ceacam1/Rsad2/Fut7/Il15/Adora2a/Btla/Bcl11b/Cd300a/Batf/Zap70	16
BP	GO:0050864	regulation of B cell activation	16/858	111/15881	0.000300356606572059	0.00963241536880744	ENSMUSG00000024610/ENSMUSG00000023067/ENSMUSG00000024778/ENSMUSG00000044303/ENSMUSG00000029082/ENSMUSG00000035873/ENSMUSG00000019850/ENSMUSG00000029084/ENSMUSG00000021457/ENSMUSG00000055994/ENSMUSG00000031548/ENSMUSG00000040329/ENSMUSG00000075370/ENSMUSG00000052013/ENSMUSG00000004266/ENSMUSG00000034652	Cd74/Cdkn1a/Fas/Cdkn2a/Bst1/Pawr/Tnfaip3/Cd38/Syk/Nod2/Sfrp1/Il7/Igll1/Btla/Ptpn6/Cd300a	16
BP	GO:0019932	second-messenger-mediated signaling	28/858	256/15881	0.000309101693061903	0.009776140444013	ENSMUSG00000026463/ENSMUSG00000006457/ENSMUSG00000029082/ENSMUSG00000062991/ENSMUSG00000020826/ENSMUSG00000026576/ENSMUSG00000026166/ENSMUSG00000021457/ENSMUSG00000050541/ENSMUSG00000029373/ENSMUSG00000034353/ENSMUSG00000061603/ENSMUSG00000015243/ENSMUSG00000074272/ENSMUSG00000002944/ENSMUSG00000026580/ENSMUSG00000027674/ENSMUSG00000041046/ENSMUSG00000034855/ENSMUSG00000028978/ENSMUSG00000020178/ENSMUSG00000049044/ENSMUSG00000059588/ENSMUSG00000031489/ENSMUSG00000035458/ENSMUSG00000044338/ENSMUSG00000038239/ENSMUSG00000026117	Atp2b4/Actn3/Bst1/Nrg1/Nos2/Atp1b1/Ccl20/Syk/Adra1b/Pf4/Ramp1/Akap6/Abca1/Ceacam1/Cd36/Selp/Pex5l/Ramp3/Cxcl10/Nos3/Adora2a/Rapgef4/Calcrl/Adrb3/Tnni3/Aplnr/Hrc/Zap70	28
BP	GO:0045765	regulation of angiogenesis	28/858	256/15881	0.000309101693061903	0.009776140444013	ENSMUSG00000024164/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000000753/ENSMUSG00000042677/ENSMUSG00000017737/ENSMUSG00000050335/ENSMUSG00000028039/ENSMUSG00000038387/ENSMUSG00000034394/ENSMUSG00000028128/ENSMUSG00000029669/ENSMUSG00000036585/ENSMUSG00000029373/ENSMUSG00000032359/ENSMUSG00000056758/ENSMUSG00000018983/ENSMUSG00000064246/ENSMUSG00000031520/ENSMUSG00000017969/ENSMUSG00000074272/ENSMUSG00000002944/ENSMUSG00000034855/ENSMUSG00000028978/ENSMUSG00000000120/ENSMUSG00000021256/ENSMUSG00000028864/ENSMUSG00000044338	C3/Ccl2/Cx3cl1/Serpinf1/Zc3h12a/Mmp9/Lgals3/Efna3/Rras/Lif/F3/Tspan12/Fgf1/Pf4/Ctsh/Hmga2/E2f2/Chil1/Vegfc/Ptgis/Ceacam1/Cd36/Cxcl10/Nos3/Ngfr/Vash1/Hgf/Aplnr	28
BP	GO:0051051	negative regulation of transport	40/858	418/15881	0.00032624342721905	0.0102476188851134	ENSMUSG00000024610/ENSMUSG00000031778/ENSMUSG00000046718/ENSMUSG00000042677/ENSMUSG00000028965/ENSMUSG00000017737/ENSMUSG00000020806/ENSMUSG00000050335/ENSMUSG00000003541/ENSMUSG00000047250/ENSMUSG00000035873/ENSMUSG00000029334/ENSMUSG00000042429/ENSMUSG00000034394/ENSMUSG00000021596/ENSMUSG00000029851/ENSMUSG00000027995/ENSMUSG00000079363/ENSMUSG00000005057/ENSMUSG00000004347/ENSMUSG00000024873/ENSMUSG00000053216/ENSMUSG00000003484/ENSMUSG00000025889/ENSMUSG00000027457/ENSMUSG00000020641/ENSMUSG00000090958/ENSMUSG00000041245/ENSMUSG00000028214/ENSMUSG00000026249/ENSMUSG00000031548/ENSMUSG00000037362/ENSMUSG00000028978/ENSMUSG00000025557/ENSMUSG00000000706/ENSMUSG00000052276/ENSMUSG00000034652/ENSMUSG00000030707/ENSMUSG00000038239/ENSMUSG00000020081	Cd74/Cx3cl1/Bst2/Zc3h12a/Tnfrsf9/Mmp9/Rhbdf2/Lgals3/Ier3/Ptgs1/Pawr/Prkg2/Adora1/Lif/Mctp1/Tcaf2/Tlr2/Gbp4/Sh2b2/Pde1c/Cnih2/Btn2a2/Cyp4f18/Snca/Snph/Rsad2/Lrrc32/Wnk3/Gem/Serpine2/Sfrp1/Nov/Nos3/Slc15a1/Btn1a1/Ostn/Cd300a/Coro1a/Hrc/Tacr2	40
BP	GO:0045058	T cell selection	9/858	42/15881	0.000334254632359693	0.0104278349932078	ENSMUSG00000024610/ENSMUSG00000024778/ENSMUSG00000021457/ENSMUSG00000066755/ENSMUSG00000049109/ENSMUSG00000031712/ENSMUSG00000048251/ENSMUSG00000034266/ENSMUSG00000026117	Cd74/Fas/Syk/Tnfsf18/Themis/Il15/Bcl11b/Batf/Zap70	9
BP	GO:0060047	heart contraction	20/858	158/15881	0.000337441777285922	0.0104293930991892	ENSMUSG00000042677/ENSMUSG00000026463/ENSMUSG00000042429/ENSMUSG00000037580/ENSMUSG00000053965/ENSMUSG00000057123/ENSMUSG00000026576/ENSMUSG00000019997/ENSMUSG00000040907/ENSMUSG00000050541/ENSMUSG00000061603/ENSMUSG00000064329/ENSMUSG00000024065/ENSMUSG00000028978/ENSMUSG00000035296/ENSMUSG00000026418/ENSMUSG00000041695/ENSMUSG00000036570/ENSMUSG00000035458/ENSMUSG00000038239	Zc3h12a/Atp2b4/Adora1/Gch1/Pde5a/Gja5/Atp1b1/Ctgf/Atp1a3/Adra1b/Akap6/Scn1a/Ehd3/Nos3/Sgcg/Tnni1/Kcnj2/Fxyd1/Tnni3/Hrc	20
BP	GO:0040017	positive regulation of locomotion	45/858	489/15881	0.000338852937588135	0.0104293930991892	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000027750/ENSMUSG00000029816/ENSMUSG00000016024/ENSMUSG00000042677/ENSMUSG00000022150/ENSMUSG00000017737/ENSMUSG00000050335/ENSMUSG00000037685/ENSMUSG00000035873/ENSMUSG00000023913/ENSMUSG00000039621/ENSMUSG00000032860/ENSMUSG00000025207/ENSMUSG00000021822/ENSMUSG00000022676/ENSMUSG00000029851/ENSMUSG00000028128/ENSMUSG00000026166/ENSMUSG00000027995/ENSMUSG00000053475/ENSMUSG00000036585/ENSMUSG00000048779/ENSMUSG00000029373/ENSMUSG00000027985/ENSMUSG00000032359/ENSMUSG00000066755/ENSMUSG00000031520/ENSMUSG00000046761/ENSMUSG00000026580/ENSMUSG00000055632/ENSMUSG00000029371/ENSMUSG00000034855/ENSMUSG00000002489/ENSMUSG00000028978/ENSMUSG00000049044/ENSMUSG00000050315/ENSMUSG00000028864/ENSMUSG00000030170/ENSMUSG00000068748/ENSMUSG00000030707/ENSMUSG00000020081	Cd74/Cxcl1/Ccl2/Cx3cl1/Postn/Gpnmb/Lbp/Zc3h12a/Dab2/Mmp9/Lgals3/Atp8a1/Pawr/Pla2g7/Prex1/P2ry2/Sema4g/Plau/Snai2/Tcaf2/F3/Ccl20/Tlr2/Tnfaip6/Fgf1/P2ry6/Pf4/Lef1/Ctsh/Tnfsf18/Vegfc/Fam83h/Selp/Hmcn2/Cxcl5/Cxcl10/Tiam1/Nos3/Rapgef4/Synpo2/Hgf/Wnt5b/Ptprz1/Coro1a/Tacr2	45
BP	GO:0090075	relaxation of muscle	7/858	26/15881	0.000348844793164584	0.0106653481430185	ENSMUSG00000006457/ENSMUSG00000035873/ENSMUSG00000042429/ENSMUSG00000053965/ENSMUSG00000026576/ENSMUSG00000061603/ENSMUSG00000041695	Actn3/Pawr/Adora1/Pde5a/Atp1b1/Akap6/Kcnj2	7
BP	GO:0010743	regulation of macrophage derived foam cell differentiation	6/858	19/15881	0.000361129436712539	0.0108845657965879	ENSMUSG00000018800/ENSMUSG00000029373/ENSMUSG00000002944/ENSMUSG00000021108/ENSMUSG00000024030/ENSMUSG00000025044	Abca5/Pf4/Cd36/Prkch/Abcg1/Msr1	6
BP	GO:0072677	eosinophil migration	6/858	19/15881	0.000361129436712539	0.0108845657965879	ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000035373/ENSMUSG00000050335/ENSMUSG00000019122/ENSMUSG00000034652	Ccl2/Cx3cl1/Ccl7/Lgals3/Ccl9/Cd300a	6
BP	GO:0050702	interleukin-1 beta secretion	8/858	34/15881	0.000363135317679448	0.0108845657965879	ENSMUSG00000042677/ENSMUSG00000033538/ENSMUSG00000027995/ENSMUSG00000055994/ENSMUSG00000015243/ENSMUSG00000002944/ENSMUSG00000037860/ENSMUSG00000025888	Zc3h12a/Casp4/Tlr2/Nod2/Abca1/Cd36/Aim2/Casp1	8
BP	GO:0042133	neurotransmitter metabolic process	16/858	113/15881	0.000369131254286211	0.0109924411178998	ENSMUSG00000042677/ENSMUSG00000026463/ENSMUSG00000006764/ENSMUSG00000037580/ENSMUSG00000020826/ENSMUSG00000079685/ENSMUSG00000027995/ENSMUSG00000017969/ENSMUSG00000076441/ENSMUSG00000002944/ENSMUSG00000006235/ENSMUSG00000040046/ENSMUSG00000028978/ENSMUSG00000079164/ENSMUSG00000007034/ENSMUSG00000043943	Zc3h12a/Atp2b4/Tph2/Gch1/Nos2/Ulbp1/Tlr2/Ptgis/Ass1/Cd36/Epor/Tph1/Nos3/Tlr5/Slc44a4/Naalad2	16
BP	GO:0033559	unsaturated fatty acid metabolic process	11/858	61/15881	0.000374774185133528	0.0110884800840152	ENSMUSG00000024610/ENSMUSG00000047250/ENSMUSG00000050737/ENSMUSG00000025002/ENSMUSG00000033715/ENSMUSG00000003484/ENSMUSG00000017969/ENSMUSG00000052974/ENSMUSG00000020892/ENSMUSG00000025955/ENSMUSG00000025197	Cd74/Ptgs1/Ptges/Cyp2c55/Akr1c14/Cyp4f18/Ptgis/Cyp2f2/Aloxe3/Akr1cl/Cyp2c23	11
BP	GO:0016045	detection of bacterium	5/858	13/15881	0.000406841158871168	0.0118839079909757	ENSMUSG00000078945/ENSMUSG00000027995/ENSMUSG00000078942/ENSMUSG00000055994/ENSMUSG00000071203	Naip2/Tlr2/Naip6/Nod2/Naip5	5
BP	GO:0098543	detection of other organism	5/858	13/15881	0.000406841158871168	0.0118839079909757	ENSMUSG00000078945/ENSMUSG00000027995/ENSMUSG00000078942/ENSMUSG00000055994/ENSMUSG00000071203	Naip2/Tlr2/Naip6/Nod2/Naip5	5
BP	GO:0006816	calcium ion transport	33/858	327/15881	0.000417435079780642	0.0121161852903419	ENSMUSG00000026463/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000021831/ENSMUSG00000026576/ENSMUSG00000019997/ENSMUSG00000032839/ENSMUSG00000044026/ENSMUSG00000022416/ENSMUSG00000027994/ENSMUSG00000050777/ENSMUSG00000057897/ENSMUSG00000034353/ENSMUSG00000061603/ENSMUSG00000025889/ENSMUSG00000032020/ENSMUSG00000041245/ENSMUSG00000028214/ENSMUSG00000028255/ENSMUSG00000041046/ENSMUSG00000053395/ENSMUSG00000034855/ENSMUSG00000024065/ENSMUSG00000028978/ENSMUSG00000020178/ENSMUSG00000020787/ENSMUSG00000037418/ENSMUSG00000030523/ENSMUSG00000059588/ENSMUSG00000004266/ENSMUSG00000030707/ENSMUSG00000044338/ENSMUSG00000038239	Atp2b4/Lgals3/Pawr/Ero1l/Atp1b1/Ctgf/Trpc1/Slc35g1/Cacna1i/Mcub/Tmem37/Camk2b/Ramp1/Akap6/Snca/Ubash3b/Wnk3/Gem/Clca1/Ramp3/Cacng8/Cxcl10/Ehd3/Nos3/Adora2a/P2rx1/Best1/Trpm1/Calcrl/Ptpn6/Coro1a/Aplnr/Hrc	33
BP	GO:0050778	positive regulation of immune response	40/858	424/15881	0.000435087229367824	0.0125491197099424	ENSMUSG00000024164/ENSMUSG00000024610/ENSMUSG00000073411/ENSMUSG00000061232/ENSMUSG00000016024/ENSMUSG00000030921/ENSMUSG00000042677/ENSMUSG00000000732/ENSMUSG00000074151/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000019850/ENSMUSG00000029084/ENSMUSG00000062300/ENSMUSG00000079685/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000026068/ENSMUSG00000055994/ENSMUSG00000005057/ENSMUSG00000053216/ENSMUSG00000026177/ENSMUSG00000049109/ENSMUSG00000017830/ENSMUSG00000020641/ENSMUSG00000002944/ENSMUSG00000079343/ENSMUSG00000037860/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000000706/ENSMUSG00000079164/ENSMUSG00000075370/ENSMUSG00000109713/ENSMUSG00000021108/ENSMUSG00000002699/ENSMUSG00000024696/ENSMUSG00000004266/ENSMUSG00000034652/ENSMUSG00000026117	C3/Cd74/H2-D1/H2-K1/Lbp/Trim30a/Zc3h12a/Icosl/Nlrc5/Lgals3/Pawr/Tnfaip3/Cd38/Nectin2/Ulbp1/Tlr2/Syk/Il18rap/Nod2/Sh2b2/Btn2a2/Slc11a1/Themis/Dhx58/Rsad2/Cd36/C1s2/Aim2/Il12rb1/Il15/Btn1a1/Tlr5/Igll1/Pvrig/Prkch/Lcp2/Lpxn/Ptpn6/Cd300a/Zap70	40
BP	GO:1901099	negative regulation of signal transduction in absence of ligand	7/858	27/15881	0.000449180833664319	0.0127571229529175	ENSMUSG00000031778/ENSMUSG00000022144/ENSMUSG00000022676/ENSMUSG00000029373/ENSMUSG00000025915/ENSMUSG00000040329/ENSMUSG00000022483	Cx3cl1/Gdnf/Snai2/Pf4/Sgk3/Il7/Col2a1	7
BP	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	7/858	27/15881	0.000449180833664319	0.0127571229529175	ENSMUSG00000031778/ENSMUSG00000022144/ENSMUSG00000022676/ENSMUSG00000029373/ENSMUSG00000025915/ENSMUSG00000040329/ENSMUSG00000022483	Cx3cl1/Gdnf/Snai2/Pf4/Sgk3/Il7/Col2a1	7
BP	GO:0070372	regulation of ERK1 and ERK2 cascade	28/858	262/15881	0.000450644116522597	0.0127571229529175	ENSMUSG00000024164/ENSMUSG00000024610/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000029816/ENSMUSG00000022150/ENSMUSG00000035373/ENSMUSG00000038387/ENSMUSG00000034394/ENSMUSG00000019997/ENSMUSG00000026166/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000019122/ENSMUSG00000055994/ENSMUSG00000042662/ENSMUSG00000025665/ENSMUSG00000053216/ENSMUSG00000064246/ENSMUSG00000041193/ENSMUSG00000002944/ENSMUSG00000041046/ENSMUSG00000006235/ENSMUSG00000002489/ENSMUSG00000039661/ENSMUSG00000031780/ENSMUSG00000024427/ENSMUSG00000004266	C3/Cd74/Ccl2/Cx3cl1/Gpnmb/Dab2/Ccl7/Rras/Lif/Ctgf/Ccl20/Tlr2/Syk/Ccl9/Nod2/Dusp15/Rps6ka6/Btn2a2/Chil1/Pla2g5/Cd36/Ramp3/Epor/Tiam1/Dusp26/Ccl17/Spry4/Ptpn6	28
BP	GO:0050854	regulation of antigen receptor-mediated signaling pathway	9/858	44/15881	0.000482356583472322	0.0135710876797796	ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000062300/ENSMUSG00000053216/ENSMUSG00000109713/ENSMUSG00000021108/ENSMUSG00000024696/ENSMUSG00000004266/ENSMUSG00000034652	Lgals3/Pawr/Nectin2/Btn2a2/Pvrig/Prkch/Lpxn/Ptpn6/Cd300a	9
BP	GO:0009595	detection of biotic stimulus	6/858	20/15881	0.000492477261652845	0.0137713458654875	ENSMUSG00000016024/ENSMUSG00000078945/ENSMUSG00000027995/ENSMUSG00000078942/ENSMUSG00000055994/ENSMUSG00000071203	Lbp/Naip2/Tlr2/Naip6/Nod2/Naip5	6
BP	GO:0010952	positive regulation of peptidase activity	18/858	139/15881	0.000498314227573973	0.01382058704367	ENSMUSG00000023030/ENSMUSG00000024778/ENSMUSG00000024066/ENSMUSG00000044303/ENSMUSG00000028039/ENSMUSG00000035873/ENSMUSG00000033538/ENSMUSG00000019997/ENSMUSG00000028128/ENSMUSG00000025507/ENSMUSG00000032359/ENSMUSG00000079017/ENSMUSG00000025889/ENSMUSG00000020340/ENSMUSG00000037860/ENSMUSG00000000120/ENSMUSG00000020787/ENSMUSG00000025888	Slc11a2/Fas/Xdh/Cdkn2a/Efna3/Pawr/Casp4/Ctgf/F3/Pidd1/Ctsh/Ifi27l2a/Snca/Cyfip2/Aim2/Ngfr/P2rx1/Casp1	18
BP	GO:0006809	nitric oxide biosynthetic process	11/858	63/15881	0.000500265470834981	0.01382058704367	ENSMUSG00000042677/ENSMUSG00000026463/ENSMUSG00000020826/ENSMUSG00000079685/ENSMUSG00000027995/ENSMUSG00000017969/ENSMUSG00000076441/ENSMUSG00000002944/ENSMUSG00000006235/ENSMUSG00000028978/ENSMUSG00000079164	Zc3h12a/Atp2b4/Nos2/Ulbp1/Tlr2/Ptgis/Ass1/Cd36/Epor/Nos3/Tlr5	11
BP	GO:0051607	defense response to virus	22/858	188/15881	0.000529484283797058	0.01443947870858	ENSMUSG00000046718/ENSMUSG00000030921/ENSMUSG00000042677/ENSMUSG00000035208/ENSMUSG00000066800/ENSMUSG00000079363/ENSMUSG00000001166/ENSMUSG00000035692/ENSMUSG00000017830/ENSMUSG00000032690/ENSMUSG00000020641/ENSMUSG00000000386/ENSMUSG00000059108/ENSMUSG00000029605/ENSMUSG00000034459/ENSMUSG00000032661/ENSMUSG00000037860/ENSMUSG00000034855/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000079339/ENSMUSG00000062157	Bst2/Trim30a/Zc3h12a/Slfn8/Rnasel/Gbp4/Oas1c/Isg15/Dhx58/Oas2/Rsad2/Mx1/Ifitm6/Oas1b/Ifit1/Oas3/Aim2/Cxcl10/Il12rb1/Il15/Ifit1bl1/Ifnlr1	22
BP	GO:0070371	ERK1 and ERK2 cascade	29/858	278/15881	0.000535251660202259	0.01443947870858	ENSMUSG00000024164/ENSMUSG00000024610/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000029816/ENSMUSG00000022150/ENSMUSG00000035373/ENSMUSG00000038387/ENSMUSG00000034394/ENSMUSG00000019997/ENSMUSG00000026166/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000019122/ENSMUSG00000055994/ENSMUSG00000032359/ENSMUSG00000042662/ENSMUSG00000025665/ENSMUSG00000053216/ENSMUSG00000064246/ENSMUSG00000041193/ENSMUSG00000002944/ENSMUSG00000041046/ENSMUSG00000006235/ENSMUSG00000002489/ENSMUSG00000039661/ENSMUSG00000031780/ENSMUSG00000024427/ENSMUSG00000004266	C3/Cd74/Ccl2/Cx3cl1/Gpnmb/Dab2/Ccl7/Rras/Lif/Ctgf/Ccl20/Tlr2/Syk/Ccl9/Nod2/Ctsh/Dusp15/Rps6ka6/Btn2a2/Chil1/Pla2g5/Cd36/Ramp3/Epor/Tiam1/Dusp26/Ccl17/Spry4/Ptpn6	29
BP	GO:1901342	regulation of vasculature development	29/858	278/15881	0.000535251660202259	0.01443947870858	ENSMUSG00000024164/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000000753/ENSMUSG00000042677/ENSMUSG00000024066/ENSMUSG00000017737/ENSMUSG00000050335/ENSMUSG00000028039/ENSMUSG00000038387/ENSMUSG00000034394/ENSMUSG00000028128/ENSMUSG00000029669/ENSMUSG00000036585/ENSMUSG00000029373/ENSMUSG00000032359/ENSMUSG00000056758/ENSMUSG00000018983/ENSMUSG00000064246/ENSMUSG00000031520/ENSMUSG00000017969/ENSMUSG00000074272/ENSMUSG00000002944/ENSMUSG00000034855/ENSMUSG00000028978/ENSMUSG00000000120/ENSMUSG00000021256/ENSMUSG00000028864/ENSMUSG00000044338	C3/Ccl2/Cx3cl1/Serpinf1/Zc3h12a/Xdh/Mmp9/Lgals3/Efna3/Rras/Lif/F3/Tspan12/Fgf1/Pf4/Ctsh/Hmga2/E2f2/Chil1/Vegfc/Ptgis/Ceacam1/Cd36/Cxcl10/Nos3/Ngfr/Vash1/Hgf/Aplnr	29
BP	GO:0048525	negative regulation of viral process	13/858	84/15881	0.000541100646624817	0.01443947870858	ENSMUSG00000017002/ENSMUSG00000046718/ENSMUSG00000042677/ENSMUSG00000066800/ENSMUSG00000001166/ENSMUSG00000035692/ENSMUSG00000074272/ENSMUSG00000032690/ENSMUSG00000020641/ENSMUSG00000059108/ENSMUSG00000029605/ENSMUSG00000032661/ENSMUSG00000000266	Slpi/Bst2/Zc3h12a/Rnasel/Oas1c/Isg15/Ceacam1/Oas2/Rsad2/Ifitm6/Oas1b/Oas3/Mid2	13
BP	GO:0002443	leukocyte mediated immunity	27/858	252/15881	0.000543307325915146	0.01443947870858	ENSMUSG00000024164/ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000073411/ENSMUSG00000061232/ENSMUSG00000024778/ENSMUSG00000000732/ENSMUSG00000062300/ENSMUSG00000079685/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000053175/ENSMUSG00000026068/ENSMUSG00000055994/ENSMUSG00000032359/ENSMUSG00000026177/ENSMUSG00000074272/ENSMUSG00000020641/ENSMUSG00000079343/ENSMUSG00000029371/ENSMUSG00000075370/ENSMUSG00000021948/ENSMUSG00000004266/ENSMUSG00000034652/ENSMUSG00000030707/ENSMUSG00000034266/ENSMUSG00000025279	C3/Cd74/Cxcl1/H2-D1/H2-K1/Fas/Icosl/Nectin2/Ulbp1/Tlr2/Syk/Bcl3/Il18rap/Nod2/Ctsh/Slc11a1/Ceacam1/Rsad2/C1s2/Cxcl5/Igll1/Prkcd/Ptpn6/Cd300a/Coro1a/Batf/Dnase1l3	27
BP	GO:0051480	regulation of cytosolic calcium ion concentration	27/858	252/15881	0.000543307325915146	0.01443947870858	ENSMUSG00000029380/ENSMUSG00000026463/ENSMUSG00000035873/ENSMUSG00000021831/ENSMUSG00000032860/ENSMUSG00000029084/ENSMUSG00000032839/ENSMUSG00000050541/ENSMUSG00000044026/ENSMUSG00000022416/ENSMUSG00000061603/ENSMUSG00000025889/ENSMUSG00000032020/ENSMUSG00000074715/ENSMUSG00000002944/ENSMUSG00000060459/ENSMUSG00000021070/ENSMUSG00000041046/ENSMUSG00000006235/ENSMUSG00000034855/ENSMUSG00000030523/ENSMUSG00000004266/ENSMUSG00000036570/ENSMUSG00000030707/ENSMUSG00000044338/ENSMUSG00000038239/ENSMUSG00000021337	Cxcl1/Atp2b4/Pawr/Ero1l/P2ry2/Cd38/Trpc1/Adra1b/Slc35g1/Cacna1i/Akap6/Snca/Ubash3b/Ccl28/Cd36/Kng2/Bdkrb2/Ramp3/Epor/Cxcl10/Trpm1/Ptpn6/Fxyd1/Coro1a/Aplnr/Hrc/Scgn	27
BP	GO:0032611	interleukin-1 beta production	10/858	54/15881	0.000550363262307986	0.01443947870858	ENSMUSG00000042677/ENSMUSG00000033538/ENSMUSG00000019850/ENSMUSG00000027995/ENSMUSG00000055994/ENSMUSG00000015243/ENSMUSG00000002944/ENSMUSG00000037860/ENSMUSG00000071203/ENSMUSG00000025888	Zc3h12a/Casp4/Tnfaip3/Tlr2/Nod2/Abca1/Cd36/Aim2/Naip5/Casp1	10
BP	GO:0006909	phagocytosis	19/858	152/15881	0.000551004965983757	0.01443947870858	ENSMUSG00000024164/ENSMUSG00000035385/ENSMUSG00000016024/ENSMUSG00000024743/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000071715/ENSMUSG00000055994/ENSMUSG00000026177/ENSMUSG00000015243/ENSMUSG00000031504/ENSMUSG00000041351/ENSMUSG00000002944/ENSMUSG00000032174/ENSMUSG00000041515/ENSMUSG00000075370/ENSMUSG00000025044/ENSMUSG00000034652/ENSMUSG00000030707	C3/Ccl2/Lbp/Syt7/Tlr2/Syk/Ncf4/Nod2/Slc11a1/Abca1/Rab20/Rap1gap/Cd36/Icam5/Irf8/Igll1/Msr1/Cd300a/Coro1a	19
BP	GO:0015893	drug transport	19/858	152/15881	0.000551004965983757	0.01443947870858	ENSMUSG00000020432/ENSMUSG00000055368/ENSMUSG00000023947/ENSMUSG00000005089/ENSMUSG00000024743/ENSMUSG00000022144/ENSMUSG00000027995/ENSMUSG00000022512/ENSMUSG00000032373/ENSMUSG00000028970/ENSMUSG00000026177/ENSMUSG00000025889/ENSMUSG00000027070/ENSMUSG00000070570/ENSMUSG00000020178/ENSMUSG00000054753/ENSMUSG00000022899/ENSMUSG00000007034/ENSMUSG00000020081	Tcn2/Slc6a2/Nfkbie/Slc1a2/Syt7/Gdnf/Tlr2/Cldn1/Car12/Abcb1b/Slc11a1/Snca/Lrp2/Slc17a7/Adora2a/AU018091/Slc15a2/Slc44a4/Tacr2	19
BP	GO:0090022	regulation of neutrophil chemotaxis	7/858	28/15881	0.000571259755077194	0.0147755938908119	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000016024/ENSMUSG00000029082/ENSMUSG00000029373/ENSMUSG00000055994/ENSMUSG00000029371	Cd74/Cxcl1/Lbp/Bst1/Pf4/Nod2/Cxcl5	7
BP	GO:0072507	divalent inorganic cation homeostasis	36/858	374/15881	0.000571379056596305	0.0147755938908119	ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000026463/ENSMUSG00000035873/ENSMUSG00000021831/ENSMUSG00000032860/ENSMUSG00000026576/ENSMUSG00000029084/ENSMUSG00000032839/ENSMUSG00000050541/ENSMUSG00000035694/ENSMUSG00000044026/ENSMUSG00000036019/ENSMUSG00000022416/ENSMUSG00000027994/ENSMUSG00000026177/ENSMUSG00000061603/ENSMUSG00000025889/ENSMUSG00000032020/ENSMUSG00000074715/ENSMUSG00000002944/ENSMUSG00000060459/ENSMUSG00000021070/ENSMUSG00000063354/ENSMUSG00000041046/ENSMUSG00000006235/ENSMUSG00000034855/ENSMUSG00000030523/ENSMUSG00000004266/ENSMUSG00000036570/ENSMUSG00000035458/ENSMUSG00000030707/ENSMUSG00000044338/ENSMUSG00000038239/ENSMUSG00000021337/ENSMUSG00000043051	Cxcl1/Ccl2/Atp2b4/Pawr/Ero1l/P2ry2/Atp1b1/Cd38/Trpc1/Adra1b/Caps2/Slc35g1/Tmtc2/Cacna1i/Mcub/Slc11a1/Akap6/Snca/Ubash3b/Ccl28/Cd36/Kng2/Bdkrb2/Slc39a4/Ramp3/Epor/Cxcl10/Trpm1/Ptpn6/Fxyd1/Tnni3/Coro1a/Aplnr/Hrc/Scgn/Disc1	36
BP	GO:0009615	response to virus	25/858	227/15881	0.000573496666499021	0.0147755938908119	ENSMUSG00000046718/ENSMUSG00000030921/ENSMUSG00000042677/ENSMUSG00000035208/ENSMUSG00000066800/ENSMUSG00000053175/ENSMUSG00000079363/ENSMUSG00000001166/ENSMUSG00000079017/ENSMUSG00000035692/ENSMUSG00000026822/ENSMUSG00000017830/ENSMUSG00000032690/ENSMUSG00000020641/ENSMUSG00000000386/ENSMUSG00000059108/ENSMUSG00000029605/ENSMUSG00000034459/ENSMUSG00000032661/ENSMUSG00000037860/ENSMUSG00000034855/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000079339/ENSMUSG00000062157	Bst2/Trim30a/Zc3h12a/Slfn8/Rnasel/Bcl3/Gbp4/Oas1c/Ifi27l2a/Isg15/Lcn2/Dhx58/Oas2/Rsad2/Mx1/Ifitm6/Oas1b/Ifit1/Oas3/Aim2/Cxcl10/Il12rb1/Il15/Ifit1bl1/Ifnlr1	25
BP	GO:0051606	detection of stimulus	21/858	177/15881	0.000584942167711563	0.0149461184621132	ENSMUSG00000016024/ENSMUSG00000035873/ENSMUSG00000042429/ENSMUSG00000078945/ENSMUSG00000035504/ENSMUSG00000027995/ENSMUSG00000078942/ENSMUSG00000055994/ENSMUSG00000030313/ENSMUSG00000062168/ENSMUSG00000035916/ENSMUSG00000026249/ENSMUSG00000042774/ENSMUSG00000064329/ENSMUSG00000000120/ENSMUSG00000071203/ENSMUSG00000037418/ENSMUSG00000045381/ENSMUSG00000062873/ENSMUSG00000046493/ENSMUSG00000061972	Lbp/Pawr/Adora1/Naip2/Reep6/Tlr2/Naip6/Nod2/Dennd5b/Ppef1/Ptprq/Serpine2/Olfr1353/Scn1a/Ngfr/Naip5/Best1/Olfr433/Olfr1355/Olfr1352/Olfr99	21
BP	GO:0055074	calcium ion homeostasis	34/858	347/15881	0.000586633520100386	0.0149461184621132	ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000026463/ENSMUSG00000035873/ENSMUSG00000021831/ENSMUSG00000032860/ENSMUSG00000026576/ENSMUSG00000029084/ENSMUSG00000032839/ENSMUSG00000050541/ENSMUSG00000035694/ENSMUSG00000044026/ENSMUSG00000036019/ENSMUSG00000022416/ENSMUSG00000027994/ENSMUSG00000061603/ENSMUSG00000025889/ENSMUSG00000032020/ENSMUSG00000074715/ENSMUSG00000002944/ENSMUSG00000060459/ENSMUSG00000021070/ENSMUSG00000041046/ENSMUSG00000006235/ENSMUSG00000034855/ENSMUSG00000030523/ENSMUSG00000004266/ENSMUSG00000036570/ENSMUSG00000035458/ENSMUSG00000030707/ENSMUSG00000044338/ENSMUSG00000038239/ENSMUSG00000021337/ENSMUSG00000043051	Cxcl1/Ccl2/Atp2b4/Pawr/Ero1l/P2ry2/Atp1b1/Cd38/Trpc1/Adra1b/Caps2/Slc35g1/Tmtc2/Cacna1i/Mcub/Akap6/Snca/Ubash3b/Ccl28/Cd36/Kng2/Bdkrb2/Ramp3/Epor/Cxcl10/Trpm1/Ptpn6/Fxyd1/Tnni3/Coro1a/Aplnr/Hrc/Scgn/Disc1	34
BP	GO:0003018	vascular process in circulatory system	19/858	153/15881	0.000598067518127224	0.0151532466195108	ENSMUSG00000031778/ENSMUSG00000059895/ENSMUSG00000047250/ENSMUSG00000042429/ENSMUSG00000037580/ENSMUSG00000053965/ENSMUSG00000057123/ENSMUSG00000020826/ENSMUSG00000032860/ENSMUSG00000029084/ENSMUSG00000024039/ENSMUSG00000050541/ENSMUSG00000074272/ENSMUSG00000021070/ENSMUSG00000028978/ENSMUSG00000020178/ENSMUSG00000020787/ENSMUSG00000031489/ENSMUSG00000020081	Cx3cl1/Ptp4a3/Ptgs1/Adora1/Gch1/Pde5a/Gja5/Nos2/P2ry2/Cd38/Cbs/Adra1b/Ceacam1/Bdkrb2/Nos3/Adora2a/P2rx1/Adrb3/Tacr2	19
BP	GO:2001056	positive regulation of cysteine-type endopeptidase activity	16/858	118/15881	0.000603054882769216	0.0151571025816052	ENSMUSG00000023030/ENSMUSG00000024778/ENSMUSG00000024066/ENSMUSG00000044303/ENSMUSG00000035873/ENSMUSG00000033538/ENSMUSG00000019997/ENSMUSG00000028128/ENSMUSG00000025507/ENSMUSG00000079017/ENSMUSG00000025889/ENSMUSG00000020340/ENSMUSG00000037860/ENSMUSG00000000120/ENSMUSG00000020787/ENSMUSG00000025888	Slc11a2/Fas/Xdh/Cdkn2a/Pawr/Casp4/Ctgf/F3/Pidd1/Ifi27l2a/Snca/Cyfip2/Aim2/Ngfr/P2rx1/Casp1	16
BP	GO:0044130	negative regulation of growth of symbiont in host	5/858	14/15881	0.000604829867517171	0.0151571025816052	ENSMUSG00000016024/ENSMUSG00000027995/ENSMUSG00000055994/ENSMUSG00000002944/ENSMUSG00000041515	Lbp/Tlr2/Nod2/Cd36/Irf8	5
BP	GO:0007596	blood coagulation	17/858	130/15881	0.000630619880035597	0.0157175150534959	ENSMUSG00000024164/ENSMUSG00000031778/ENSMUSG00000021822/ENSMUSG00000027082/ENSMUSG00000028128/ENSMUSG00000021457/ENSMUSG00000029373/ENSMUSG00000032020/ENSMUSG00000074272/ENSMUSG00000002944/ENSMUSG00000060459/ENSMUSG00000026580/ENSMUSG00000027611/ENSMUSG00000026249/ENSMUSG00000020787/ENSMUSG00000021948/ENSMUSG00000004266	C3/Cx3cl1/Plau/Tfpi/F3/Syk/Pf4/Ubash3b/Ceacam1/Cd36/Kng2/Selp/Procr/Serpine2/P2rx1/Prkcd/Ptpn6	17
BP	GO:0044419	interspecies interaction between organisms	33/858	335/15881	0.000639610983265425	0.0157953347131211	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000017002/ENSMUSG00000046718/ENSMUSG00000016024/ENSMUSG00000030921/ENSMUSG00000042677/ENSMUSG00000017737/ENSMUSG00000066800/ENSMUSG00000020826/ENSMUSG00000062300/ENSMUSG00000027995/ENSMUSG00000040253/ENSMUSG00000029373/ENSMUSG00000001166/ENSMUSG00000055994/ENSMUSG00000027985/ENSMUSG00000029298/ENSMUSG00000035692/ENSMUSG00000028268/ENSMUSG00000074272/ENSMUSG00000032690/ENSMUSG00000020641/ENSMUSG00000002944/ENSMUSG00000104713/ENSMUSG00000059108/ENSMUSG00000029605/ENSMUSG00000029371/ENSMUSG00000032661/ENSMUSG00000006235/ENSMUSG00000041515/ENSMUSG00000000266	Cd74/Cxcl1/Ccl2/Slpi/Bst2/Lbp/Trim30a/Zc3h12a/Mmp9/Rnasel/Nos2/Nectin2/Tlr2/Gbp7/Pf4/Oas1c/Nod2/Lef1/Gbp9/Isg15/Gbp3/Ceacam1/Oas2/Rsad2/Cd36/Gbp6/Ifitm6/Oas1b/Cxcl5/Oas3/Epor/Irf8/Mid2	33
BP	GO:0001910	regulation of leukocyte mediated cytotoxicity	10/858	55/15881	0.000640630670876695	0.0157953347131211	ENSMUSG00000029380/ENSMUSG00000073411/ENSMUSG00000035385/ENSMUSG00000061232/ENSMUSG00000062300/ENSMUSG00000079685/ENSMUSG00000026068/ENSMUSG00000074272/ENSMUSG00000029371/ENSMUSG00000025279	Cxcl1/H2-D1/Ccl2/H2-K1/Nectin2/Ulbp1/Il18rap/Ceacam1/Cxcl5/Dnase1l3	10
BP	GO:0001818	negative regulation of cytokine production	23/858	204/15881	0.000676907739947814	0.01660052885241	ENSMUSG00000031778/ENSMUSG00000029816/ENSMUSG00000016024/ENSMUSG00000030921/ENSMUSG00000042677/ENSMUSG00000028965/ENSMUSG00000049577/ENSMUSG00000019850/ENSMUSG00000027995/ENSMUSG00000053175/ENSMUSG00000079363/ENSMUSG00000007805/ENSMUSG00000055994/ENSMUSG00000027985/ENSMUSG00000053216/ENSMUSG00000026177/ENSMUSG00000017830/ENSMUSG00000074272/ENSMUSG00000090958/ENSMUSG00000025494/ENSMUSG00000031438/ENSMUSG00000000706/ENSMUSG00000028864	Cx3cl1/Gpnmb/Lbp/Trim30a/Zc3h12a/Tnfrsf9/Zfpm1/Tnfaip3/Tlr2/Bcl3/Gbp4/Twist2/Nod2/Lef1/Btn2a2/Slc11a1/Dhx58/Ceacam1/Lrrc32/Sigirr/Rnf128/Btn1a1/Hgf	23
BP	GO:0045785	positive regulation of cell adhesion	32/858	324/15881	0.0007341327752338	0.0179081537618203	ENSMUSG00000024610/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000031785/ENSMUSG00000022150/ENSMUSG00000037440/ENSMUSG00000000732/ENSMUSG00000035873/ENSMUSG00000039621/ENSMUSG00000021457/ENSMUSG00000029307/ENSMUSG00000027985/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000031520/ENSMUSG00000041351/ENSMUSG00000074715/ENSMUSG00000074272/ENSMUSG00000002944/ENSMUSG00000026580/ENSMUSG00000035258/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000040329/ENSMUSG00000039661/ENSMUSG00000039323/ENSMUSG00000004266/ENSMUSG00000020325/ENSMUSG00000030707/ENSMUSG00000026117/ENSMUSG00000043051	Cd74/Ccl2/Cx3cl1/Adgrg1/Dab2/Vnn1/Icosl/Pawr/Prex1/Syk/Dmp1/Lef1/Cd80/Tnfsf18/Btn2a2/Vegfc/Rap1gap/Ccl28/Ceacam1/Cd36/Selp/Abi3bp/Il12rb1/Il15/Il7/Dusp26/Igfbp2/Ptpn6/Fstl3/Coro1a/Zap70/Disc1	32
BP	GO:0007599	hemostasis	17/858	132/15881	0.00075207878783594	0.0179855496941041	ENSMUSG00000024164/ENSMUSG00000031778/ENSMUSG00000021822/ENSMUSG00000027082/ENSMUSG00000028128/ENSMUSG00000021457/ENSMUSG00000029373/ENSMUSG00000032020/ENSMUSG00000074272/ENSMUSG00000002944/ENSMUSG00000060459/ENSMUSG00000026580/ENSMUSG00000027611/ENSMUSG00000026249/ENSMUSG00000020787/ENSMUSG00000021948/ENSMUSG00000004266	C3/Cx3cl1/Plau/Tfpi/F3/Syk/Pf4/Ubash3b/Ceacam1/Cd36/Kng2/Selp/Procr/Serpine2/P2rx1/Prkcd/Ptpn6	17
BP	GO:0010950	positive regulation of endopeptidase activity	17/858	132/15881	0.00075207878783594	0.0179855496941041	ENSMUSG00000023030/ENSMUSG00000024778/ENSMUSG00000024066/ENSMUSG00000044303/ENSMUSG00000028039/ENSMUSG00000035873/ENSMUSG00000033538/ENSMUSG00000019997/ENSMUSG00000028128/ENSMUSG00000025507/ENSMUSG00000079017/ENSMUSG00000025889/ENSMUSG00000020340/ENSMUSG00000037860/ENSMUSG00000000120/ENSMUSG00000020787/ENSMUSG00000025888	Slc11a2/Fas/Xdh/Cdkn2a/Efna3/Pawr/Casp4/Ctgf/F3/Pidd1/Ifi27l2a/Snca/Cyfip2/Aim2/Ngfr/P2rx1/Casp1	17
BP	GO:0015844	monoamine transport	11/858	66/15881	0.00075299292221282	0.0179855496941041	ENSMUSG00000055368/ENSMUSG00000050335/ENSMUSG00000047250/ENSMUSG00000024743/ENSMUSG00000022144/ENSMUSG00000021457/ENSMUSG00000025889/ENSMUSG00000020178/ENSMUSG00000020787/ENSMUSG00000054423/ENSMUSG00000034652	Slc6a2/Lgals3/Ptgs1/Syt7/Gdnf/Syk/Snca/Adora2a/P2rx1/Cadps/Cd300a	11
BP	GO:0046209	nitric oxide metabolic process	11/858	66/15881	0.00075299292221282	0.0179855496941041	ENSMUSG00000042677/ENSMUSG00000026463/ENSMUSG00000020826/ENSMUSG00000079685/ENSMUSG00000027995/ENSMUSG00000017969/ENSMUSG00000076441/ENSMUSG00000002944/ENSMUSG00000006235/ENSMUSG00000028978/ENSMUSG00000079164	Zc3h12a/Atp2b4/Nos2/Ulbp1/Tlr2/Ptgis/Ass1/Cd36/Epor/Nos3/Tlr5	11
BP	GO:0046394	carboxylic acid biosynthetic process	30/858	298/15881	0.00077931721660527	0.0185178691987138	ENSMUSG00000024610/ENSMUSG00000060600/ENSMUSG00000053279/ENSMUSG00000026463/ENSMUSG00000006457/ENSMUSG00000021196/ENSMUSG00000003541/ENSMUSG00000047250/ENSMUSG00000037580/ENSMUSG00000006344/ENSMUSG00000019577/ENSMUSG00000050737/ENSMUSG00000042010/ENSMUSG00000023963/ENSMUSG00000021457/ENSMUSG00000026688/ENSMUSG00000024039/ENSMUSG00000028497/ENSMUSG00000029167/ENSMUSG00000027068/ENSMUSG00000074604/ENSMUSG00000017969/ENSMUSG00000076441/ENSMUSG00000041193/ENSMUSG00000020892/ENSMUSG00000032262/ENSMUSG00000026435/ENSMUSG00000046687/ENSMUSG00000060063/ENSMUSG00000002475	Cd74/Eno3/Aldh1a1/Atp2b4/Actn3/Pfkp/Ier3/Ptgs1/Gch1/Ggt5/Pdk4/Ptges/Acacb/Cyp39a1/Syk/Mgst3/Cbs/Hacd4/Ppargc1a/Dhrs9/Mgst2/Ptgis/Ass1/Pla2g5/Aloxe3/Elovl4/Slc45a3/Gm5424/Alox5ap/Abhd3	30
