Abstract
Ferritin-containing fractions with different degrees of iron loading were prepared. All ferritin fractions stimulated the peroxidation of bovine brain phospholipid liposomes, as measured by the formation of thiobarbituric acid-reactive material. This stimulation was increased in the presence of ascorbate. Iron salts of equivalent concentration to those of the ferritin fractions were more stimulatory to lipid peroxidation at the higher iron concentrations. None of the fractions inhibited ascorbate-dependent peroxidation in the presence of added iron salts.
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Selected References
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- Aisen P., Listowsky I. Iron transport and storage proteins. Annu Rev Biochem. 1980;49:357–393. doi: 10.1146/annurev.bi.49.070180.002041. [DOI] [PubMed] [Google Scholar]
- Barber A. A., Bernheim F. Lipid peroxidation: its measurement, occurrence, and significance in animal tissues. Adv Gerontol Res. 1967;2:355–403. [PubMed] [Google Scholar]
- Blake D. R., Bacon P. A. Serum ferritin and rheumatoid disease. Br Med J (Clin Res Ed) 1981 Apr 18;282(6272):1273–1274. doi: 10.1136/bmj.282.6272.1273. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Blake D. R., Hall N. D., Bacon P. A., Dieppe P. A., Halliwell B., Gutteridge J. M. The importance of iron in rheumatoid disease. Lancet. 1981 Nov 21;2(8256):1142–1144. doi: 10.1016/s0140-6736(81)90590-0. [DOI] [PubMed] [Google Scholar]
- Clegg G. A., Fitton J. E., Harrison P. M., Treffry A. Ferritin: molecular structure and iron-storage mechanisms. Prog Biophys Mol Biol. 1980;36(2-3):56–86. [PubMed] [Google Scholar]
- DRYSDALE J. W., MUNRO H. N. SMALL-SCALE ISOLATION OF FERRITIN FOR THE ASSAY OF THE INCORPORATION OF 14C-LABELLED AMINO ACIDS. Biochem J. 1965 Jun;95:851–858. doi: 10.1042/bj0950851. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gutteridge J. M., Richmond R., Halliwell B. Inhibition of the iron-catalysed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine. Biochem J. 1979 Nov 15;184(2):469–472. doi: 10.1042/bj1840469. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gutteridge J. M., Rowley D. A., Halliwell B. Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts. Detection of 'free' iron in biological systems by using bleomycin-dependent degradation of DNA. Biochem J. 1981 Oct 1;199(1):263–265. doi: 10.1042/bj1990263. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gutteridge J. M. The measurement of malondialdehyde in peroxidised ox-brain phospholipid liposomes. Anal Biochem. 1977 Sep;82(1):76–82. doi: 10.1016/0003-2697(77)90136-1. [DOI] [PubMed] [Google Scholar]
- Halliwell B. Production of superoxide, hydrogen peroxide and hydroxyl radicals by phagocytic cells: a cause of chronic inflammatory disease? Cell Biol Int Rep. 1982 Jun;6(6):529–542. doi: 10.1016/0309-1651(82)90175-8. [DOI] [PubMed] [Google Scholar]
- Hann H. W., Levy H. M., Evans A. E. Serum ferritin as a guide to therapy in neuroblastoma. Cancer Res. 1980 May;40(5):1411–1413. [PubMed] [Google Scholar]
- Kohgo Y., Niitsu Y., Watanabe N., Ohtsuka S., Koseki J. [Radioimmunoassay of serum ferritin and its clinical implication in diseases of the digestive organs]. Nihon Shokakibyo Gakkai Zasshi. 1976 Dec;73(12):1553–1566. [PubMed] [Google Scholar]
- Treffry A., Harrison P. M. The binding of ferric iron by ferritin. Biochem J. 1979 Sep 1;181(3):709–716. doi: 10.1042/bj1810709. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Whiting R. F., Wei L., Stich H. F. Chromosome-damaging activity of ferritin and its relation to chelation and reduction of iron. Cancer Res. 1981 May;41(5):1628–1636. [PubMed] [Google Scholar]
- Wills E. D. Lipid peroxide formation in microsomes. The role of non-haem iron. Biochem J. 1969 Jun;113(2):325–332. doi: 10.1042/bj1130325. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wills E. D. Mechanisms of lipid peroxide formation in animal tissues. Biochem J. 1966 Jun;99(3):667–676. doi: 10.1042/bj0990667. [DOI] [PMC free article] [PubMed] [Google Scholar]