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. 1982 Feb 15;202(2):551–553. doi: 10.1042/bj2020551

Evidence that poly(ADP-ribose) polymerase is involved in the loss of NAD from cultured rat liver cells.

A J Paine, C M Allen, B W Durkacz, S Shall
PMCID: PMC1158142  PMID: 6284133

Abstract

Rat hepatocytes cultured from 24h lose 60% of their NAD content. By using the differential response to inhibitors of the two major enzymes that catabolize NAD in mammalian cells, it is shown that poly(ADP-ribose) polymerase is responsible for the loss of NAD. The relevance of this observation to the use of cultured hepatocytes for the study of DNA repair induced by carcinogens is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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