BP	GO:0043410	positive regulation of MAPK cascade	39/858	423/15881	0.000794890589252611	0.0187405349921828	ENSMUSG00000024164/ENSMUSG00000024610/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000029816/ENSMUSG00000024778/ENSMUSG00000042677/ENSMUSG00000022150/ENSMUSG00000024066/ENSMUSG00000035373/ENSMUSG00000042429/ENSMUSG00000053965/ENSMUSG00000034394/ENSMUSG00000019997/ENSMUSG00000020901/ENSMUSG00000026166/ENSMUSG00000027995/ENSMUSG00000028599/ENSMUSG00000021457/ENSMUSG00000019122/ENSMUSG00000036585/ENSMUSG00000050541/ENSMUSG00000055994/ENSMUSG00000042662/ENSMUSG00000024013/ENSMUSG00000064246/ENSMUSG00000041193/ENSMUSG00000074272/ENSMUSG00000002944/ENSMUSG00000041046/ENSMUSG00000006235/ENSMUSG00000002489/ENSMUSG00000020312/ENSMUSG00000000120/ENSMUSG00000060548/ENSMUSG00000028864/ENSMUSG00000031780/ENSMUSG00000021948/ENSMUSG00000031489	C3/Cd74/Ccl2/Cx3cl1/Gpnmb/Fas/Zc3h12a/Dab2/Xdh/Ccl7/Adora1/Pde5a/Lif/Ctgf/Pik3r5/Ccl20/Tlr2/Tnfrsf1b/Syk/Ccl9/Fgf1/Adra1b/Nod2/Dusp15/Fgd2/Chil1/Pla2g5/Ceacam1/Cd36/Ramp3/Epor/Tiam1/Shc2/Ngfr/Tnfrsf19/Hgf/Ccl17/Prkcd/Adrb3	39
BP	GO:0002831	regulation of response to biotic stimulus	16/858	121/15881	0.000796860951477464	0.0187405349921828	ENSMUSG00000029380/ENSMUSG00000042677/ENSMUSG00000019850/ENSMUSG00000032501/ENSMUSG00000062300/ENSMUSG00000079685/ENSMUSG00000027995/ENSMUSG00000079363/ENSMUSG00000055994/ENSMUSG00000017830/ENSMUSG00000074272/ENSMUSG00000029371/ENSMUSG00000037860/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000062157	Cxcl1/Zc3h12a/Tnfaip3/Trib1/Nectin2/Ulbp1/Tlr2/Gbp4/Nod2/Dhx58/Ceacam1/Cxcl5/Aim2/Il12rb1/Il15/Ifnlr1	16
BP	GO:0071675	regulation of mononuclear cell migration	8/858	38/15881	0.000807592760747748	0.018896022453006	ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000050335/ENSMUSG00000023913/ENSMUSG00000066755/ENSMUSG00000034855/ENSMUSG00000037362/ENSMUSG00000053318	Ccl2/Cx3cl1/Lgals3/Pla2g7/Tnfsf18/Cxcl10/Nov/Slamf8	8
BP	GO:0050817	coagulation	17/858	133/15881	0.000819959118850693	0.0190586968613609	ENSMUSG00000024164/ENSMUSG00000031778/ENSMUSG00000021822/ENSMUSG00000027082/ENSMUSG00000028128/ENSMUSG00000021457/ENSMUSG00000029373/ENSMUSG00000032020/ENSMUSG00000074272/ENSMUSG00000002944/ENSMUSG00000060459/ENSMUSG00000026580/ENSMUSG00000027611/ENSMUSG00000026249/ENSMUSG00000020787/ENSMUSG00000021948/ENSMUSG00000004266	C3/Cx3cl1/Plau/Tfpi/F3/Syk/Pf4/Ubash3b/Ceacam1/Cd36/Kng2/Selp/Procr/Serpine2/P2rx1/Prkcd/Ptpn6	17
BP	GO:0016053	organic acid biosynthetic process	30/858	299/15881	0.000822856951275501	0.0190586968613609	ENSMUSG00000024610/ENSMUSG00000060600/ENSMUSG00000053279/ENSMUSG00000026463/ENSMUSG00000006457/ENSMUSG00000021196/ENSMUSG00000003541/ENSMUSG00000047250/ENSMUSG00000037580/ENSMUSG00000006344/ENSMUSG00000019577/ENSMUSG00000050737/ENSMUSG00000042010/ENSMUSG00000023963/ENSMUSG00000021457/ENSMUSG00000026688/ENSMUSG00000024039/ENSMUSG00000028497/ENSMUSG00000029167/ENSMUSG00000027068/ENSMUSG00000074604/ENSMUSG00000017969/ENSMUSG00000076441/ENSMUSG00000041193/ENSMUSG00000020892/ENSMUSG00000032262/ENSMUSG00000026435/ENSMUSG00000046687/ENSMUSG00000060063/ENSMUSG00000002475	Cd74/Eno3/Aldh1a1/Atp2b4/Actn3/Pfkp/Ier3/Ptgs1/Gch1/Ggt5/Pdk4/Ptges/Acacb/Cyp39a1/Syk/Mgst3/Cbs/Hacd4/Ppargc1a/Dhrs9/Mgst2/Ptgis/Ass1/Pla2g5/Aloxe3/Elovl4/Slc45a3/Gm5424/Alox5ap/Abhd3	30
BP	GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	23/858	207/15881	0.000828651915640465	0.0190953375232548	ENSMUSG00000024164/ENSMUSG00000024610/ENSMUSG00000073411/ENSMUSG00000061232/ENSMUSG00000024778/ENSMUSG00000000732/ENSMUSG00000019850/ENSMUSG00000062300/ENSMUSG00000079685/ENSMUSG00000053175/ENSMUSG00000026068/ENSMUSG00000055994/ENSMUSG00000027985/ENSMUSG00000032359/ENSMUSG00000066755/ENSMUSG00000026177/ENSMUSG00000020641/ENSMUSG00000079343/ENSMUSG00000000791/ENSMUSG00000075370/ENSMUSG00000021948/ENSMUSG00000004266/ENSMUSG00000034266	C3/Cd74/H2-D1/H2-K1/Fas/Icosl/Tnfaip3/Nectin2/Ulbp1/Bcl3/Il18rap/Nod2/Lef1/Ctsh/Tnfsf18/Slc11a1/Rsad2/C1s2/Il12rb1/Igll1/Prkcd/Ptpn6/Batf	23
BP	GO:0072503	cellular divalent inorganic cation homeostasis	34/858	354/15881	0.000834557744598251	0.0190953375232548	ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000026463/ENSMUSG00000035873/ENSMUSG00000021831/ENSMUSG00000032860/ENSMUSG00000026576/ENSMUSG00000029084/ENSMUSG00000032839/ENSMUSG00000050541/ENSMUSG00000044026/ENSMUSG00000022416/ENSMUSG00000027994/ENSMUSG00000026177/ENSMUSG00000061603/ENSMUSG00000025889/ENSMUSG00000032020/ENSMUSG00000074715/ENSMUSG00000002944/ENSMUSG00000060459/ENSMUSG00000021070/ENSMUSG00000063354/ENSMUSG00000041046/ENSMUSG00000006235/ENSMUSG00000034855/ENSMUSG00000030523/ENSMUSG00000004266/ENSMUSG00000036570/ENSMUSG00000035458/ENSMUSG00000030707/ENSMUSG00000044338/ENSMUSG00000038239/ENSMUSG00000021337/ENSMUSG00000043051	Cxcl1/Ccl2/Atp2b4/Pawr/Ero1l/P2ry2/Atp1b1/Cd38/Trpc1/Adra1b/Slc35g1/Cacna1i/Mcub/Slc11a1/Akap6/Snca/Ubash3b/Ccl28/Cd36/Kng2/Bdkrb2/Slc39a4/Ramp3/Epor/Cxcl10/Trpm1/Ptpn6/Fxyd1/Tnni3/Coro1a/Aplnr/Hrc/Scgn/Disc1	34
BP	GO:0006766	vitamin metabolic process	10/858	57/15881	0.00085795936568356	0.0190953375232548	ENSMUSG00000032561/ENSMUSG00000037440/ENSMUSG00000022676/ENSMUSG00000020010/ENSMUSG00000025545/ENSMUSG00000003484/ENSMUSG00000027070/ENSMUSG00000090700/ENSMUSG00000063415/ENSMUSG00000025069	Acpp/Vnn1/Snai2/Vnn3/Clybl/Cyp4f18/Lrp2/Cyp4f40/Cyp26b1/Gsto2	10
BP	GO:0001525	angiogenesis	40/858	439/15881	0.000860648906622334	0.0190953375232548	ENSMUSG00000024164/ENSMUSG00000038146/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000000753/ENSMUSG00000042677/ENSMUSG00000031785/ENSMUSG00000017737/ENSMUSG00000050335/ENSMUSG00000028039/ENSMUSG00000028024/ENSMUSG00000038387/ENSMUSG00000021822/ENSMUSG00000034394/ENSMUSG00000019997/ENSMUSG00000028128/ENSMUSG00000021457/ENSMUSG00000029669/ENSMUSG00000036585/ENSMUSG00000026921/ENSMUSG00000029373/ENSMUSG00000027985/ENSMUSG00000032359/ENSMUSG00000056758/ENSMUSG00000018983/ENSMUSG00000064246/ENSMUSG00000034353/ENSMUSG00000031520/ENSMUSG00000017969/ENSMUSG00000074272/ENSMUSG00000002944/ENSMUSG00000041046/ENSMUSG00000034855/ENSMUSG00000037362/ENSMUSG00000028978/ENSMUSG00000000120/ENSMUSG00000021256/ENSMUSG00000059588/ENSMUSG00000028864/ENSMUSG00000044338	C3/Notch3/Ccl2/Cx3cl1/Serpinf1/Zc3h12a/Adgrg1/Mmp9/Lgals3/Efna3/Enpep/Rras/Plau/Lif/Ctgf/F3/Syk/Tspan12/Fgf1/Egfl7/Pf4/Lef1/Ctsh/Hmga2/E2f2/Chil1/Ramp1/Vegfc/Ptgis/Ceacam1/Cd36/Ramp3/Cxcl10/Nov/Nos3/Ngfr/Vash1/Calcrl/Hgf/Aplnr	40
BP	GO:0042119	neutrophil activation	6/858	22/15881	0.000864026997747057	0.0190953375232548	ENSMUSG00000021457/ENSMUSG00000026068/ENSMUSG00000029371/ENSMUSG00000021948/ENSMUSG00000034652/ENSMUSG00000025279	Syk/Il18rap/Cxcl5/Prkcd/Cd300a/Dnase1l3	6
BP	GO:0006837	serotonin transport	5/858	15/15881	0.000867112810748753	0.0190953375232548	ENSMUSG00000050335/ENSMUSG00000021457/ENSMUSG00000025889/ENSMUSG00000020787/ENSMUSG00000034652	Lgals3/Syk/Snca/P2rx1/Cd300a	5
BP	GO:0042448	progesterone metabolic process	5/858	15/15881	0.000867112810748753	0.0190953375232548	ENSMUSG00000029167/ENSMUSG00000033715/ENSMUSG00000027068/ENSMUSG00000025955/ENSMUSG00000054932	Ppargc1a/Akr1c14/Dhrs9/Akr1cl/Afp	5
BP	GO:0044126	regulation of growth of symbiont in host	5/858	15/15881	0.000867112810748753	0.0190953375232548	ENSMUSG00000016024/ENSMUSG00000027995/ENSMUSG00000055994/ENSMUSG00000002944/ENSMUSG00000041515	Lbp/Tlr2/Nod2/Cd36/Irf8	5
BP	GO:0044146	negative regulation of growth of symbiont involved in interaction with host	5/858	15/15881	0.000867112810748753	0.0190953375232548	ENSMUSG00000016024/ENSMUSG00000027995/ENSMUSG00000055994/ENSMUSG00000002944/ENSMUSG00000041515	Lbp/Tlr2/Nod2/Cd36/Irf8	5
BP	GO:0048245	eosinophil chemotaxis	5/858	15/15881	0.000867112810748753	0.0190953375232548	ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000035373/ENSMUSG00000050335/ENSMUSG00000019122	Ccl2/Cx3cl1/Ccl7/Lgals3/Ccl9	5
BP	GO:1903522	regulation of blood circulation	20/858	170/15881	0.000870241068983918	0.0190953375232548	ENSMUSG00000031778/ENSMUSG00000042677/ENSMUSG00000026463/ENSMUSG00000047250/ENSMUSG00000042429/ENSMUSG00000037580/ENSMUSG00000053965/ENSMUSG00000057123/ENSMUSG00000026576/ENSMUSG00000029084/ENSMUSG00000019997/ENSMUSG00000050541/ENSMUSG00000061603/ENSMUSG00000024065/ENSMUSG00000028978/ENSMUSG00000020787/ENSMUSG00000041695/ENSMUSG00000036570/ENSMUSG00000035458/ENSMUSG00000038239	Cx3cl1/Zc3h12a/Atp2b4/Ptgs1/Adora1/Gch1/Pde5a/Gja5/Atp1b1/Cd38/Ctgf/Adra1b/Akap6/Ehd3/Nos3/P2rx1/Kcnj2/Fxyd1/Tnni3/Hrc	20
BP	GO:0071827	plasma lipoprotein particle organization	7/858	30/15881	0.000893728924968136	0.0195173373804946	ENSMUSG00000018800/ENSMUSG00000057074/ENSMUSG00000023913/ENSMUSG00000056973/ENSMUSG00000041193/ENSMUSG00000015243/ENSMUSG00000024030	Abca5/Ces1g/Pla2g7/Ces1d/Pla2g5/Abca1/Abcg1	7
BP	GO:0002791	regulation of peptide secretion	37/858	398/15881	0.000921525026239421	0.020028975214853	ENSMUSG00000024610/ENSMUSG00000031778/ENSMUSG00000027750/ENSMUSG00000042677/ENSMUSG00000028965/ENSMUSG00000020806/ENSMUSG00000042429/ENSMUSG00000033538/ENSMUSG00000022514/ENSMUSG00000057123/ENSMUSG00000020826/ENSMUSG00000029084/ENSMUSG00000024743/ENSMUSG00000034394/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000055994/ENSMUSG00000004347/ENSMUSG00000056758/ENSMUSG00000053216/ENSMUSG00000031520/ENSMUSG00000074272/ENSMUSG00000020641/ENSMUSG00000002944/ENSMUSG00000090958/ENSMUSG00000027674/ENSMUSG00000037860/ENSMUSG00000031548/ENSMUSG00000002489/ENSMUSG00000037362/ENSMUSG00000020178/ENSMUSG00000049044/ENSMUSG00000000706/ENSMUSG00000079164/ENSMUSG00000029716/ENSMUSG00000050578/ENSMUSG00000025888	Cd74/Cx3cl1/Postn/Zc3h12a/Tnfrsf9/Rhbdf2/Adora1/Casp4/Il1rap/Gja5/Nos2/Cd38/Syt7/Lif/Tlr2/Syk/Nod2/Pde1c/Hmga2/Btn2a2/Vegfc/Ceacam1/Rsad2/Cd36/Lrrc32/Pex5l/Aim2/Sfrp1/Tiam1/Nov/Adora2a/Rapgef4/Btn1a1/Tlr5/Tfr2/Mmp13/Casp1	37
BP	GO:0030217	T cell differentiation	23/858	209/15881	0.000945460086560352	0.0203257037707111	ENSMUSG00000024610/ENSMUSG00000024778/ENSMUSG00000029570/ENSMUSG00000023927/ENSMUSG00000044303/ENSMUSG00000037440/ENSMUSG00000039621/ENSMUSG00000034023/ENSMUSG00000021457/ENSMUSG00000053175/ENSMUSG00000027985/ENSMUSG00000066755/ENSMUSG00000053216/ENSMUSG00000049109/ENSMUSG00000020641/ENSMUSG00000036587/ENSMUSG00000031712/ENSMUSG00000040329/ENSMUSG00000063415/ENSMUSG00000044258/ENSMUSG00000048251/ENSMUSG00000034266/ENSMUSG00000026117	Cd74/Fas/Lfng/Satb1/Cdkn2a/Vnn1/Prex1/Fancd2/Syk/Bcl3/Lef1/Tnfsf18/Btn2a2/Themis/Rsad2/Fut7/Il15/Il7/Cyp26b1/Ctla2a/Bcl11b/Batf/Zap70	23
BP	GO:0044070	regulation of anion transport	13/858	89/15881	0.000948473747695634	0.0203257037707111	ENSMUSG00000037685/ENSMUSG00000029334/ENSMUSG00000042429/ENSMUSG00000032860/ENSMUSG00000020333/ENSMUSG00000029851/ENSMUSG00000021457/ENSMUSG00000003484/ENSMUSG00000025889/ENSMUSG00000020178/ENSMUSG00000025557/ENSMUSG00000021948/ENSMUSG00000036570	Atp8a1/Prkg2/Adora1/P2ry2/Acsl6/Tcaf2/Syk/Cyp4f18/Snca/Adora2a/Slc15a1/Prkcd/Fxyd1	13
BP	GO:0050852	T cell receptor signaling pathway	13/858	89/15881	0.000948473747695634	0.0203257037707111	ENSMUSG00000042677/ENSMUSG00000000732/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000062300/ENSMUSG00000053216/ENSMUSG00000049109/ENSMUSG00000000706/ENSMUSG00000109713/ENSMUSG00000002699/ENSMUSG00000004266/ENSMUSG00000034652/ENSMUSG00000026117	Zc3h12a/Icosl/Lgals3/Pawr/Nectin2/Btn2a2/Themis/Btn1a1/Pvrig/Lcp2/Ptpn6/Cd300a/Zap70	13
BP	GO:0050701	interleukin-1 secretion	8/858	39/15881	0.000968583783366871	0.0205902738885799	ENSMUSG00000042677/ENSMUSG00000033538/ENSMUSG00000027995/ENSMUSG00000055994/ENSMUSG00000015243/ENSMUSG00000002944/ENSMUSG00000037860/ENSMUSG00000025888	Zc3h12a/Casp4/Tlr2/Nod2/Abca1/Cd36/Aim2/Casp1	8
BP	GO:0031341	regulation of cell killing	11/858	68/15881	0.000974289017405545	0.0205902738885799	ENSMUSG00000029380/ENSMUSG00000073411/ENSMUSG00000035385/ENSMUSG00000061232/ENSMUSG00000020826/ENSMUSG00000062300/ENSMUSG00000079685/ENSMUSG00000026068/ENSMUSG00000074272/ENSMUSG00000029371/ENSMUSG00000025279	Cxcl1/H2-D1/Ccl2/H2-K1/Nos2/Nectin2/Ulbp1/Il18rap/Ceacam1/Cxcl5/Dnase1l3	11
BP	GO:0050818	regulation of coagulation	11/858	68/15881	0.000974289017405545	0.0205902738885799	ENSMUSG00000021822/ENSMUSG00000027082/ENSMUSG00000021457/ENSMUSG00000032020/ENSMUSG00000074272/ENSMUSG00000002944/ENSMUSG00000060459/ENSMUSG00000026580/ENSMUSG00000027611/ENSMUSG00000026249/ENSMUSG00000021948	Plau/Tfpi/Syk/Ubash3b/Ceacam1/Cd36/Kng2/Selp/Procr/Serpine2/Prkcd	11
BP	GO:0032652	regulation of interleukin-1 production	10/858	58/15881	0.000987409633426868	0.0207718375178698	ENSMUSG00000042677/ENSMUSG00000033538/ENSMUSG00000019850/ENSMUSG00000026166/ENSMUSG00000027995/ENSMUSG00000055994/ENSMUSG00000074272/ENSMUSG00000037860/ENSMUSG00000071203/ENSMUSG00000025888	Zc3h12a/Casp4/Tnfaip3/Ccl20/Tlr2/Nod2/Ceacam1/Aim2/Naip5/Casp1	10
BP	GO:0044403	symbiont process	31/858	317/15881	0.00103735755028291	0.0217229302538695	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000017002/ENSMUSG00000046718/ENSMUSG00000016024/ENSMUSG00000030921/ENSMUSG00000042677/ENSMUSG00000017737/ENSMUSG00000066800/ENSMUSG00000062300/ENSMUSG00000027995/ENSMUSG00000040253/ENSMUSG00000029373/ENSMUSG00000001166/ENSMUSG00000055994/ENSMUSG00000027985/ENSMUSG00000029298/ENSMUSG00000035692/ENSMUSG00000028268/ENSMUSG00000074272/ENSMUSG00000032690/ENSMUSG00000020641/ENSMUSG00000002944/ENSMUSG00000104713/ENSMUSG00000059108/ENSMUSG00000029605/ENSMUSG00000029371/ENSMUSG00000032661/ENSMUSG00000006235/ENSMUSG00000041515/ENSMUSG00000000266	Cd74/Cxcl1/Slpi/Bst2/Lbp/Trim30a/Zc3h12a/Mmp9/Rnasel/Nectin2/Tlr2/Gbp7/Pf4/Oas1c/Nod2/Lef1/Gbp9/Isg15/Gbp3/Ceacam1/Oas2/Rsad2/Cd36/Gbp6/Ifitm6/Oas1b/Cxcl5/Oas3/Epor/Irf8/Mid2	31
BP	GO:0050869	negative regulation of B cell activation	7/858	31/15881	0.00110125116707285	0.0226956242244217	ENSMUSG00000024778/ENSMUSG00000044303/ENSMUSG00000035873/ENSMUSG00000019850/ENSMUSG00000031548/ENSMUSG00000052013/ENSMUSG00000034652	Fas/Cdkn2a/Pawr/Tnfaip3/Sfrp1/Btla/Cd300a	7
BP	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	11/858	69/15881	0.00110360318404842	0.0226956242244217	ENSMUSG00000023030/ENSMUSG00000024066/ENSMUSG00000044303/ENSMUSG00000033538/ENSMUSG00000028128/ENSMUSG00000025507/ENSMUSG00000079017/ENSMUSG00000025889/ENSMUSG00000000120/ENSMUSG00000020787/ENSMUSG00000025888	Slc11a2/Xdh/Cdkn2a/Casp4/F3/Pidd1/Ifi27l2a/Snca/Ngfr/P2rx1/Casp1	11
BP	GO:0030799	regulation of cyclic nucleotide metabolic process	11/858	69/15881	0.00110360318404842	0.0226956242244217	ENSMUSG00000053965/ENSMUSG00000020826/ENSMUSG00000024039/ENSMUSG00000029373/ENSMUSG00000034353/ENSMUSG00000061603/ENSMUSG00000040133/ENSMUSG00000041046/ENSMUSG00000034855/ENSMUSG00000028978/ENSMUSG00000052276	Pde5a/Nos2/Cbs/Pf4/Ramp1/Akap6/Gpr176/Ramp3/Cxcl10/Nos3/Ostn	11
BP	GO:0032642	regulation of chemokine production	11/858	69/15881	0.00110360318404842	0.0226956242244217	ENSMUSG00000024610/ENSMUSG00000027750/ENSMUSG00000016024/ENSMUSG00000049577/ENSMUSG00000032860/ENSMUSG00000022676/ENSMUSG00000027995/ENSMUSG00000055994/ENSMUSG00000029371/ENSMUSG00000025494/ENSMUSG00000040329	Cd74/Postn/Lbp/Zfpm1/P2ry2/Snai2/Tlr2/Nod2/Cxcl5/Sigirr/Il7	11
BP	GO:0010742	macrophage derived foam cell differentiation	6/858	23/15881	0.00111608100566222	0.0228497655891382	ENSMUSG00000018800/ENSMUSG00000029373/ENSMUSG00000002944/ENSMUSG00000021108/ENSMUSG00000024030/ENSMUSG00000025044	Abca5/Pf4/Cd36/Prkch/Abcg1/Msr1	6
BP	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	43/858	489/15881	0.00114523803998889	0.0233424962283959	ENSMUSG00000035385/ENSMUSG00000059895/ENSMUSG00000026185/ENSMUSG00000024066/ENSMUSG00000061132/ENSMUSG00000017737/ENSMUSG00000020806/ENSMUSG00000028039/ENSMUSG00000022103/ENSMUSG00000042429/ENSMUSG00000019831/ENSMUSG00000062991/ENSMUSG00000019577/ENSMUSG00000022144/ENSMUSG00000046733/ENSMUSG00000019997/ENSMUSG00000028128/ENSMUSG00000021457/ENSMUSG00000036585/ENSMUSG00000035109/ENSMUSG00000006435/ENSMUSG00000046223/ENSMUSG00000051225/ENSMUSG00000005057/ENSMUSG00000056486/ENSMUSG00000082361/ENSMUSG00000025889/ENSMUSG00000031520/ENSMUSG00000032020/ENSMUSG00000039481/ENSMUSG00000074272/ENSMUSG00000020340/ENSMUSG00000053141/ENSMUSG00000002489/ENSMUSG00000020312/ENSMUSG00000000120/ENSMUSG00000039323/ENSMUSG00000002699/ENSMUSG00000028864/ENSMUSG00000051379/ENSMUSG00000024427/ENSMUSG00000021948/ENSMUSG00000026117	Ccl2/Ptp4a3/Igfbp5/Xdh/Blnk/Mmp9/Rhbdf2/Efna3/Gfra2/Adora1/Wasf1/Nrg1/Pdk4/Gdnf/Gprc5a/Ctgf/F3/Syk/Fgf1/Shc4/Neurl1a/Plaur/Fam83a/Sh2b2/Chn1/Btc/Snca/Vegfc/Ubash3b/Nrtn/Ceacam1/Cyfip2/Ptprt/Tiam1/Shc2/Ngfr/Igfbp2/Lcp2/Hgf/Flrt3/Spry4/Prkcd/Zap70	43
BP	GO:0050663	cytokine secretion	20/858	174/15881	0.00116335624141006	0.0235028710269011	ENSMUSG00000031778/ENSMUSG00000027750/ENSMUSG00000042677/ENSMUSG00000028965/ENSMUSG00000033538/ENSMUSG00000022514/ENSMUSG00000020826/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000055994/ENSMUSG00000053216/ENSMUSG00000064246/ENSMUSG00000015243/ENSMUSG00000002944/ENSMUSG00000090958/ENSMUSG00000037860/ENSMUSG00000000706/ENSMUSG00000079164/ENSMUSG00000002699/ENSMUSG00000025888	Cx3cl1/Postn/Zc3h12a/Tnfrsf9/Casp4/Il1rap/Nos2/Tlr2/Syk/Nod2/Btn2a2/Chil1/Abca1/Cd36/Lrrc32/Aim2/Btn1a1/Tlr5/Lcp2/Casp1	20
BP	GO:0050920	regulation of chemotaxis	20/858	174/15881	0.00116335624141006	0.0235028710269011	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000016024/ENSMUSG00000029082/ENSMUSG00000023913/ENSMUSG00000025207/ENSMUSG00000022676/ENSMUSG00000036585/ENSMUSG00000029373/ENSMUSG00000055994/ENSMUSG00000066755/ENSMUSG00000031520/ENSMUSG00000029371/ENSMUSG00000052516/ENSMUSG00000034855/ENSMUSG00000002489/ENSMUSG00000037362/ENSMUSG00000053318	Cd74/Cxcl1/Ccl2/Cx3cl1/Lbp/Bst1/Pla2g7/Sema4g/Snai2/Fgf1/Pf4/Nod2/Tnfsf18/Vegfc/Cxcl5/Robo2/Cxcl10/Tiam1/Nov/Slamf8	20
BP	GO:0002449	lymphocyte mediated immunity	21/858	187/15881	0.00119563833956626	0.023933413967212	ENSMUSG00000024164/ENSMUSG00000024610/ENSMUSG00000073411/ENSMUSG00000061232/ENSMUSG00000024778/ENSMUSG00000000732/ENSMUSG00000062300/ENSMUSG00000079685/ENSMUSG00000053175/ENSMUSG00000026068/ENSMUSG00000055994/ENSMUSG00000032359/ENSMUSG00000026177/ENSMUSG00000074272/ENSMUSG00000020641/ENSMUSG00000079343/ENSMUSG00000075370/ENSMUSG00000021948/ENSMUSG00000004266/ENSMUSG00000030707/ENSMUSG00000034266	C3/Cd74/H2-D1/H2-K1/Fas/Icosl/Nectin2/Ulbp1/Bcl3/Il18rap/Nod2/Ctsh/Slc11a1/Ceacam1/Rsad2/C1s2/Igll1/Prkcd/Ptpn6/Coro1a/Batf	21
BP	GO:0006525	arginine metabolic process	5/858	16/15881	0.00120554265731051	0.023933413967212	ENSMUSG00000026463/ENSMUSG00000020826/ENSMUSG00000076441/ENSMUSG00000028978/ENSMUSG00000046687	Atp2b4/Nos2/Ass1/Nos3/Gm5424	5
BP	GO:0044144	modulation of growth of symbiont involved in interaction with host	5/858	16/15881	0.00120554265731051	0.023933413967212	ENSMUSG00000016024/ENSMUSG00000027995/ENSMUSG00000055994/ENSMUSG00000002944/ENSMUSG00000041515	Lbp/Tlr2/Nod2/Cd36/Irf8	5
BP	GO:0050860	negative regulation of T cell receptor signaling pathway	5/858	16/15881	0.00120554265731051	0.023933413967212	ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000053216/ENSMUSG00000109713/ENSMUSG00000004266	Lgals3/Pawr/Btn2a2/Pvrig/Ptpn6	5
BP	GO:0006874	cellular calcium ion homeostasis	32/858	334/15881	0.00121934418079007	0.0241030707461347	ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000026463/ENSMUSG00000035873/ENSMUSG00000021831/ENSMUSG00000032860/ENSMUSG00000026576/ENSMUSG00000029084/ENSMUSG00000032839/ENSMUSG00000050541/ENSMUSG00000044026/ENSMUSG00000022416/ENSMUSG00000027994/ENSMUSG00000061603/ENSMUSG00000025889/ENSMUSG00000032020/ENSMUSG00000074715/ENSMUSG00000002944/ENSMUSG00000060459/ENSMUSG00000021070/ENSMUSG00000041046/ENSMUSG00000006235/ENSMUSG00000034855/ENSMUSG00000030523/ENSMUSG00000004266/ENSMUSG00000036570/ENSMUSG00000035458/ENSMUSG00000030707/ENSMUSG00000044338/ENSMUSG00000038239/ENSMUSG00000021337/ENSMUSG00000043051	Cxcl1/Ccl2/Atp2b4/Pawr/Ero1l/P2ry2/Atp1b1/Cd38/Trpc1/Adra1b/Slc35g1/Cacna1i/Mcub/Akap6/Snca/Ubash3b/Ccl28/Cd36/Kng2/Bdkrb2/Ramp3/Epor/Cxcl10/Trpm1/Ptpn6/Fxyd1/Tnni3/Coro1a/Aplnr/Hrc/Scgn/Disc1	32
BP	GO:0008016	regulation of heart contraction	16/858	126/15881	0.00123736441713481	0.0242267883593022	ENSMUSG00000042677/ENSMUSG00000026463/ENSMUSG00000042429/ENSMUSG00000037580/ENSMUSG00000053965/ENSMUSG00000057123/ENSMUSG00000026576/ENSMUSG00000019997/ENSMUSG00000050541/ENSMUSG00000061603/ENSMUSG00000024065/ENSMUSG00000028978/ENSMUSG00000041695/ENSMUSG00000036570/ENSMUSG00000035458/ENSMUSG00000038239	Zc3h12a/Atp2b4/Adora1/Gch1/Pde5a/Gja5/Atp1b1/Ctgf/Adra1b/Akap6/Ehd3/Nos3/Kcnj2/Fxyd1/Tnni3/Hrc	16
BP	GO:0002690	positive regulation of leukocyte chemotaxis	11/858	70/15881	0.00124673398447347	0.0242267883593022	ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000016024/ENSMUSG00000023913/ENSMUSG00000029373/ENSMUSG00000066755/ENSMUSG00000031520/ENSMUSG00000029371/ENSMUSG00000034855	Cd74/Cxcl1/Ccl2/Cx3cl1/Lbp/Pla2g7/Pf4/Tnfsf18/Vegfc/Cxcl5/Cxcl10	11
BP	GO:0033209	tumor necrosis factor-mediated signaling pathway	11/858	70/15881	0.00124673398447347	0.0242267883593022	ENSMUSG00000024778/ENSMUSG00000028965/ENSMUSG00000033538/ENSMUSG00000028599/ENSMUSG00000021457/ENSMUSG00000066755/ENSMUSG00000008318/ENSMUSG00000037860/ENSMUSG00000000120/ENSMUSG00000028602/ENSMUSG00000025888	Fas/Tnfrsf9/Casp4/Tnfrsf1b/Syk/Tnfsf18/Relt/Aim2/Ngfr/Tnfrsf8/Casp1	11
BP	GO:0050764	regulation of phagocytosis	11/858	70/15881	0.00124673398447347	0.0242267883593022	ENSMUSG00000024164/ENSMUSG00000035385/ENSMUSG00000016024/ENSMUSG00000024743/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000055994/ENSMUSG00000026177/ENSMUSG00000041351/ENSMUSG00000002944/ENSMUSG00000034652	C3/Ccl2/Lbp/Syt7/Tlr2/Syk/Nod2/Slc11a1/Rap1gap/Cd36/Cd300a	11
BP	GO:0034121	regulation of toll-like receptor signaling pathway	9/858	50/15881	0.00127562254790761	0.0246835654206933	ENSMUSG00000016024/ENSMUSG00000030921/ENSMUSG00000019850/ENSMUSG00000027995/ENSMUSG00000055994/ENSMUSG00000020641/ENSMUSG00000002944/ENSMUSG00000079164/ENSMUSG00000034652	Lbp/Trim30a/Tnfaip3/Tlr2/Nod2/Rsad2/Cd36/Tlr5/Cd300a	9
BP	GO:0071219	cellular response to molecule of bacterial origin	19/858	163/15881	0.00129377613459593	0.0247670525307079	ENSMUSG00000035385/ENSMUSG00000016024/ENSMUSG00000042677/ENSMUSG00000037580/ENSMUSG00000020826/ENSMUSG00000019850/ENSMUSG00000032501/ENSMUSG00000027995/ENSMUSG00000028599/ENSMUSG00000055994/ENSMUSG00000075122/ENSMUSG00000015243/ENSMUSG00000002944/ENSMUSG00000104713/ENSMUSG00000029371/ENSMUSG00000034855/ENSMUSG00000028978/ENSMUSG00000041515/ENSMUSG00000025888	Ccl2/Lbp/Zc3h12a/Gch1/Nos2/Tnfaip3/Trib1/Tlr2/Tnfrsf1b/Nod2/Cd80/Abca1/Cd36/Gbp6/Cxcl5/Cxcl10/Nos3/Irf8/Casp1	19
BP	GO:0030330	DNA damage response, signal transduction by p53 class mediator	10/858	60/15881	0.00129437102440467	0.0247670525307079	ENSMUSG00000024610/ENSMUSG00000023067/ENSMUSG00000044303/ENSMUSG00000022676/ENSMUSG00000025507/ENSMUSG00000022510/ENSMUSG00000053175/ENSMUSG00000016526/ENSMUSG00000025665/ENSMUSG00000034266	Cd74/Cdkn1a/Cdkn2a/Snai2/Pidd1/Trp63/Bcl3/Dyrk3/Rps6ka6/Batf	10
BP	GO:0045069	regulation of viral genome replication	12/858	81/15881	0.00129679616114618	0.0247670525307079	ENSMUSG00000017002/ENSMUSG00000046718/ENSMUSG00000042677/ENSMUSG00000066800/ENSMUSG00000001166/ENSMUSG00000035692/ENSMUSG00000074272/ENSMUSG00000032690/ENSMUSG00000020641/ENSMUSG00000059108/ENSMUSG00000029605/ENSMUSG00000032661	Slpi/Bst2/Zc3h12a/Rnasel/Oas1c/Isg15/Ceacam1/Oas2/Rsad2/Ifitm6/Oas1b/Oas3	12
BP	GO:0030336	negative regulation of cell migration	23/858	214/15881	0.00130153939378557	0.0247670525307079	ENSMUSG00000031778/ENSMUSG00000026185/ENSMUSG00000000753/ENSMUSG00000031785/ENSMUSG00000042429/ENSMUSG00000038387/ENSMUSG00000062991/ENSMUSG00000032501/ENSMUSG00000030220/ENSMUSG00000021596/ENSMUSG00000026921/ENSMUSG00000029167/ENSMUSG00000115388/ENSMUSG00000074715/ENSMUSG00000031548/ENSMUSG00000037362/ENSMUSG00000024451/ENSMUSG00000020121/ENSMUSG00000021256/ENSMUSG00000026109/ENSMUSG00000019278/ENSMUSG00000053318/ENSMUSG00000034652	Cx3cl1/Igfbp5/Serpinf1/Adgrg1/Adora1/Rras/Nrg1/Trib1/Arhgdib/Mctp1/Egfl7/Ppargc1a/Eppk1/Ccl28/Sfrp1/Nov/Arap3/Srgap1/Vash1/Tmeff2/Dpep1/Slamf8/Cd300a	23
BP	GO:1903900	regulation of viral life cycle	16/858	127/15881	0.00134652360402521	0.0254887351510843	ENSMUSG00000024610/ENSMUSG00000017002/ENSMUSG00000046718/ENSMUSG00000030921/ENSMUSG00000042677/ENSMUSG00000066800/ENSMUSG00000062300/ENSMUSG00000001166/ENSMUSG00000035692/ENSMUSG00000074272/ENSMUSG00000032690/ENSMUSG00000020641/ENSMUSG00000059108/ENSMUSG00000029605/ENSMUSG00000032661/ENSMUSG00000000266	Cd74/Slpi/Bst2/Trim30a/Zc3h12a/Rnasel/Nectin2/Oas1c/Isg15/Ceacam1/Oas2/Rsad2/Ifitm6/Oas1b/Oas3/Mid2	16
BP	GO:0002315	marginal zone B cell differentiation	4/858	10/15881	0.00136681093810026	0.0254887351510843	ENSMUSG00000029570/ENSMUSG00000019850/ENSMUSG00000053175/ENSMUSG00000018169	Lfng/Tnfaip3/Bcl3/Mfng	4
BP	GO:0010744	positive regulation of macrophage derived foam cell differentiation	4/858	10/15881	0.00136681093810026	0.0254887351510843	ENSMUSG00000029373/ENSMUSG00000002944/ENSMUSG00000021108/ENSMUSG00000025044	Pf4/Cd36/Prkch/Msr1	4
BP	GO:0035634	response to stilbenoid	4/858	10/15881	0.00136681093810026	0.0254887351510843	ENSMUSG00000040026/ENSMUSG00000002944/ENSMUSG00000031594/ENSMUSG00000030107	Saa3/Cd36/Fgl1/Usp18	4
BP	GO:2001239	regulation of extrinsic apoptotic signaling pathway in absence of ligand	8/858	41/15881	0.00136725443680042	0.0254887351510843	ENSMUSG00000031778/ENSMUSG00000024778/ENSMUSG00000022144/ENSMUSG00000022676/ENSMUSG00000029373/ENSMUSG00000025915/ENSMUSG00000040329/ENSMUSG00000022483	Cx3cl1/Fas/Gdnf/Snai2/Pf4/Sgk3/Il7/Col2a1	8
BP	GO:2001057	reactive nitrogen species metabolic process	11/858	71/15881	0.00140477443187214	0.026082168196622	ENSMUSG00000042677/ENSMUSG00000026463/ENSMUSG00000020826/ENSMUSG00000079685/ENSMUSG00000027995/ENSMUSG00000017969/ENSMUSG00000076441/ENSMUSG00000002944/ENSMUSG00000006235/ENSMUSG00000028978/ENSMUSG00000079164	Zc3h12a/Atp2b4/Nos2/Ulbp1/Tlr2/Ptgis/Ass1/Cd36/Epor/Nos3/Tlr5	11
BP	GO:0008207	C21-steroid hormone metabolic process	6/858	24/15881	0.00142084627024591	0.0261686786961757	ENSMUSG00000022150/ENSMUSG00000029167/ENSMUSG00000033715/ENSMUSG00000027068/ENSMUSG00000025955/ENSMUSG00000054932	Dab2/Ppargc1a/Akr1c14/Dhrs9/Akr1cl/Afp	6
BP	GO:0090077	foam cell differentiation	6/858	24/15881	0.00142084627024591	0.0261686786961757	ENSMUSG00000018800/ENSMUSG00000029373/ENSMUSG00000002944/ENSMUSG00000021108/ENSMUSG00000024030/ENSMUSG00000025044	Abca5/Pf4/Cd36/Prkch/Abcg1/Msr1	6
BP	GO:0040013	negative regulation of locomotion	27/858	269/15881	0.00145720336316006	0.0267309384938081	ENSMUSG00000031778/ENSMUSG00000026185/ENSMUSG00000000753/ENSMUSG00000031785/ENSMUSG00000042429/ENSMUSG00000038387/ENSMUSG00000062991/ENSMUSG00000025207/ENSMUSG00000032501/ENSMUSG00000030220/ENSMUSG00000021596/ENSMUSG00000026921/ENSMUSG00000029167/ENSMUSG00000115388/ENSMUSG00000074715/ENSMUSG00000052516/ENSMUSG00000031548/ENSMUSG00000037362/ENSMUSG00000020178/ENSMUSG00000024451/ENSMUSG00000020121/ENSMUSG00000021256/ENSMUSG00000000266/ENSMUSG00000026109/ENSMUSG00000019278/ENSMUSG00000053318/ENSMUSG00000034652	Cx3cl1/Igfbp5/Serpinf1/Adgrg1/Adora1/Rras/Nrg1/Sema4g/Trib1/Arhgdib/Mctp1/Egfl7/Ppargc1a/Eppk1/Ccl28/Robo2/Sfrp1/Nov/Adora2a/Arap3/Srgap1/Vash1/Mid2/Tmeff2/Dpep1/Slamf8/Cd300a	27
BP	GO:0019226	transmission of nerve impulse	10/858	61/15881	0.00147468413014411	0.0268619575886901	ENSMUSG00000035873/ENSMUSG00000057182/ENSMUSG00000022416/ENSMUSG00000075318/ENSMUSG00000026442/ENSMUSG00000064329/ENSMUSG00000053395/ENSMUSG00000020787/ENSMUSG00000049044/ENSMUSG00000027071	Pawr/Scn3a/Cacna1i/Scn2a/Nfasc/Scn1a/Cacng8/P2rx1/Rapgef4/P2rx3	10
BP	GO:0097006	regulation of plasma lipoprotein particle levels	9/858	51/15881	0.00147606046933055	0.0268619575886901	ENSMUSG00000018800/ENSMUSG00000057074/ENSMUSG00000023913/ENSMUSG00000056973/ENSMUSG00000041193/ENSMUSG00000015243/ENSMUSG00000002944/ENSMUSG00000024030/ENSMUSG00000025044	Abca5/Ces1g/Pla2g7/Ces1d/Pla2g5/Abca1/Cd36/Abcg1/Msr1	9
BP	GO:0042326	negative regulation of phosphorylation	38/858	423/15881	0.00148197254410488	0.0268629489615216	ENSMUSG00000023067/ENSMUSG00000042677/ENSMUSG00000022150/ENSMUSG00000024066/ENSMUSG00000044303/ENSMUSG00000006457/ENSMUSG00000003541/ENSMUSG00000022103/ENSMUSG00000039621/ENSMUSG00000019850/ENSMUSG00000032501/ENSMUSG00000034570/ENSMUSG00000096472/ENSMUSG00000021892/ENSMUSG00000034394/ENSMUSG00000046733/ENSMUSG00000019823/ENSMUSG00000012889/ENSMUSG00000079363/ENSMUSG00000029167/ENSMUSG00000025665/ENSMUSG00000026483/ENSMUSG00000053216/ENSMUSG00000025889/ENSMUSG00000032020/ENSMUSG00000055003/ENSMUSG00000074272/ENSMUSG00000037664/ENSMUSG00000021070/ENSMUSG00000031548/ENSMUSG00000020178/ENSMUSG00000039661/ENSMUSG00000028864/ENSMUSG00000051379/ENSMUSG00000024427/ENSMUSG00000021948/ENSMUSG00000004266/ENSMUSG00000034652	Cdkn1a/Zc3h12a/Dab2/Xdh/Cdkn2a/Actn3/Ier3/Gfra2/Prex1/Tnfaip3/Trib1/Inpp5j/Cdkn2d/Sh3bp5/Lif/Gprc5a/Mical1/Podnl1/Gbp4/Ppargc1a/Rps6ka6/Fam129a/Btn2a2/Snca/Ubash3b/Lrtm2/Ceacam1/Cdkn1c/Bdkrb2/Sfrp1/Adora2a/Dusp26/Hgf/Flrt3/Spry4/Prkcd/Ptpn6/Cd300a	38
BP	GO:0032602	chemokine production	11/858	72/15881	0.00157886833822346	0.0284666974228401	ENSMUSG00000024610/ENSMUSG00000027750/ENSMUSG00000016024/ENSMUSG00000049577/ENSMUSG00000032860/ENSMUSG00000022676/ENSMUSG00000027995/ENSMUSG00000055994/ENSMUSG00000029371/ENSMUSG00000025494/ENSMUSG00000040329	Cd74/Postn/Lbp/Zfpm1/P2ry2/Snai2/Tlr2/Nod2/Cxcl5/Sigirr/Il7	11
BP	GO:0035150	regulation of tube size	16/858	129/15881	0.00158930886063044	0.0284666974228401	ENSMUSG00000031778/ENSMUSG00000047250/ENSMUSG00000042429/ENSMUSG00000037580/ENSMUSG00000053965/ENSMUSG00000057123/ENSMUSG00000020826/ENSMUSG00000032860/ENSMUSG00000029084/ENSMUSG00000024039/ENSMUSG00000050541/ENSMUSG00000021070/ENSMUSG00000028978/ENSMUSG00000020178/ENSMUSG00000020787/ENSMUSG00000031489	Cx3cl1/Ptgs1/Adora1/Gch1/Pde5a/Gja5/Nos2/P2ry2/Cd38/Cbs/Adra1b/Bdkrb2/Nos3/Adora2a/P2rx1/Adrb3	16
BP	GO:0050880	regulation of blood vessel size	16/858	129/15881	0.00158930886063044	0.0284666974228401	ENSMUSG00000031778/ENSMUSG00000047250/ENSMUSG00000042429/ENSMUSG00000037580/ENSMUSG00000053965/ENSMUSG00000057123/ENSMUSG00000020826/ENSMUSG00000032860/ENSMUSG00000029084/ENSMUSG00000024039/ENSMUSG00000050541/ENSMUSG00000021070/ENSMUSG00000028978/ENSMUSG00000020178/ENSMUSG00000020787/ENSMUSG00000031489	Cx3cl1/Ptgs1/Adora1/Gch1/Pde5a/Gja5/Nos2/P2ry2/Cd38/Cbs/Adra1b/Bdkrb2/Nos3/Adora2a/P2rx1/Adrb3	16
BP	GO:0050819	negative regulation of coagulation	8/858	42/15881	0.00161031321431589	0.0284666974228401	ENSMUSG00000021822/ENSMUSG00000027082/ENSMUSG00000032020/ENSMUSG00000074272/ENSMUSG00000060459/ENSMUSG00000027611/ENSMUSG00000026249/ENSMUSG00000021948	Plau/Tfpi/Ubash3b/Ceacam1/Kng2/Procr/Serpine2/Prkcd	8
