Skip to main content
NCBI home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1995 Jan 15;482(Pt 2):435–448. doi: 10.1113/jphysiol.1995.sp020530

Involvement of vasodilator mechanisms in arterial pressure lability after sino-aortic baroreceptor denervation in rat.

Z Q Zhang 1, C Barrès 1, C Julien 1
PMCID: PMC1157741  PMID: 7714834

Abstract

1. To examine the regional haemodynamic basis of arterial pressure lability seen after sino-aortic baroreceptor denervation (SAD), simultaneous beat-to-beat recordings of arterial pressure and indices of regional blood flows (Doppler probes around the subdiaphragmatic and lower abdominal aortae and the superior mesenteric artery) were performed in the same conscious rats (n = 7) before, 1 and 14 days after SAD. 2. Acute SAD increased arterial pressure, decreased regional blood flows and vascular conductances, and potentiated the depressor and vasodilator effects of ganglionic blockade with trimethaphan, suggesting sympathetic overactivity. All parameters chronically returned to or near normal. 3. Both acute and chronic SAD increased the variability of arterial pressure and of regional conductances. Arterial pressure lability was characterized by a mixture of depressor and pressor events which were associated with regional vasodilatations and vasoconstrictions, respectively. This haemodynamic pattern was not affected by acute beta-adrenoceptor blockade with propranolol. 4. In conscious rats, the baroreceptor reflex acts to buffer the spontaneous variability of regional vascular conductances and thereby stabilizes arterial pressure. Sino-aortic baroreceptor denervation-induced arterial pressure lability does not depend on the level of sympathetic activation, and is determined by the relative contribution of depressor and pressor events accompanied by extensive vasodilatations and vasoconstrictions, respectively. Vasodilatations are not caused by the stimulation of vascular beta 2-adrenoceptors.

