Abstract
INTRODUCTION
Intentions to quit are the strongest predictor of successful smoking cessation and future quit attempts. This study assesses factors associated with quit intentions among adults who smoke in Spain.
METHODS
Data are from the 2021 International Tobacco Control (ITC) EUREST-PLUS Spain Wave 3 Survey, a nationally representative survey of adults aged ≥18 years who smoke (n=1006). Analysis was restricted to 867 adults who provided information about quit intentions. Multivariable Poisson regression was used to examine several correlates of quit intentions. Adjusted prevalence ratios (APR) were estimated.
RESULTS
Less than half (45.6%) of adults who smoke reported intending to quit, with only 13.0% intending to quit in the next 6 months; 11.3% reported at least one quit attempt in the past year. Factors associated with quit intentions were having a high income (APR=1.39; 95% CI: 1.01–1.92), having at least one quit attempt in the previous year (APR=1.41; 95% CI: 1.16–1.71), worrying that smoking will damage one’s health (APR=1.52; 95% CI: 1.05–2.20), regretting starting to smoke (agree, APR=1.25; 95% CI: 1.03–1.52; disagree, APR=0.66; 95% CI: 0.46–0.95), health concerns (APR=1.46; 95% CI: 1.17–1.82), and smoking restrictions in public places (APR=1.28; 95% CI: 1.06–1.54).
CONCLUSIONS
Only13% of adults from Spain who smoke intend to quit in the next 6 months. Factors associated with quitting were high income, at least one quit attempt in the past year, worrying about health damage from smoking, regretting starting to smoke, having health concerns, and smoking restrictions in public places. There is a need for comprehensive measures that encourage and support people to quit.
Keywords: global health, smoking cessation, quit intentions, Spain, cigarettes
INTRODUCTION
Globally, tobacco use is the leading cause of preventable disease, disability, and death. It kills 8 million people annually, including 1.3 million people who do not smoke but are exposed to secondhand smoke. In 2022, 22% of adults from Spain reported smoking; 20% smoked daily1. Based on data from the 1987 National Health Survey (ENSE) and the 2020 European Health Survey in Spain (EESE), tobacco use prevalence in Spain’s adult population has slowly decreased2. However, the smoking burden remains high, with 53800 to 69000 deaths attributable to smoking each year in Spain3. Smoking cessation remains a national priority.
The WHO Framework Convention on Tobacco Control (WHO FCTC) is an evidence-based global health treaty developed in response to the tobacco epidemic4. Spain became a Party to the WHO FCTC on 16 June 2003 and ratified the treaty on 11 January 20054. Article 14 of the WHO FCTC obligates Parties to implement effective measures to promote tobacco cessation and provide adequate treatment for tobacco dependence4. Several Spanish regions have quit lines for people seeking support to quit. Moreover, in both primary and hospital care, nicotine replacement therapy and/or some cessation services are provided5.
Increasing cessation rates among people who smoke is key to reducing smoking-related morbidity and mortality in Spain. The smoking cessation process has been explained using different behavioral theories including the Theory of Planned Behaviour (TPB)6 and the Transtheoretical Model of Change (TTM)7. Although TPB and TTM differ in their theoretical foundations and in the constructs they include, both models include intentions to quit smoking as a critically important variable, and empirical studies have confirmed this: intentions to quit smoking are known to be among the strongest predictors of future quit attempts and successful smoking cessation8. Because intentions to quit smoking are such a strong predictor of quit attempts and successful quitting, it is critically important to identify and understand the factors associated with quit intentions to provide insights into how those intentions might be strengthened to increase quit attempts as well as what factors seem to inhibit those who smoke from attempting to quit.
Past research has found that quit intentions are associated with a number of factors including sociodemographics9-12, smoking-related behavior (e.g. nicotine dependence, past quit attempts and receiving quit advice)11-15, health concerns11-15, regretting starting smoking15,16, attitudes and perceptions (e.g. beliefs about health effects of smoking and quitting)11,14, knowledge of health risks17,18, and smoking restrictions in public venues19. This study assessed the extent to which these factors predict quit intentions among adults who smoke in Spain. Although a few studies from Spain have examined factors associated with quit intentions, most of these studies have used smaller sample sizes from specific populations20-22; however, our study is nationally representative and uses standardized measures associated with quit intentions, which have been used in 30 countries participating in the ITC Project, allowing comparisons to be made across countries.
