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. 1982 Oct 15;208(1):141–146. doi: 10.1042/bj2080141

Beryllium toxicity. The selective inhibition of casein kinase 1.

B Cummings, M R Kaser, G Wiggins, M G Ord, L A Stocken
PMCID: PMC1153939  PMID: 6961919

Abstract

1. Cyclic AMP-independent casein kinase 1 in liver cytoplasm and nuclei was inhibited by Be2+ in vitro (Ki 2.5 microM and 29 microM respectively). Casein kinase 2 (phosvitin kinase) and cyclic AMP-dependent protein kinase were unaffected. 2. The inhibition of casein kinase 1 by Be2+ was competitive with respect to the protein substrate; at non-saturating concentrations of casein, inhibition was non-competitive with respect to ATP. 3. In rats given LD50 doses of Be2+ 24 h before death, the activities of cytoplasmic and nuclear casein kinase 1 in livers from partially hepatectomized animals were diminished approx. 50%; with intact rats, nuclear casein kinase 1 was inhibited at concentrations of casein less than the Km.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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