Full text

PDF
435

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aksamit T. R., Floras J. S., Victor R. G., Aylward P. E. Paroxysmal hypertension due to sinoaortic baroreceptor denervation in humans. Hypertension. 1987 Mar;9(3):309–314. doi: 10.1161/01.hyp.9.3.309. [DOI] [PubMed] [Google Scholar]
  2. Alexander N., DeQuattro V. Regional and systemic hemodynamic patterns in rabbits with neurogenic hypertension. Circ Res. 1974 Oct;35(4):636–645. doi: 10.1161/01.res.35.4.636. [DOI] [PubMed] [Google Scholar]
  3. Alper R. H., Jacob H. J., Brody M. J. Regulation of arterial pressure lability in rats with chronic sinoaortic deafferentation. Am J Physiol. 1987 Aug;253(2 Pt 2):H466–H474. doi: 10.1152/ajpheart.1987.253.2.H466. [DOI] [PubMed] [Google Scholar]
  4. Barres C., Lewis S. J., Jacob H. J., Brody M. J. Arterial pressure lability and renal sympathetic nerve activity are dissociated in SAD rats. Am J Physiol. 1992 Sep;263(3 Pt 2):R639–R646. doi: 10.1152/ajpregu.1992.263.3.R639. [DOI] [PubMed] [Google Scholar]
  5. Bishop V. S., Shade R. E., Haywood J. R., Hamm C. Sinoaortic denervation in the nonhuman primate. Am J Physiol. 1987 Feb;252(2 Pt 2):R294–R298. doi: 10.1152/ajpregu.1987.252.2.R294. [DOI] [PubMed] [Google Scholar]
  6. Bromberger-Barnea B. Mechanical effects of inspiration on heart functions: a review. Fed Proc. 1981 Jun;40(8):2172–2177. [PubMed] [Google Scholar]
  7. Buchholz R. A., Hubbard J. W., Nathan M. A. Comparison of 1-hour and 24-hour blood pressure recordings in central or peripheral baroreceptor-denervated rats. Hypertension. 1986 Dec;8(12):1154–1163. doi: 10.1161/01.hyp.8.12.1154. [DOI] [PubMed] [Google Scholar]
  8. Buchholz R. A., Nathan M. A. Chronic lability of the arterial blood pressure produced by electrolytic lesions of the nucleus tractus solitarii in the rat. Circ Res. 1984 Mar;54(3):227–238. doi: 10.1161/01.res.54.3.227. [DOI] [PubMed] [Google Scholar]
  9. Cornish K. G., Gilmore J. P. Sino-aortic denervation in the monkey. J Physiol. 1985 Mar;360:423–432. doi: 10.1113/jphysiol.1985.sp015625. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Cowley A. W., Jr, Liard J. F., Guyton A. C. Role of baroreceptor reflex in daily control of arterial blood pressure and other variables in dogs. Circ Res. 1973 May;32(5):564–576. doi: 10.1161/01.res.32.5.564. [DOI] [PubMed] [Google Scholar]
  11. Di Rienzo M., Parati G., Castiglioni P., Omboni S., Ferrari A. U., Ramirez A. J., Pedotti A., Mancia G. Role of sinoaortic afferents in modulating BP and pulse-interval spectral characteristics in unanesthetized cats. Am J Physiol. 1991 Dec;261(6 Pt 2):H1811–H1818. doi: 10.1152/ajpheart.1991.261.6.H1811. [DOI] [PubMed] [Google Scholar]
  12. Franchini K. G., Krieger E. M. Carotid chemoreceptors influence arterial pressure in intact and aortic-denervated rats. Am J Physiol. 1992 Apr;262(4 Pt 2):R677–R683. doi: 10.1152/ajpregu.1992.262.4.R677. [DOI] [PubMed] [Google Scholar]
  13. Gardiner S. M., Bennett T. Regional hemodynamic responses to adrenoceptor antagonism in conscious rats. Am J Physiol. 1988 Oct;255(4 Pt 2):H813–H824. doi: 10.1152/ajpheart.1988.255.4.H813. [DOI] [PubMed] [Google Scholar]
  14. Gustin M. P., Cerutti C., Paultre C. Z. Heterogeneous computer network for real-time hemodynamic signal processing. Comput Biol Med. 1990;20(3):205–215. doi: 10.1016/0010-4825(90)90006-b. [DOI] [PubMed] [Google Scholar]
  15. Hales J. R., Ludbrook J. Baroreflex participation in redistribution of cardiac output at onset of exercise. J Appl Physiol (1985) 1988 Feb;64(2):627–634. doi: 10.1152/jappl.1988.64.2.627. [DOI] [PubMed] [Google Scholar]
  16. Haywood J. R., Shaffer R. A., Fastenow C., Fink G. D., Brody M. J. Regional blood flow measurement with pulsed Doppler flowmeter in conscious rat. Am J Physiol. 1981 Aug;241(2):H273–H278. doi: 10.1152/ajpheart.1981.241.2.H273. [DOI] [PubMed] [Google Scholar]
  17. Hinojosa-Laborde C., Frohlich B. H., Cowley A. W., Jr Contribution of regional vascular responses to whole body autoregulation in conscious areflexic rats. Hypertension. 1991 Jun;17(6 Pt 2):1078–1084. doi: 10.1161/01.hyp.17.6.1078. [DOI] [PubMed] [Google Scholar]