METHODS
Study design and sample
Data came from the 2021 International Tobacco Control (ITC) EUREST-PLUS Spain Wave 3 Survey, a nationally representative survey of adults who smoke (n=1006), aged ≥18 years. The ITC EUREST-PLUS Spain Wave 3 (2021) Survey is a follow-up survey of the ITC EUREST-PLUS Wave 2 Survey (2018). The Wave 3 survey was conducted from 9 June to 5 August 2021 using computer-assisted personal interviewing or a modified computer-assisted telephone interview for respondents preferring to be interviewed by telephone due to concerns about COVID-1923,24. Analysis was restricted to the adults who smoked at least monthly and answered the questions on quit intentions (n=847).
The ITC EUREST-PLUS Spain Project received ethics approval from the Research Ethics Board at the Bellvitge University Hospital in Spain (PR248/17) and the University of Waterloo in Canada (REB#41105). All respondents received information on data confidentiality, security, the potential risks, and benefits of their participation and gave consent to participate.
Measures
Dependent variable: Intentions to quit smoking
Intentions to quit was measured using the following question: ‘Are you planning to quit smoking?’. Respondents who answered ‘in the next month’, ‘in the next 6 months’, or ‘sometime in the future, beyond 6 months’ were classified as intending to quit whereas those who responded ‘not planning to quit’ were classified as not intending to quit. ‘Don't know’ responses were set to missing (n=17).
Independent variables
The sociodemographic variables used in this study were: 1) sex (male, female); 2) age at the time of the survey (18–24, 25–39, 40–54, and ≥55 years); 3) monthly household income (€) (low: <1250, moderate: 1250 to <2000, high: ≥2000, not stated); and 4) highest level of education (low: ≤ lower secondary, moderate: upper secondary to some college/university, high: completed university/postgraduate).
Smoking behaviors assessed were smoking status (non-daily, daily), any attempt to quit in the past year (yes, no), and cigarettes smoked per day (1–10, 11–20, ≥21). Nicotine dependence was measured using the Heaviness of Smoking Index (HSI 7 levels: 0=lowest level of addiction to 6=highest level of addiction), defined as the sum of the number of cigarettes smoked per day (‘0’=1–10; ‘1’=11–20; ‘2’=21–30; and ‘3’ ≥31), and time to first cigarette of the day (‘0’ >60 min, ‘1’=31–60 min, ‘2’=6–30 min, ‘3’ ≤5 min)25.
Two motivational variables were assessed. The first was worry that smoking will damage health; responses were dichotomized to ‘not at all worried’ and ‘a little/moderately/very worried’. ‘Don't know’ and ‘refused’ responses were set to missing (n=13). The second was on concern that smoking has damaged health; responses were dichotomized to ‘not at all’ and ‘just a little/a fair amount/a great deal’. ‘Don't know’ and ‘refused’ responses were set to missing (n=67).
Regret over starting to smoke was assessed by rating of agreement with the statement: ‘If you had to do it over again, you would not have started smoking’. This variable was recoded into three categories: agree (‘agree/strongly agree’), disagree (‘disagree/strongly disagree’), and neutral (‘neither agree nor disagree)’. ‘Don't know’ and ‘refused’ responses were set to missing (n=18).
Finally, reasons that led respondents to think about quitting were assessed by rating of agreement with the statement: ‘In the past 6 months, have each of the following things led you to think about quitting: 1) concern for health; 2) advice from a doctor, dentist, or other health professional to quit; and 3) smoking restrictions in public places like restaurants, cafés and pubs’. Responses to these three items were dichotomized (‘not at all’ and ‘somewhat/very much’). ‘Don't know’ and ‘refused’ responses were set to missing, i.e. ‘concern for health’ as a reason to quit (n=10), ‘advice from health professional’ (n=2), and ‘smoking restrictions’ (n=1).
A ‘wave of recruitment’ variable was constructed to represent the number of times a respondent participated in the survey to account for potential differences in individuals’ responses between those who were newly recruited compared with those who participated in one or more prior survey waves26.
Statistical analyses
Data were analyzed using SUDAAN (version 11.0.3) to account for the multistage sampling design and sampling weights. Multivariable Poisson regression models were estimated to examine associations between the independent variables and intentions to quit. Models were also used to estimate the predicted marginal probability of intending to quit, or adjusted percentages, and adjusted prevalence ratios (APR)27. The variables were adjusted for sex, age, income, and education level. Bootstrap replicate weights were used for variance estimation (500 bootstrap weights, ADJFAY=12 in SUDAAN, denominator degrees of freedom=80). Models also adjusted for the survey wave of recruitment to account for the number of times a respondent previously participated in the survey.
