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. 2024 Nov 6;635(8037):201–209. doi: 10.1038/s41586-024-07861-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — (a-b) Representative time-lapsed images of TetR-mNeonGreen labelled TetO-MYC ecDNAs in COLO 320DM cells undergoing early to late mitosis (3 dividing cell pairs) (a) and G2 to late mitosis (2 dividing cell pairs) (b) (n = 30 cell divisions over 5 independent time-lapse experiments). H2B-emiRFP670 labels histone H2B to aid identification of mitotic chromosomes and/or nuclear boundaries. White dash lines denote the mitotic cell across time frames; clumps of ecDNA molecules observed throughout mitosis are indicated with yellow arrowheads. Time stamp is denoted in hh:mm format. Scale bar = 10 μm.