Table 1.
Demographic descriptions of both analyzed cohorts.
| ABC-DSa (N = 357) | Legacya (N = 468) | p-value | |
|---|---|---|---|
| Age (baseline) | |||
| Mean (SD) | 45.7 (9.91) | 51.3 (7.1) | <0.0001 |
| Range | 25–81 | 30.3–78.1 | |
| Sex assigned at birth (% Female) | 46.2% | 63.2% | <0.0001 |
| Intellectual impairment (% Mild or higher) | 51.8% | 31% | <0.0001 |
| Self-reported race (% White) | 95.5% | 91.9% | 0.29 |
| APOE | |||
| APOE2 allele frequency | 7.99% | 8.5% | 0.83 |
| APOE4 allele frequency | 13.5% | 11.6% | 0.41 |
| % mosaic (all sources) | 7.3% | 9.6% | 0.24 |
| % mosaic with 50% or more disomic cells | 1.4% | 0.85% | 0.51 |
| AD Status | |||
| AD at baseline (%) | 12.3% | 8.8% | 0.02 |
| Converted to AD dementia in follow-up (%) | 19.1% | 22.9% | 0.21 |
a
Values are either means with standard variations and range for continuous variables, or percentages for categorical variables.