RESULTS
Table 1 shows the sociodemographic characteristics of the study sample. On average, these adults were aged 45 years, 50.5% male, and 10.6% had a high level of education. Table 2 presents weighted estimates for adults from Spain who smoke: 11.3% had made at least one quit attempt in the past year and less than half (45.6%) reported they intended to quit smoking at any point in the future. Only 13.0% reported intending to quit in the next 6 months.
Table 1.
Sociodemographic characteristics of a nationally representative sample of adults who smoke from the ITC EUREST-PLUS Spain Survey, Spain, 2021 (N=864)
| Characteristics | Unweighted | Weighted | ||
|---|---|---|---|---|
| n | % | % | 95 % CI | |
| Wave of recruitmenta | ||||
| Wave 1 (2016) | 311 | 36.0 | 37.0 | 32.3–42.0 |
| Wave 2 (2018) | 117 | 13.5 | 12.5 | 9.8–15.8 |
| Wave 3 (2021) | 436 | 50.5 | 50.5 | 45.5–55.5 |
| Sex | ||||
| Male | 464 | 53.7 | 50.5 | 46.9–54.1 |
| Female | 400 | 46.3 | 49.5 | 45.9–53.1 |
| Age (years) | ||||
| 18–24 | 65 | 7.5 | 8.6 | 6.8–11.0 |
| 25–39 | 246 | 28.5 | 27.6 | 24.4–31.2 |
| 40–54 | 316 | 36.6 | 31.5 | 28.1–35.1 |
| ≥55 | 237 | 27.4 | 32.2 | 28.4–36.3 |
| Income level | ||||
| Low | 186 | 21.5 | 22.4 | 18.4–27.0 |
| Moderate | 273 | 31.6 | 32.4 | 27.7–37.4 |
| High | 84 | 9.7 | 8.9 | 6.2–12.6 |
| Not stated | 321 | 37.2 | 36.4 | 30.5–42.7 |
| Education level | ||||
| Low | 430 | 49.8 | 51.6 | 47.0–56.1 |
| Moderate | 336 | 38.9 | 37.9 | 34.2–41.6 |
| High | 98 | 11.3 | 10.6 | 8.4–13.2 |
The ‘Wave of recruitment’ variable was constructed to represent the number of times a Wave 3 respondent previously participated in the survey to account for potential differences in individuals’ responses between those who were newly recruited at Wave 3 compared with those who participated in one or more prior survey waves26.
Table 2.
Smoking behaviors of a nationally representative sample of adults who smoke from the ITC EUREST-PLUS Spain Survey, Spain, 2021 (N=864)
| Smoking behavior | Unweighted n | Weighted % | 95 % CI |
|---|---|---|---|
| Smoking status | |||
| Non-daily | 37 | 4.4 | 3.1–6.1 |
| Daily | 827 | 95.6 | 93.9–96.9 |
| Any attempt to quit in the past year | |||
| No attempt | 765 | 88.7 | 86.2–90.8 |
| At least one | 99 | 11.3 | 9.2–13.8 |
| Intention to quit (binary) | |||
| Not planning to quit | 467 | 54.4 | 49.8–58.8 |
| Planning to quit | 380 | 45.6 | 41.2–50.2 |
| Intention to quit (nominal) | |||
| In the next month | 35 | 4.7 | 3.2–6.7 |
| In the next 6 months | 66 | 8.3 | 6.2–11.0 |
| Beyond 6 months | 279 | 32.7 | 28.4–37.2 |
| Not planning to quit | 467 | 54.4 | 49.8–58.8 |
| Cigarettes smoked per day | |||
| 1–10 | 432 | 49.9 | 46.5–53.4 |
| 11–20 | 373 | 42.8 | 39.2–46.4 |
| ≥21 | 59 | 7.3 | 5.8–9.0 |
| Smoking behavior | n | Mean | 95 % CI |
| Heaviness of smoking index | |||
| Overall | 864 | 2.13 | 2.02–2.24 |
| Non-daily | 37 | 0.23a | 0.08–0.39 |
| Daily | 827 | 2.22 | 2.11–2.33 |
Relative standard error >0.3 (high sampling variability), interpret with caution.
