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. 1982 Oct 15;208(1):47–52. doi: 10.1042/bj2080047

Studies on the stimulation of dolichol-mediated glycosylation by dexamethasone in HeLa cells.

C K Ramachandran, S L Gray, G Melnykovych
PMCID: PMC1153927  PMID: 6186247

Abstract

The effect of the addition of 1 microM-dexamethasone on the temporal sequence of the glycosylation process has been studied in HeLa S3G cells. In the presence of delipidized serum, dexamethasone caused an increase in 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase and an accelerated synthesis of dolichols. These events were followed by an increase in the transfer of mannose from GDP-mannose to mannolipid. An increase in the rate of synthesis of lipid-linked oligosaccharides and a stimulation of glycosylation were observed in cells grown in the presence of delipidized serum in the culture medium. The data are consistent with the view that cellular syntheses of lipids and glycoproteins are co-ordinately controlled.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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