Table 2.
Summary table of characteristics when UWB-OlaJR rechallenges with different PARPis.
| UWB-OlaJR | Olaparib | Veliparib | Talazoparib | Rucaparib | Niraparib |
|---|---|---|---|---|---|
| Sensitivity | + | + | ++ | +++ | +++ |
| DSB induction | ↑ | ↑ | ↑ | ↑ | ↑↑ |
| RAD51 foci formation | + | + | + | + | ++ |
| RF speed | ↓ | ↓ | ↓↓ | ↓↓↓ | ↓↓↓ |
| RF protection | - | - | - | - | - |
| SSB induction | - | - | - | ↑↑ | ↑↑↑ |
| RPA1 foci | - | - | - | ↑↑ | ↑↑↑ |
+, ++, +++: increasing levels of the indicated phenotype (e.g., sensitivity); -: no effect on the indicated phenotype; ↑: increasing levels of induction of the indicated phenotype; ↓: increasing levels of reduction in the indicated phenotype.