BP	GO:0034762	regulation of transmembrane transport	38/858	425/15881	0.00161247769690439	0.0284666974228401	ENSMUSG00000024164/ENSMUSG00000066152/ENSMUSG00000026463/ENSMUSG00000017737/ENSMUSG00000005089/ENSMUSG00000057123/ENSMUSG00000066800/ENSMUSG00000028931/ENSMUSG00000026576/ENSMUSG00000020333/ENSMUSG00000029851/ENSMUSG00000032839/ENSMUSG00000029167/ENSMUSG00000005057/ENSMUSG00000050777/ENSMUSG00000024873/ENSMUSG00000061603/ENSMUSG00000025889/ENSMUSG00000041329/ENSMUSG00000032020/ENSMUSG00000041245/ENSMUSG00000028214/ENSMUSG00000041046/ENSMUSG00000009687/ENSMUSG00000064329/ENSMUSG00000053395/ENSMUSG00000034855/ENSMUSG00000024065/ENSMUSG00000000120/ENSMUSG00000041695/ENSMUSG00000018470/ENSMUSG00000052276/ENSMUSG00000021948/ENSMUSG00000004266/ENSMUSG00000036570/ENSMUSG00000030707/ENSMUSG00000044338/ENSMUSG00000038239	C3/Slc31a2/Atp2b4/Mmp9/Slc1a2/Gja5/Rnasel/Kcnab2/Atp1b1/Acsl6/Tcaf2/Trpc1/Ppargc1a/Sh2b2/Tmem37/Cnih2/Akap6/Snca/Atp1b2/Ubash3b/Wnk3/Gem/Ramp3/Fxyd5/Scn1a/Cacng8/Cxcl10/Ehd3/Ngfr/Kcnj2/Kcnab3/Ostn/Prkcd/Ptpn6/Fxyd1/Coro1a/Aplnr/Hrc	38
BP	GO:0003009	skeletal muscle contraction	7/858	33/15881	0.00162837649528217	0.0284666974228401	ENSMUSG00000006457/ENSMUSG00000026251/ENSMUSG00000026253/ENSMUSG00000026418/ENSMUSG00000041695/ENSMUSG00000027470/ENSMUSG00000035458	Actn3/Chrnd/Chrng/Tnni1/Kcnj2/Mylk2/Tnni3	7
BP	GO:0071825	protein-lipid complex subunit organization	7/858	33/15881	0.00162837649528217	0.0284666974228401	ENSMUSG00000018800/ENSMUSG00000057074/ENSMUSG00000023913/ENSMUSG00000056973/ENSMUSG00000041193/ENSMUSG00000015243/ENSMUSG00000024030	Abca5/Ces1g/Pla2g7/Ces1d/Pla2g5/Abca1/Abcg1	7
BP	GO:0006825	copper ion transport	5/858	17/15881	0.0016325210253395	0.0284666974228401	ENSMUSG00000012428/ENSMUSG00000003617/ENSMUSG00000023030/ENSMUSG00000066152/ENSMUSG00000031936	Steap4/Cp/Slc11a2/Slc31a2/Hephl1	5
BP	GO:0044117	growth of symbiont in host	5/858	17/15881	0.0016325210253395	0.0284666974228401	ENSMUSG00000016024/ENSMUSG00000027995/ENSMUSG00000055994/ENSMUSG00000002944/ENSMUSG00000041515	Lbp/Tlr2/Nod2/Cd36/Irf8	5
BP	GO:0090330	regulation of platelet aggregation	5/858	17/15881	0.0016325210253395	0.0284666974228401	ENSMUSG00000021457/ENSMUSG00000032020/ENSMUSG00000074272/ENSMUSG00000026249/ENSMUSG00000021948	Syk/Ubash3b/Ceacam1/Serpine2/Prkcd	5
BP	GO:1903706	regulation of hemopoiesis	30/858	313/15881	0.00169695781394299	0.0294782141467521	ENSMUSG00000023367/ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000029810/ENSMUSG00000024778/ENSMUSG00000044303/ENSMUSG00000037440/ENSMUSG00000049577/ENSMUSG00000024014/ENSMUSG00000032501/ENSMUSG00000034394/ENSMUSG00000034023/ENSMUSG00000021457/ENSMUSG00000007805/ENSMUSG00000029373/ENSMUSG00000027985/ENSMUSG00000066755/ENSMUSG00000035692/ENSMUSG00000035158/ENSMUSG00000053216/ENSMUSG00000032020/ENSMUSG00000074272/ENSMUSG00000031548/ENSMUSG00000031712/ENSMUSG00000040329/ENSMUSG00000063415/ENSMUSG00000044258/ENSMUSG00000004266/ENSMUSG00000020325/ENSMUSG00000026117	Tmem176a/Cd74/Cxcl1/Tmem176b/Fas/Cdkn2a/Vnn1/Zfpm1/Pim1/Trib1/Lif/Fancd2/Syk/Twist2/Pf4/Lef1/Tnfsf18/Isg15/Mitf/Btn2a2/Ubash3b/Ceacam1/Sfrp1/Il15/Il7/Cyp26b1/Ctla2a/Ptpn6/Fstl3/Zap70	30
BP	GO:0001819	positive regulation of cytokine production	32/858	341/15881	0.00170716898164206	0.0295436866030584	ENSMUSG00000024164/ENSMUSG00000024610/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000027750/ENSMUSG00000016024/ENSMUSG00000000732/ENSMUSG00000049577/ENSMUSG00000033538/ENSMUSG00000022514/ENSMUSG00000032860/ENSMUSG00000079685/ENSMUSG00000026166/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000053175/ENSMUSG00000029373/ENSMUSG00000055994/ENSMUSG00000026177/ENSMUSG00000017830/ENSMUSG00000020641/ENSMUSG00000002944/ENSMUSG00000037860/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000040329/ENSMUSG00000041515/ENSMUSG00000071203/ENSMUSG00000079164/ENSMUSG00000028602/ENSMUSG00000028864/ENSMUSG00000025888	C3/Cd74/Ccl2/Cx3cl1/Postn/Lbp/Icosl/Zfpm1/Casp4/Il1rap/P2ry2/Ulbp1/Ccl20/Tlr2/Syk/Bcl3/Pf4/Nod2/Slc11a1/Dhx58/Rsad2/Cd36/Aim2/Il12rb1/Il15/Il7/Irf8/Naip5/Tlr5/Tnfrsf8/Hgf/Casp1	32
BP	GO:0035637	multicellular organismal signaling	13/858	95/15881	0.00174885102166627	0.0301512435539907	ENSMUSG00000035873/ENSMUSG00000057123/ENSMUSG00000057182/ENSMUSG00000022416/ENSMUSG00000075318/ENSMUSG00000026442/ENSMUSG00000064329/ENSMUSG00000053395/ENSMUSG00000024065/ENSMUSG00000020787/ENSMUSG00000049044/ENSMUSG00000041695/ENSMUSG00000027071	Pawr/Gja5/Scn3a/Cacna1i/Scn2a/Nfasc/Scn1a/Cacng8/Ehd3/P2rx1/Rapgef4/Kcnj2/P2rx3	13
BP	GO:0003073	regulation of systemic arterial blood pressure	11/858	73/15881	0.00177021003816535	0.0304051806555292	ENSMUSG00000027750/ENSMUSG00000028024/ENSMUSG00000003541/ENSMUSG00000042429/ENSMUSG00000057123/ENSMUSG00000050541/ENSMUSG00000002944/ENSMUSG00000068323/ENSMUSG00000028978/ENSMUSG00000031489/ENSMUSG00000035458	Postn/Enpep/Ier3/Adora1/Gja5/Adra1b/Cd36/Slc4a5/Nos3/Adrb3/Tnni3	11
BP	GO:0010959	regulation of metal ion transport	30/858	314/15881	0.00178242277914055	0.0304329607049726	ENSMUSG00000029380/ENSMUSG00000066152/ENSMUSG00000026463/ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000042429/ENSMUSG00000028931/ENSMUSG00000026576/ENSMUSG00000032839/ENSMUSG00000061603/ENSMUSG00000025889/ENSMUSG00000041329/ENSMUSG00000032020/ENSMUSG00000041245/ENSMUSG00000028214/ENSMUSG00000026249/ENSMUSG00000041046/ENSMUSG00000009687/ENSMUSG00000034855/ENSMUSG00000024065/ENSMUSG00000028978/ENSMUSG00000020178/ENSMUSG00000020787/ENSMUSG00000037418/ENSMUSG00000041695/ENSMUSG00000004266/ENSMUSG00000036570/ENSMUSG00000030707/ENSMUSG00000044338/ENSMUSG00000038239	Cxcl1/Slc31a2/Atp2b4/Lgals3/Pawr/Adora1/Kcnab2/Atp1b1/Trpc1/Akap6/Snca/Atp1b2/Ubash3b/Wnk3/Gem/Serpine2/Ramp3/Fxyd5/Cxcl10/Ehd3/Nos3/Adora2a/P2rx1/Best1/Kcnj2/Ptpn6/Fxyd1/Coro1a/Aplnr/Hrc	30
BP	GO:0006939	smooth muscle contraction	12/858	84/15881	0.00178725695158576	0.0304329607049726	ENSMUSG00000047250/ENSMUSG00000035873/ENSMUSG00000042429/ENSMUSG00000022144/ENSMUSG00000050541/ENSMUSG00000021070/ENSMUSG00000055632/ENSMUSG00000020787/ENSMUSG00000059588/ENSMUSG00000027071/ENSMUSG00000035458/ENSMUSG00000020081	Ptgs1/Pawr/Adora1/Gdnf/Adra1b/Bdkrb2/Hmcn2/P2rx1/Calcrl/P2rx3/Tnni3/Tacr2	12
BP	GO:0051345	positive regulation of hydrolase activity	39/858	442/15881	0.00179173558446197	0.0304329607049726	ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000023030/ENSMUSG00000024778/ENSMUSG00000024066/ENSMUSG00000044303/ENSMUSG00000035373/ENSMUSG00000038235/ENSMUSG00000028039/ENSMUSG00000035873/ENSMUSG00000033538/ENSMUSG00000039621/ENSMUSG00000026576/ENSMUSG00000019997/ENSMUSG00000028128/ENSMUSG00000026166/ENSMUSG00000025507/ENSMUSG00000019122/ENSMUSG00000031292/ENSMUSG00000032359/ENSMUSG00000079017/ENSMUSG00000057897/ENSMUSG00000020599/ENSMUSG00000061603/ENSMUSG00000025889/ENSMUSG00000041329/ENSMUSG00000041193/ENSMUSG00000041351/ENSMUSG00000003134/ENSMUSG00000039813/ENSMUSG00000020340/ENSMUSG00000037860/ENSMUSG00000002489/ENSMUSG00000000120/ENSMUSG00000020787/ENSMUSG00000031780/ENSMUSG00000021948/ENSMUSG00000025888/ENSMUSG00000034652	Ccl2/Cx3cl1/Slc11a2/Fas/Xdh/Cdkn2a/Ccl7/F11r/Efna3/Pawr/Casp4/Prex1/Atp1b1/Ctgf/F3/Ccl20/Pidd1/Ccl9/Cdkl5/Ctsh/Ifi27l2a/Camk2b/Rgs9/Akap6/Snca/Atp1b2/Pla2g5/Rap1gap/Tbc1d8/Tbc1d2/Cyfip2/Aim2/Tiam1/Ngfr/P2rx1/Ccl17/Prkcd/Casp1/Cd300a	39
BP	GO:1904062	regulation of cation transmembrane transport	25/858	246/15881	0.00180931780421647	0.0306181972329769	ENSMUSG00000066152/ENSMUSG00000026463/ENSMUSG00000017737/ENSMUSG00000028931/ENSMUSG00000026576/ENSMUSG00000032839/ENSMUSG00000029167/ENSMUSG00000024873/ENSMUSG00000061603/ENSMUSG00000025889/ENSMUSG00000041329/ENSMUSG00000032020/ENSMUSG00000041245/ENSMUSG00000028214/ENSMUSG00000041046/ENSMUSG00000009687/ENSMUSG00000053395/ENSMUSG00000034855/ENSMUSG00000024065/ENSMUSG00000041695/ENSMUSG00000004266/ENSMUSG00000036570/ENSMUSG00000030707/ENSMUSG00000044338/ENSMUSG00000038239	Slc31a2/Atp2b4/Mmp9/Kcnab2/Atp1b1/Trpc1/Ppargc1a/Cnih2/Akap6/Snca/Atp1b2/Ubash3b/Wnk3/Gem/Ramp3/Fxyd5/Cacng8/Cxcl10/Ehd3/Kcnj2/Ptpn6/Fxyd1/Coro1a/Aplnr/Hrc	25
BP	GO:0071216	cellular response to biotic stimulus	20/858	181/15881	0.0018804602633178	0.0317051131160862	ENSMUSG00000035385/ENSMUSG00000016024/ENSMUSG00000042677/ENSMUSG00000037580/ENSMUSG00000020826/ENSMUSG00000019850/ENSMUSG00000032501/ENSMUSG00000027995/ENSMUSG00000028599/ENSMUSG00000021457/ENSMUSG00000055994/ENSMUSG00000075122/ENSMUSG00000015243/ENSMUSG00000002944/ENSMUSG00000104713/ENSMUSG00000029371/ENSMUSG00000034855/ENSMUSG00000028978/ENSMUSG00000041515/ENSMUSG00000025888	Ccl2/Lbp/Zc3h12a/Gch1/Nos2/Tnfaip3/Trib1/Tlr2/Tnfrsf1b/Syk/Nod2/Cd80/Abca1/Cd36/Gbp6/Cxcl5/Cxcl10/Nos3/Irf8/Casp1	20
BP	GO:0002274	myeloid leukocyte activation	18/858	156/15881	0.00192194680836292	0.0322858903412174	ENSMUSG00000031778/ENSMUSG00000016024/ENSMUSG00000062300/ENSMUSG00000079685/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000026068/ENSMUSG00000026177/ENSMUSG00000025889/ENSMUSG00000041193/ENSMUSG00000035186/ENSMUSG00000029371/ENSMUSG00000002699/ENSMUSG00000021948/ENSMUSG00000025888/ENSMUSG00000034652/ENSMUSG00000034266/ENSMUSG00000025279	Cx3cl1/Lbp/Nectin2/Ulbp1/Tlr2/Syk/Il18rap/Slc11a1/Snca/Pla2g5/Ubd/Cxcl5/Lcp2/Prkcd/Casp1/Cd300a/Batf/Dnase1l3	18
BP	GO:0015696	ammonium transport	12/858	85/15881	0.00198113405759571	0.0330381119568506	ENSMUSG00000055368/ENSMUSG00000050335/ENSMUSG00000024743/ENSMUSG00000022144/ENSMUSG00000021457/ENSMUSG00000025889/ENSMUSG00000028825/ENSMUSG00000020178/ENSMUSG00000020787/ENSMUSG00000007034/ENSMUSG00000034652/ENSMUSG00000020081	Slc6a2/Lgals3/Syt7/Gdnf/Syk/Snca/Rhd/Adora2a/P2rx1/Slc44a4/Cd300a/Tacr2	12
BP	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	12/858	85/15881	0.00198113405759571	0.0330381119568506	ENSMUSG00000031778/ENSMUSG00000022150/ENSMUSG00000050335/ENSMUSG00000019850/ENSMUSG00000022144/ENSMUSG00000022676/ENSMUSG00000029373/ENSMUSG00000023011/ENSMUSG00000025915/ENSMUSG00000040329/ENSMUSG00000028864/ENSMUSG00000022483	Cx3cl1/Dab2/Lgals3/Tnfaip3/Gdnf/Snai2/Pf4/Faim2/Sgk3/Il7/Hgf/Col2a1	12
BP	GO:0016054	organic acid catabolic process	21/858	195/15881	0.00201875962440186	0.0334224968863067	ENSMUSG00000026463/ENSMUSG00000027332/ENSMUSG00000020826/ENSMUSG00000056973/ENSMUSG00000042010/ENSMUSG00000023963/ENSMUSG00000019806/ENSMUSG00000031387/ENSMUSG00000015890/ENSMUSG00000003484/ENSMUSG00000017453/ENSMUSG00000031725/ENSMUSG00000055782/ENSMUSG00000027412/ENSMUSG00000028978/ENSMUSG00000063415/ENSMUSG00000010651/ENSMUSG00000007908/ENSMUSG00000028011/ENSMUSG00000002475/ENSMUSG00000034456	Atp2b4/Ivd/Nos2/Ces1d/Acacb/Cyp39a1/Aig1/Renbp/Amdhd1/Cyp4f18/Pipox/Ces1f/Abcd2/Lpin3/Nos3/Cyp26b1/Acaa1b/Hmgcll1/Tdo2/Abhd3/Uroc1	21
BP	GO:0046395	carboxylic acid catabolic process	21/858	195/15881	0.00201875962440186	0.0334224968863067	ENSMUSG00000026463/ENSMUSG00000027332/ENSMUSG00000020826/ENSMUSG00000056973/ENSMUSG00000042010/ENSMUSG00000023963/ENSMUSG00000019806/ENSMUSG00000031387/ENSMUSG00000015890/ENSMUSG00000003484/ENSMUSG00000017453/ENSMUSG00000031725/ENSMUSG00000055782/ENSMUSG00000027412/ENSMUSG00000028978/ENSMUSG00000063415/ENSMUSG00000010651/ENSMUSG00000007908/ENSMUSG00000028011/ENSMUSG00000002475/ENSMUSG00000034456	Atp2b4/Ivd/Nos2/Ces1d/Acacb/Cyp39a1/Aig1/Renbp/Amdhd1/Cyp4f18/Pipox/Ces1f/Abcd2/Lpin3/Nos3/Cyp26b1/Acaa1b/Hmgcll1/Tdo2/Abhd3/Uroc1	21
BP	GO:0001820	serotonin secretion	4/858	11/15881	0.00205645791870863	0.0334429645928999	ENSMUSG00000050335/ENSMUSG00000021457/ENSMUSG00000020787/ENSMUSG00000034652	Lgals3/Syk/P2rx1/Cd300a	4
BP	GO:0036376	sodium ion export across plasma membrane	4/858	11/15881	0.00205645791870863	0.0334429645928999	ENSMUSG00000026576/ENSMUSG00000040907/ENSMUSG00000041329/ENSMUSG00000036570	Atp1b1/Atp1a3/Atp1b2/Fxyd1	4
BP	GO:0043383	negative T cell selection	4/858	11/15881	0.00205645791870863	0.0334429645928999	ENSMUSG00000024610/ENSMUSG00000024778/ENSMUSG00000049109/ENSMUSG00000026117	Cd74/Fas/Themis/Zap70	4
BP	GO:0050855	regulation of B cell receptor signaling pathway	4/858	11/15881	0.00205645791870863	0.0334429645928999	ENSMUSG00000021108/ENSMUSG00000024696/ENSMUSG00000004266/ENSMUSG00000034652	Prkch/Lpxn/Ptpn6/Cd300a	4
BP	GO:0090331	negative regulation of platelet aggregation	4/858	11/15881	0.00205645791870863	0.0334429645928999	ENSMUSG00000032020/ENSMUSG00000074272/ENSMUSG00000026249/ENSMUSG00000021948	Ubash3b/Ceacam1/Serpine2/Prkcd	4
BP	GO:0009636	response to toxic substance	27/858	276/15881	0.00211207639675461	0.0341055716743544	ENSMUSG00000053279/ENSMUSG00000024778/ENSMUSG00000042677/ENSMUSG00000044303/ENSMUSG00000035373/ENSMUSG00000035873/ENSMUSG00000037580/ENSMUSG00000019850/ENSMUSG00000056973/ENSMUSG00000057182/ENSMUSG00000050541/ENSMUSG00000015709/ENSMUSG00000026251/ENSMUSG00000026253/ENSMUSG00000076441/ENSMUSG00000026822/ENSMUSG00000002944/ENSMUSG00000052974/ENSMUSG00000006235/ENSMUSG00000028978/ENSMUSG00000020178/ENSMUSG00000010651/ENSMUSG00000003477/ENSMUSG00000025069/ENSMUSG00000028864/ENSMUSG00000004231/ENSMUSG00000021948	Aldh1a1/Fas/Zc3h12a/Cdkn2a/Ccl7/Pawr/Gch1/Tnfaip3/Ces1d/Scn3a/Adra1b/Arnt2/Chrnd/Chrng/Ass1/Lcn2/Cd36/Cyp2f2/Epor/Nos3/Adora2a/Acaa1b/Inmt/Gsto2/Hgf/Pax2/Prkcd	27
BP	GO:0044282	small molecule catabolic process	27/858	276/15881	0.00211207639675461	0.0341055716743544	ENSMUSG00000026463/ENSMUSG00000006457/ENSMUSG00000027332/ENSMUSG00000020826/ENSMUSG00000056973/ENSMUSG00000042010/ENSMUSG00000023963/ENSMUSG00000028755/ENSMUSG00000035473/ENSMUSG00000019806/ENSMUSG00000031387/ENSMUSG00000015890/ENSMUSG00000003484/ENSMUSG00000017453/ENSMUSG00000031725/ENSMUSG00000055782/ENSMUSG00000041731/ENSMUSG00000020407/ENSMUSG00000027412/ENSMUSG00000090700/ENSMUSG00000028978/ENSMUSG00000063415/ENSMUSG00000010651/ENSMUSG00000007908/ENSMUSG00000028011/ENSMUSG00000002475/ENSMUSG00000034456	Atp2b4/Actn3/Ivd/Nos2/Ces1d/Acacb/Cyp39a1/Cda/Galm/Aig1/Renbp/Amdhd1/Cyp4f18/Pipox/Ces1f/Abcd2/Pgm5/Upp1/Lpin3/Cyp4f40/Nos3/Cyp26b1/Acaa1b/Hmgcll1/Tdo2/Abhd3/Uroc1	27
BP	GO:0030193	regulation of blood coagulation	10/858	64/15881	0.00214118879501847	0.0341713105640575	ENSMUSG00000021822/ENSMUSG00000027082/ENSMUSG00000021457/ENSMUSG00000032020/ENSMUSG00000074272/ENSMUSG00000002944/ENSMUSG00000060459/ENSMUSG00000026580/ENSMUSG00000026249/ENSMUSG00000021948	Plau/Tfpi/Syk/Ubash3b/Ceacam1/Cd36/Kng2/Selp/Serpine2/Prkcd	10
BP	GO:1900046	regulation of hemostasis	10/858	64/15881	0.00214118879501847	0.0341713105640575	ENSMUSG00000021822/ENSMUSG00000027082/ENSMUSG00000021457/ENSMUSG00000032020/ENSMUSG00000074272/ENSMUSG00000002944/ENSMUSG00000060459/ENSMUSG00000026580/ENSMUSG00000026249/ENSMUSG00000021948	Plau/Tfpi/Syk/Ubash3b/Ceacam1/Cd36/Kng2/Selp/Serpine2/Prkcd	10
BP	GO:0007266	Rho protein signal transduction	20/858	183/15881	0.00214374906163245	0.0341713105640575	ENSMUSG00000031785/ENSMUSG00000039960/ENSMUSG00000054855/ENSMUSG00000039621/ENSMUSG00000020021/ENSMUSG00000030220/ENSMUSG00000037999/ENSMUSG00000050541/ENSMUSG00000034226/ENSMUSG00000031442/ENSMUSG00000024013/ENSMUSG00000015243/ENSMUSG00000028841/ENSMUSG00000002489/ENSMUSG00000021895/ENSMUSG00000000120/ENSMUSG00000024451/ENSMUSG00000020121/ENSMUSG00000037509/ENSMUSG00000030433	Adgrg1/Rhou/Rnd1/Prex1/Fgd6/Arhgdib/Arap2/Adra1b/Rhov/Mcf2l/Fgd2/Abca1/Cnksr1/Tiam1/Arhgef3/Ngfr/Arap3/Srgap1/Arhgef4/Sbk2	20
BP	GO:0044110	growth involved in symbiotic interaction	5/858	18/15881	0.00216085478926661	0.0341713105640575	ENSMUSG00000016024/ENSMUSG00000027995/ENSMUSG00000055994/ENSMUSG00000002944/ENSMUSG00000041515	Lbp/Tlr2/Nod2/Cd36/Irf8	5
BP	GO:0044116	growth of symbiont involved in interaction with host	5/858	18/15881	0.00216085478926661	0.0341713105640575	ENSMUSG00000016024/ENSMUSG00000027995/ENSMUSG00000055994/ENSMUSG00000002944/ENSMUSG00000041515	Lbp/Tlr2/Nod2/Cd36/Irf8	5
BP	GO:0071677	positive regulation of mononuclear cell migration	5/858	18/15881	0.00216085478926661	0.0341713105640575	ENSMUSG00000035385/ENSMUSG00000050335/ENSMUSG00000023913/ENSMUSG00000066755/ENSMUSG00000034855	Ccl2/Lgals3/Pla2g7/Tnfsf18/Cxcl10	5
BP	GO:2000379	positive regulation of reactive oxygen species metabolic process	12/858	86/15881	0.00219190357541935	0.0345315442876197	ENSMUSG00000029380/ENSMUSG00000023067/ENSMUSG00000042677/ENSMUSG00000024066/ENSMUSG00000021822/ENSMUSG00000079685/ENSMUSG00000027995/ENSMUSG00000025889/ENSMUSG00000076441/ENSMUSG00000002944/ENSMUSG00000079164/ENSMUSG00000021948	Cxcl1/Cdkn1a/Zc3h12a/Xdh/Plau/Ulbp1/Tlr2/Snca/Ass1/Cd36/Tlr5/Prkcd	12
BP	GO:0035296	regulation of tube diameter	15/858	121/15881	0.00220622382823213	0.0345315442876197	ENSMUSG00000031778/ENSMUSG00000047250/ENSMUSG00000042429/ENSMUSG00000037580/ENSMUSG00000053965/ENSMUSG00000057123/ENSMUSG00000020826/ENSMUSG00000032860/ENSMUSG00000029084/ENSMUSG00000050541/ENSMUSG00000021070/ENSMUSG00000028978/ENSMUSG00000020178/ENSMUSG00000020787/ENSMUSG00000031489	Cx3cl1/Ptgs1/Adora1/Gch1/Pde5a/Gja5/Nos2/P2ry2/Cd38/Adra1b/Bdkrb2/Nos3/Adora2a/P2rx1/Adrb3	15
BP	GO:0097746	regulation of blood vessel diameter	15/858	121/15881	0.00220622382823213	0.0345315442876197	ENSMUSG00000031778/ENSMUSG00000047250/ENSMUSG00000042429/ENSMUSG00000037580/ENSMUSG00000053965/ENSMUSG00000057123/ENSMUSG00000020826/ENSMUSG00000032860/ENSMUSG00000029084/ENSMUSG00000050541/ENSMUSG00000021070/ENSMUSG00000028978/ENSMUSG00000020178/ENSMUSG00000020787/ENSMUSG00000031489	Cx3cl1/Ptgs1/Adora1/Gch1/Pde5a/Gja5/Nos2/P2ry2/Cd38/Adra1b/Bdkrb2/Nos3/Adora2a/P2rx1/Adrb3	15
BP	GO:0036230	granulocyte activation	6/858	26/15881	0.00221601371584453	0.0345667989825273	ENSMUSG00000021457/ENSMUSG00000026068/ENSMUSG00000029371/ENSMUSG00000021948/ENSMUSG00000034652/ENSMUSG00000025279	Syk/Il18rap/Cxcl5/Prkcd/Cd300a/Dnase1l3	6
BP	GO:0009611	response to wounding	35/858	390/15881	0.00227353553332968	0.0353438439181353	ENSMUSG00000024164/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000005089/ENSMUSG00000019850/ENSMUSG00000021822/ENSMUSG00000024743/ENSMUSG00000022144/ENSMUSG00000027082/ENSMUSG00000022676/ENSMUSG00000028128/ENSMUSG00000021457/ENSMUSG00000029373/ENSMUSG00000115388/ENSMUSG00000021469/ENSMUSG00000026177/ENSMUSG00000032020/ENSMUSG00000074272/ENSMUSG00000002944/ENSMUSG00000060459/ENSMUSG00000026580/ENSMUSG00000027611/ENSMUSG00000026249/ENSMUSG00000030468/ENSMUSG00000037362/ENSMUSG00000000120/ENSMUSG00000021256/ENSMUSG00000020787/ENSMUSG00000026109/ENSMUSG00000051379/ENSMUSG00000028475/ENSMUSG00000021948/ENSMUSG00000004266/ENSMUSG00000021998/ENSMUSG00000097636	C3/Ccl2/Cx3cl1/Slc1a2/Tnfaip3/Plau/Syt7/Gdnf/Tfpi/Snai2/F3/Syk/Pf4/Eppk1/Msx2/Slc11a1/Ubash3b/Ceacam1/Cd36/Kng2/Selp/Procr/Serpine2/Siglecg/Nov/Ngfr/Vash1/P2rx1/Tmeff2/Flrt3/Spaar/Prkcd/Ptpn6/Lcp1/Mirt1	35
BP	GO:0043062	extracellular structure organization	24/858	237/15881	0.00231645124249755	0.0358512656051958	ENSMUSG00000027750/ENSMUSG00000059901/ENSMUSG00000026574/ENSMUSG00000017737/ENSMUSG00000050335/ENSMUSG00000021831/ENSMUSG00000018800/ENSMUSG00000057074/ENSMUSG00000023913/ENSMUSG00000056973/ENSMUSG00000019997/ENSMUSG00000053175/ENSMUSG00000029307/ENSMUSG00000003051/ENSMUSG00000033327/ENSMUSG00000041193/ENSMUSG00000015243/ENSMUSG00000002944/ENSMUSG00000035258/ENSMUSG00000063765/ENSMUSG00000024030/ENSMUSG00000050578/ENSMUSG00000022483/ENSMUSG00000021998	Postn/Adamts14/Dpt/Mmp9/Lgals3/Ero1l/Abca5/Ces1g/Pla2g7/Ces1d/Ctgf/Bcl3/Dmp1/Elf3/Tnxb/Pla2g5/Abca1/Cd36/Abi3bp/Chadl/Abcg1/Mmp13/Col2a1/Lcp1	24
BP	GO:0050906	detection of stimulus involved in sensory perception	13/858	98/15881	0.0023218111392811	0.0358512656051958	ENSMUSG00000035873/ENSMUSG00000042429/ENSMUSG00000035504/ENSMUSG00000062168/ENSMUSG00000035916/ENSMUSG00000026249/ENSMUSG00000042774/ENSMUSG00000064329/ENSMUSG00000037418/ENSMUSG00000045381/ENSMUSG00000062873/ENSMUSG00000046493/ENSMUSG00000061972	Pawr/Adora1/Reep6/Ppef1/Ptprq/Serpine2/Olfr1353/Scn1a/Best1/Olfr433/Olfr1355/Olfr1352/Olfr99	13
BP	GO:0050856	regulation of T cell receptor signaling pathway	7/858	35/15881	0.00233332864309985	0.0359082052256909	ENSMUSG00000050335/ENSMUSG00000035873/ENSMUSG00000062300/ENSMUSG00000053216/ENSMUSG00000109713/ENSMUSG00000004266/ENSMUSG00000034652	Lgals3/Pawr/Nectin2/Btn2a2/Pvrig/Ptpn6/Cd300a	7
BP	GO:0042391	regulation of membrane potential	32/858	348/15881	0.00235557361622772	0.0361292996789978	ENSMUSG00000031778/ENSMUSG00000044303/ENSMUSG00000035873/ENSMUSG00000042429/ENSMUSG00000057123/ENSMUSG00000026576/ENSMUSG00000040907/ENSMUSG00000057182/ENSMUSG00000026251/ENSMUSG00000022416/ENSMUSG00000024873/ENSMUSG00000031654/ENSMUSG00000026253/ENSMUSG00000023243/ENSMUSG00000061603/ENSMUSG00000025889/ENSMUSG00000041329/ENSMUSG00000075318/ENSMUSG00000070570/ENSMUSG00000027674/ENSMUSG00000064329/ENSMUSG00000024065/ENSMUSG00000032066/ENSMUSG00000000120/ENSMUSG00000020178/ENSMUSG00000020787/ENSMUSG00000049044/ENSMUSG00000028020/ENSMUSG00000041695/ENSMUSG00000027071/ENSMUSG00000025888/ENSMUSG00000036570	Cx3cl1/Cdkn2a/Pawr/Adora1/Gja5/Atp1b1/Atp1a3/Scn3a/Chrnd/Cacna1i/Cnih2/Cbln1/Chrng/Kcnk5/Akap6/Snca/Atp1b2/Scn2a/Slc17a7/Pex5l/Scn1a/Ehd3/Bco2/Ngfr/Adora2a/P2rx1/Rapgef4/Glrb/Kcnj2/P2rx3/Casp1/Fxyd1	32
BP	GO:0001505	regulation of neurotransmitter levels	25/858	251/15881	0.00238007276199455	0.0363833789550234	ENSMUSG00000042677/ENSMUSG00000055368/ENSMUSG00000026463/ENSMUSG00000006764/ENSMUSG00000037580/ENSMUSG00000005089/ENSMUSG00000020826/ENSMUSG00000024743/ENSMUSG00000022144/ENSMUSG00000079685/ENSMUSG00000027995/ENSMUSG00000025889/ENSMUSG00000017969/ENSMUSG00000076441/ENSMUSG00000002944/ENSMUSG00000070570/ENSMUSG00000006235/ENSMUSG00000040046/ENSMUSG00000028978/ENSMUSG00000020178/ENSMUSG00000079164/ENSMUSG00000007034/ENSMUSG00000054423/ENSMUSG00000043943/ENSMUSG00000020081	Zc3h12a/Slc6a2/Atp2b4/Tph2/Gch1/Slc1a2/Nos2/Syt7/Gdnf/Ulbp1/Tlr2/Snca/Ptgis/Ass1/Cd36/Slc17a7/Epor/Tph1/Nos3/Adora2a/Tlr5/Slc44a4/Cadps/Naalad2/Tacr2	25
BP	GO:0030168	platelet activation	10/858	65/15881	0.00241066331419337	0.0367285779365142	ENSMUSG00000031778/ENSMUSG00000021457/ENSMUSG00000029373/ENSMUSG00000032020/ENSMUSG00000074272/ENSMUSG00000026580/ENSMUSG00000026249/ENSMUSG00000020787/ENSMUSG00000021948/ENSMUSG00000004266	Cx3cl1/Syk/Pf4/Ubash3b/Ceacam1/Selp/Serpine2/P2rx1/Prkcd/Ptpn6	10
BP	GO:0019724	B cell mediated immunity	12/858	87/15881	0.00242064114459723	0.0367584777785526	ENSMUSG00000024164/ENSMUSG00000024610/ENSMUSG00000024778/ENSMUSG00000000732/ENSMUSG00000062300/ENSMUSG00000053175/ENSMUSG00000055994/ENSMUSG00000079343/ENSMUSG00000075370/ENSMUSG00000021948/ENSMUSG00000004266/ENSMUSG00000034266	C3/Cd74/Fas/Icosl/Nectin2/Bcl3/Nod2/C1s2/Igll1/Prkcd/Ptpn6/Batf	12
BP	GO:0000041	transition metal ion transport	11/858	76/15881	0.00246041213609845	0.037116612026801	ENSMUSG00000012428/ENSMUSG00000003617/ENSMUSG00000023030/ENSMUSG00000020432/ENSMUSG00000066152/ENSMUSG00000022032/ENSMUSG00000032839/ENSMUSG00000026177/ENSMUSG00000063354/ENSMUSG00000029716/ENSMUSG00000031936	Steap4/Cp/Slc11a2/Tcn2/Slc31a2/Scara5/Trpc1/Slc11a1/Slc39a4/Tfr2/Hephl1	11
BP	GO:1902106	negative regulation of leukocyte differentiation	11/858	76/15881	0.00246041213609845	0.037116612026801	ENSMUSG00000023367/ENSMUSG00000024610/ENSMUSG00000029810/ENSMUSG00000044303/ENSMUSG00000049577/ENSMUSG00000032501/ENSMUSG00000066755/ENSMUSG00000032020/ENSMUSG00000074272/ENSMUSG00000031548/ENSMUSG00000020325	Tmem176a/Cd74/Tmem176b/Cdkn2a/Zfpm1/Trib1/Tnfsf18/Ubash3b/Ceacam1/Sfrp1/Fstl3	11
BP	GO:0045428	regulation of nitric oxide biosynthetic process	9/858	55/15881	0.00254469654133343	0.037960058516757	ENSMUSG00000042677/ENSMUSG00000026463/ENSMUSG00000079685/ENSMUSG00000027995/ENSMUSG00000017969/ENSMUSG00000076441/ENSMUSG00000002944/ENSMUSG00000006235/ENSMUSG00000079164	Zc3h12a/Atp2b4/Ulbp1/Tlr2/Ptgis/Ass1/Cd36/Epor/Tlr5	9
BP	GO:0060401	cytosolic calcium ion transport	16/858	135/15881	0.00254828427618717	0.037960058516757	ENSMUSG00000035873/ENSMUSG00000021831/ENSMUSG00000019997/ENSMUSG00000032839/ENSMUSG00000022416/ENSMUSG00000027994/ENSMUSG00000061603/ENSMUSG00000025889/ENSMUSG00000032020/ENSMUSG00000041046/ENSMUSG00000034855/ENSMUSG00000030523/ENSMUSG00000004266/ENSMUSG00000030707/ENSMUSG00000044338/ENSMUSG00000038239	Pawr/Ero1l/Ctgf/Trpc1/Cacna1i/Mcub/Akap6/Snca/Ubash3b/Ramp3/Cxcl10/Trpm1/Ptpn6/Coro1a/Aplnr/Hrc	16
BP	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	16/858	135/15881	0.00254828427618717	0.037960058516757	ENSMUSG00000031778/ENSMUSG00000090523/ENSMUSG00000022636/ENSMUSG00000019850/ENSMUSG00000054793/ENSMUSG00000062300/ENSMUSG00000022512/ENSMUSG00000031654/ENSMUSG00000051375/ENSMUSG00000074272/ENSMUSG00000026580/ENSMUSG00000052516/ENSMUSG00000053141/ENSMUSG00000008153/ENSMUSG00000051379/ENSMUSG00000028519	Cx3cl1/Gypc/Alcam/Tnfaip3/Cadm4/Nectin2/Cldn1/Cbln1/Pcdh1/Ceacam1/Selp/Robo2/Ptprt/Clstn3/Flrt3/Dab1	16
BP	GO:0032651	regulation of interleukin-1 beta production	8/858	45/15881	0.0025494326260709	0.037960058516757	ENSMUSG00000042677/ENSMUSG00000033538/ENSMUSG00000019850/ENSMUSG00000027995/ENSMUSG00000055994/ENSMUSG00000037860/ENSMUSG00000071203/ENSMUSG00000025888	Zc3h12a/Casp4/Tnfaip3/Tlr2/Nod2/Aim2/Naip5/Casp1	8
BP	GO:0048871	multicellular organismal homeostasis	27/858	280/15881	0.00258892284483278	0.0382842032084685	ENSMUSG00000023030/ENSMUSG00000042429/ENSMUSG00000040612/ENSMUSG00000019577/ENSMUSG00000029084/ENSMUSG00000042010/ENSMUSG00000019997/ENSMUSG00000021457/ENSMUSG00000022510/ENSMUSG00000022512/ENSMUSG00000029167/ENSMUSG00000055994/ENSMUSG00000032359/ENSMUSG00000026177/ENSMUSG00000032020/ENSMUSG00000074272/ENSMUSG00000028825/ENSMUSG00000002944/ENSMUSG00000020892/ENSMUSG00000072437/ENSMUSG00000040329/ENSMUSG00000063415/ENSMUSG00000034829/ENSMUSG00000022483/ENSMUSG00000031489/ENSMUSG00000002204/ENSMUSG00000030707	Slc11a2/Adora1/Ildr2/Pdk4/Cd38/Acacb/Ctgf/Syk/Trp63/Cldn1/Ppargc1a/Nod2/Ctsh/Slc11a1/Ubash3b/Ceacam1/Rhd/Cd36/Aloxe3/Nanos1/Il7/Cyp26b1/Nxnl1/Col2a1/Adrb3/Napsa/Coro1a	27
BP	GO:0002244	hematopoietic progenitor cell differentiation	15/858	123/15881	0.00259317707209265	0.0382842032084685	ENSMUSG00000071637/ENSMUSG00000028931/ENSMUSG00000022034/ENSMUSG00000029851/ENSMUSG00000048826/ENSMUSG00000035916/ENSMUSG00000048416/ENSMUSG00000031548/ENSMUSG00000030468/ENSMUSG00000031125/ENSMUSG00000043157/ENSMUSG00000004266/ENSMUSG00000020325/ENSMUSG00000068748/ENSMUSG00000034266	Cebpd/Kcnab2/Esco2/Tcaf2/Dact2/Ptprq/Mlf1/Sfrp1/Siglecg/3830403N18Rik/Arl11/Ptpn6/Fstl3/Ptprz1/Batf	15
BP	GO:0050671	positive regulation of lymphocyte proliferation	14/858	111/15881	0.0025962466632869	0.0382842032084685	ENSMUSG00000024610/ENSMUSG00000023067/ENSMUSG00000000732/ENSMUSG00000029082/ENSMUSG00000029084/ENSMUSG00000021457/ENSMUSG00000075122/ENSMUSG00000074272/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000040329/ENSMUSG00000039323/ENSMUSG00000030707/ENSMUSG00000026117	Cd74/Cdkn1a/Icosl/Bst1/Cd38/Syk/Cd80/Ceacam1/Il12rb1/Il15/Il7/Igfbp2/Coro1a/Zap70	14
BP	GO:0051271	negative regulation of cellular component movement	25/858	253/15881	0.00264789280319661	0.0388493871732586	ENSMUSG00000031778/ENSMUSG00000026185/ENSMUSG00000000753/ENSMUSG00000031785/ENSMUSG00000042429/ENSMUSG00000038387/ENSMUSG00000062991/ENSMUSG00000025207/ENSMUSG00000032501/ENSMUSG00000030220/ENSMUSG00000021596/ENSMUSG00000026921/ENSMUSG00000029167/ENSMUSG00000115388/ENSMUSG00000024873/ENSMUSG00000074715/ENSMUSG00000031548/ENSMUSG00000037362/ENSMUSG00000024451/ENSMUSG00000020121/ENSMUSG00000021256/ENSMUSG00000026109/ENSMUSG00000019278/ENSMUSG00000053318/ENSMUSG00000034652	Cx3cl1/Igfbp5/Serpinf1/Adgrg1/Adora1/Rras/Nrg1/Sema4g/Trib1/Arhgdib/Mctp1/Egfl7/Ppargc1a/Eppk1/Cnih2/Ccl28/Sfrp1/Nov/Arap3/Srgap1/Vash1/Tmeff2/Dpep1/Slamf8/Cd300a	25
BP	GO:2000146	negative regulation of cell motility	23/858	226/15881	0.00265308653152312	0.0388493871732586	ENSMUSG00000031778/ENSMUSG00000026185/ENSMUSG00000000753/ENSMUSG00000031785/ENSMUSG00000042429/ENSMUSG00000038387/ENSMUSG00000062991/ENSMUSG00000032501/ENSMUSG00000030220/ENSMUSG00000021596/ENSMUSG00000026921/ENSMUSG00000029167/ENSMUSG00000115388/ENSMUSG00000074715/ENSMUSG00000031548/ENSMUSG00000037362/ENSMUSG00000024451/ENSMUSG00000020121/ENSMUSG00000021256/ENSMUSG00000026109/ENSMUSG00000019278/ENSMUSG00000053318/ENSMUSG00000034652	Cx3cl1/Igfbp5/Serpinf1/Adgrg1/Adora1/Rras/Nrg1/Trib1/Arhgdib/Mctp1/Egfl7/Ppargc1a/Eppk1/Ccl28/Sfrp1/Nov/Arap3/Srgap1/Vash1/Tmeff2/Dpep1/Slamf8/Cd300a	23
BP	GO:0002526	acute inflammatory response	12/858	88/15881	0.00266845986907467	0.0388493871732586	ENSMUSG00000024164/ENSMUSG00000029380/ENSMUSG00000016024/ENSMUSG00000037440/ENSMUSG00000042429/ENSMUSG00000028128/ENSMUSG00000040026/ENSMUSG00000021070/ENSMUSG00000025494/ENSMUSG00000060063/ENSMUSG00000074115/ENSMUSG00000025279	C3/Cxcl1/Lbp/Vnn1/Adora1/F3/Saa3/Bdkrb2/Sigirr/Alox5ap/Saa1/Dnase1l3	12
BP	GO:0042089	cytokine biosynthetic process	12/858	88/15881	0.00266845986907467	0.0388493871732586	ENSMUSG00000016024/ENSMUSG00000000732/ENSMUSG00000049577/ENSMUSG00000035873/ENSMUSG00000022514/ENSMUSG00000026166/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000053175/ENSMUSG00000025494/ENSMUSG00000031438/ENSMUSG00000028602	Lbp/Icosl/Zfpm1/Pawr/Il1rap/Ccl20/Tlr2/Syk/Bcl3/Sigirr/Rnf128/Tnfrsf8	12
BP	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	22/858	213/15881	0.00270711722506927	0.0392380339179686	ENSMUSG00000024610/ENSMUSG00000029082/ENSMUSG00000042429/ENSMUSG00000062991/ENSMUSG00000022144/ENSMUSG00000021892/ENSMUSG00000034394/ENSMUSG00000046733/ENSMUSG00000021457/ENSMUSG00000006435/ENSMUSG00000055994/ENSMUSG00000075122/ENSMUSG00000066755/ENSMUSG00000031520/ENSMUSG00000002944/ENSMUSG00000031548/ENSMUSG00000031712/ENSMUSG00000028864/ENSMUSG00000021948/ENSMUSG00000004266/ENSMUSG00000068748/ENSMUSG00000034652	Cd74/Bst1/Adora1/Nrg1/Gdnf/Sh3bp5/Lif/Gprc5a/Syk/Neurl1a/Nod2/Cd80/Tnfsf18/Vegfc/Cd36/Sfrp1/Il15/Hgf/Prkcd/Ptpn6/Ptprz1/Cd300a	22
BP	GO:0002455	humoral immune response mediated by circulating immunoglobulin	6/858	27/15881	0.00272082311075316	0.0392380339179686	ENSMUSG00000024164/ENSMUSG00000053175/ENSMUSG00000055994/ENSMUSG00000079343/ENSMUSG00000075370/ENSMUSG00000004266	C3/Bcl3/Nod2/C1s2/Igll1/Ptpn6	6
BP	GO:0043171	peptide catabolic process	6/858	27/15881	0.00272082311075316	0.0392380339179686	ENSMUSG00000028024/ENSMUSG00000006344/ENSMUSG00000032359/ENSMUSG00000024481/ENSMUSG00000040471/ENSMUSG00000050578	Enpep/Ggt5/Ctsh/Lvrn/Ggt6/Mmp13	6
