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. 1982 Apr 15;204(1):301–305. doi: 10.1042/bj2040301

Human gamma-melanotropin precursor potentiates corticotropin-induced adrenal steroidogenesis by stimulating mRNA synthesis.

E A Al-Dujaili, B C Williams, C R Edwards, P Salacinski, P J Lowry
PMCID: PMC1158345  PMID: 6288016

Abstract

Circulating human gamma-melanotropin precursor (76 amino acids) [N-POC(1-76) enhances the corticosterone and aldosterone response to corticotropin by isolated perfused rat adrenal cells [Al-Dujaili, Hope, Estivariz, Lowry & Edwards (1981) Nature (London) 291, 156-159]. Actinomycin D (4 x 10(-6) mol/litre) did not significantly affect corticotropin-induced corticosterone or aldosterone outputs, but completely inhibited the potentiating action of gamma-melanotropin precursor on rat adrenal cells. This suggests that the precursor enhances corticotropin-induced steroidogenesis via an increase in available mRNA produced from DNA transcription.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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