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. 1982 Nov 15;208(2):513–515. doi: 10.1042/bj2080513

Selective uptake of alloxan by pancreatic B-cells

Frans K Gorus *,, Willy J Malaisse , Daniël G Pipeleers *
PMCID: PMC1153992  PMID: 6760861

Abstract

Alloxan rapidly binds to or accumulates in pancreatic B-cells as distinct from non-B-cells. The selective uptake of this cytotoxic agent by the insulin-producing B-cells might account for its well-known diabetogenic effect.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Fischer L. J., Hamburger S. A. Inhibition of alloxan action in isolated pancreatic islets by superoxide dismutase, catalase, and a metal chelator. Diabetes. 1980 Mar;29(3):213–216. doi: 10.2337/diab.29.3.213. [DOI] [PubMed] [Google Scholar]
  2. Grankvist K., Marklund S. L., Täljedal I. B. CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse. Biochem J. 1981 Nov 1;199(2):393–398. doi: 10.1042/bj1990393. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Grankvist K., Marklund S., Sehlin J., Täljedal I. B. Superoxide dismutase, catalase and scavengers of hydroxyl radical protect against the toxic action of alloxan on pancreatic islet cells in vitro. Biochem J. 1979 Jul 15;182(1):17–25. doi: 10.1042/bj1820017. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Grankvist K., Marklund S., Täljedal I. B. Superoxide dismutase is a prophylactic against alloxan diabetes. Nature. 1981 Nov 12;294(5837):158–160. doi: 10.1038/294158a0. [DOI] [PubMed] [Google Scholar]
  5. Hellman B., Sehlin J., Täljedal I. B. Evidence for mediated transport of glucose in mammalian pancreatic -cells. Biochim Biophys Acta. 1971 Jul 6;241(1):147–154. doi: 10.1016/0005-2736(71)90312-9. [DOI] [PubMed] [Google Scholar]
  6. Lacy P. E., Kostianovsky M. Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes. 1967 Jan;16(1):35–39. doi: 10.2337/diab.16.1.35. [DOI] [PubMed] [Google Scholar]
  7. Malaisse W. J., Malaisse-Lagae F., Sener A., Pipeleers D. G. Determinants of the selective toxicity of alloxan to the pancreatic B cell. Proc Natl Acad Sci U S A. 1982 Feb;79(3):927–930. doi: 10.1073/pnas.79.3.927. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. McDaniel M. L., Anderson S., Fink J., Roth C., Lacy P. E. Effect of alloxan on permeability and hexose transport in rat pancreatic islets. Endocrinology. 1975 Jul;97(1):68–75. doi: 10.1210/endo-97-1-68. [DOI] [PubMed] [Google Scholar]
  9. Pipeleers D. G., Pipeleers-Marichal M. A. A method for the purification of single A, B and D cells and for the isolation of coupled cells from isolated rat islets. Diabetologia. 1981 Jun;20(6):654–663. doi: 10.1007/BF00257436. [DOI] [PubMed] [Google Scholar]
  10. Sener A., Malaisse-Lagae F., Malaisse W. J. Noncarbohydrate nutrients protect against alloxan-induced inhibition of insulin release. Endocrinology. 1982 Jun;110(6):2210–2212. doi: 10.1210/endo-110-6-2210. [DOI] [PubMed] [Google Scholar]
  11. Van de Winkle M., Maes E., Pipeleers D. Islet cell analysis and purification by light scatter and autofluorescence. Biochem Biophys Res Commun. 1982 Jul 30;107(2):525–532. doi: 10.1016/0006-291x(82)91523-6. [DOI] [PubMed] [Google Scholar]
  12. Watkins D., Cooperstein S. J., Lazarow A. Effect of alloxan on islet tissue permeability: protection and reversal by sugars. Am J Physiol. 1973 Mar;224(3):718–722. doi: 10.1152/ajplegacy.1973.224.3.718. [DOI] [PubMed] [Google Scholar]
  13. Weaver D. C., McDaniel M. L., Lacy P. E. Alloxan uptake by isolated rat islets of Langerhans. Endocrinology. 1978 Jun;102(6):1847–1855. doi: 10.1210/endo-102-6-1847. [DOI] [PubMed] [Google Scholar]

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