BP	GO:0006140	regulation of nucleotide metabolic process	16/858	136/15881	0.00274727768142211	0.0392409591224036	ENSMUSG00000006457/ENSMUSG00000016194/ENSMUSG00000003541/ENSMUSG00000053965/ENSMUSG00000020826/ENSMUSG00000024039/ENSMUSG00000028755/ENSMUSG00000029167/ENSMUSG00000029373/ENSMUSG00000034353/ENSMUSG00000061603/ENSMUSG00000040133/ENSMUSG00000041046/ENSMUSG00000034855/ENSMUSG00000028978/ENSMUSG00000052276	Actn3/Hsd11b1/Ier3/Pde5a/Nos2/Cbs/Cda/Ppargc1a/Pf4/Ramp1/Akap6/Gpr176/Ramp3/Cxcl10/Nos3/Ostn	16
BP	GO:0030801	positive regulation of cyclic nucleotide metabolic process	7/858	36/15881	0.00276380937560758	0.0392409591224036	ENSMUSG00000020826/ENSMUSG00000029373/ENSMUSG00000034353/ENSMUSG00000041046/ENSMUSG00000034855/ENSMUSG00000028978/ENSMUSG00000052276	Nos2/Pf4/Ramp1/Ramp3/Cxcl10/Nos3/Ostn	7
BP	GO:0032732	positive regulation of interleukin-1 production	7/858	36/15881	0.00276380937560758	0.0392409591224036	ENSMUSG00000033538/ENSMUSG00000026166/ENSMUSG00000027995/ENSMUSG00000055994/ENSMUSG00000037860/ENSMUSG00000071203/ENSMUSG00000025888	Casp4/Ccl20/Tlr2/Nod2/Aim2/Naip5/Casp1	7
BP	GO:0048247	lymphocyte chemotaxis	7/858	36/15881	0.00276380937560758	0.0392409591224036	ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000035373/ENSMUSG00000026166/ENSMUSG00000019122/ENSMUSG00000034855/ENSMUSG00000031780	Ccl2/Cx3cl1/Ccl7/Ccl20/Ccl9/Cxcl10/Ccl17	7
BP	GO:0050853	B cell receptor signaling pathway	7/858	36/15881	0.00276380937560758	0.0392409591224036	ENSMUSG00000029084/ENSMUSG00000021457/ENSMUSG00000075370/ENSMUSG00000021108/ENSMUSG00000024696/ENSMUSG00000004266/ENSMUSG00000034652	Cd38/Syk/Igll1/Prkch/Lpxn/Ptpn6/Cd300a	7
BP	GO:0010884	positive regulation of lipid storage	5/858	19/15881	0.00280361384375021	0.0395953814769855	ENSMUSG00000024164/ENSMUSG00000042677/ENSMUSG00000042010/ENSMUSG00000002944/ENSMUSG00000025044	C3/Zc3h12a/Acacb/Cd36/Msr1	5
BP	GO:0043270	positive regulation of ion transport	23/858	227/15881	0.00280603989969915	0.0395953814769855	ENSMUSG00000029380/ENSMUSG00000050335/ENSMUSG00000037685/ENSMUSG00000042429/ENSMUSG00000032860/ENSMUSG00000026576/ENSMUSG00000020333/ENSMUSG00000032839/ENSMUSG00000003484/ENSMUSG00000061603/ENSMUSG00000025889/ENSMUSG00000041329/ENSMUSG00000041245/ENSMUSG00000041046/ENSMUSG00000034855/ENSMUSG00000024065/ENSMUSG00000020178/ENSMUSG00000020787/ENSMUSG00000041695/ENSMUSG00000021948/ENSMUSG00000036570/ENSMUSG00000044338/ENSMUSG00000020081	Cxcl1/Lgals3/Atp8a1/Adora1/P2ry2/Atp1b1/Acsl6/Trpc1/Cyp4f18/Akap6/Snca/Atp1b2/Wnk3/Ramp3/Cxcl10/Ehd3/Adora2a/P2rx1/Kcnj2/Prkcd/Fxyd1/Aplnr/Tacr2	23
BP	GO:0019935	cyclic-nucleotide-mediated signaling	14/858	112/15881	0.00282356237197936	0.0397204203616483	ENSMUSG00000026463/ENSMUSG00000050541/ENSMUSG00000029373/ENSMUSG00000034353/ENSMUSG00000015243/ENSMUSG00000002944/ENSMUSG00000027674/ENSMUSG00000041046/ENSMUSG00000034855/ENSMUSG00000020178/ENSMUSG00000049044/ENSMUSG00000059588/ENSMUSG00000031489/ENSMUSG00000044338	Atp2b4/Adra1b/Pf4/Ramp1/Abca1/Cd36/Pex5l/Ramp3/Cxcl10/Adora2a/Rapgef4/Calcrl/Adrb3/Aplnr	14
BP	GO:0001676	long-chain fatty acid metabolic process	9/858	56/15881	0.00288974515629302	0.0404035709962189	ENSMUSG00000047250/ENSMUSG00000020333/ENSMUSG00000019806/ENSMUSG00000025002/ENSMUSG00000003484/ENSMUSG00000002944/ENSMUSG00000052974/ENSMUSG00000020892/ENSMUSG00000025197	Ptgs1/Acsl6/Aig1/Cyp2c55/Cyp4f18/Cd36/Cyp2f2/Aloxe3/Cyp2c23	9
BP	GO:0032890	regulation of organic acid transport	9/858	56/15881	0.00288974515629302	0.0404035709962189	ENSMUSG00000042429/ENSMUSG00000032860/ENSMUSG00000020333/ENSMUSG00000021457/ENSMUSG00000003484/ENSMUSG00000025889/ENSMUSG00000020178/ENSMUSG00000025557/ENSMUSG00000036570	Adora1/P2ry2/Acsl6/Syk/Cyp4f18/Snca/Adora2a/Slc15a1/Fxyd1	9
BP	GO:0046851	negative regulation of bone remodeling	4/858	12/15881	0.00295369428976226	0.0410474000389386	ENSMUSG00000029084/ENSMUSG00000032020/ENSMUSG00000074272/ENSMUSG00000031548	Cd38/Ubash3b/Ceacam1/Sfrp1	4
BP	GO:0055119	relaxation of cardiac muscle	4/858	12/15881	0.00295369428976226	0.0410474000389386	ENSMUSG00000053965/ENSMUSG00000026576/ENSMUSG00000061603/ENSMUSG00000041695	Pde5a/Atp1b1/Akap6/Kcnj2	4
BP	GO:0031644	regulation of neurological system process	10/858	67/15881	0.00303104895763129	0.0419951375217435	ENSMUSG00000032561/ENSMUSG00000035873/ENSMUSG00000042429/ENSMUSG00000062991/ENSMUSG00000037362/ENSMUSG00000000120/ENSMUSG00000049044/ENSMUSG00000028602/ENSMUSG00000027071/ENSMUSG00000028864	Acpp/Pawr/Adora1/Nrg1/Nov/Ngfr/Rapgef4/Tnfrsf8/P2rx3/Hgf	10
BP	GO:0032946	positive regulation of mononuclear cell proliferation	14/858	113/15881	0.00306696343098743	0.0423647418509288	ENSMUSG00000024610/ENSMUSG00000023067/ENSMUSG00000000732/ENSMUSG00000029082/ENSMUSG00000029084/ENSMUSG00000021457/ENSMUSG00000075122/ENSMUSG00000074272/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000040329/ENSMUSG00000039323/ENSMUSG00000030707/ENSMUSG00000026117	Cd74/Cdkn1a/Icosl/Bst1/Cd38/Syk/Cd80/Ceacam1/Il12rb1/Il15/Il7/Igfbp2/Coro1a/Zap70	14
BP	GO:0002699	positive regulation of immune effector process	18/858	163/15881	0.0031172595275525	0.0429301867668341	ENSMUSG00000024164/ENSMUSG00000024610/ENSMUSG00000029380/ENSMUSG00000073411/ENSMUSG00000035385/ENSMUSG00000061232/ENSMUSG00000016024/ENSMUSG00000062300/ENSMUSG00000079685/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000026068/ENSMUSG00000055994/ENSMUSG00000017830/ENSMUSG00000074272/ENSMUSG00000020641/ENSMUSG00000002944/ENSMUSG00000034652	C3/Cd74/Cxcl1/H2-D1/Ccl2/H2-K1/Lbp/Nectin2/Ulbp1/Tlr2/Syk/Il18rap/Nod2/Dhx58/Ceacam1/Rsad2/Cd36/Cd300a	18
BP	GO:0007204	positive regulation of cytosolic calcium ion concentration	23/858	229/15881	0.00313436383782651	0.0430365046714741	ENSMUSG00000029380/ENSMUSG00000035873/ENSMUSG00000021831/ENSMUSG00000032860/ENSMUSG00000029084/ENSMUSG00000032839/ENSMUSG00000050541/ENSMUSG00000022416/ENSMUSG00000061603/ENSMUSG00000025889/ENSMUSG00000032020/ENSMUSG00000074715/ENSMUSG00000002944/ENSMUSG00000060459/ENSMUSG00000021070/ENSMUSG00000041046/ENSMUSG00000006235/ENSMUSG00000034855/ENSMUSG00000030523/ENSMUSG00000004266/ENSMUSG00000030707/ENSMUSG00000044338/ENSMUSG00000038239	Cxcl1/Pawr/Ero1l/P2ry2/Cd38/Trpc1/Adra1b/Cacna1i/Akap6/Snca/Ubash3b/Ccl28/Cd36/Kng2/Bdkrb2/Ramp3/Epor/Cxcl10/Trpm1/Ptpn6/Coro1a/Aplnr/Hrc	23
BP	GO:0034765	regulation of ion transmembrane transport	31/858	341/15881	0.00324649881831469	0.0443456499979914	ENSMUSG00000066152/ENSMUSG00000026463/ENSMUSG00000017737/ENSMUSG00000057123/ENSMUSG00000028931/ENSMUSG00000026576/ENSMUSG00000020333/ENSMUSG00000029851/ENSMUSG00000032839/ENSMUSG00000029167/ENSMUSG00000050777/ENSMUSG00000024873/ENSMUSG00000061603/ENSMUSG00000025889/ENSMUSG00000041329/ENSMUSG00000032020/ENSMUSG00000041245/ENSMUSG00000028214/ENSMUSG00000041046/ENSMUSG00000009687/ENSMUSG00000064329/ENSMUSG00000053395/ENSMUSG00000034855/ENSMUSG00000024065/ENSMUSG00000041695/ENSMUSG00000018470/ENSMUSG00000004266/ENSMUSG00000036570/ENSMUSG00000030707/ENSMUSG00000044338/ENSMUSG00000038239	Slc31a2/Atp2b4/Mmp9/Gja5/Kcnab2/Atp1b1/Acsl6/Tcaf2/Trpc1/Ppargc1a/Tmem37/Cnih2/Akap6/Snca/Atp1b2/Ubash3b/Wnk3/Gem/Ramp3/Fxyd5/Scn1a/Cacng8/Cxcl10/Ehd3/Kcnj2/Kcnab3/Ptpn6/Fxyd1/Coro1a/Aplnr/Hrc	31
BP	GO:0001912	positive regulation of leukocyte mediated cytotoxicity	7/858	37/15881	0.00325264204988118	0.0443456499979914	ENSMUSG00000029380/ENSMUSG00000073411/ENSMUSG00000035385/ENSMUSG00000061232/ENSMUSG00000062300/ENSMUSG00000079685/ENSMUSG00000026068	Cxcl1/H2-D1/Ccl2/H2-K1/Nectin2/Ulbp1/Il18rap	7
BP	GO:0002532	production of molecular mediator involved in inflammatory response	9/858	57/15881	0.00327070499203229	0.0443456499979914	ENSMUSG00000016024/ENSMUSG00000042677/ENSMUSG00000020826/ENSMUSG00000021457/ENSMUSG00000055994/ENSMUSG00000060063/ENSMUSG00000020787/ENSMUSG00000053318/ENSMUSG00000034652	Lbp/Zc3h12a/Nos2/Syk/Nod2/Alox5ap/P2rx1/Slamf8/Cd300a	9
BP	GO:0010543	regulation of platelet activation	6/858	28/15881	0.00330706766230114	0.0443456499979914	ENSMUSG00000021457/ENSMUSG00000032020/ENSMUSG00000074272/ENSMUSG00000026580/ENSMUSG00000026249/ENSMUSG00000021948	Syk/Ubash3b/Ceacam1/Selp/Serpine2/Prkcd	6
BP	GO:0019369	arachidonic acid metabolic process	6/858	28/15881	0.00330706766230114	0.0443456499979914	ENSMUSG00000047250/ENSMUSG00000025002/ENSMUSG00000003484/ENSMUSG00000052974/ENSMUSG00000020892/ENSMUSG00000025197	Ptgs1/Cyp2c55/Cyp4f18/Cyp2f2/Aloxe3/Cyp2c23	6
BP	GO:0043368	positive T cell selection	6/858	28/15881	0.00330706766230114	0.0443456499979914	ENSMUSG00000024610/ENSMUSG00000066755/ENSMUSG00000049109/ENSMUSG00000048251/ENSMUSG00000034266/ENSMUSG00000026117	Cd74/Tnfsf18/Themis/Bcl11b/Batf/Zap70	6
BP	GO:0046633	alpha-beta T cell proliferation	6/858	28/15881	0.00330706766230114	0.0443456499979914	ENSMUSG00000021457/ENSMUSG00000075122/ENSMUSG00000074272/ENSMUSG00000031712/ENSMUSG00000052013/ENSMUSG00000026117	Syk/Cd80/Ceacam1/Il15/Btla/Zap70	6
BP	GO:0050706	regulation of interleukin-1 beta secretion	6/858	28/15881	0.00330706766230114	0.0443456499979914	ENSMUSG00000042677/ENSMUSG00000033538/ENSMUSG00000027995/ENSMUSG00000055994/ENSMUSG00000037860/ENSMUSG00000025888	Zc3h12a/Casp4/Tlr2/Nod2/Aim2/Casp1	6
BP	GO:0050803	regulation of synapse structure or activity	18/858	164/15881	0.00333005811052573	0.0444418604677112	ENSMUSG00000026825/ENSMUSG00000022514/ENSMUSG00000027995/ENSMUSG00000006435/ENSMUSG00000057897/ENSMUSG00000031654/ENSMUSG00000025889/ENSMUSG00000055003/ENSMUSG00000070570/ENSMUSG00000027296/ENSMUSG00000002104/ENSMUSG00000002489/ENSMUSG00000033214/ENSMUSG00000008153/ENSMUSG00000051379/ENSMUSG00000036295/ENSMUSG00000002341/ENSMUSG00000043051	Dnm1/Il1rap/Tlr2/Neurl1a/Camk2b/Cbln1/Snca/Lrtm2/Slc17a7/Itpka/Rapsn/Tiam1/Slitrk5/Clstn3/Flrt3/Lrrn3/Ncan/Disc1	18
BP	GO:0050673	epithelial cell proliferation	32/858	356/15881	0.00334574204581342	0.0444418604677112	ENSMUSG00000035385/ENSMUSG00000026185/ENSMUSG00000000753/ENSMUSG00000022150/ENSMUSG00000024066/ENSMUSG00000044303/ENSMUSG00000019850/ENSMUSG00000021822/ENSMUSG00000022676/ENSMUSG00000028128/ENSMUSG00000022510/ENSMUSG00000036585/ENSMUSG00000026921/ENSMUSG00000007805/ENSMUSG00000055994/ENSMUSG00000115388/ENSMUSG00000056758/ENSMUSG00000028640/ENSMUSG00000031520/ENSMUSG00000041351/ENSMUSG00000074272/ENSMUSG00000029754/ENSMUSG00000017724/ENSMUSG00000031548/ENSMUSG00000037362/ENSMUSG00000000120/ENSMUSG00000021256/ENSMUSG00000004231/ENSMUSG00000048251/ENSMUSG00000012350/ENSMUSG00000038259/ENSMUSG00000044338	Ccl2/Igfbp5/Serpinf1/Dab2/Xdh/Cdkn2a/Tnfaip3/Plau/Snai2/F3/Trp63/Fgf1/Egfl7/Twist2/Nod2/Eppk1/Hmga2/Tfap2c/Vegfc/Rap1gap/Ceacam1/Dlx6/Etv4/Sfrp1/Nov/Ngfr/Vash1/Pax2/Bcl11b/Ehf/Gdf5/Aplnr	32
BP	GO:0042100	B cell proliferation	11/858	79/15881	0.00335355768919327	0.0444418604677112	ENSMUSG00000024610/ENSMUSG00000023067/ENSMUSG00000044303/ENSMUSG00000029082/ENSMUSG00000035873/ENSMUSG00000029084/ENSMUSG00000027985/ENSMUSG00000040329/ENSMUSG00000052013/ENSMUSG00000021948/ENSMUSG00000034652	Cd74/Cdkn1a/Cdkn2a/Bst1/Pawr/Cd38/Lef1/Il7/Btla/Prkcd/Cd300a	11
BP	GO:0001933	negative regulation of protein phosphorylation	34/858	385/15881	0.00336844405070206	0.0444418604677112	ENSMUSG00000023067/ENSMUSG00000042677/ENSMUSG00000022150/ENSMUSG00000024066/ENSMUSG00000044303/ENSMUSG00000022103/ENSMUSG00000039621/ENSMUSG00000019850/ENSMUSG00000032501/ENSMUSG00000034570/ENSMUSG00000021892/ENSMUSG00000034394/ENSMUSG00000046733/ENSMUSG00000019823/ENSMUSG00000012889/ENSMUSG00000079363/ENSMUSG00000029167/ENSMUSG00000025665/ENSMUSG00000026483/ENSMUSG00000053216/ENSMUSG00000025889/ENSMUSG00000032020/ENSMUSG00000055003/ENSMUSG00000074272/ENSMUSG00000021070/ENSMUSG00000031548/ENSMUSG00000020178/ENSMUSG00000039661/ENSMUSG00000028864/ENSMUSG00000051379/ENSMUSG00000024427/ENSMUSG00000021948/ENSMUSG00000004266/ENSMUSG00000034652	Cdkn1a/Zc3h12a/Dab2/Xdh/Cdkn2a/Gfra2/Prex1/Tnfaip3/Trib1/Inpp5j/Sh3bp5/Lif/Gprc5a/Mical1/Podnl1/Gbp4/Ppargc1a/Rps6ka6/Fam129a/Btn2a2/Snca/Ubash3b/Lrtm2/Ceacam1/Bdkrb2/Sfrp1/Adora2a/Dusp26/Hgf/Flrt3/Spry4/Prkcd/Ptpn6/Cd300a	34
BP	GO:0006801	superoxide metabolic process	8/858	47/15881	0.00338207791173816	0.0444418604677112	ENSMUSG00000029380/ENSMUSG00000037580/ENSMUSG00000020826/ENSMUSG00000021457/ENSMUSG00000024039/ENSMUSG00000002944/ENSMUSG00000028978/ENSMUSG00000021948	Cxcl1/Gch1/Nos2/Syk/Cbs/Cd36/Nos3/Prkcd	8
BP	GO:0031343	positive regulation of cell killing	8/858	47/15881	0.00338207791173816	0.0444418604677112	ENSMUSG00000029380/ENSMUSG00000073411/ENSMUSG00000035385/ENSMUSG00000061232/ENSMUSG00000020826/ENSMUSG00000062300/ENSMUSG00000079685/ENSMUSG00000026068	Cxcl1/H2-D1/Ccl2/H2-K1/Nos2/Nectin2/Ulbp1/Il18rap	8
BP	GO:0032720	negative regulation of tumor necrosis factor production	8/858	47/15881	0.00338207791173816	0.0444418604677112	ENSMUSG00000029816/ENSMUSG00000016024/ENSMUSG00000030921/ENSMUSG00000042677/ENSMUSG00000019850/ENSMUSG00000053175/ENSMUSG00000007805/ENSMUSG00000055994	Gpnmb/Lbp/Trim30a/Zc3h12a/Tnfaip3/Bcl3/Twist2/Nod2	8
BP	GO:0051048	negative regulation of secretion	20/858	191/15881	0.0035293658472873	0.0462268956322619	ENSMUSG00000024610/ENSMUSG00000031778/ENSMUSG00000042677/ENSMUSG00000028965/ENSMUSG00000020806/ENSMUSG00000047250/ENSMUSG00000042429/ENSMUSG00000034394/ENSMUSG00000004347/ENSMUSG00000053216/ENSMUSG00000003484/ENSMUSG00000025889/ENSMUSG00000020641/ENSMUSG00000090958/ENSMUSG00000041245/ENSMUSG00000031548/ENSMUSG00000037362/ENSMUSG00000000706/ENSMUSG00000034652/ENSMUSG00000020081	Cd74/Cx3cl1/Zc3h12a/Tnfrsf9/Rhbdf2/Ptgs1/Adora1/Lif/Pde1c/Btn2a2/Cyp4f18/Snca/Rsad2/Lrrc32/Wnk3/Sfrp1/Nov/Btn1a1/Cd300a/Tacr2	20
BP	GO:0042107	cytokine metabolic process	12/858	91/15881	0.00353808119645092	0.0462268956322619	ENSMUSG00000016024/ENSMUSG00000000732/ENSMUSG00000049577/ENSMUSG00000035873/ENSMUSG00000022514/ENSMUSG00000026166/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000053175/ENSMUSG00000025494/ENSMUSG00000031438/ENSMUSG00000028602	Lbp/Icosl/Zfpm1/Pawr/Il1rap/Ccl20/Tlr2/Syk/Bcl3/Sigirr/Rnf128/Tnfrsf8	12
BP	GO:1905952	regulation of lipid localization	14/858	115/15881	0.00360538405126218	0.0469426198710991	ENSMUSG00000024164/ENSMUSG00000042677/ENSMUSG00000022150/ENSMUSG00000037685/ENSMUSG00000032860/ENSMUSG00000020333/ENSMUSG00000042010/ENSMUSG00000021457/ENSMUSG00000003484/ENSMUSG00000015243/ENSMUSG00000002944/ENSMUSG00000024030/ENSMUSG00000025044/ENSMUSG00000021948	C3/Zc3h12a/Dab2/Atp8a1/P2ry2/Acsl6/Acacb/Syk/Cyp4f18/Abca1/Cd36/Abcg1/Msr1/Prkcd	14
BP	GO:0009187	cyclic nucleotide metabolic process	13/858	103/15881	0.00361333292945879	0.0469426198710991	ENSMUSG00000053965/ENSMUSG00000020826/ENSMUSG00000024039/ENSMUSG00000029373/ENSMUSG00000004347/ENSMUSG00000034353/ENSMUSG00000061603/ENSMUSG00000040133/ENSMUSG00000041046/ENSMUSG00000034855/ENSMUSG00000028978/ENSMUSG00000059173/ENSMUSG00000052276	Pde5a/Nos2/Cbs/Pf4/Pde1c/Ramp1/Akap6/Gpr176/Ramp3/Cxcl10/Nos3/Pde1a/Ostn	13
BP	GO:0050678	regulation of epithelial cell proliferation	28/858	301/15881	0.00363776690419702	0.0471265509114338	ENSMUSG00000035385/ENSMUSG00000000753/ENSMUSG00000022150/ENSMUSG00000024066/ENSMUSG00000044303/ENSMUSG00000019850/ENSMUSG00000021822/ENSMUSG00000022676/ENSMUSG00000028128/ENSMUSG00000022510/ENSMUSG00000036585/ENSMUSG00000026921/ENSMUSG00000007805/ENSMUSG00000055994/ENSMUSG00000115388/ENSMUSG00000056758/ENSMUSG00000031520/ENSMUSG00000041351/ENSMUSG00000074272/ENSMUSG00000029754/ENSMUSG00000017724/ENSMUSG00000031548/ENSMUSG00000000120/ENSMUSG00000021256/ENSMUSG00000004231/ENSMUSG00000048251/ENSMUSG00000038259/ENSMUSG00000044338	Ccl2/Serpinf1/Dab2/Xdh/Cdkn2a/Tnfaip3/Plau/Snai2/F3/Trp63/Fgf1/Egfl7/Twist2/Nod2/Eppk1/Hmga2/Vegfc/Rap1gap/Ceacam1/Dlx6/Etv4/Sfrp1/Ngfr/Vash1/Pax2/Bcl11b/Gdf5/Aplnr	28
BP	GO:0030888	regulation of B cell proliferation	9/858	58/15881	0.00369008577218431	0.0476696714119359	ENSMUSG00000024610/ENSMUSG00000023067/ENSMUSG00000044303/ENSMUSG00000029082/ENSMUSG00000035873/ENSMUSG00000029084/ENSMUSG00000040329/ENSMUSG00000052013/ENSMUSG00000034652	Cd74/Cdkn1a/Cdkn2a/Bst1/Pawr/Cd38/Il7/Btla/Cd300a	9
BP	GO:2000027	regulation of organ morphogenesis	18/858	166/15881	0.00379191908610651	0.0488475868788889	ENSMUSG00000022150/ENSMUSG00000044303/ENSMUSG00000024014/ENSMUSG00000019850/ENSMUSG00000021822/ENSMUSG00000022144/ENSMUSG00000034394/ENSMUSG00000022676/ENSMUSG00000029307/ENSMUSG00000036585/ENSMUSG00000056758/ENSMUSG00000074272/ENSMUSG00000017724/ENSMUSG00000031548/ENSMUSG00000033227/ENSMUSG00000000120/ENSMUSG00000028864/ENSMUSG00000004231	Dab2/Cdkn2a/Pim1/Tnfaip3/Plau/Gdnf/Lif/Snai2/Dmp1/Fgf1/Hmga2/Ceacam1/Etv4/Sfrp1/Wnt6/Ngfr/Hgf/Pax2	18
BP	GO:0042108	positive regulation of cytokine biosynthetic process	8/858	48/15881	0.00387041031930306	0.0495801724143124	ENSMUSG00000016024/ENSMUSG00000000732/ENSMUSG00000049577/ENSMUSG00000026166/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000053175/ENSMUSG00000028602	Lbp/Icosl/Zfpm1/Ccl20/Tlr2/Syk/Bcl3/Tnfrsf8	8
BP	GO:1903556	negative regulation of tumor necrosis factor superfamily cytokine production	8/858	48/15881	0.00387041031930306	0.0495801724143124	ENSMUSG00000029816/ENSMUSG00000016024/ENSMUSG00000030921/ENSMUSG00000042677/ENSMUSG00000019850/ENSMUSG00000053175/ENSMUSG00000007805/ENSMUSG00000055994	Gpnmb/Lbp/Trim30a/Zc3h12a/Tnfaip3/Bcl3/Twist2/Nod2	8
BP	GO:0070665	positive regulation of leukocyte proliferation	14/858	116/15881	0.00390214261942506	0.0498474263305942	ENSMUSG00000024610/ENSMUSG00000023067/ENSMUSG00000000732/ENSMUSG00000029082/ENSMUSG00000029084/ENSMUSG00000021457/ENSMUSG00000075122/ENSMUSG00000074272/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000040329/ENSMUSG00000039323/ENSMUSG00000030707/ENSMUSG00000026117	Cd74/Cdkn1a/Icosl/Bst1/Cd38/Syk/Cd80/Ceacam1/Il12rb1/Il15/Il7/Igfbp2/Coro1a/Zap70	14
CC	GO:0009897	external side of plasma membrane	37/852	239/15881	5.46E-09	2.51E-06	ENSMUSG00000024610/ENSMUSG00000073411/ENSMUSG00000075602/ENSMUSG00000061232/ENSMUSG00000024778/ENSMUSG00000022636/ENSMUSG00000028965/ENSMUSG00000079018/ENSMUSG00000000732/ENSMUSG00000050335/ENSMUSG00000028024/ENSMUSG00000022103/ENSMUSG00000062991/ENSMUSG00000026980/ENSMUSG00000079685/ENSMUSG00000027995/ENSMUSG00000075122/ENSMUSG00000053216/ENSMUSG00000015243/ENSMUSG00000074272/ENSMUSG00000068227/ENSMUSG00000027070/ENSMUSG00000002944/ENSMUSG00000026580/ENSMUSG00000026249/ENSMUSG00000006235/ENSMUSG00000034855/ENSMUSG00000000791/ENSMUSG00000000120/ENSMUSG00000020787/ENSMUSG00000000706/ENSMUSG00000075370/ENSMUSG00000029716/ENSMUSG00000005947/ENSMUSG00000028020/ENSMUSG00000052013/ENSMUSG00000024030	Cd74/H2-D1/Ly6a/H2-K1/Fas/Alcam/Tnfrsf9/Ly6c1/Icosl/Lgals3/Enpep/Gfra2/Nrg1/Ly75/Ulbp1/Tlr2/Cd80/Btn2a2/Abca1/Ceacam1/Il2rb/Lrp2/Cd36/Selp/Serpine2/Epor/Cxcl10/Il12rb1/Ngfr/P2rx1/Btn1a1/Igll1/Tfr2/Itgae/Glrb/Btla/Abcg1	37
CC	GO:0098552	side of membrane	50/852	413/15881	5.79E-08	1.03E-05	ENSMUSG00000024610/ENSMUSG00000073411/ENSMUSG00000075602/ENSMUSG00000043004/ENSMUSG00000061232/ENSMUSG00000024778/ENSMUSG00000022636/ENSMUSG00000028965/ENSMUSG00000079018/ENSMUSG00000000732/ENSMUSG00000050335/ENSMUSG00000028024/ENSMUSG00000022103/ENSMUSG00000062991/ENSMUSG00000026980/ENSMUSG00000028931/ENSMUSG00000027669/ENSMUSG00000079685/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000075122/ENSMUSG00000031442/ENSMUSG00000053216/ENSMUSG00000020599/ENSMUSG00000015243/ENSMUSG00000074272/ENSMUSG00000068227/ENSMUSG00000027070/ENSMUSG00000041731/ENSMUSG00000002944/ENSMUSG00000026580/ENSMUSG00000028214/ENSMUSG00000026249/ENSMUSG00000006235/ENSMUSG00000034855/ENSMUSG00000041361/ENSMUSG00000002489/ENSMUSG00000000791/ENSMUSG00000031506/ENSMUSG00000000120/ENSMUSG00000020787/ENSMUSG00000000706/ENSMUSG00000075370/ENSMUSG00000029716/ENSMUSG00000005947/ENSMUSG00000038811/ENSMUSG00000028020/ENSMUSG00000052013/ENSMUSG00000024030/ENSMUSG00000026117	Cd74/H2-D1/Ly6a/Gng2/H2-K1/Fas/Alcam/Tnfrsf9/Ly6c1/Icosl/Lgals3/Enpep/Gfra2/Nrg1/Ly75/Kcnab2/Gnb4/Ulbp1/Tlr2/Syk/Cd80/Mcf2l/Btn2a2/Rgs9/Abca1/Ceacam1/Il2rb/Lrp2/Pgm5/Cd36/Selp/Gem/Serpine2/Epor/Cxcl10/Myzap/Tiam1/Il12rb1/Ptpn7/Ngfr/P2rx1/Btn1a1/Igll1/Tfr2/Itgae/Gngt2/Glrb/Btla/Abcg1/Zap70	50
CC	GO:0065010	extracellular membrane-bounded organelle	8/852	13/15881	6.72E-08	1.03E-05	ENSMUSG00000040253/ENSMUSG00000029373/ENSMUSG00000028766/ENSMUSG00000029298/ENSMUSG00000054072/ENSMUSG00000028268/ENSMUSG00000104713/ENSMUSG00000050860	Gbp7/Pf4/Alpl/Gbp9/Iigp1/Gbp3/Gbp6/Phospho1	8
CC	GO:0020003	symbiont-containing vacuole	6/852	11/15881	8.58E-06	0.000986574387421807	ENSMUSG00000040253/ENSMUSG00000029373/ENSMUSG00000029298/ENSMUSG00000054072/ENSMUSG00000028268/ENSMUSG00000104713	Gbp7/Pf4/Gbp9/Iigp1/Gbp3/Gbp6	6
CC	GO:0098797	plasma membrane protein complex	43/852	402/15881	1.25E-05	0.00115366663755321	ENSMUSG00000024610/ENSMUSG00000073411/ENSMUSG00000043004/ENSMUSG00000061232/ENSMUSG00000024778/ENSMUSG00000022150/ENSMUSG00000022636/ENSMUSG00000035929/ENSMUSG00000029082/ENSMUSG00000057123/ENSMUSG00000028931/ENSMUSG00000026576/ENSMUSG00000027669/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000040907/ENSMUSG00000071715/ENSMUSG00000057182/ENSMUSG00000038403/ENSMUSG00000026251/ENSMUSG00000024873/ENSMUSG00000020599/ENSMUSG00000026253/ENSMUSG00000034353/ENSMUSG00000041329/ENSMUSG00000075318/ENSMUSG00000074272/ENSMUSG00000041731/ENSMUSG00000041046/ENSMUSG00000064329/ENSMUSG00000053395/ENSMUSG00000000791/ENSMUSG00000035296/ENSMUSG00000029716/ENSMUSG00000005947/ENSMUSG00000038811/ENSMUSG00000028020/ENSMUSG00000041695/ENSMUSG00000062157/ENSMUSG00000059588/ENSMUSG00000004266/ENSMUSG00000050623/ENSMUSG00000026117	Cd74/H2-D1/Gng2/H2-K1/Fas/Dab2/Alcam/H2-Q4/Bst1/Gja5/Kcnab2/Atp1b1/Gnb4/Tlr2/Syk/Atp1a3/Ncf4/Scn3a/Hfe2/Chrnd/Cnih2/Rgs9/Chrng/Ramp1/Atp1b2/Scn2a/Ceacam1/Pgm5/Ramp3/Scn1a/Cacng8/Il12rb1/Sgcg/Tfr2/Itgae/Gngt2/Glrb/Kcnj2/Ifnlr1/Calcrl/Ptpn6/Catsperz/Zap70	43
CC	GO:0005578	proteinaceous extracellular matrix	34/852	301/15881	3.34E-05	0.00223125368093994	ENSMUSG00000027750/ENSMUSG00000000753/ENSMUSG00000026574/ENSMUSG00000017737/ENSMUSG00000050335/ENSMUSG00000048126/ENSMUSG00000043822/ENSMUSG00000019997/ENSMUSG00000012889/ENSMUSG00000029436/ENSMUSG00000029307/ENSMUSG00000036585/ENSMUSG00000028766/ENSMUSG00000033327/ENSMUSG00000002020/ENSMUSG00000019846/ENSMUSG00000035258/ENSMUSG00000055632/ENSMUSG00000042501/ENSMUSG00000031548/ENSMUSG00000037362/ENSMUSG00000033227/ENSMUSG00000050860/ENSMUSG00000063765/ENSMUSG00000033214/ENSMUSG00000021613/ENSMUSG00000028339/ENSMUSG00000030606/ENSMUSG00000050578/ENSMUSG00000030170/ENSMUSG00000036295/ENSMUSG00000022483/ENSMUSG00000002341/ENSMUSG00000068748	Postn/Serpinf1/Dpt/Mmp9/Lgals3/Col6a3/Adamtsl5/Ctgf/Podnl1/Mmp17/Dmp1/Fgf1/Alpl/Tnxb/Ltbp2/Lama4/Abi3bp/Hmcn2/Cpa6/Sfrp1/Nov/Wnt6/Phospho1/Chadl/Slitrk5/Hapln1/Col15a1/Hapln3/Mmp13/Wnt5b/Lrrn3/Col2a1/Ncan/Ptprz1	34
CC	GO:0044304	main axon	13/852	65/15881	3.40E-05	0.00223125368093994	ENSMUSG00000026825/ENSMUSG00000042429/ENSMUSG00000005089/ENSMUSG00000062991/ENSMUSG00000028931/ENSMUSG00000028599/ENSMUSG00000075318/ENSMUSG00000026442/ENSMUSG00000064329/ENSMUSG00000052516/ENSMUSG00000002489/ENSMUSG00000020178/ENSMUSG00000024044	Dnm1/Adora1/Slc1a2/Nrg1/Kcnab2/Tnfrsf1b/Scn2a/Nfasc/Scn1a/Robo2/Tiam1/Adora2a/Epb41l3	13
CC	GO:0098802	plasma membrane receptor complex	20/852	137/15881	4.20E-05	0.00223125368093994	ENSMUSG00000022150/ENSMUSG00000022636/ENSMUSG00000029082/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000038403/ENSMUSG00000026251/ENSMUSG00000024873/ENSMUSG00000026253/ENSMUSG00000034353/ENSMUSG00000074272/ENSMUSG00000041046/ENSMUSG00000053395/ENSMUSG00000000791/ENSMUSG00000029716/ENSMUSG00000005947/ENSMUSG00000062157/ENSMUSG00000059588/ENSMUSG00000004266/ENSMUSG00000026117	Dab2/Alcam/Bst1/Tlr2/Syk/Hfe2/Chrnd/Cnih2/Chrng/Ramp1/Ceacam1/Ramp3/Cacng8/Il12rb1/Tfr2/Itgae/Ifnlr1/Calcrl/Ptpn6/Zap70	20
CC	GO:0030430	host cell cytoplasm	6/852	14/15881	4.85E-05	0.00223125368093994	ENSMUSG00000040253/ENSMUSG00000029373/ENSMUSG00000029298/ENSMUSG00000054072/ENSMUSG00000028268/ENSMUSG00000104713	Gbp7/Pf4/Gbp9/Iigp1/Gbp3/Gbp6	6
CC	GO:0033655	host cell cytoplasm part	6/852	14/15881	4.85E-05	0.00223125368093994	ENSMUSG00000040253/ENSMUSG00000029373/ENSMUSG00000029298/ENSMUSG00000054072/ENSMUSG00000028268/ENSMUSG00000104713	Gbp7/Pf4/Gbp9/Iigp1/Gbp3/Gbp6	6
CC	GO:0031012	extracellular matrix	38/852	367/15881	8.00E-05	0.00334368252198233	ENSMUSG00000017002/ENSMUSG00000027750/ENSMUSG00000000753/ENSMUSG00000026574/ENSMUSG00000017737/ENSMUSG00000050335/ENSMUSG00000048126/ENSMUSG00000043822/ENSMUSG00000019997/ENSMUSG00000028128/ENSMUSG00000012889/ENSMUSG00000029436/ENSMUSG00000029307/ENSMUSG00000036585/ENSMUSG00000028766/ENSMUSG00000033327/ENSMUSG00000002020/ENSMUSG00000060459/ENSMUSG00000019846/ENSMUSG00000035258/ENSMUSG00000055632/ENSMUSG00000042501/ENSMUSG00000026249/ENSMUSG00000031548/ENSMUSG00000037362/ENSMUSG00000033227/ENSMUSG00000050860/ENSMUSG00000063765/ENSMUSG00000033214/ENSMUSG00000021613/ENSMUSG00000028339/ENSMUSG00000030606/ENSMUSG00000050578/ENSMUSG00000030170/ENSMUSG00000036295/ENSMUSG00000022483/ENSMUSG00000002341/ENSMUSG00000068748	Slpi/Postn/Serpinf1/Dpt/Mmp9/Lgals3/Col6a3/Adamtsl5/Ctgf/F3/Podnl1/Mmp17/Dmp1/Fgf1/Alpl/Tnxb/Ltbp2/Kng2/Lama4/Abi3bp/Hmcn2/Cpa6/Serpine2/Sfrp1/Nov/Wnt6/Phospho1/Chadl/Slitrk5/Hapln1/Col15a1/Hapln3/Mmp13/Wnt5b/Lrrn3/Col2a1/Ncan/Ptprz1	38
CC	GO:0043235	receptor complex	32/852	290/15881	8.82E-05	0.00338227559290138	ENSMUSG00000024610/ENSMUSG00000038146/ENSMUSG00000022150/ENSMUSG00000022636/ENSMUSG00000029082/ENSMUSG00000022103/ENSMUSG00000022144/ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000032839/ENSMUSG00000038403/ENSMUSG00000026251/ENSMUSG00000024873/ENSMUSG00000026253/ENSMUSG00000034353/ENSMUSG00000074272/ENSMUSG00000027070/ENSMUSG00000002944/ENSMUSG00000027674/ENSMUSG00000041046/ENSMUSG00000053395/ENSMUSG00000000791/ENSMUSG00000033214/ENSMUSG00000029716/ENSMUSG00000005947/ENSMUSG00000062157/ENSMUSG00000059588/ENSMUSG00000027071/ENSMUSG00000041633/ENSMUSG00000004266/ENSMUSG00000031489/ENSMUSG00000026117	Cd74/Notch3/Dab2/Alcam/Bst1/Gfra2/Gdnf/Tlr2/Syk/Trpc1/Hfe2/Chrnd/Cnih2/Chrng/Ramp1/Ceacam1/Lrp2/Cd36/Pex5l/Ramp3/Cacng8/Il12rb1/Slitrk5/Tfr2/Itgae/Ifnlr1/Calcrl/P2rx3/Kctd12b/Ptpn6/Adrb3/Zap70	32
CC	GO:0061702	inflammasome complex	6/852	16/15881	0.000117894815338806	0.0041716626966039	ENSMUSG00000033538/ENSMUSG00000078945/ENSMUSG00000078942/ENSMUSG00000037860/ENSMUSG00000071203/ENSMUSG00000025888	Casp4/Naip2/Naip6/Aim2/Naip5/Casp1	6
CC	GO:0030673	axolemma	6/852	17/15881	0.000173960348538133	0.00500136002047131	ENSMUSG00000042429/ENSMUSG00000005089/ENSMUSG00000062991/ENSMUSG00000052516/ENSMUSG00000020178/ENSMUSG00000024044	Adora1/Slc1a2/Nrg1/Robo2/Adora2a/Epb41l3	6
CC	GO:0033646	host intracellular part	6/852	17/15881	0.000173960348538133	0.00500136002047131	ENSMUSG00000040253/ENSMUSG00000029373/ENSMUSG00000029298/ENSMUSG00000054072/ENSMUSG00000028268/ENSMUSG00000104713	Gbp7/Pf4/Gbp9/Iigp1/Gbp3/Gbp6	6
CC	GO:0043656	intracellular region of host	6/852	17/15881	0.000173960348538133	0.00500136002047131	ENSMUSG00000040253/ENSMUSG00000029373/ENSMUSG00000029298/ENSMUSG00000054072/ENSMUSG00000028268/ENSMUSG00000104713	Gbp7/Pf4/Gbp9/Iigp1/Gbp3/Gbp6	6
CC	GO:0031225	anchored component of membrane	17/852	123/15881	0.00030248262793128	0.00754829604168526	ENSMUSG00000003617/ENSMUSG00000075602/ENSMUSG00000046718/ENSMUSG00000037440/ENSMUSG00000079018/ENSMUSG00000029082/ENSMUSG00000028039/ENSMUSG00000022103/ENSMUSG00000022583/ENSMUSG00000020010/ENSMUSG00000079685/ENSMUSG00000029436/ENSMUSG00000046223/ENSMUSG00000038403/ENSMUSG00000028766/ENSMUSG00000019278/ENSMUSG00000034842	Cp/Ly6a/Bst2/Vnn1/Ly6c1/Bst1/Efna3/Gfra2/Ly6f/Vnn3/Ulbp1/Mmp17/Plaur/Hfe2/Alpl/Dpep1/Art3	17
CC	GO:0005911	cell-cell junction	39/852	408/15881	0.00034325123941767	0.00754829604168526	ENSMUSG00000090523/ENSMUSG00000036718/ENSMUSG00000026208/ENSMUSG00000038235/ENSMUSG00000057123/ENSMUSG00000026576/ENSMUSG00000054793/ENSMUSG00000062300/ENSMUSG00000022512/ENSMUSG00000050541/ENSMUSG00000115388/ENSMUSG00000028970/ENSMUSG00000061603/ENSMUSG00000049109/ENSMUSG00000075318/ENSMUSG00000051375/ENSMUSG00000074272/ENSMUSG00000041731/ENSMUSG00000041245/ENSMUSG00000026442/ENSMUSG00000064329/ENSMUSG00000002489/ENSMUSG00000037362/ENSMUSG00000000120/ENSMUSG00000022286/ENSMUSG00000041695/ENSMUSG00000024044/ENSMUSG00000021108/ENSMUSG00000002699/ENSMUSG00000034917/ENSMUSG00000001739/ENSMUSG00000051379/ENSMUSG00000050578/ENSMUSG00000021948/ENSMUSG00000030064/ENSMUSG00000004266/ENSMUSG00000036570/ENSMUSG00000030707/ENSMUSG00000026117	Gypc/Micall2/Des/F11r/Gja5/Atp1b1/Cadm4/Nectin2/Cldn1/Adra1b/Eppk1/Abcb1b/Akap6/Themis/Scn2a/Pcdh1/Ceacam1/Pgm5/Wnk3/Nfasc/Scn1a/Tiam1/Nov/Ngfr/Grhl2/Kcnj2/Epb41l3/Prkch/Lcp2/Tjp3/Cldn15/Flrt3/Mmp13/Prkcd/Frmd4b/Ptpn6/Fxyd1/Coro1a/Zap70	39
CC	GO:0018995	host	6/852	19/15881	0.00034770844064436	0.00754829604168526	ENSMUSG00000040253/ENSMUSG00000029373/ENSMUSG00000029298/ENSMUSG00000054072/ENSMUSG00000028268/ENSMUSG00000104713	Gbp7/Pf4/Gbp9/Iigp1/Gbp3/Gbp6	6
CC	GO:0033643	host cell part	6/852	19/15881	0.00034770844064436	0.00754829604168526	ENSMUSG00000040253/ENSMUSG00000029373/ENSMUSG00000029298/ENSMUSG00000054072/ENSMUSG00000028268/ENSMUSG00000104713	Gbp7/Pf4/Gbp9/Iigp1/Gbp3/Gbp6	6
CC	GO:0043657	host cell	6/852	19/15881	0.00034770844064436	0.00754829604168526	ENSMUSG00000040253/ENSMUSG00000029373/ENSMUSG00000029298/ENSMUSG00000054072/ENSMUSG00000028268/ENSMUSG00000104713	Gbp7/Pf4/Gbp9/Iigp1/Gbp3/Gbp6	6
CC	GO:0044291	cell-cell contact zone	12/852	71/15881	0.000361005462863208	0.00754829604168526	ENSMUSG00000026208/ENSMUSG00000057123/ENSMUSG00000026576/ENSMUSG00000062300/ENSMUSG00000050541/ENSMUSG00000061603/ENSMUSG00000075318/ENSMUSG00000041731/ENSMUSG00000064329/ENSMUSG00000002489/ENSMUSG00000041695/ENSMUSG00000036570	Des/Gja5/Atp1b1/Nectin2/Adra1b/Akap6/Scn2a/Pgm5/Scn1a/Tiam1/Kcnj2/Fxyd1	12
CC	GO:0042101	T cell receptor complex	5/852	14/15881	0.000585642909125921	0.0116257490482953	ENSMUSG00000022636/ENSMUSG00000021457/ENSMUSG00000074272/ENSMUSG00000004266/ENSMUSG00000026117	Alcam/Syk/Ceacam1/Ptpn6/Zap70	5
CC	GO:0014704	intercalated disc	10/852	55/15881	0.000606560819911058	0.0116257490482953	ENSMUSG00000026208/ENSMUSG00000057123/ENSMUSG00000026576/ENSMUSG00000050541/ENSMUSG00000061603/ENSMUSG00000075318/ENSMUSG00000041731/ENSMUSG00000064329/ENSMUSG00000041695/ENSMUSG00000036570	Des/Gja5/Atp1b1/Adra1b/Akap6/Scn2a/Pgm5/Scn1a/Kcnj2/Fxyd1	10
