In Table 1, the Echochardiographic values of LVIDs should not have been a duplicate of what is in LVIDd to both Sham and TAC groups. Please see the correct Table 1 here. Please see the correct Table 1 here.
Table 1. Echocardiography and pathology of mice treated with and without dh404 for 4 wks after TAC.
| Dh404 (mg/kg/d) | |||||
|---|---|---|---|---|---|
| 0 | 5 | 10 | 20 | ||
| Sham | Echocardiography (n) | 10 | 4 | 7 | 4 |
| IVSd (mm) | 0.77 ± 0.04 | 0.74 ± 0.05 | 0.84 ± 0.05 | 0.83 ± 0.03 | |
| LVIDd (mm) | 4.06 ± 0. 13 | 4.14 ± 0.13 | 3.96 ± 0.22 | 3.93 ± 0.23 | |
| LVIDs (mm) | 3.18 ± 0.15 | 3.21 ± 0.21 | 3.04 ± 0.24 | 3.17 ± 0.21 | |
| LVPWd (mm) | 0.69 ± 0.03 | 0.64 ± 0.02 | 0.68 ± 0.02 | 0.65 ± 0.05 | |
| FS (%) | 21.81 ± 1.78 | 22.53 ± 3.20 | 24.03 ± 2.01 | 19.35 ± 2.00 | |
| Pathology (n) | 8 | 4 | 6 | 3 | |
| BW (g) | 25.43 ± 0.79 | 26.05 ± 1.46 | 25.53 ± 1.10 | 25.03 ± 0.50 | |
| HW/Tibia-L (g/cm) | 7.52 ± 0.29 | 7.61 ± 0.53 | 7.40 ± 0.34 | 7.02 ± 0.17 | |
| LW/Tibia-L (g/cm) | 10.61 ± 0.29 | 10.21 ± 0.84 | 11.03 ± 0.23 | 8.96 ± 0.82 | |
| TAC | Echocardiography (n) | 16 | 5 | 13 | 8 |
| IVSd (mm) | 1.14 ± 0.04a | 0.91 ± 0.06a,b | 0.99 ± 0.03a,b | 0.94 ± 0.05a,b | |
| LVIDd (mm) | 5.11 ± 0.14a | 4.73 ± 0.17a,b | 4.73 ± 0.11a,b | 4.71 ± 0.17a,b | |
| LVIDs (mm) | 4.76 ± 0.16a | 3.36 ± 0.22a,b | 4.25 ± 0.12a,b | 4.01 ± 0.18a,b | |
| LVPWd (mm) | 1.08 ± 0.04a | 0.92 ± 0.06a,b | 0.90 ± 0.03a,b | 0.90 ± 0.08a,b | |
| FS (%) | 7.02 ± 1.10a | 7.88 ± 1.40a,b | 10.42 ± 0.94a,b,c | 14.77 ± 1.97a,b,c,d | |
| Pathology (n) | 16 | 5 | 13 | 8 | |
| BW (g) | 22.85 ± 0.73a | 23.56 ± 0.80a | 22.34 ± 0.67a | 20.65 ± 0.97a | |
| HW/Tibia-L (g/cm) | 15.54 ± 0.48a | 12.23 ± 0.65a,b | 11.68 ± 0.42a,b | 11.56 ± 0.37a,b | |
| LW/Tibia-L (g/cm) | 26.55 ± 2.23a | 15.79 ± 4.30a,b | 17.23 ± 1.21a,b | 21.17 ± 2.76a,b | |
Two dimensional echocardiography-guided M-mode echocardiography and pathology were performed 4 weeks after the initiation of TAC or sham surgery in C57BL/6J mice treated with vehicle or dh404 as indicated.
Abbreviations: IVSd, interventricular septal thickness at end-diastole; LVIDd, left ventricular internal dimension at end-diastole; LVIDs, left ventricular internal dimension at end-diastole; LVPWd, left ventricular posterior wall thickness at end-diastole; FS, fractional shortening; BW, body weight; HW/Tibia L, heart weight/tibia length ratio; LW/Tibia-L, lung weight/tibia length ratio.
ap<0.05 vs sham (0);
bp<0.05 vs TAC (0);
cp<0.05 vs TAC + dh404 (5 mg/kg/d);
dp<0.05 vs TAC + dh404 (10 mg/kg/d)
Reference
- 1.Xing Y, Niu T, Wang W, Li J, Li S, Janicki JS, et al. (2012) Triterpenoid Dihydro-CDDO-Trifluoroethyl Amide Protects against Maladaptive Cardiac Remodeling and Dysfunction in Mice: A Critical Role of Nrf2. PLOS ONE 7(9): e44899. 10.1371/journal.pone.0044899 [DOI] [PMC free article] [PubMed] [Google Scholar]