Table 3.
GAS master regulators and associated non-synonymous mutations of the 17 clinical GAS isolates analysed in this study.
| Isolate | covR | covS | rocA | ropB | ||||
|---|---|---|---|---|---|---|---|---|
| Carriage | Mutation | Carriage | Mutation | Carriage | Mutation | Carriage | Mutation | |
| SP1492 | + | − | + | − | + | − | + | − |
| SP1493 | + | − | + | − | + | − | + | − |
| SP1494 | + | − | + | truncation | + | − | + | T104I a |
| SP1495 | + | − | + | − | + | insertion | + | − |
| SP1496 | + | − | + | − | + | insertion | + | − |
| SP1497 | + | − | + | − | + | − | + | − |
| SP1498 | + | − | + | − | + | − | + | − |
| SP1499 | + | − | + | − | + | insertion | + | − |
| SP1500 | + | − | + | − | + | − | + | − |
| SP1501 | + | − | + | − | + | − | + | − |
| SP1502 | + | − | + | − | + | − | + | − |
| SP1503 | + | − | + | − | + | − | + | − |
| SP1504 | + | − | + | − | + | − | + | − |
| SP1505 | + | − | + | − | + | − | + | − |
| SP1506 | + | − | + | − | + | − | + | − |
| SP1507 | + | − | + | insertion | + | − | + | − |
| SP1508 | + | − | + | truncation | + | − | + | − |
GAS, Group A Streptococcus; +, gene detected; −, mutation not detected. a Threonine substituted for isoleucine at position 104 of the amino acid sequence.