Table 3 shows the adjusted prevalence of adults who intend to quit smoking by sociodemographic characteristics, behavioral characteristics, and intentions to quit smoking. The adults who smoke with the following characteristics reported the highest percentage of quit intentions: females (48.7%), aged 25–39 years (49.4%), have high levels of income (56.0%) and education (53.2%), smoke less than daily (58.6%), reported at least one quit attempt in the past year (63.6%), worried (49.4%) or thinking that smoking has damaged their health (48.8%), regretting starting to smoke (51.7%), concerned about their health (50.7%), received quitting advice from health professionals (51.6%), and reported the presence of smoking restrictions in public places (56.1%) as reasons that would lead them to quit.
Table 3.
Association between sociodemographic and behavioral characteristics and intentions to quit smoking among a nationally representative sample of adults who smoke, ITC EUREST-PLUS Spain Survey, Spain, 2021 (N=755)
| Characteristics | Adjusted prevalence | Adjusted prevalence ratio | ||
|---|---|---|---|---|
| Adj. %b | 95% CI | APR c | 95 % CI | |
| Wave of recruitmenta | ||||
| Wave 1 (2016) | 40.5 | 33.8–47.5 | 0.73 | 0.61–0.88 |
| Wave 2 (2018) | 39.7 | 31.8–48.2 | 0.72 | 0.58–0.89 |
| Wave 3 (2021) | 55.2 | 49.4–60.8 | 1.00 | |
| Sex | ||||
| Male | 46.0 | 40.1–52.0 | 0.95 | 0.82–1.10 |
| Female | 48.7 | 42.9–54.5 | 1.00 | |
| Age (years) | ||||
| 18–24 | 45.1 | 31.9–59.1 | 0.96 | 0.70–1.31 |
| 25–39 | 49.4 | 42.1–56.8 | 1.05 | 0.86–1.28 |
| 40–54 | 46.4 | 40.3–52.5 | 0.99 | 0.82–1.19 |
| ≥55 | 47.1 | 39.8–54.4 | 1.00 | |
| Income level | ||||
| Not stated | 50.7 | 44.5–56.9 | 1.26 | 0.95–1.68 |
| High | 56.0 | 45.3–66.1 | 1.39 | 1.01–1.92 |
| Moderate | 46.4 | 40.3–52.7 | 1.15 | 0.84–1.58 |
| Low | 40.2 | 29.8–51.6 | 1.00 | |
| Education level | ||||
| High | 53.2 | 43.1–63.0 | 1.44 | 0.84–2.45 |
| Moderate | 48.1 | 41.3–55.0 | 1.12 | 0.76–1.65 |
| Low | 45.7 | 39.9–51.6 | 1.00 | |
| Smoking status | ||||
| Daily | 46.9 | 42.2–51.6 | 0.80 | 0.63–1.02 |
| Non-daily | 58.6 | 43.7–72.0 | 1.00 | |
| Any attempts to quit in the past year | ||||
| At least one | 63.6 | 53.3–72.8 | 1.41 | 1.16–1.71 |
| No attempt | 45.1 | 39.9–50.4 | 1.00 | |
| Worried smoking will damage one's health | ||||
| A little or more | 49.4 | 44.2–54.6 | 1.52 | 1.05–2.20 |
| Not at all | 32.4 | 22.3–44.5 | 1.00 | |
| Extent smoking has damaged health | ||||
| Just a little or more | 48.8 | 43.9–53.8 | 1.13 | 0.94–1.37 |
| Not at all | 43.2 | 35.2–51.5 | 1.00 | |
| Regret over starting to smoke | ||||
| Agree | 51.7 | 46.2–57.1 | 1.25 | 1.03–1.52 |
| Disagree | 27.3 | 18.9–37.8 | 0.66 | 0.46–0.95 |
| Neutral | 41.3 | 33.4–49.7 | 1.00 | |
| Reason to quit: concern for health | ||||
| Somewhat or more | 50.7 | 45.4–56.0 | 1.46 | 1.17–1.82 |
| Not at all | 34.8 | 27.4–43.0 | 1.00 | |
| Reason to quit: advice from health care professional | ||||
| Somewhat or more | 51.6 | 43.9–59.2 | 1.16 | 0.96–1.39 |
| Not at all | 44.5 | 39.0–50.2 | 1.00 | |
| Reason to quit: restrictions in public places | ||||
| Somewhat or more | 56.1 | 47.1–64.8 | 1.28 | 1.06–1.54 |
| Not at all | 43.9 | 38.7–49.2 | 1.00 | |
The ‘Wave of recruitment’ variable was constructed to represent the number of times a Wave 3 respondent previously participated in the survey to account for potential differences in individuals’ responses between those who were newly recruited at Wave 3 compared with those who participated in one or more prior survey waves26.
Adj. %: adjusted percentage, or predictive margins, from a weighted Poisson regression model examining the association between sociodemographic and behavioral characteristics and intentions to quit smoking.
APR: adjusted prevalence ratio estimated from a weighted Poisson regression model examining the association between sociodemographic and behavioral characteristics and intentions to quit smoking. Intentions to quit smoking (outcome variable): No intentions to quit smoking (0) versus Any intentions to quit smoking (1).
Several factors were associated with quit intentions, including , having high income level (adjusted prevalence ratio, APR=1.39; 95% CI:1.01–1.92), having at least one quit attempt in the past year (APR=1.41; 95% CI: 1.16–1.71), worrying that smoking will damage one’s health (APR=1.52; 95% CI: 1.05–2.20), regretting starting to smoke (agree: APR=1.25; 95% CI: 1.03–1.52 and disagree: APR=0.66; 95% CI: 0.46–0.95 compared to having a neutral opinion), being concerned about one’s health (APR=1.46; 95% CI: 1.17–1.82), and existence of smoking restrictions in public places (APR=1.28; 95% CI: 1.06–1.54).
DISCUSSION
In 2021, less than half of adults who smoke in Spain intended to quit smoking and only 13.0% planned to quit in the next 6 months. The percentage of adults who smoke and who plan to quit in the next 6 months is lower than in other high- and middle-income countries surveyed by the ITC Project, including Brazil (48% in 2017), Malaysia (31% in 2014), Canada (43% in 2018), Australia (42% in 2018), the Netherlands (36% in 2017), South Korea (32% in 2016), France (33% in 2012), the United States (33% in 2018), China (28% in 2015), and Mexico (24% in 2015), but is higher than Japan (12% in 2019) and Germany (10% in 2018)28. Moreover, only 11.3% reported making any attempt to quit in the past year. Again, this was low compared to other ITC countries: Canada (44.5% in 2018), United States (31.7% in 2018), England (28.5% in 2018), and Australia (45.2% in 2018)29.
In this study, six factors were associated with intending to quit smoking: having a high income level, reporting at least one quit attempt in the past year, worrying that smoking will damage one’s health, regretting starting to smoke, being concerned about one’s health, and the existence of smoking restrictions in public places.
The first of these factors – high income – is consistent with other studies among adults who smoke9,30 and is worthy of further comment. Having more income increases financial accessibility to a variety of cessation products beyond what the government subsidizes; this may encourage quit intentions among adults who smoke. This finding highlights the lower rates of cessation and lower quit intentions that have been reported in other countries30. There is need for policy makers in Spain to address this disparity so that those who wish to quit have access to affordable cessation products of their choice. In Spain, smoking cessation treatments have only recently been offered to people who smoke and currently only one drug is subsidized31. The low support for cessation in Spain has been noted by the Tobacco Control Scale (TCS): Spain’s score assigned to cessation treatment provision has been low; however, there has been an improvement since 2019 (score in 2019: 5/10 points; score in 2021: 8/10 points)32. Further increases in support for cessation will lead to greater increases in quit intentions among those who smoke in Spain. This will lead to greater rates of quit attempts and successful quitting, ultimately leading to public health benefits that are known to be among the most cost-effective disease prevention measures33.
The finding that quit attempts in the past year were associated with quit intentions was also consistent with previous studies11-15. This is not surprising because adults who smoke often need multiple attempts to quit34. This finding highlights the need for legislation that encourages and supports people who smoke in their attempts to quit.
The finding that worrying about tobacco-related health effects or having any health concern was associated with quit intentions is consistent with other studies11-15. Additionally, health-related motivations are likely to have increased due to the COVID-19 pandemic that was ongoing when this study was conducted. During the same time period, there were several health education campaigns and the government implemented smoking restrictions in outdoor settings35. The study results highlight the importance of educating the public regarding tobacco-related harms, for example, using regular mass media campaigns, encouraging quitting, and implementing strong health warnings.