CC	GO:0044215	other organism	6/852	23/15881	0.00107601595409398	0.0183321236623419	ENSMUSG00000040253/ENSMUSG00000029373/ENSMUSG00000029298/ENSMUSG00000054072/ENSMUSG00000028268/ENSMUSG00000104713	Gbp7/Pf4/Gbp9/Iigp1/Gbp3/Gbp6	6
CC	GO:0044216	other organism cell	6/852	23/15881	0.00107601595409398	0.0183321236623419	ENSMUSG00000040253/ENSMUSG00000029373/ENSMUSG00000029298/ENSMUSG00000054072/ENSMUSG00000028268/ENSMUSG00000104713	Gbp7/Pf4/Gbp9/Iigp1/Gbp3/Gbp6	6
CC	GO:0044217	other organism part	6/852	23/15881	0.00107601595409398	0.0183321236623419	ENSMUSG00000040253/ENSMUSG00000029373/ENSMUSG00000029298/ENSMUSG00000054072/ENSMUSG00000028268/ENSMUSG00000104713	Gbp7/Pf4/Gbp9/Iigp1/Gbp3/Gbp6	6
MF	GO:0004771	sterol esterase activity	9/846	16/15605	3.14E-08	2.43E-05	ENSMUSG00000031877/ENSMUSG00000031886/ENSMUSG00000057074/ENSMUSG00000056973/ENSMUSG00000071047/ENSMUSG00000062826/ENSMUSG00000031725/ENSMUSG00000061825/ENSMUSG00000050097	Ces2g/Ces2e/Ces1g/Ces1d/Ces1a/Ces2f/Ces1f/Ces2c/Ces2b	9
MF	GO:0008009	chemokine activity	11/846	29/15605	1.57E-07	6.05E-05	ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000035373/ENSMUSG00000026166/ENSMUSG00000019122/ENSMUSG00000029373/ENSMUSG00000074715/ENSMUSG00000029371/ENSMUSG00000034855/ENSMUSG00000031780	Cxcl1/Ccl2/Cx3cl1/Ccl7/Ccl20/Ccl9/Pf4/Ccl28/Cxcl5/Cxcl10/Ccl17	11
MF	GO:0030414	peptidase inhibitor activity	23/846	134/15605	8.02E-07	0.000127054805142688	ENSMUSG00000024164/ENSMUSG00000017002/ENSMUSG00000046718/ENSMUSG00000000753/ENSMUSG00000078945/ENSMUSG00000042842/ENSMUSG00000027082/ENSMUSG00000041481/ENSMUSG00000078942/ENSMUSG00000031387/ENSMUSG00000027985/ENSMUSG00000021403/ENSMUSG00000079014/ENSMUSG00000025889/ENSMUSG00000060459/ENSMUSG00000078949/ENSMUSG00000026315/ENSMUSG00000026249/ENSMUSG00000027834/ENSMUSG00000071203/ENSMUSG00000051029/ENSMUSG00000019278/ENSMUSG00000079012	C3/Slpi/Bst2/Serpinf1/Naip2/Serpinb6b/Tfpi/Serpina3g/Naip6/Renbp/Lef1/Serpinb9b/Serpina3i/Snca/Kng2/R3hdml/Serpinb8/Serpine2/Serpini1/Naip5/Serpinb1b/Dpep1/Serpina3m	23
MF	GO:0042379	chemokine receptor binding	12/846	40/15605	8.14E-07	0.000127054805142688	ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000035373/ENSMUSG00000026166/ENSMUSG00000019122/ENSMUSG00000029373/ENSMUSG00000074715/ENSMUSG00000029371/ENSMUSG00000034855/ENSMUSG00000031780/ENSMUSG00000043953	Cxcl1/Ccl2/Cx3cl1/Ccl7/Ccl20/Ccl9/Pf4/Ccl28/Cxcl5/Cxcl10/Ccl17/Ccrl2	12
MF	GO:0004806	triglyceride lipase activity	9/846	22/15605	1.02E-06	0.000127054805142688	ENSMUSG00000031877/ENSMUSG00000031886/ENSMUSG00000057074/ENSMUSG00000056973/ENSMUSG00000071047/ENSMUSG00000062826/ENSMUSG00000031725/ENSMUSG00000061825/ENSMUSG00000050097	Ces2g/Ces2e/Ces1g/Ces1d/Ces1a/Ces2f/Ces1f/Ces2c/Ces2b	9
MF	GO:0004497	monooxygenase activity	16/846	72/15605	1.14E-06	0.000127054805142688	ENSMUSG00000006764/ENSMUSG00000020826/ENSMUSG00000023963/ENSMUSG00000019823/ENSMUSG00000025002/ENSMUSG00000033715/ENSMUSG00000003484/ENSMUSG00000017969/ENSMUSG00000052974/ENSMUSG00000040046/ENSMUSG00000090700/ENSMUSG00000050103/ENSMUSG00000028978/ENSMUSG00000063415/ENSMUSG00000025955/ENSMUSG00000025197	Tph2/Nos2/Cyp39a1/Mical1/Cyp2c55/Akr1c14/Cyp4f18/Ptgis/Cyp2f2/Tph1/Cyp4f40/Agmo/Nos3/Cyp26b1/Akr1cl/Cyp2c23	16
MF	GO:0005539	glycosaminoglycan binding	25/846	157/15605	1.15E-06	0.000127054805142688	ENSMUSG00000035385/ENSMUSG00000027750/ENSMUSG00000029816/ENSMUSG00000031785/ENSMUSG00000035373/ENSMUSG00000043822/ENSMUSG00000019997/ENSMUSG00000027995/ENSMUSG00000053475/ENSMUSG00000036585/ENSMUSG00000029373/ENSMUSG00000055994/ENSMUSG00000033327/ENSMUSG00000002020/ENSMUSG00000041193/ENSMUSG00000026580/ENSMUSG00000035258/ENSMUSG00000026249/ENSMUSG00000031548/ENSMUSG00000034855/ENSMUSG00000037362/ENSMUSG00000021613/ENSMUSG00000074115/ENSMUSG00000030606/ENSMUSG00000002341	Ccl2/Postn/Gpnmb/Adgrg1/Ccl7/Adamtsl5/Ctgf/Tlr2/Tnfaip6/Fgf1/Pf4/Nod2/Tnxb/Ltbp2/Pla2g5/Selp/Abi3bp/Serpine2/Sfrp1/Cxcl10/Nov/Hapln1/Saa1/Hapln3/Ncan	25
MF	GO:0004866	endopeptidase inhibitor activity	22/846	128/15605	1.35E-06	0.000130565521725583	ENSMUSG00000024164/ENSMUSG00000017002/ENSMUSG00000046718/ENSMUSG00000000753/ENSMUSG00000078945/ENSMUSG00000042842/ENSMUSG00000027082/ENSMUSG00000041481/ENSMUSG00000078942/ENSMUSG00000031387/ENSMUSG00000027985/ENSMUSG00000021403/ENSMUSG00000079014/ENSMUSG00000025889/ENSMUSG00000060459/ENSMUSG00000026315/ENSMUSG00000026249/ENSMUSG00000027834/ENSMUSG00000071203/ENSMUSG00000051029/ENSMUSG00000019278/ENSMUSG00000079012	C3/Slpi/Bst2/Serpinf1/Naip2/Serpinb6b/Tfpi/Serpina3g/Naip6/Renbp/Lef1/Serpinb9b/Serpina3i/Snca/Kng2/Serpinb8/Serpine2/Serpini1/Naip5/Serpinb1b/Dpep1/Serpina3m	22
MF	GO:0061135	endopeptidase regulator activity	22/846	134/15605	2.98E-06	0.000255644265339066	ENSMUSG00000024164/ENSMUSG00000017002/ENSMUSG00000046718/ENSMUSG00000000753/ENSMUSG00000078945/ENSMUSG00000042842/ENSMUSG00000027082/ENSMUSG00000041481/ENSMUSG00000078942/ENSMUSG00000031387/ENSMUSG00000027985/ENSMUSG00000021403/ENSMUSG00000079014/ENSMUSG00000025889/ENSMUSG00000060459/ENSMUSG00000026315/ENSMUSG00000026249/ENSMUSG00000027834/ENSMUSG00000071203/ENSMUSG00000051029/ENSMUSG00000019278/ENSMUSG00000079012	C3/Slpi/Bst2/Serpinf1/Naip2/Serpinb6b/Tfpi/Serpina3g/Naip6/Renbp/Lef1/Serpinb9b/Serpina3i/Snca/Kng2/Serpinb8/Serpine2/Serpini1/Naip5/Serpinb1b/Dpep1/Serpina3m	22
MF	GO:0061134	peptidase regulator activity	24/846	163/15605	7.61E-06	0.000587861742518015	ENSMUSG00000024164/ENSMUSG00000017002/ENSMUSG00000046718/ENSMUSG00000000753/ENSMUSG00000078945/ENSMUSG00000042842/ENSMUSG00000027082/ENSMUSG00000041481/ENSMUSG00000078942/ENSMUSG00000031387/ENSMUSG00000027985/ENSMUSG00000032359/ENSMUSG00000021403/ENSMUSG00000079014/ENSMUSG00000025889/ENSMUSG00000060459/ENSMUSG00000078949/ENSMUSG00000026315/ENSMUSG00000026249/ENSMUSG00000027834/ENSMUSG00000071203/ENSMUSG00000051029/ENSMUSG00000019278/ENSMUSG00000079012	C3/Slpi/Bst2/Serpinf1/Naip2/Serpinb6b/Tfpi/Serpina3g/Naip6/Renbp/Lef1/Ctsh/Serpinb9b/Serpina3i/Snca/Kng2/R3hdml/Serpinb8/Serpine2/Serpini1/Naip5/Serpinb1b/Dpep1/Serpina3m	24
MF	GO:0008201	heparin binding	19/846	117/15605	1.63E-05	0.0011458430265883	ENSMUSG00000035385/ENSMUSG00000027750/ENSMUSG00000029816/ENSMUSG00000031785/ENSMUSG00000035373/ENSMUSG00000043822/ENSMUSG00000019997/ENSMUSG00000036585/ENSMUSG00000029373/ENSMUSG00000033327/ENSMUSG00000002020/ENSMUSG00000041193/ENSMUSG00000026580/ENSMUSG00000035258/ENSMUSG00000026249/ENSMUSG00000031548/ENSMUSG00000034855/ENSMUSG00000037362/ENSMUSG00000074115	Ccl2/Postn/Gpnmb/Adgrg1/Ccl7/Adamtsl5/Ctgf/Fgf1/Pf4/Tnxb/Ltbp2/Pla2g5/Selp/Abi3bp/Serpine2/Sfrp1/Cxcl10/Nov/Saa1	19
MF	GO:0048018	receptor ligand activity	35/846	308/15605	2.80E-05	0.00180012997301589	ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000029816/ENSMUSG00000096188/ENSMUSG00000035373/ENSMUSG00000050335/ENSMUSG00000062991/ENSMUSG00000025207/ENSMUSG00000022144/ENSMUSG00000034394/ENSMUSG00000019997/ENSMUSG00000026166/ENSMUSG00000019122/ENSMUSG00000036585/ENSMUSG00000029373/ENSMUSG00000066755/ENSMUSG00000082361/ENSMUSG00000031520/ENSMUSG00000040026/ENSMUSG00000074715/ENSMUSG00000039481/ENSMUSG00000029371/ENSMUSG00000034855/ENSMUSG00000037362/ENSMUSG00000031712/ENSMUSG00000040329/ENSMUSG00000038508/ENSMUSG00000006488/ENSMUSG00000074115/ENSMUSG00000028864/ENSMUSG00000051379/ENSMUSG00000031780/ENSMUSG00000052276/ENSMUSG00000038259	Cxcl1/Ccl2/Cx3cl1/Gpnmb/Cmtm4/Ccl7/Lgals3/Nrg1/Sema4g/Gdnf/Lif/Ctgf/Ccl20/Ccl9/Fgf1/Pf4/Tnfsf18/Btc/Vegfc/Saa3/Ccl28/Nrtn/Cxcl5/Cxcl10/Nov/Il15/Il7/Gdf15/Prl7a1/Saa1/Hgf/Flrt3/Ccl17/Ostn/Gdf5	35
MF	GO:0005126	cytokine receptor binding	27/846	217/15605	4.80E-05	0.00285019267355016	ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000035373/ENSMUSG00000022514/ENSMUSG00000022144/ENSMUSG00000034394/ENSMUSG00000026166/ENSMUSG00000019122/ENSMUSG00000029373/ENSMUSG00000066755/ENSMUSG00000031520/ENSMUSG00000074715/ENSMUSG00000026875/ENSMUSG00000074272/ENSMUSG00000029371/ENSMUSG00000034855/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000000120/ENSMUSG00000040329/ENSMUSG00000038508/ENSMUSG00000079164/ENSMUSG00000006488/ENSMUSG00000031780/ENSMUSG00000043953/ENSMUSG00000038259	Cxcl1/Ccl2/Cx3cl1/Ccl7/Il1rap/Gdnf/Lif/Ccl20/Ccl9/Pf4/Tnfsf18/Vegfc/Ccl28/Traf1/Ceacam1/Cxcl5/Cxcl10/Il12rb1/Il15/Ngfr/Il7/Gdf15/Tlr5/Prl7a1/Ccl17/Ccrl2/Gdf5	27
MF	GO:1901681	sulfur compound binding	25/846	195/15605	5.52E-05	0.00304371692630842	ENSMUSG00000035385/ENSMUSG00000027750/ENSMUSG00000029816/ENSMUSG00000031785/ENSMUSG00000035373/ENSMUSG00000050737/ENSMUSG00000042010/ENSMUSG00000043822/ENSMUSG00000019997/ENSMUSG00000024039/ENSMUSG00000040907/ENSMUSG00000036585/ENSMUSG00000029373/ENSMUSG00000033327/ENSMUSG00000002020/ENSMUSG00000041193/ENSMUSG00000026580/ENSMUSG00000035258/ENSMUSG00000004540/ENSMUSG00000026249/ENSMUSG00000031548/ENSMUSG00000034855/ENSMUSG00000032348/ENSMUSG00000037362/ENSMUSG00000074115	Ccl2/Postn/Gpnmb/Adgrg1/Ccl7/Ptges/Acacb/Adamtsl5/Ctgf/Cbs/Atp1a3/Fgf1/Pf4/Tnxb/Ltbp2/Pla2g5/Selp/Abi3bp/Psg17/Serpine2/Sfrp1/Cxcl10/Gsta4/Nov/Saa1	25
MF	GO:0004857	enzyme inhibitor activity	34/846	310/15605	7.42E-05	0.00382079903837775	ENSMUSG00000024164/ENSMUSG00000017002/ENSMUSG00000046718/ENSMUSG00000000753/ENSMUSG00000023067/ENSMUSG00000044303/ENSMUSG00000026463/ENSMUSG00000078945/ENSMUSG00000032501/ENSMUSG00000042842/ENSMUSG00000096472/ENSMUSG00000021892/ENSMUSG00000027082/ENSMUSG00000012889/ENSMUSG00000041481/ENSMUSG00000078942/ENSMUSG00000031387/ENSMUSG00000027985/ENSMUSG00000021403/ENSMUSG00000079014/ENSMUSG00000037166/ENSMUSG00000025889/ENSMUSG00000055003/ENSMUSG00000037664/ENSMUSG00000060459/ENSMUSG00000078949/ENSMUSG00000026315/ENSMUSG00000026249/ENSMUSG00000027834/ENSMUSG00000071203/ENSMUSG00000051029/ENSMUSG00000019278/ENSMUSG00000051379/ENSMUSG00000079012	C3/Slpi/Bst2/Serpinf1/Cdkn1a/Cdkn2a/Atp2b4/Naip2/Trib1/Serpinb6b/Cdkn2d/Sh3bp5/Tfpi/Podnl1/Serpina3g/Naip6/Renbp/Lef1/Serpinb9b/Serpina3i/Ppp1r14a/Snca/Lrtm2/Cdkn1c/Kng2/R3hdml/Serpinb8/Serpine2/Serpini1/Naip5/Serpinb1b/Dpep1/Flrt3/Serpina3m	34
MF	GO:0005506	iron ion binding	18/846	121/15605	8.90E-05	0.00429472702214898	ENSMUSG00000023030/ENSMUSG00000024066/ENSMUSG00000006764/ENSMUSG00000020826/ENSMUSG00000023963/ENSMUSG00000025002/ENSMUSG00000062168/ENSMUSG00000003484/ENSMUSG00000025889/ENSMUSG00000017969/ENSMUSG00000026822/ENSMUSG00000052974/ENSMUSG00000020892/ENSMUSG00000040046/ENSMUSG00000050103/ENSMUSG00000028978/ENSMUSG00000064294/ENSMUSG00000063415	Slc11a2/Xdh/Tph2/Nos2/Cyp39a1/Cyp2c55/Ppef1/Cyp4f18/Snca/Ptgis/Lcn2/Cyp2f2/Aloxe3/Tph1/Agmo/Nos3/Aox3/Cyp26b1	18
MF	GO:0022890	inorganic cation transmembrane transporter activity	44/846	448/15605	9.98E-05	0.00453035536083189	ENSMUSG00000023030/ENSMUSG00000055368/ENSMUSG00000026463/ENSMUSG00000036067/ENSMUSG00000005089/ENSMUSG00000028931/ENSMUSG00000026576/ENSMUSG00000040907/ENSMUSG00000032839/ENSMUSG00000057182/ENSMUSG00000035694/ENSMUSG00000030313/ENSMUSG00000026251/ENSMUSG00000060961/ENSMUSG00000022416/ENSMUSG00000027994/ENSMUSG00000050777/ENSMUSG00000026177/ENSMUSG00000026253/ENSMUSG00000023243/ENSMUSG00000041329/ENSMUSG00000075318/ENSMUSG00000070570/ENSMUSG00000023032/ENSMUSG00000027674/ENSMUSG00000063354/ENSMUSG00000064329/ENSMUSG00000053395/ENSMUSG00000026435/ENSMUSG00000068323/ENSMUSG00000030109/ENSMUSG00000000794/ENSMUSG00000036298/ENSMUSG00000020787/ENSMUSG00000025557/ENSMUSG00000022899/ENSMUSG00000029716/ENSMUSG00000038600/ENSMUSG00000041695/ENSMUSG00000018470/ENSMUSG00000030523/ENSMUSG00000027071/ENSMUSG00000042686/ENSMUSG00000052387	Slc11a2/Slc6a2/Atp2b4/Slc2a6/Slc1a2/Kcnab2/Atp1b1/Atp1a3/Trpc1/Scn3a/Caps2/Dennd5b/Chrnd/Slc4a4/Cacna1i/Mcub/Tmem37/Slc11a1/Chrng/Kcnk5/Atp1b2/Scn2a/Slc17a7/Slc4a8/Pex5l/Slc39a4/Scn1a/Cacng8/Slc45a3/Slc4a5/Slc6a12/Kcnn3/Slc2a13/P2rx1/Slc15a1/Slc15a2/Tfr2/Atp6v0a4/Kcnj2/Kcnab3/Trpm1/P2rx3/Jph1/Trpm3	44
MF	GO:0008324	cation transmembrane transporter activity	47/846	492/15605	0.000113848727372682	0.00488284541842836	ENSMUSG00000023030/ENSMUSG00000055368/ENSMUSG00000026463/ENSMUSG00000036067/ENSMUSG00000005089/ENSMUSG00000028931/ENSMUSG00000026576/ENSMUSG00000040907/ENSMUSG00000032839/ENSMUSG00000057182/ENSMUSG00000035694/ENSMUSG00000030313/ENSMUSG00000026251/ENSMUSG00000060961/ENSMUSG00000022416/ENSMUSG00000027994/ENSMUSG00000050777/ENSMUSG00000026177/ENSMUSG00000026253/ENSMUSG00000023243/ENSMUSG00000041329/ENSMUSG00000075318/ENSMUSG00000028825/ENSMUSG00000070570/ENSMUSG00000023032/ENSMUSG00000027674/ENSMUSG00000063354/ENSMUSG00000064329/ENSMUSG00000053395/ENSMUSG00000026435/ENSMUSG00000068323/ENSMUSG00000030109/ENSMUSG00000000794/ENSMUSG00000054753/ENSMUSG00000036298/ENSMUSG00000020787/ENSMUSG00000025557/ENSMUSG00000022899/ENSMUSG00000029716/ENSMUSG00000038600/ENSMUSG00000041695/ENSMUSG00000018470/ENSMUSG00000030523/ENSMUSG00000007034/ENSMUSG00000027071/ENSMUSG00000042686/ENSMUSG00000052387	Slc11a2/Slc6a2/Atp2b4/Slc2a6/Slc1a2/Kcnab2/Atp1b1/Atp1a3/Trpc1/Scn3a/Caps2/Dennd5b/Chrnd/Slc4a4/Cacna1i/Mcub/Tmem37/Slc11a1/Chrng/Kcnk5/Atp1b2/Scn2a/Rhd/Slc17a7/Slc4a8/Pex5l/Slc39a4/Scn1a/Cacng8/Slc45a3/Slc4a5/Slc6a12/Kcnn3/AU018091/Slc2a13/P2rx1/Slc15a1/Slc15a2/Tfr2/Atp6v0a4/Kcnj2/Kcnab3/Trpm1/Slc44a4/P2rx3/Jph1/Trpm3	47
MF	GO:0030545	receptor regulator activity	35/846	332/15605	0.000129472773523971	0.00526068321897399	ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000029816/ENSMUSG00000096188/ENSMUSG00000035373/ENSMUSG00000050335/ENSMUSG00000062991/ENSMUSG00000025207/ENSMUSG00000022144/ENSMUSG00000034394/ENSMUSG00000019997/ENSMUSG00000026166/ENSMUSG00000019122/ENSMUSG00000036585/ENSMUSG00000029373/ENSMUSG00000066755/ENSMUSG00000082361/ENSMUSG00000031520/ENSMUSG00000040026/ENSMUSG00000074715/ENSMUSG00000039481/ENSMUSG00000029371/ENSMUSG00000034855/ENSMUSG00000037362/ENSMUSG00000031712/ENSMUSG00000040329/ENSMUSG00000038508/ENSMUSG00000006488/ENSMUSG00000074115/ENSMUSG00000028864/ENSMUSG00000051379/ENSMUSG00000031780/ENSMUSG00000052276/ENSMUSG00000038259	Cxcl1/Ccl2/Cx3cl1/Gpnmb/Cmtm4/Ccl7/Lgals3/Nrg1/Sema4g/Gdnf/Lif/Ctgf/Ccl20/Ccl9/Fgf1/Pf4/Tnfsf18/Btc/Vegfc/Saa3/Ccl28/Nrtn/Cxcl5/Cxcl10/Nov/Il15/Il7/Gdf15/Prl7a1/Saa1/Hgf/Flrt3/Ccl17/Ostn/Gdf5	35
MF	GO:0048020	CCR chemokine receptor binding	7/846	23/15605	0.000153085172772263	0.00590908766900936	ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000035373/ENSMUSG00000026166/ENSMUSG00000019122/ENSMUSG00000031780/ENSMUSG00000043953	Ccl2/Cx3cl1/Ccl7/Ccl20/Ccl9/Ccl17/Ccrl2	7
MF	GO:0001664	G-protein coupled receptor binding	25/846	210/15605	0.000183331439190674	0.00646390795870355	ENSMUSG00000024164/ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000035373/ENSMUSG00000026825/ENSMUSG00000042429/ENSMUSG00000032860/ENSMUSG00000026166/ENSMUSG00000019122/ENSMUSG00000040907/ENSMUSG00000029373/ENSMUSG00000074715/ENSMUSG00000021070/ENSMUSG00000029371/ENSMUSG00000031548/ENSMUSG00000034855/ENSMUSG00000033227/ENSMUSG00000020178/ENSMUSG00000024232/ENSMUSG00000074115/ENSMUSG00000031780/ENSMUSG00000043953/ENSMUSG00000030170/ENSMUSG00000031489	C3/Cxcl1/Ccl2/Cx3cl1/Ccl7/Dnm1/Adora1/P2ry2/Ccl20/Ccl9/Atp1a3/Pf4/Ccl28/Bdkrb2/Cxcl5/Sfrp1/Cxcl10/Wnt6/Adora2a/Bambi/Saa1/Ccl17/Ccrl2/Wnt5b/Adrb3	25
MF	GO:0015295	solute:proton symporter activity	6/846	17/15605	0.00018420463094751	0.00646390795870355	ENSMUSG00000023030/ENSMUSG00000036067/ENSMUSG00000026435/ENSMUSG00000036298/ENSMUSG00000025557/ENSMUSG00000022899	Slc11a2/Slc2a6/Slc45a3/Slc2a13/Slc15a1/Slc15a2	6
MF	GO:0022804	active transmembrane transporter activity	32/846	304/15605	0.000254750056302953	0.00846484020591681	ENSMUSG00000023030/ENSMUSG00000055368/ENSMUSG00000026463/ENSMUSG00000020620/ENSMUSG00000018800/ENSMUSG00000036067/ENSMUSG00000005089/ENSMUSG00000026576/ENSMUSG00000040907/ENSMUSG00000037762/ENSMUSG00000035694/ENSMUSG00000060961/ENSMUSG00000027994/ENSMUSG00000028970/ENSMUSG00000026177/ENSMUSG00000041329/ENSMUSG00000015243/ENSMUSG00000055782/ENSMUSG00000070570/ENSMUSG00000023032/ENSMUSG00000070280/ENSMUSG00000026435/ENSMUSG00000068323/ENSMUSG00000020600/ENSMUSG00000030109/ENSMUSG00000036298/ENSMUSG00000025557/ENSMUSG00000022899/ENSMUSG00000038963/ENSMUSG00000038600/ENSMUSG00000024030/ENSMUSG00000025938	Slc11a2/Slc6a2/Atp2b4/Abca8b/Abca5/Slc2a6/Slc1a2/Atp1b1/Atp1a3/Slc16a9/Caps2/Slc4a4/Mcub/Abcb1b/Slc11a1/Atp1b2/Abca1/Abcd2/Slc17a7/Slc4a8/Slc22a14/Slc45a3/Slc4a5/Slc7a15/Slc6a12/Slc2a13/Slc15a1/Slc15a2/Slco4a1/Atp6v0a4/Abcg1/Slco5a1	32
MF	GO:0035325	Toll-like receptor binding	5/846	12/15605	0.000266206031848792	0.00846484020591681	ENSMUSG00000027995/ENSMUSG00000021457/ENSMUSG00000040026/ENSMUSG00000074272/ENSMUSG00000002944	Tlr2/Syk/Saa3/Ceacam1/Cd36	5
MF	GO:0016298	lipase activity	15/846	99/15605	0.000274120472989534	0.00846484020591681	ENSMUSG00000031877/ENSMUSG00000031886/ENSMUSG00000057074/ENSMUSG00000042429/ENSMUSG00000023913/ENSMUSG00000056973/ENSMUSG00000002847/ENSMUSG00000071047/ENSMUSG00000041193/ENSMUSG00000062826/ENSMUSG00000031725/ENSMUSG00000061825/ENSMUSG00000050097/ENSMUSG00000036834/ENSMUSG00000002475	Ces2g/Ces2e/Ces1g/Adora1/Pla2g7/Ces1d/Pla1a/Ces1a/Pla2g5/Ces2f/Ces1f/Ces2c/Ces2b/Plch1/Abhd3	15
MF	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	8/846	33/15605	0.000298129910973567	0.00864413413439358	ENSMUSG00000020826/ENSMUSG00000019823/ENSMUSG00000033715/ENSMUSG00000003484/ENSMUSG00000090700/ENSMUSG00000028978/ENSMUSG00000063415/ENSMUSG00000025955	Nos2/Mical1/Akr1c14/Cyp4f18/Cyp4f40/Nos3/Cyp26b1/Akr1cl	8
MF	GO:0015294	solute:cation symporter activity	13/846	79/15605	0.000302320753404957	0.00864413413439358	ENSMUSG00000023030/ENSMUSG00000055368/ENSMUSG00000036067/ENSMUSG00000005089/ENSMUSG00000060961/ENSMUSG00000070570/ENSMUSG00000023032/ENSMUSG00000026435/ENSMUSG00000068323/ENSMUSG00000030109/ENSMUSG00000036298/ENSMUSG00000025557/ENSMUSG00000022899	Slc11a2/Slc6a2/Slc2a6/Slc1a2/Slc4a4/Slc17a7/Slc4a8/Slc45a3/Slc4a5/Slc6a12/Slc2a13/Slc15a1/Slc15a2	13
MF	GO:0035586	purinergic receptor activity	6/846	19/15605	0.000367824312343666	0.0101414417546182	ENSMUSG00000042429/ENSMUSG00000032860/ENSMUSG00000048779/ENSMUSG00000020178/ENSMUSG00000020787/ENSMUSG00000027071	Adora1/P2ry2/P2ry6/Adora2a/P2rx1/P2rx3	6
MF	GO:0005125	cytokine activity	18/846	136/15605	0.000396851415705717	0.0105644583767177	ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000096188/ENSMUSG00000035373/ENSMUSG00000034394/ENSMUSG00000026166/ENSMUSG00000019122/ENSMUSG00000029373/ENSMUSG00000066755/ENSMUSG00000074715/ENSMUSG00000029371/ENSMUSG00000034855/ENSMUSG00000031712/ENSMUSG00000040329/ENSMUSG00000038508/ENSMUSG00000031780/ENSMUSG00000038259	Cxcl1/Ccl2/Cx3cl1/Cmtm4/Ccl7/Lif/Ccl20/Ccl9/Pf4/Tnfsf18/Ccl28/Cxcl5/Cxcl10/Il15/Il7/Gdf15/Ccl17/Gdf5	18
MF	GO:0004867	serine-type endopeptidase inhibitor activity	12/846	72/15605	0.000452873276147785	0.0116539389728697	ENSMUSG00000017002/ENSMUSG00000000753/ENSMUSG00000042842/ENSMUSG00000027082/ENSMUSG00000041481/ENSMUSG00000021403/ENSMUSG00000079014/ENSMUSG00000026315/ENSMUSG00000026249/ENSMUSG00000027834/ENSMUSG00000051029/ENSMUSG00000079012	Slpi/Serpinf1/Serpinb6b/Tfpi/Serpina3g/Serpinb9b/Serpina3i/Serpinb8/Serpine2/Serpini1/Serpinb1b/Serpina3m	12
MF	GO:0005031	tumor necrosis factor-activated receptor activity	6/846	21/15605	0.000670191001447566	0.0161683579099225	ENSMUSG00000024778/ENSMUSG00000028965/ENSMUSG00000028599/ENSMUSG00000008318/ENSMUSG00000000120/ENSMUSG00000028602	Fas/Tnfrsf9/Tnfrsf1b/Relt/Ngfr/Tnfrsf8	6
MF	GO:0005035	death receptor activity	6/846	21/15605	0.000670191001447566	0.0161683579099225	ENSMUSG00000024778/ENSMUSG00000028965/ENSMUSG00000028599/ENSMUSG00000008318/ENSMUSG00000000120/ENSMUSG00000028602	Fas/Tnfrsf9/Tnfrsf1b/Relt/Ngfr/Tnfrsf8	6
MF	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	17/846	131/15605	0.000715350847136183	0.0167348743633071	ENSMUSG00000047250/ENSMUSG00000006764/ENSMUSG00000020826/ENSMUSG00000023963/ENSMUSG00000019823/ENSMUSG00000025002/ENSMUSG00000033715/ENSMUSG00000003484/ENSMUSG00000017969/ENSMUSG00000052974/ENSMUSG00000040046/ENSMUSG00000090700/ENSMUSG00000050103/ENSMUSG00000028978/ENSMUSG00000063415/ENSMUSG00000025955/ENSMUSG00000025197	Ptgs1/Tph2/Nos2/Cyp39a1/Mical1/Cyp2c55/Akr1c14/Cyp4f18/Ptgis/Cyp2f2/Tph1/Cyp4f40/Agmo/Nos3/Cyp26b1/Akr1cl/Cyp2c23	17
MF	GO:0005216	ion channel activity	29/846	287/15605	0.00093941190219142	0.0213301761321111	ENSMUSG00000028931/ENSMUSG00000054720/ENSMUSG00000032839/ENSMUSG00000057182/ENSMUSG00000030313/ENSMUSG00000026251/ENSMUSG00000022416/ENSMUSG00000027994/ENSMUSG00000050777/ENSMUSG00000026253/ENSMUSG00000023243/ENSMUSG00000075318/ENSMUSG00000070570/ENSMUSG00000027674/ENSMUSG00000028255/ENSMUSG00000009687/ENSMUSG00000064329/ENSMUSG00000053395/ENSMUSG00000000794/ENSMUSG00000020787/ENSMUSG00000037418/ENSMUSG00000028020/ENSMUSG00000041695/ENSMUSG00000018470/ENSMUSG00000030523/ENSMUSG00000027071/ENSMUSG00000036570/ENSMUSG00000042686/ENSMUSG00000052387	Kcnab2/Lrrc8c/Trpc1/Scn3a/Dennd5b/Chrnd/Cacna1i/Mcub/Tmem37/Chrng/Kcnk5/Scn2a/Slc17a7/Pex5l/Clca1/Fxyd5/Scn1a/Cacng8/Kcnn3/P2rx1/Best1/Glrb/Kcnj2/Kcnab3/Trpm1/P2rx3/Fxyd1/Jph1/Trpm3	29
MF	GO:0003924	GTPase activity	27/846	263/15605	0.0010957252557679	0.0241685684986519	ENSMUSG00000043004/ENSMUSG00000028278/ENSMUSG00000026825/ENSMUSG00000039960/ENSMUSG00000038387/ENSMUSG00000054855/ENSMUSG00000037580/ENSMUSG00000030220/ENSMUSG00000027669/ENSMUSG00000020486/ENSMUSG00000022456/ENSMUSG00000069893/ENSMUSG00000034226/ENSMUSG00000054072/ENSMUSG00000019845/ENSMUSG00000028268/ENSMUSG00000031504/ENSMUSG00000000386/ENSMUSG00000048852/ENSMUSG00000071723/ENSMUSG00000028214/ENSMUSG00000020732/ENSMUSG00000068606/ENSMUSG00000078922/ENSMUSG00000058163/ENSMUSG00000021062/ENSMUSG00000078921	Gng2/Rragd/Dnm1/Rhou/Rras/Rnd1/Gch1/Arhgdib/Gnb4/Sept4/Sept3/9930111J21Rik1/Rhov/Iigp1/Tube1/Gbp3/Rab20/Mx1/Gm12185/Gspt2/Gem/Rab37/Gm4841/Tgtp1/Gm5431/Rab15/Tgtp2	27
MF	GO:0015081	sodium ion transmembrane transporter activity	15/846	114/15605	0.00124872331537827	0.0260631823713061	ENSMUSG00000055368/ENSMUSG00000005089/ENSMUSG00000026576/ENSMUSG00000040907/ENSMUSG00000057182/ENSMUSG00000035694/ENSMUSG00000060961/ENSMUSG00000022416/ENSMUSG00000041329/ENSMUSG00000075318/ENSMUSG00000070570/ENSMUSG00000023032/ENSMUSG00000064329/ENSMUSG00000068323/ENSMUSG00000030109	Slc6a2/Slc1a2/Atp1b1/Atp1a3/Scn3a/Caps2/Slc4a4/Cacna1i/Atp1b2/Scn2a/Slc17a7/Slc4a8/Scn1a/Slc4a5/Slc6a12	15
MF	GO:0015077	monovalent inorganic cation transmembrane transporter activity	28/846	279/15605	0.00126527383713634	0.0260631823713061	ENSMUSG00000023030/ENSMUSG00000055368/ENSMUSG00000036067/ENSMUSG00000005089/ENSMUSG00000028931/ENSMUSG00000026576/ENSMUSG00000040907/ENSMUSG00000057182/ENSMUSG00000035694/ENSMUSG00000060961/ENSMUSG00000022416/ENSMUSG00000026177/ENSMUSG00000023243/ENSMUSG00000041329/ENSMUSG00000075318/ENSMUSG00000070570/ENSMUSG00000023032/ENSMUSG00000064329/ENSMUSG00000026435/ENSMUSG00000068323/ENSMUSG00000030109/ENSMUSG00000000794/ENSMUSG00000036298/ENSMUSG00000025557/ENSMUSG00000022899/ENSMUSG00000038600/ENSMUSG00000041695/ENSMUSG00000018470	Slc11a2/Slc6a2/Slc2a6/Slc1a2/Kcnab2/Atp1b1/Atp1a3/Scn3a/Caps2/Slc4a4/Cacna1i/Slc11a1/Kcnk5/Atp1b2/Scn2a/Slc17a7/Slc4a8/Scn1a/Slc45a3/Slc4a5/Slc6a12/Kcnn3/Slc2a13/Slc15a1/Slc15a2/Atp6v0a4/Kcnj2/Kcnab3	28
MF	GO:0022838	substrate-specific channel activity	29/846	293/15605	0.0012966616620637	0.0260631823713061	ENSMUSG00000028931/ENSMUSG00000054720/ENSMUSG00000032839/ENSMUSG00000057182/ENSMUSG00000030313/ENSMUSG00000026251/ENSMUSG00000022416/ENSMUSG00000027994/ENSMUSG00000050777/ENSMUSG00000026253/ENSMUSG00000023243/ENSMUSG00000075318/ENSMUSG00000070570/ENSMUSG00000027674/ENSMUSG00000028255/ENSMUSG00000009687/ENSMUSG00000064329/ENSMUSG00000053395/ENSMUSG00000000794/ENSMUSG00000020787/ENSMUSG00000037418/ENSMUSG00000028020/ENSMUSG00000041695/ENSMUSG00000018470/ENSMUSG00000030523/ENSMUSG00000027071/ENSMUSG00000036570/ENSMUSG00000042686/ENSMUSG00000052387	Kcnab2/Lrrc8c/Trpc1/Scn3a/Dennd5b/Chrnd/Cacna1i/Mcub/Tmem37/Chrng/Kcnk5/Scn2a/Slc17a7/Pex5l/Clca1/Fxyd5/Scn1a/Cacng8/Kcnn3/P2rx1/Best1/Glrb/Kcnj2/Kcnab3/Trpm1/P2rx3/Fxyd1/Jph1/Trpm3	29
MF	GO:0001730	2′-5′-oligoadenylate synthetase activity	4/846	10/15605	0.00138440459790158	0.0260631823713061	ENSMUSG00000001166/ENSMUSG00000032690/ENSMUSG00000029605/ENSMUSG00000032661	Oas1c/Oas2/Oas1b/Oas3	4
MF	GO:0015267	channel activity	30/846	308/15605	0.00139014896321833	0.0260631823713061	ENSMUSG00000057123/ENSMUSG00000028931/ENSMUSG00000054720/ENSMUSG00000032839/ENSMUSG00000057182/ENSMUSG00000030313/ENSMUSG00000026251/ENSMUSG00000022416/ENSMUSG00000027994/ENSMUSG00000050777/ENSMUSG00000026253/ENSMUSG00000023243/ENSMUSG00000075318/ENSMUSG00000070570/ENSMUSG00000027674/ENSMUSG00000028255/ENSMUSG00000009687/ENSMUSG00000064329/ENSMUSG00000053395/ENSMUSG00000000794/ENSMUSG00000020787/ENSMUSG00000037418/ENSMUSG00000028020/ENSMUSG00000041695/ENSMUSG00000018470/ENSMUSG00000030523/ENSMUSG00000027071/ENSMUSG00000036570/ENSMUSG00000042686/ENSMUSG00000052387	Gja5/Kcnab2/Lrrc8c/Trpc1/Scn3a/Dennd5b/Chrnd/Cacna1i/Mcub/Tmem37/Chrng/Kcnk5/Scn2a/Slc17a7/Pex5l/Clca1/Fxyd5/Scn1a/Cacng8/Kcnn3/P2rx1/Best1/Glrb/Kcnj2/Kcnab3/Trpm1/P2rx3/Fxyd1/Jph1/Trpm3	30
MF	GO:0022803	passive transmembrane transporter activity	30/846	308/15605	0.00139014896321833	0.0260631823713061	ENSMUSG00000057123/ENSMUSG00000028931/ENSMUSG00000054720/ENSMUSG00000032839/ENSMUSG00000057182/ENSMUSG00000030313/ENSMUSG00000026251/ENSMUSG00000022416/ENSMUSG00000027994/ENSMUSG00000050777/ENSMUSG00000026253/ENSMUSG00000023243/ENSMUSG00000075318/ENSMUSG00000070570/ENSMUSG00000027674/ENSMUSG00000028255/ENSMUSG00000009687/ENSMUSG00000064329/ENSMUSG00000053395/ENSMUSG00000000794/ENSMUSG00000020787/ENSMUSG00000037418/ENSMUSG00000028020/ENSMUSG00000041695/ENSMUSG00000018470/ENSMUSG00000030523/ENSMUSG00000027071/ENSMUSG00000036570/ENSMUSG00000042686/ENSMUSG00000052387	Gja5/Kcnab2/Lrrc8c/Trpc1/Scn3a/Dennd5b/Chrnd/Cacna1i/Mcub/Tmem37/Chrng/Kcnk5/Scn2a/Slc17a7/Pex5l/Clca1/Fxyd5/Scn1a/Cacng8/Kcnn3/P2rx1/Best1/Glrb/Kcnj2/Kcnab3/Trpm1/P2rx3/Fxyd1/Jph1/Trpm3	30
MF	GO:0046873	metal ion transmembrane transporter activity	32/846	336/15605	0.00141794515491562	0.0260631823713061	ENSMUSG00000023030/ENSMUSG00000055368/ENSMUSG00000026463/ENSMUSG00000005089/ENSMUSG00000028931/ENSMUSG00000026576/ENSMUSG00000040907/ENSMUSG00000032839/ENSMUSG00000057182/ENSMUSG00000035694/ENSMUSG00000030313/ENSMUSG00000060961/ENSMUSG00000022416/ENSMUSG00000027994/ENSMUSG00000050777/ENSMUSG00000026177/ENSMUSG00000023243/ENSMUSG00000041329/ENSMUSG00000075318/ENSMUSG00000070570/ENSMUSG00000023032/ENSMUSG00000063354/ENSMUSG00000064329/ENSMUSG00000053395/ENSMUSG00000068323/ENSMUSG00000030109/ENSMUSG00000000794/ENSMUSG00000029716/ENSMUSG00000041695/ENSMUSG00000018470/ENSMUSG00000030523/ENSMUSG00000042686	Slc11a2/Slc6a2/Atp2b4/Slc1a2/Kcnab2/Atp1b1/Atp1a3/Trpc1/Scn3a/Caps2/Dennd5b/Slc4a4/Cacna1i/Mcub/Tmem37/Slc11a1/Kcnk5/Atp1b2/Scn2a/Slc17a7/Slc4a8/Slc39a4/Scn1a/Cacng8/Slc4a5/Slc6a12/Kcnn3/Tfr2/Kcnj2/Kcnab3/Trpm1/Jph1	32
MF	GO:0046906	tetrapyrrole binding	13/846	93/15605	0.00148025937170051	0.0265758194175068	ENSMUSG00000020432/ENSMUSG00000047250/ENSMUSG00000020826/ENSMUSG00000023963/ENSMUSG00000024039/ENSMUSG00000025002/ENSMUSG00000003484/ENSMUSG00000017969/ENSMUSG00000052974/ENSMUSG00000028978/ENSMUSG00000063415/ENSMUSG00000028011/ENSMUSG00000025197	Tcn2/Ptgs1/Nos2/Cyp39a1/Cbs/Cyp2c55/Cyp4f18/Ptgis/Cyp2f2/Nos3/Cyp26b1/Tdo2/Cyp2c23	13
MF	GO:0015291	secondary active transmembrane transporter activity	21/846	191/15605	0.00162665559214818	0.0285404117531454	ENSMUSG00000023030/ENSMUSG00000055368/ENSMUSG00000036067/ENSMUSG00000005089/ENSMUSG00000037762/ENSMUSG00000035694/ENSMUSG00000060961/ENSMUSG00000027994/ENSMUSG00000026177/ENSMUSG00000070570/ENSMUSG00000023032/ENSMUSG00000070280/ENSMUSG00000026435/ENSMUSG00000068323/ENSMUSG00000020600/ENSMUSG00000030109/ENSMUSG00000036298/ENSMUSG00000025557/ENSMUSG00000022899/ENSMUSG00000038963/ENSMUSG00000025938	Slc11a2/Slc6a2/Slc2a6/Slc1a2/Slc16a9/Caps2/Slc4a4/Mcub/Slc11a1/Slc17a7/Slc4a8/Slc22a14/Slc45a3/Slc4a5/Slc7a15/Slc6a12/Slc2a13/Slc15a1/Slc15a2/Slco4a1/Slco5a1	21
MF	GO:0020037	heme binding	12/846	84/15605	0.00183869457335977	0.0315438269029721	ENSMUSG00000047250/ENSMUSG00000020826/ENSMUSG00000023963/ENSMUSG00000024039/ENSMUSG00000025002/ENSMUSG00000003484/ENSMUSG00000017969/ENSMUSG00000052974/ENSMUSG00000028978/ENSMUSG00000063415/ENSMUSG00000028011/ENSMUSG00000025197	Ptgs1/Nos2/Cyp39a1/Cbs/Cyp2c55/Cyp4f18/Ptgis/Cyp2f2/Nos3/Cyp26b1/Tdo2/Cyp2c23	12
MF	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	4/846	11/15605	0.00208261827768964	0.0334954439661751	ENSMUSG00000023067/ENSMUSG00000044303/ENSMUSG00000096472/ENSMUSG00000037664	Cdkn1a/Cdkn2a/Cdkn2d/Cdkn1c	4
MF	GO:0008391	arachidonic acid monooxygenase activity	4/846	11/15605	0.00208261827768964	0.0334954439661751	ENSMUSG00000025002/ENSMUSG00000003484/ENSMUSG00000052974/ENSMUSG00000025197	Cyp2c55/Cyp4f18/Cyp2f2/Cyp2c23	4
MF	GO:0045236	CXCR chemokine receptor binding	4/846	11/15605	0.00208261827768964	0.0334954439661751	ENSMUSG00000029380/ENSMUSG00000029373/ENSMUSG00000029371/ENSMUSG00000034855	Cxcl1/Pf4/Cxcl5/Cxcl10	4
MF	GO:0004869	cysteine-type endopeptidase inhibitor activity	8/846	44/15605	0.00224560158573312	0.0348113229720445	ENSMUSG00000078945/ENSMUSG00000041481/ENSMUSG00000078942/ENSMUSG00000027985/ENSMUSG00000025889/ENSMUSG00000060459/ENSMUSG00000071203/ENSMUSG00000019278	Naip2/Serpina3g/Naip6/Lef1/Snca/Kng2/Naip5/Dpep1	8
MF	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	6/846	26/15605	0.00225461936347438	0.0348113229720445	ENSMUSG00000078945/ENSMUSG00000078942/ENSMUSG00000027985/ENSMUSG00000025889/ENSMUSG00000071203/ENSMUSG00000019278	Naip2/Naip6/Lef1/Snca/Naip5/Dpep1	6
MF	GO:0004364	glutathione transferase activity	6/846	27/15605	0.00276779322467024	0.0418245580919213	ENSMUSG00000050737/ENSMUSG00000026688/ENSMUSG00000074604/ENSMUSG00000032348/ENSMUSG00000060063/ENSMUSG00000025069	Ptges/Mgst3/Mgst2/Gsta4/Alox5ap/Gsto2	6
MF	GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	7/846	36/15605	0.00281719821344548	0.0418245580919213	ENSMUSG00000078945/ENSMUSG00000078942/ENSMUSG00000027985/ENSMUSG00000032359/ENSMUSG00000025889/ENSMUSG00000071203/ENSMUSG00000019278	Naip2/Naip6/Lef1/Ctsh/Snca/Naip5/Dpep1	7
MF	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	4/846	12/15605	0.00299082440061008	0.0435644610805845	ENSMUSG00000046711/ENSMUSG00000039396/ENSMUSG00000056758/ENSMUSG00000078249	Hmga1/Neil3/Hmga2/Hmga1b	4

