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. 1990 Mar;10(1):73–98. doi: 10.1007/BF00733637

Neuropeptide gene expression and neural activity: Assessing a working hypothesis in nucleus caudalis and dorsal horn neurons expressing preproenkephalin and preprodynorphin

George R Uhl 1,✉, Toshikazu Nishimori 1
PMCID: PMC11567324  PMID: 1970758

Abstract

  1. The working hypothesis that neuropeptide gene expression in a neuron is an indicator of that neuron's physiological activity is discussed.

  2. Representative examples from the literature are presented to support the hypothesis.

  3. Further, we discuss the regulation of expression of two opioid peptides, preproenkephalin and preprodynorphin, in laminae I and II of the spinal cord and in nucleus caudalis of the trigeminal nuclear complex, where they may play a role in pain modulation.

  4. The expression of the opioid peptide genes can be induced by both painful and nonnoxious stimuli in neurons in time-dependent and sensory-specific fashions.

Key words: molecular biology of peptidergic neurons, in situ hybridization, gene expression, preproenkephalin, preprodynorphin

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