Figure 1. The COX pathway is active in embryonic cell types across vertebrate species.

Analysis was performed of publicly available scRNA-seq data from whole embryos, staged around early organogenesis, of 4 chordate species — Zebrafish (Danio rerio), African clawed frog (Xenopus laevis), House mouse (Mus musculus) and Cynomolgus macaque (Macaca fascicularis). (A, H, O, V) UMAP demonstrating clustering results of whole embryos from vertebrate species. (B-D, I-K, P-R, W-Y) Feature UMAPs demonstrating gene expression of select enzymes across species. (E-G, L-N, S-U, Z-AB) Violin plots demonstrating expression of select enzymes across the major cell types identified by species. NC= neural crest, LP= lateral plate, Prog.= progenitor, Def.= definitive, ExE= extra embryonic.