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. 1984 May 15;220(1):35–42. doi: 10.1042/bj2200035

The contribution of both extracellular and intracellular calcium to the action of alpha-adrenergic agonists in perfused rat liver.

P H Reinhart, W M Taylor, F L Bygrave
PMCID: PMC1153591  PMID: 6743271

Abstract

The role of both intracellular and extracellular Ca2+ pools in the expression of alpha-adrenergic-agonist-mediated responses was examined in perfused rat liver. Responses studied included glycogenolysis, respiration, lactate and pyruvate formation, ketone-body production, changes in the cytoplasmic and mitochondrial redox ratio and cellular K+ fluxes. Each of these was shown to be dependent on the mobilization of intracellular Ca2+ and can be grouped into one of two response types. Transient responses (ion fluxes and the redox ratios) are obligatorily dependent on the mobilization of intracellular Ca2+ and occur irrespective of the extracellular Ca2+ concentration. Sustained responses, on the other hand, initially require intracellular Ca2+ and, subsequently, extracellular Ca2+. The data indicate that alpha-adrenergic agonists mobilize extracellular Ca2+ as well as intracellular Ca2+ and that both pools are required for the full expression of hormone-induced responses in rat liver.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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