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. 1992 Oct;12(5):429–438. doi: 10.1007/BF00711543

Modulation of voltage-activated ion currents on identified neurons ofHelix pomatia L. by interleukin-1

A Szûcs 1, G B Stefano 2, T K Hughes 3, K S-Rózsa 1,3
PMCID: PMC11567299  PMID: 1281756

Abstract

  1. The effect of interleukin-1 (IL-1) was studied on voltage-activated ion currents of the identified central neurons ofHelix pomatia L. using a twomicroelectrode voltage clamp. The voltage-activated inward current (I Ca) was decreased, whereas the outward current (I net K) was increased by IL-1.

  2. IL-1 affects both the transient and the delayed rectifying potassium currents. The IL-1 modulatory effect on the voltage-activated ion currents was voltage and dose dependent. The threshold concentration for IL-1 was 2 U/ml.

  3. The proposed modulatory effect of IL-1 appears to have more than one site of action on the neuron membrane ion channels.

  4. Rabbit anti-human IL-1 polyclonal antiserum eliminated the IL-1 effects on the voltage-activated inward and outward currents. This is the first report demonstrating a direct effect of IL-1 modulation of voltage-activated ion currents on neurons of mollusks.

Key words: immunotransmitter, cytokine, interleukin-1, antiserum, inward-outward currents, Helix neurons

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