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. 1983 Jan 1;209(1):251–255. doi: 10.1042/bj2090251

Certain mouse strains are deficient in a kidney brush-border metallo-endopeptidase activity.

J S Bond, J D Shannon, R J Beynon
PMCID: PMC1154079  PMID: 6342606

Abstract

Preparations of microvilli from kidneys of BALB/c mice contain an alkaline metallo-endopeptidase, meprin (metallo-endopeptidase from renal tissue). Certain genealogically related inbred mice are markedly deficient in meprin activity. The meprin-deficient strains (CBA/J and C3H/HeJ) exhibit normal levels of other brush-border enzymes: alkaline phosphatase, aminopeptidase M and another proteinase, a phosphoramidon-sensitive neutral endopeptidase. Meprin deficiency cannot be attributed to a shift in pH optimum and is unlikely to be due to the presence of endogenous inhibitors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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