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. 1995 Feb;15(1):25–42. doi: 10.1007/BF02069557

Functional domains of the gonadotropin-releasing hormone receptor

Stuart C Sealfon 1,✉, Robert P Millar 2
PMCID: PMC11563151  PMID: 7648608

Abstract

1. The cloning of the mammalian gonadotropin-releasing hormone receptor sets the stage for rapid progress in understanding the structure of the receptor, its interaction with ligand, and its mechanisms of activation.

2. The receptor is a 327 to 328-amino acid seven-transmembrane domain G protein-coupled receptor.

3. Recent site-direct mutagenesis studies have provided considerable insight into glycosylation of the receptor, the arrangement of the helices, and the ligand binding domains.

Key words: cDNA, gene structure, mutagenesis, receptor model, binding site

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