  18. Hinojosa-Laborde C., Greene A. S., Cowley A. W., Jr Autoregulation of the systemic circulation in conscious rats. Hypertension. 1988 Jun;11(6 Pt 2):685–691. doi: 10.1161/01.hyp.11.6.685. [DOI] [PubMed] [Google Scholar]
  19. Irigoyen M. C., Cestari I. A., Moreira E. D., Oshiro M. S., Krieger E. M. Measurements of renal sympathetic nerve activity in conscious sinoaortic denervated rats. Braz J Med Biol Res. 1988;21(4):869–872. [PubMed] [Google Scholar]
  20. Jacob H. J., Alper R. H., Grosskreutz C. L., Lewis S. J., Brody M. J. Vascular tone influences arterial pressure lability after sinoaortic deafferentation. Am J Physiol. 1991 Feb;260(2 Pt 2):R359–R367. doi: 10.1152/ajpregu.1991.260.2.R359. [DOI] [PubMed] [Google Scholar]
  21. Julien C., Kandza P., Barres C., Lo M., Cerutti C., Sassard J. Effects of sympathectomy on blood pressure and its variability in conscious rats. Am J Physiol. 1990 Nov;259(5 Pt 2):H1337–H1342. doi: 10.1152/ajpheart.1990.259.5.H1337. [DOI] [PubMed] [Google Scholar]
  22. Julien C., Zhang Z. Q., Barrès C. Role of vasoconstrictor tone in arterial pressure lability after chronic sympathectomy and sinoaortic denervation in rats. J Auton Nerv Syst. 1993 Jan;42(1):1–10. doi: 10.1016/0165-1838(93)90336-s. [DOI] [PubMed] [Google Scholar]
  23. Junqeira F. L., Jr, Krieger E. M. Blood pressure and sleep in the rat in normotension and in neurogenic hypertension. J Physiol. 1976 Aug;259(3):725–735. doi: 10.1113/jphysiol.1976.sp011491. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. KRIEGER E. M. NEUROGENIC HYPERTENSION IN THE RAT. Circ Res. 1964 Dec;15:511–521. doi: 10.1161/01.res.15.6.511. [DOI] [PubMed] [Google Scholar]
  25. Kiel J. W., Bishop V. S. Effect of fasting and refeeding on mesenteric autoregulation in conscious rabbits. Am J Physiol. 1992 May;262(5 Pt 2):H1407–H1414. doi: 10.1152/ajpheart.1992.262.5.H1407. [DOI] [PubMed] [Google Scholar]
  26. Machado B. H. Arterial pressure responses to adrenoceptor antagonism in rats with sino-aortic deafferentation. Braz J Med Biol Res. 1990;23(3-4):343–353. [PubMed] [Google Scholar]
  27. Machado B. H., Mauad H., Glass M. L. Transient changes in blood pressure during spontaneous deep breaths in rats with sinoaortic deafferentation. J Appl Physiol (1985) 1992 Mar;72(3):920–924. doi: 10.1152/jappl.1992.72.3.920. [DOI] [PubMed] [Google Scholar]
  28. Nathan M. A., Reis D. J. Chronic labile hypertension produced by lesions of the nucleus tractus solitarii in the cat. Circ Res. 1977 Jan;40(1):72–81. doi: 10.1161/01.res.40.1.72. [DOI] [PubMed] [Google Scholar]
  29. Norman R. A., Jr, Coleman T. G., Dent A. C. Continuous monitoring of arterial pressure indicates sinoaortic denervated rats are not hypertensive. Hypertension. 1981 Jan-Feb;3(1):119–125. doi: 10.1161/01.hyp.3.1.119. [DOI] [PubMed] [Google Scholar]
  30. Persson P. B., Ehmke H., Kirchheim H. R. Blood pressure control in arterial- and cardiopulmonary receptor denervated dogs. Acta Physiol Scand. 1991 Jun;142(2):221–228. doi: 10.1111/j.1748-1716.1991.tb09150.x. [DOI] [PubMed] [Google Scholar]
  31. Saito M., Terui N., Numao Y., Kumada M. Absence of sustained hypertension in sinoaortic-denervated rabbits. Am J Physiol. 1986 Oct;251(4 Pt 2):H742–H747. doi: 10.1152/ajpheart.1986.251.4.H742. [DOI] [PubMed] [Google Scholar]
  32. Schreihofer A. M., Sved A. F. Nucleus tractus solitarius and control of blood pressure in chronic sinoaortic denervated rats. Am J Physiol. 1992 Aug;263(2 Pt 2):R258–R266. doi: 10.1152/ajpregu.1992.263.2.R258. [DOI] [PubMed] [Google Scholar]
  33. Trapani A. J., Barron K. W., Brody M. J. Analysis of hemodynamic variability after sinoaortic denervation in the conscious rat. Am J Physiol. 1986 Dec;251(6 Pt 2):R1163–R1169. doi: 10.1152/ajpregu.1986.251.6.R1163. [DOI] [PubMed] [Google Scholar]
  34. Yardley R. W., Bowes G., Wilkinson M., Cannata J. P., Maloney J. E., Ritchie B. C., Walker A. M. Increased arterial pressure variability after arterial baroreceptor denervation in fetal lambs. Circ Res. 1983 May;52(5):580–588. doi: 10.1161/01.res.52.5.580. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES