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Co-injection caused an increase in the expression of genes related to hypoxia, oxidative stress, and apoptosis. (A,B) Gene expression levels of several targets, including hypoxia (Hif-2alpha), oxidative stress (Ho-1), and apoptosis (BCL-2, Bax) genes, were determined over the first 48h. The ratio of Bax to BCL-2 was determined to be 0.379 after 24 h and 0.65 after 48 h post-injection. Data expressed as percent change from baseline. Data shown are mean ± SD, * p < 0.05.
