Figure 5. Glutamate and LDCVs from CGRPPBel neurons are required to mediate positive and negative emotional responses, respectively.
(A) Time spent in the paired chamber induced by 4 Hz and 40 Hz photostimulation in mCherry injected mice, (N = 6).
(B) Time spent in the paired chamber induced by 4 Hz and 40 Hz photostimulation in NEP injected mice, (N = 7).
(C) Light-induced change in time spent in the paired chamber induced by 4 Hz or 40 Hz photostimulation.
(D) Heatmaps showing the changes in movement speed (cm/s) after the onset of 4 Hz (continuous) and 40 Hz (phasic) photostimulation in mCherry (top), NEP (middle) and sgSlc17A6 (bottom) injected mice.
(E) Percentage time spent freezing in chamber paired with 4 Hz photostimulation.
(F) Number of flight bouts as a percentage of entries.
****P < 0.0001, **P < 0.01, *P < 0.05. Data are presented as mean ± s.e.m.