Consistent with other studies16, regretting starting to smoke serves as a powerful emotional motivator for future behavior change. Thus, anti-smoking campaigns need to integrate approaches that not only rely on rational explanations, but also appeal to the emotions of people who smoke (e.g. depicting negative social norms towards smoking) to effectively elicit regret and induce quit intentions16.
Our findings show that smoking restrictions in public places were associated with quit intentions, which is consistent with other studies. This finding is not surprising because during the COVID-19 pandemic, Spanish health authorities extended smoking restrictions outdoors, when a safe distance could not be maintained35. This emphasizes the importance of enforcing smoking restrictions in public places. Recently, the Spanish government announced that it will introduce additional tobacco control legislation, such as smoke-free terraces in hospitality venues36. This is a window of opportunity to advance this legislation in order to protect bystanders and workers from secondhand smoke. In addition, it is an opportunity to increase quit intentions31.
Strengths and limitations
The limitations of this study include the use of cross-sectional data, which limits the ability to determine causality; and the reliance on self-reports, which can result in recall bias. Nevertheless, our results are consistent with other studies, showing similar factors that have been associated with quit intentions. Another limitation is the timing of our study, which was conducted during the COVID-19 pandemic. The government implemented several health education campaigns and smoking restrictions in outdoor settings that may have influenced the factors assessed. The two strengths of this study are the use of population-based data and standardized measures associated with quit intentions, which have been used in 30 countries participating in the ITC Project, allowing comparisons to be made across countries.
CONCLUSIONS
In 2021, only 13% of adults from Spain who smoke reported that they intended to quit in the next 6 months. Factors associated with quitting were high income, having at least one quit attempt in the past year, worrying about health damage from smoking, regretting starting to smoke, having health concerns, and smoking restrictions in public places. There is a need for comprehensive programs that consider these factors and increase support for smoking cessation efforts among adults who smoke in Spain. Additionally, the implementation of other tobacco control measures can also serve to increase intentions to quit and quit attempts, and thus cessation should be seen in the broader context of tobacco control.
Supplementary Material
Funding Statement
FUNDING The ITC EUREST PLUS Spain Survey was partially supported by grants from the Instituto de Salud Carlos III through the project PI17/01338 (Co-funded by European Regional Development Fund ERDF, a way to build Europe), and the Canadian Institute for Health Research Foundation Grant (FDN-148477). YC, EF, MF and OT are partly supported by the Ministry of Universities and Research, Government of Catalonia (2021SGR00906). Additional support is provided to GTF from a Senior Investigator Award from the Ontario Institute for Cancer Research (A1-004). YC, EF, MF, and OT acknowledge CERCA Program for institutional support to IDIBELL.
CONFLICTS OF INTEREST
The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none was reported.
ETHICAL APPROVAL AND INFORMED CONSENT
Ethical approval was obtained from the Research Ethics Board at the Bellvitge University Hospital in Spain (Approval number: PR248/17; Date: 6 September 2018) and the University of Waterloo in Canada (Approval number: REB#41105; Date: 10 December 2019). Participants provided informed consent.
DATA AVAILABILITY
The data supporting this research are available from the authors on reasonable request.
AUTHORS’ CONTRIBUTIONS
Conceptualization: SCK, MF, YC, OT, GTF and EF. Methodology: SCK, MF, PD, MY, ACK, GTF and EF. Visualization: SCK and MF. Investigation: ACKQ. Software: PD, MY and ACK. Validation: PD, MY, ACKQ and GTF. Formal analysis: PD and MY. Data curation: ACKQ and GTF. Supervision: SCK, MF, ACKQ, GTF and EF. Resources: ACKQ and GTF. Project administration: SCK, MF, ACKQ, YC, OT, GTF and EF. Funding acquisition: MF, GTF and EF. Writing of original draft: SCK and EF. Writing, reviewing and editing of the manuscript: All authors. Read and approved the final version of the manuscript: All authors.
PROVENANCE AND PEER REVIEW
Not commissioned; externally peer-reviewed.
DISCLAIMER
P. Driezen, Editorial Board member of the journal, had no involvement in the peer-review or acceptance of this article and had no access to information regarding its peer-review. Full responsibility for the editorial process for this article was delegated to a handling editor of the journal.
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Data Availability Statement
The data supporting this research are available from the authors on reasonable request.