downregulated DEGs
Category	GOID	Description	GeneRatio	BgRatio	pvalue	padj	geneID	geneName	Count
CC	GO:0005578	proteinaceous extracellular matrix	19/186	301/15881	2.60E-09	6.73E-07	ENSMUSG00000041559/ENSMUSG00000042254/ENSMUSG00000036040/ENSMUSG00000041577/ENSMUSG00000030116/ENSMUSG00000019929/ENSMUSG00000058571/ENSMUSG00000019899/ENSMUSG00000045672/ENSMUSG00000024330/ENSMUSG00000027111/ENSMUSG00000048915/ENSMUSG00000031849/ENSMUSG00000028600/ENSMUSG00000017344/ENSMUSG00000021388/ENSMUSG00000025784/ENSMUSG00000026668/ENSMUSG00000027966	Fmod/Cilp/Adamtsl2/Prelp/Mfap5/Dcn/Gpc6/Lama2/Col27a1/Col11a2/Itga6/Efna5/Comp/Podn/Vtn/Aspn/Clec3b/Ucma/Col11a1	19
CC	GO:0031012	extracellular matrix	20/186	367/15881	1.20E-08	1.55E-06	ENSMUSG00000041559/ENSMUSG00000042254/ENSMUSG00000036040/ENSMUSG00000041577/ENSMUSG00000030116/ENSMUSG00000019929/ENSMUSG00000058571/ENSMUSG00000019899/ENSMUSG00000045672/ENSMUSG00000024330/ENSMUSG00000027111/ENSMUSG00000048915/ENSMUSG00000031849/ENSMUSG00000028600/ENSMUSG00000017344/ENSMUSG00000021388/ENSMUSG00000025784/ENSMUSG00000026668/ENSMUSG00000030862/ENSMUSG00000027966	Fmod/Cilp/Adamtsl2/Prelp/Mfap5/Dcn/Gpc6/Lama2/Col27a1/Col11a2/Itga6/Efna5/Comp/Podn/Vtn/Aspn/Clec3b/Ucma/Cpxm2/Col11a1	20
CC	GO:0044420	extracellular matrix component	7/186	119/15881	0.00050175587003438	0.0433182567796348	ENSMUSG00000030116/ENSMUSG00000019899/ENSMUSG00000045672/ENSMUSG00000027111/ENSMUSG00000048915/ENSMUSG00000017344/ENSMUSG00000027966	Mfap5/Lama2/Col27a1/Itga6/Efna5/Vtn/Col11a1	7
MF	GO:0005044	scavenger receptor activity	6/183	36/15605	3.48E-06	0.000869278969210754	ENSMUSG00000024593/ENSMUSG00000017344/ENSMUSG00000032268/ENSMUSG00000008845/ENSMUSG00000038188/ENSMUSG00000024034	Megf10/Vtn/Tmprss5/Cd163/Scarf1/Tmprss3	6
MF	GO:0005201	extracellular matrix structural constituent	6/183	38/15605	4.84E-06	0.000869278969210754	ENSMUSG00000041577/ENSMUSG00000030116/ENSMUSG00000045672/ENSMUSG00000024330/ENSMUSG00000031849/ENSMUSG00000027966	Prelp/Mfap5/Col27a1/Col11a2/Comp/Col11a1	6
MF	GO:0038024	cargo receptor activity	7/183	66/15605	1.18E-05	0.00141386955310093	ENSMUSG00000024593/ENSMUSG00000017344/ENSMUSG00000032268/ENSMUSG00000008845/ENSMUSG00000001247/ENSMUSG00000038188/ENSMUSG00000024034	Megf10/Vtn/Tmprss5/Cd163/Lsr/Scarf1/Tmprss3	7
MF	GO:0017147	Wnt-protein binding	4/183	27/15605	0.000260074704252757	0.023341704706685	ENSMUSG00000027253/ENSMUSG00000018822/ENSMUSG00000070867/ENSMUSG00000022297	Lrp4/Sfrp5/Trabd2b/Fzd6	4
MF	GO:0005518	collagen binding	5/183	57/15605	0.000536670339370086	0.0385329303667722	ENSMUSG00000019929/ENSMUSG00000031849/ENSMUSG00000028600/ENSMUSG00000017344/ENSMUSG00000021388	Dcn/Comp/Podn/Vtn/Aspn	5
MF	GO:0097110	scaffold protein binding	5/183	62/15605	0.000791196372794239	0.0473399163055219	ENSMUSG00000022840/ENSMUSG00000029361/ENSMUSG00000032511/ENSMUSG00000027253/ENSMUSG00000074657	Adcy5/Nos1/Scn5a/Lrp4/Kif5a	5

