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. 1992 Oct;12(5):439–445. doi: 10.1007/BF00711544

Reduction of the acetylcholine-induced K+ current in identifiedAplysia neurons by human interleukin-1 and interleukin-2

Masashi Sawada 1,✉, Nobumasa Hara 2, Takashi Maeno 1
PMCID: PMC11567237  PMID: 1468114

Abstract

  1. Effects of bath-applied recombinant human interleukin-1 (rhIL-1) and interleukin-2 (rhIL-2) on the acetylcholine (ACh)-induced K+ current recorded from identified neurons (R9 and R10) ofAplysia kurodai were investigated with voltage-clamp and pressure ejection techniques.

  2. Bath-applied rhIL-1 and rhIL-2 (10–40 U/ml) reduced the ACh-induced current in the neurons without affecting the resting membrane conductance and holding current.

  3. The suppressing effects of these cytokines on the current were completely reversible.

  4. Heat-inactivated rhIL-1 and rhIL-2 were without effect.

  5. These results suggest that the immunomodulators, IL-1 and IL-2, can modulate the ACh-induced response in the nervous system.

Key words: interleukin-1, interleukin-2, acetylcholine-induced K+ current, inhibitory modulation, Aplysia neuron

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