Abstract
1. To investigate the effect of the female reproductive hormones on muscle function, patients undergoing in vitro fertilization were tested during two phases of treatment. The first was following the downregulation of pituitary gonadotrophin releasing hormone (GnRH) receptors and the second after 9 days of gonadotrophin injections. 2. Maximal strength and fatiguability of the first dorsal interosseus muscle were assessed when oestrogen and progesterone were low, and less than 2 weeks later when oestrogen production reached supraphysiological levels. 3. There were no significant changes in either strength or fatigue resistance during acute, massive fluctuations in oestrogen. These results occurred at a time when progesterone levels remained relatively low. 4. Contrary to previous work, the present results suggest that oestrogen does not affect muscle strength.
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- Bruce S. A., Newton D., Woledge R. C. Effect of age on voluntary force and cross-sectional area of human adductor pollicis muscle. Q J Exp Physiol. 1989 May;74(3):359–362. doi: 10.1113/expphysiol.1989.sp003278. [DOI] [PubMed] [Google Scholar]
- Burke R. E., Levine D. N., Tsairis P., Zajac F. E., 3rd Physiological types and histochemical profiles in motor units of the cat gastrocnemius. J Physiol. 1973 Nov;234(3):723–748. doi: 10.1113/jphysiol.1973.sp010369. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Harada T., Yoshida S., Katagiri C., Takao N., Ikenari T., Toda T., Mio Y., Terakawa N. Reduced implantation rate associated with a subtle rise in serum progesterone concentration during the follicular phase of cycles stimulated with a combination of a gonadotrophin-releasing hormone agonist and gonadotrophin. Hum Reprod. 1995 May;10(5):1060–1064. doi: 10.1093/oxfordjournals.humrep.a136094. [DOI] [PubMed] [Google Scholar]
- Phillips S. K., Rook K. M., Siddle N. C., Bruce S. A., Woledge R. C. Muscle weakness in women occurs at an earlier age than in men, but strength is preserved by hormone replacement therapy. Clin Sci (Lond) 1993 Jan;84(1):95–98. doi: 10.1042/cs0840095. [DOI] [PubMed] [Google Scholar]
- Rutherford O. M., Jones D. A. Contractile properties and fatiguability of the human adductor pollicis and first dorsal interosseus: a comparison of the effects of two chronic stimulation patterns. J Neurol Sci. 1988 Jul;85(3):319–331. doi: 10.1016/0022-510x(88)90190-6. [DOI] [PubMed] [Google Scholar]
- Rutherford O. M., Jones D. A. The relationship of muscle and bone loss and activity levels with age in women. Age Ageing. 1992 Jul;21(4):286–293. doi: 10.1093/ageing/21.4.286. [DOI] [PubMed] [Google Scholar]
- Santolaya-Forgas J., Ramakrishnan V., Scommegna A. The menstrual cycle: relations of biophysical and hormonal determinations in normal women of reproductive age. Fertil Steril. 1992 Dec;58(6):1230–1233. doi: 10.1016/s0015-0282(16)55574-5. [DOI] [PubMed] [Google Scholar]
- Sarwar R., Niclos B. B., Rutherford O. M. Changes in muscle strength, relaxation rate and fatiguability during the human menstrual cycle. J Physiol. 1996 May 15;493(Pt 1):267–272. doi: 10.1113/jphysiol.1996.sp021381. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tanaka M., McDonagh M. J., Davies C. T. A comparison of the mechanical properties of the first dorsal interosseous in the dominant and non-dominant hand. Eur J Appl Physiol Occup Physiol. 1984;53(1):17–20. doi: 10.1007/BF00964683. [DOI] [PubMed] [Google Scholar]
- Toner J. P. The significance of elevated FSH for reproductive function. Baillieres Clin Obstet Gynaecol. 1993 Jun;7(2):283–295. doi: 10.1016/s0950-3552(05)80131-2. [DOI] [PubMed] [Google Scholar]