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. 1982 Oct 15;208(1):147–151. doi: 10.1042/bj2080147

The differing responses of four muscle types to dexamethasone treatment in the rat

Frank J Kelly 1, David F Goldspink 1
PMCID: PMC1153940  PMID: 6186244

Abstract

The glucocorticoid dexamethasone dramatically altered growth patterns in four muscle types, inducing atrophy of smooth and fast-twitch skeletal muscle, suppressing protein accumulation in slow-twitch muscle and enhancing growth in the heart. These differing responses were explained by steroid-induced changes in RNA content, protein synthesis and protein breakdown.

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Selected References

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