Table 3.

Secondary analysis regression estimates

Model term	Consistent	Random	Random f. residuals
AV45	0.2326 [0.1468,0.2576]	0.2167 [0.2146,0.2188]	0.2358 [0.2317,0.2396]
CSF tau	0.2014 [0.0967,0.2799]	0.1853 [0.1831,0.1874]	0.2051 [0.2011,0.2094]
HippoV	−0.6360 [−0.6735, −0.4790]	−0.6107 [−0.6144, −0.6065]	−0.6053 [−0.6094, −0.6015]
AV45∗HippoV	−0.1168 [−0.1442, −0.0115]	−0.2272 [−0.2303, −0.2244]	−0.1222 [−0.1280, −0.1167]
CSF tau∗HippoV	−0.1315 [−0.1667, −0.0033]	−0.1953 [−0.1987, −0.1921]	−0.1394 [−0.1446, 0.1339]

This table summarizes standardized regression coefficient estimates, average, and 95% confidence interval, on the simulated data from the mathematical model that had an added cognitive reserve component. Consistent, data points were sampled cross-sectionally from one corresponding time point after baseline from each individual trajectory (consistently across trajectories). Random, data points were sampled from a random time point cross-sectionally from each individual trajectory. Random f. residuals, as in random sampling but with the variance associated with time after baseline removed from main effect variables. AV45, florbetapir amyloid-PET summary score; CSF tau, corticospinal fluid total tau; HippoV, hippocampal volume.