Table 1.

Half-life times of oligonucleotides in the presence of 50% fetal bovine serum.

Oligonucleotide	Modification	Half-Life Time (τ½)
agtctcgacttgctacc	deoxy/PO	10 min
aSgStScStScSgSaScStStSgScStSaScSc	deoxy/PS	10 h
a*g*t*c*t*c*g*a*c*t*t*g*c*t*a*c*c	deoxy/PG	>21 days
AGUCUCGACUUGCUACC	2′-OMe/PO	70 min
ASGSUSCSUSCSGSASCSUSUSGSCSUSASCSC	2′-OMe/PS	>24 h
A*G*U*C*U*C*G*A*C*U*U*G*C*U*A*C*C	2′-OMe/PG	>21 days