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. 1983 Mar 1;209(3):573–580. doi: 10.1042/bj2090573

Low-frequency vibrations of helical structures in protein molecules.

K C Chou
PMCID: PMC1154133  PMID: 6870784

Abstract

A physically intuitive and mathematically easily handled formula is presented for calculating the low-frequency vibrations of helical structures in protein molecules. alpha-Chymotrypsin is taken as an example, and the calculated result shows precise agreement with observations of the low-frequency Raman spectra. As reflected in the formula, this kind of low frequency is very sensitive to the conformation of a biomacromolecule, and can therefore serve as a vehicle to investigate the mechanism of action of a biomacromolecule from the viewpoint of dynamics. On this basis a feasible experiment is suggested by which one can examine the relationship between a presumed mode of low-frequency vibration in a biomacromolecule and its activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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