Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

[Preprint]. 2024 Nov 7:2024.11.07.622521. [Version 1] doi: 10.1101/2024.11.07.622521

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This work is licensed under a Creative Commons Attribution 4.0 International License, which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.

PMC Copyright notice

Figure 4. — (A) 30mer DNA sequences with short 3’ (3DSB) and 5’ overhangs (5DSB) used for modeling LIG1 mediated ligation. (B) Conformational ensemble of LIG1 with 5DSB, illustrating suboptimal DNA positioning with a protruding end and reduced contact area with the enzymatic site. (C) Conformational ensemble of LIG1 with 3DSB, demonstrating optimal DNA positioning centrally within the catalytic site, facilitating efficient catalysis. (D) Structural representation of the LIG3b-5DSB complex, showing the DNA enveloped in the central cavity of LIG3b. (E) Structural representation of the LIG3b-3DSB complex, with a large protruding end stabilized by the N-terminal zinc finger domain of LIG3b.