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Within the CC category, the top 10 significantly enriched terms were characterized as follows (Fig. 5-C): external side of the plasma membrane (37 genes), side of the membrane (50 genes), extracellular membrane-bounded organelle (8 genes), symbiont-containing vacuole (6 genes), plasma membrane protein complex (43 genes), proteinaceous extracellular matrix (34 genes), main axon (13 genes), plasma membrane receptor complex (20 genes), host cell cytoplasm (6 genes), and host cell cytoplasm part (6 genes), as illustrated in Table 3.

The MF category exhibited the top 10 significantly enriched terms as follows (Fig. 5-C): sterol esterase activity (9 genes), chemokine activity (11 genes), peptidase inhibitor activity (23 genes), chemokine receptor binding (12 genes), triglyceride lipase activity (9 genes), monooxygenase activity (16 genes), glycosaminoglycan binding (25 genes), endopeptidase inhibitor activity (22 genes), endopeptidase regulator activity (22 genes), and peptidase regulator activity (24 genes), as shown in Table 3.

Furthermore, a Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis was conducted on the upregulated DEGs. The findings disclosed four significantly enriched pathways: drug metabolism - other enzymes (15 genes), cytokine-cytokine receptor interaction (30 genes), Tumor Necrosis Factor (TNF) signaling pathway (17 genes), and retinol metabolism (nine genes) (Supplementary Figs. 2–A/B and Table 4).

