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. 1988 Mar;8(1):7–17. doi: 10.1007/BF00712906

Presynaptic regulation of dopaminergic transmission in the striatum

J Glowinski 1, A Chéramy 1,2, R Romo 1, L Barbeito 1
PMCID: PMC11567314  PMID: 2900072

Abstract

  1. In vitro studies have indicated that several transmitters present in the striatum can regulate presynaptically the release of dopamine (DA) from nerve terminals of the nigrostriatal DA neurons.

  2. The receptors involved in these local regulatory processes are located or not located on DA nerve terminals.

  3. Recentin vivo investigations have demonstrated that the corticostriatal glutamatergic neurons facilitate presynaptically the release of DA and have allowed the analysis of the respective roles of presynaptic events and nerve activity in the control of DA transmission.

Key words: dopamine, caudate nucleus, release, glutamate presynaptic regulation

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