Table 4.

KEGG pathways significantly enriched for differentially expressed genes (DEGs) in differentiated C17.2 cells.

KEGGID	Description	GeneRatio	BgRatio	pvalue	padj	geneID	geneName	keggID	Count
mmu00983	Drug metabolism - other enzymes	15/385	58/5966	2.45E-06	0.000678458232980981	ENSMUSG00000031877/ENSMUSG00000024066/ENSMUSG00000031886/ENSMUSG00000056973/ENSMUSG00000026688/ENSMUSG00000028755/ENSMUSG00000074604/ENSMUSG00000031725/ENSMUSG00000061825/ENSMUSG00000020407/ENSMUSG00000032348/ENSMUSG00000090145/ENSMUSG00000050097/ENSMUSG00000025069/ENSMUSG00000054545	Ces2g/Xdh/Ces2e/Ces1d/Mgst3/Cda/Mgst2/Ces1f/Ces2c/Upp1/Gsta4/Ugt1a6b/Ces2b/Gsto2/Ugt1a6a	mmu:72361/mmu:22436/mmu:234673/mmu:104158/mmu:66447/mmu:72269/mmu:211666/mmu:234564/mmu:234671/mmu:22271/mmu:14860/mmu:394435/mmu:234669/mmu:68214/mmu:94284	15
mmu04060	Cytokine-cytokine receptor interaction	30/385	194/5966	5.36E-06	0.00074232585500892	ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000024778/ENSMUSG00000035373/ENSMUSG00000028965/ENSMUSG00000022514/ENSMUSG00000034394/ENSMUSG00000026166/ENSMUSG00000028599/ENSMUSG00000019122/ENSMUSG00000026068/ENSMUSG00000029373/ENSMUSG00000066755/ENSMUSG00000008318/ENSMUSG00000074715/ENSMUSG00000068227/ENSMUSG00000029371/ENSMUSG00000006235/ENSMUSG00000034855/ENSMUSG00000000791/ENSMUSG00000031712/ENSMUSG00000000120/ENSMUSG00000040329/ENSMUSG00000038508/ENSMUSG00000060548/ENSMUSG00000062157/ENSMUSG00000028602/ENSMUSG00000031780/ENSMUSG00000038259	Cxcl1/Ccl2/Cx3cl1/Fas/Ccl7/Tnfrsf9/Il1rap/Lif/Ccl20/Tnfrsf1b/Ccl9/Il18rap/Pf4/Tnfsf18/Relt/Ccl28/Il2rb/Cxcl5/Epor/Cxcl10/Il12rb1/Il15/Ngfr/Il7/Gdf15/Tnfrsf19/Ifnlr1/Tnfrsf8/Ccl17/Gdf5	mmu:14825/mmu:20296/mmu:20312/mmu:14102/mmu:20306/mmu:21942/mmu:16180/mmu:16878/mmu:20297/mmu:21938/mmu:20308/mmu:16174/mmu:56744/mmu:240873/mmu:320100/mmu:56838/mmu:16185/mmu:20311/mmu:13857/mmu:15945/mmu:16161/mmu:16168/mmu:18053/mmu:16196/mmu:23886/mmu:29820/mmu:242700/mmu:21941/mmu:20295/mmu:14563	30
mmu04668	TNF signaling pathway	17/385	106/5966	0.00039117767481587	0.036118738641332	ENSMUSG00000029380/ENSMUSG00000035385/ENSMUSG00000031778/ENSMUSG00000024778/ENSMUSG00000017737/ENSMUSG00000019850/ENSMUSG00000053007/ENSMUSG00000034394/ENSMUSG00000026166/ENSMUSG00000024235/ENSMUSG00000028599/ENSMUSG00000053175/ENSMUSG00000055994/ENSMUSG00000026875/ENSMUSG00000034855/ENSMUSG00000031712/ENSMUSG00000058163	Cxcl1/Ccl2/Cx3cl1/Fas/Mmp9/Tnfaip3/Creb5/Lif/Ccl20/Map3k8/Tnfrsf1b/Bcl3/Nod2/Traf1/Cxcl10/Il15/Gm5431	mmu:14825/mmu:20296/mmu:20312/mmu:14102/mmu:17395/mmu:21929/mmu:231991/mmu:16878/mmu:20297/mmu:26410/mmu:21938/mmu:12051/mmu:257632/mmu:22029/mmu:15945/mmu:16168/mmu:432555	17
mmu00830	Retinol metabolism	9/385	39/5966	0.000660315483169279	0.0457268472094726	ENSMUSG00000053279/ENSMUSG00000025002/ENSMUSG00000027068/ENSMUSG00000090145/ENSMUSG00000064294/ENSMUSG00000063415/ENSMUSG00000024747/ENSMUSG00000054545/ENSMUSG00000025197	Aldh1a1/Cyp2c55/Dhrs9/Ugt1a6b/Aox3/Cyp26b1/Aldh1a7/Ugt1a6a/Cyp2c23	mmu:11668/mmu:72082/mmu:241452/mmu:394435/mmu:71724/mmu:232174/mmu:26358/mmu:94284/mmu:226143	9

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IKKβ/NF-κB, a pro-inflammatory pathway downstream of the TNF, mediates high-fat diet-induced hypothalamic inflammation, and inflammatory changes can inhibit neurogenesis. Juxue Li et al. found that activation of IKKβ/NF-κB significantly reduces NSC survival and neurogenesis [22], whereas inhibition of IKKβ/NF-κB increases both cell survival and neurogenesis.

In KEGG analysis, seventeen genes exhibited associations with the Tumor Necrosis Factor (TNF) signaling pathway, while thirty genes demonstrated connections with cytokine-cytokine receptor interactions. Furthermore, previous GO analyses identified forty genes linked to the cytokine-mediated signaling pathway. Intriguingly, we discerned the presence of eight genes that concurrently participated in all three functional categories (Cxcl1/Cxcl10/Cx3cl1/Ccl2/Ccl20/Fas/Tnfrsf1b/Il15), as visually represented in Supplementary Figs. 2–C/D. Notably, in the schematic depiction of the TNF signaling pathway (Supplementary Fig. 3), these eight genes are distinctly highlighted in red.

In contrast to upregulated DEGs, the downregulated DEGs exhibited limited functional clustering composed of only nine terms. These include three CC and six MF categories (Fig. 5-D). The three CC terms were proteinaceous ECM (19 genes), ECM (20 genes), and ECM components (7 genes). The six MF terms included scavenger receptor activity (6 genes), extracellular matrix structural constituent (6 genes), cargo receptor activity (7 genes), Wnt protein binding (4 genes), collagen binding (5 genes), and scaffold protein binding (5 genes), as shown in Table 3. These findings suggested that in differentiated C17.2 cells, Toe1 influences downregulated DEGs primarily associated with the ECM.

3.5. qPCR validation of gene expression in differentiated C17.2 cells

According to the results of transcriptome sequencing of differentiated cells, several genes potentially crucial in cell differentiation showing significant differential expression between the two groups were selected for qPCR verification (Fig. 6-A). These genes include: (1) Ucma (Ucma upper zone of growth plate and cartilage matrix associated), which encodes a chondrocyte-specific highly charged protein. Upon protein hydrolysis, this gene generates mature proteins secreted into the ECM. GO analysis revealed a strong association between Ucma and ECM-related functions. (2) Cdkn1a (cyclin-dependent kinase inhibitor 1A) encodes a potent cyclin-dependent kinase inhibitor, inhibiting the activity of CDK2/4. GO analysis indicated that this gene is associated with biological processes such as cell proliferation, leukocyte activation, reactive oxygen species metabolism, DNA damage response, and p53-mediated signal transduction. (3) Tnfsf18 (tumor necrosis factor (ligand) superfamily, member 18) encodes a protein that belongs to the tumor necrosis factor ligand superfamily. GO analysis indicated that this gene was associated with biological processes such as cell-cell adhesion, monocyte chemotaxis, granulocyte migration, defense response regulation, lymphocyte proliferation regulation, lymphocyte activation regulation, and inflammation response regulation; (4) Cd74 (CD74 antigen) encodes a protein that acts upstream or internally in various processes, including antigen processing, MHC class II presentation of exogenous peptide antigens, and regulation of T-cell differentiation. GO analysis indicated that this gene is associated with biological processes including class II MHC metabolism, fatty acid derivative metabolism, cytokine-mediated signaling pathways, cell chemotaxis, cell adhesion, granulocyte migration, defense response regulation, and lymphocyte proliferation regulation; (5) Btn2a2 (butyrophilin, subfamily 2, member A2) encodes a protein that belongs to the butyrophilin protein subfamily A2, and is involved in the regulation of signal receptor binding activity. GO analysis indicated that this gene is associated with biological processes such as negative regulation of cell adhesion, lymphocyte proliferation, and cell activation. (6) Vnn1 (vanin 1) encodes a protein predicted to be a component of the membrane, and participates in the regulation of theanine hydrolase activity. GO analysis indicated that this gene is associated with biological processes, such as cell-cell adhesion regulation, lymphocyte activation regulation, monocarboxylic acid metabolism, leukocyte differentiation, chronic inflammatory response, and cellular oxidative stress.

qPCR validation confirmed that the expression trends of these six genes were consistent with the sequencing results (Fig. 6-B), demonstrating the accuracy and reliability of the RNA-seq outcomes.

4. Discussion

PCH7 is an autosomal recessive neurodegenerative disorder characterized by severe cerebellar and brainstem underdevelopment and atrophy. Currently, there are no effective treatments and supportive care remains the primary approach [23]. During brain development, NSCs undergo rapid symmetric division to expand their cell pool, followed by differentiation to generate neuronal and glial cell progeny. Therefore, understanding the molecular mechanisms of NSC proliferation and differentiation is crucial to identify potential therapeutic targets for neurodegenerative diseases.

Our study focused on the NSC line C17.2 to investigate the effect of Toe1 on the proliferation and differentiation of NSCs. The findings revealed that Toe1 plays a considerable regulatory role in the proliferation and differentiation of NSCs, with Toe1 knockout inhibiting the proliferation and differentiation of C17.2 cells. The RNA-seq results indicated that (1) in undifferentiated C17.2 cells, Toe1 primarily affects biological metabolic processes such as calcium ion binding, the ECM, and alpha-amino acid catabolism. (2) In differentiated C17.2 cells, Toe1 predominantly influences biological functions related to peptidase activity, chemotactic factors, the ECM, and the TNF signaling pathway. We validated the expression of selected genes to confirm the accuracy and reliability of the RNA-seq results. In future studies, we will focus on validating the expression of other genes associated with peptidase activity, chemotactic factors, extracellular matrix, and the TNF signaling pathway.

Peptidases are enzymes capable of hydrolyzing peptide chains and disrupting protein hydrolysis cascades, including those involving hormones, cytokines, membrane receptors, and ECM structures. This disruption leads to the transmission of downstream signals that regulate various functions of bioactive molecules.

Chemokines constitute a class of small secreted proteins that exert biological effects by interacting with G protein-coupled transmembrane receptors. Owing to their ability to guide the migration or aggregation of cells, they are referred to as chemotactic cytokines, and this process is chemotaxis. Chemokines regulate multiple cell signaling pathways, including actin polymerization, cytoskeletal rearrangement, adhesion plaque assembly, and disaggregation. They play important roles in cell survival, proliferation, and other biological activities.

The ECM is a product secreted by cells that remains in the extracellular space and is primarily composed of fibronectin and glycoproteins. The ECM dynamically responds to changes in the microenvironment of an organism, influencing cell behavior by determining the cell shape, affecting cell survival, and controlling cell differentiation.

The TNF signaling pathway is involved in normal inflammatory and immune responses and acts synergistically to coordinate tissue homeostasis by regulating the production of other cytokines. TNF also promotes cell proliferation and differentiation. TNF facilitates MHC class I antigen expression in T cells, enhances IL-2-dependent thymocyte and T-cell proliferative capacity, and stimulates the production of lymphokines such as IL-2, CSF, and IFN-γ. TNF-α exhibits growth factor-like effects on specific tumor cells and collaborates with EGF, PDGF, and insulin to promote proliferation, thereby enhancing EGF receptor expression.

Peptidase activity, chemotactic factors, extracellular matrix (ECM), and TNF signaling pathways, while representing distinct biological processes, intricately interplay to collectively regulate cellular activities. In our investigation, we have identified eight overlapping genes implicated in the TNF signaling pathway, cytokine-cytokine receptor interaction, and cytokine-mediated signaling pathway (refer to Supplementary Fig. 2). Notably, these genes possess multifaceted functions, including the regulation of cell growth, migration, adhesion, and chemotaxis. Moving forward, our research endeavors will be directed towards unraveling the pivotal molecular mechanisms through which Toe1 governs NSC differentiation, with a particular focus on these identified genes.

Of significant relevance is the classical signaling cascade orchestrated by the Notch pathway, which plays a pivotal role in modulating various facets of neural differentiation and function. Therefore, our future investigations will incorporate additional experiments aimed at elucidating the intricate involvement of Toe1 in NSC proliferation and differentiation via the Notch pathway. Our commitment lies in conducting comprehensive research endeavors aimed at advancing our understanding of the intricate mechanisms underlying neurodevelopment, with a particular emphasis on unraveling the regulatory role of Toe1 within this intricate framework.

Our overarching objective is to delineate the intricate crosstalk within the Toe1 regulatory network, thereby laying the foundation for the development of innovative therapeutic strategies targeted towards addressing neurodegenerative diseases, including Pontocerebellar Hypoplasia type 7 (PCH7).

CRediT authorship contribution statement

Tingting Deng: Writing – original draft. Xingxing Wu: Visualization, Software, Methodology. Yujie Wang: Project administration. Xiaoqin Fan: Validation, Methodology. Bing Hu: Writing – review & editing, Supervision.

Data availability statement

The RNA sequencing data were uploaded to the GEO database with accession number GSE254608 and GSE254609, respectively. The another original datasets supporting the conclusions of this article will be made available by the authors. Data will be made available on request.

Declaration of competing interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Acknowledgements

This work was supported by Shenzhen Science and Technology Innovation Committee JCYJ20190806163209126, National Natural Science Foundation of China (82002936 and 81902777), Shenzhen Science and Technology Innovation Committee (JCYJ20220530150414031, JCYJ20210324103005014 and JCYJ20230807115103007), China Postdoctoral Science Foundation (2019TQ0211 and 2020M672833).

Footnotes

^{Appendix A}

Supplementary data to this article can be found online at https://doi.org/10.1016/j.heliyon.2024.e39535.

Contributor Information

Tingting Deng, Email: dttmuye@163.com.

Xingxing Wu, Email: wuxiaodouaran05@163.com.

Yujie Wang, Email: wang_maggie_223@163.com.

Xiaoqin Fan, Email: fanxiaoqin83@163.com.

Bing Hu, Email: szshent@email.szu.edu.cn.

Appendix A. Supplementary data

The following is/are the supplementary data to this article:

Multimedia component 1

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References

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Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Supplementary Materials

Multimedia component 1

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Data Availability Statement

[bib1] 1.Kimbrel E.A., Lanza R. Pluripotent stem cells: the last 10 years. Regen. Med. 2016;11(8):831–847. doi: 10.2217/rme-2016-0117. [DOI] [PubMed] [Google Scholar]

[bib2] 2.Temple S. Embryonic stem cell self-renewal, analyzed. Cell. 2003;115(3):247–248. doi: 10.1016/s0092-8674(03)00853-5. [DOI] [PubMed] [Google Scholar]

[bib3] 3.Grochowski C., Radzikowska E., Maciejewski R. Neural stem cell therapy-Brief review. Clin. Neurol. Neurosurg. 2018;173:8–14. doi: 10.1016/j.clineuro.2018.07.013. [DOI] [PubMed] [Google Scholar]

[bib4] 4.Tuazon J.P., et al. Neural stem cells. Adv. Exp. Med. Biol. 2019;1201:79–91. doi: 10.1007/978-3-030-31206-0_4. [DOI] [PubMed] [Google Scholar]

[bib5] 5.Juric-Sekhar G., Hevner R.F. Malformations of cerebral cortex development: molecules and mechanisms. Annu. Rev. Pathol. 2019;14:293–318. doi: 10.1146/annurev-pathmechdis-012418-012927. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bib6] 6.Namavar Y., et al. Classification, diagnosis and potential mechanisms in pontocerebellar hypoplasia. Orphanet J. Rare Dis. 2011;6:50. doi: 10.1186/1750-1172-6-50. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bib7] 7.Rudnik-Schoneborn S., Barth P.G., Zerres K. Pontocerebellar hypoplasia. Am J Med Genet C Semin Med Genet. 2014;166C(2):173–183. doi: 10.1002/ajmg.c.31403. [DOI] [PubMed] [Google Scholar]

[bib8] 8.van Dijk T., et al. What's new in pontocerebellar hypoplasia? An update on genes and subtypes. Orphanet J. Rare Dis. 2018;13(1):92. doi: 10.1186/s13023-018-0826-2. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bib9] 9.Siriwardena K., et al. XY sex reversal, pontocerebellar hypoplasia and intellectual disability: confirmation of a new syndrome. Am. J. Med. Genet. 2013;161A(7):1714–1717. doi: 10.1002/ajmg.a.35945. [DOI] [PubMed] [Google Scholar]

[bib10] 10.Mahbubul Huq A.H., Nigro M.A. XY sex reversal and a nonprogressive neurologic disorder: a new syndrome? Pediatr. Neurol. 2000;23(4):357–360. doi: 10.1016/s0887-8994(00)00200-9. [DOI] [PubMed] [Google Scholar]

[bib11] 11.Anderson C., et al. Early pontocerebellar hypoplasia with vanishing testes: a new syndrome? Am. J. Med. Genet. 2021;155A(4):667–672. doi: 10.1002/ajmg.a.33897. [DOI] [PubMed] [Google Scholar]

[bib12] 12.Lardelli R.M., et al. Biallelic mutations in the 3' exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing. Nat. Genet. 2017;49(3):457–464. doi: 10.1038/ng.3762. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bib13] 13.Budde B.S., et al. tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia. Nat. Genet. 2008;40(9):1113–1118. doi: 10.1038/ng.204. [DOI] [PubMed] [Google Scholar]

[bib14] 14.Guo H., et al. Genetic and prenatal diagnosis of a Chinese pedigree with pathogenic TOE1 variants causing pontocerebellar hypoplasia type 7. J. Matern. Fetal Neonatal Med. 2023;36(2) doi: 10.1080/14767058.2023.2250895. [DOI] [PubMed] [Google Scholar]

[bib15] 15.Wang C., et al. Novel compound heterozygous missense variants in TOE1 gene associated with pontocerebellar hypoplasia type 7. Gene. 2023;862 doi: 10.1016/j.gene.2023.147250. [DOI] [PubMed] [Google Scholar]

[bib16] 16.Chen H., et al. Novel compound heterozygous variant of TOE1 results in a mild type of pontocerebellar hypoplasia type 7: an expansion of the clinical phenotype. Neurogenetics. 2022;23(1):11–17. doi: 10.1007/s10048-021-00675-0. [DOI] [PubMed] [Google Scholar]

[bib17] 17.Shiozawa T., et al. Dimethylarginine dimethylaminohydrolase 2 promotes tumor angiogenesis in lung adenocarcinoma. Virchows Arch. 2016;468(2):179–190. doi: 10.1007/s00428-015-1863-z. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bib18] 18.Xue C., Zehao H., Chengjian Z. Effects of MCCC2 knockdown on proliferation, migration and apoptosis of DU145 prostate cancer cells. Journal of Pharmaceutical Practice and Service. 2021;39(3):115–220. [Google Scholar]

[bib19] 19.Yu C., et al. TDO2 was downregulated in hepatocellular carcinoma and inhibited cell proliferation by upregulating the expression of p21 and p27. BioMed Res. Int. 2021;2021 doi: 10.1155/2021/4708439. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bib20] 20.Zhou B., et al. Notch signaling pathway: architecture, disease, and therapeutics. Signal Transduct. Targeted Ther. 2022;7(1):95. doi: 10.1038/s41392-022-00934-y. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bib21] 21.Engler A., Zhang R., Taylor V. Notch and neurogenesis. Adv. Exp. Med. Biol. 2018;1066:223–234. doi: 10.1007/978-3-319-89512-3_11. [DOI] [PubMed] [Google Scholar]

[bib22] 22.Li J., Tang Y., Cai D. IKKbeta/NF-kappaB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes. Nat. Cell Biol. 2012;14(10):999–1012. doi: 10.1038/ncb2562. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bib23] 23.Kasinathan A., et al. Clinico-radiological profile of children with pontocerebellar hypoplasia. J. Pediatr. Neurosci. 2020;15(2):94–98. doi: 10.4103/jpn.JPN_6_19. [DOI] [PMC free article] [PubMed] [Google Scholar]

PERMALINK

Toe1 promotes proliferation and differentiation of neural progenitor cells

Tingting Deng

Xingxing Wu

Yujie Wang

Xiaoqin Fan

Bing Hu

Abstract

1. Introduction

2. Materials and methods

2.1. The C17.2 cell line and culture conditions

2.2. Colony formation and 5-ethynyl-2′-deoxyuridine incorporation assays

2.3. Cell cycle analysis using flow cytometry

2.4. Reverse transcription and real-time quantitative PCR

Table 1.

2.5. Protein expression detected using Western blot (WB) analysis

2.6. RNA sequencing analysis

2.7. Statistical analyses

3. Results

3.1. Toe1 knockout inhibited the proliferation of neural stem cells

Fig. 1.

Fig. 2.

3.2. Transcriptome analysis of undifferentiated C17.2 cells

Fig. 3.

Table 2.

3.3. Toe1 knockout inhibited the C17.2 cell differentiation

Fig. 4.

3.4. Transcriptome analysis of differentiated C17.2 cells

Fig. 5.

Table 3.

Table 4.

3.5. qPCR validation of gene expression in differentiated C17.2 cells

Fig. 6.

4. Discussion

CRediT authorship contribution statement

Data availability statement

Declaration of competing interest

Acknowledgements

Footnotes

Contributor Information

Appendix A. Supplementary data

References

Associated Data

Supplementary Materials

Data Availability Statement

ACTIONS

PERMALINK

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