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. 1979 Sep 15;182(3):881–884. doi: 10.1042/bj1820881

Stimulation by secretin of bilirubin UDP-glycosyltransferase activities and of cytochrome P-450 concentration in rat liver.

G L Ricci, J Fevery
PMCID: PMC1161424  PMID: 117800

Abstract

The activity of bilirubin UDP-glucuronyltransferase in liver tissue was increased 1.5-fold after 90 min of secretion administration (4 i.u./h per kg body wt.) in anaesthetized Wistar rats biopsied half-hourly over a period of 2 h. In unanaesthetized R/A Wistar rats, activities of liver enzymes were assayed after administration secretin for 1 h. Bilirubin UDP-glycosyltransferase activities and cytochrome P-450 concentration were increased, but p-nitrophenol UDP-glucuronyltransferase and UDP-glucose dehydrogenase activities remained unchanged.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Austin G. L., Johnson S. M., Shires S. M., 3rd, Jones R. S. The effect of feeding on the bile salt-independent canalicular secretion in dogs. Am J Surg. 1978 Jan;135(1):36–39. doi: 10.1016/0002-9610(78)90006-5. [DOI] [PubMed] [Google Scholar]
  2. Bataille D., Freychet P., Rosselin G. Interactions of glucagon, gut glucagon, vasoactive intestinal polypeptide and secretin with liver and fat cell plasma membranes: binding to specific sites and stimulation of adenylate cyclase. Endocrinology. 1974 Sep;95(3):713–721. doi: 10.1210/endo-95-3-713. [DOI] [PubMed] [Google Scholar]
  3. Constantopoulos A., Matsaniotis N. Augmentation of uridine diphosphate glucuronyltransferase activity in rat liver by adenosine 3',5'-monophosphate. Gastroenterology. 1978 Sep;75(3):486–491. [PubMed] [Google Scholar]
  4. Cooper B., Eakins M. N., Slater T. F. The effect of various anaesthetic techniques on the flow rate, constituents and enzymic composition of rat bile. Biochem Pharmacol. 1976 Aug 1;25(15):1711–1718. doi: 10.1016/0006-2952(76)90403-2. [DOI] [PubMed] [Google Scholar]
  5. Curtis P. J., Fender H. R., Rayford P. L., Thompson J. C. Catabolism of secretin by the liver and kidney. Surgery. 1976 Aug;80(2):259–265. [PubMed] [Google Scholar]
  6. DEBRAY C., VAILLE C., DE LA TOUR J., ROZE C., SOUCHARD M. [Action of commercial secretins on the external pancreatic secretion in the rat]. J Physiol (Paris) 1962;54:549–577. [PubMed] [Google Scholar]
  7. Fevery J., Leroy P., Heirwegh K. P. Enzymic transfer of glucose and xylose from uridine diphosphate glucose and uridine diphosphate xylose to bilirubin by untreated and digitonin-activated preparations from rat liver. Biochem J. 1972 Sep;129(3):619–633. doi: 10.1042/bj1290619. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Forker E. L., Hicklin T., Sornson H. The clearance of mannitol and erythritol in rat bile. Proc Soc Exp Biol Med. 1967 Oct;126(1):115–119. doi: 10.3181/00379727-126-32380. [DOI] [PubMed] [Google Scholar]
  9. Forker E. L. Mechanisms of hepatic bile formation. Annu Rev Physiol. 1977;39:323–347. doi: 10.1146/annurev.ph.39.030177.001543. [DOI] [PubMed] [Google Scholar]
  10. Gainey P. A., Phelps C. F. Uridine diphosphate glucuronic acid production and utilization in various tissues actively synthesizing glycosaminoglycans. Biochem J. 1972 Jun;128(2):215–227. doi: 10.1042/bj1280215. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. HACKI W. H., Bloom S. R., Mitznegg P., Domschke W., Domschke S., Belohlavek D., Demling L., Wünsch E. Plasma secretin and pancreatic bicarbonate response to exogenous secretin in man. Gut. 1977 Mar;18(3):191–195. doi: 10.1136/gut.18.3.191. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Heirwegh K. P., Van de Vijver M., Fevery J. Assay and properties of dititonin-activated bilirubin uridine diphosphate glucuronyltransferase from rat liver. Biochem J. 1972 Sep;129(3):605–618. doi: 10.1042/bj1290605. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Johnson L. R. Gastrointestinal hormones and their functions. Annu Rev Physiol. 1977;39:135–158. doi: 10.1146/annurev.ph.39.030177.001031. [DOI] [PubMed] [Google Scholar]
  14. Merle L., Dangoumau J., Balabaud C. Effect of food and light schedule on bile flow in the rat. Experientia. 1978 Jun 15;34(6):764–765. doi: 10.1007/BF01947312. [DOI] [PubMed] [Google Scholar]
  15. Mulder G. J. The effect of phenobarbital on the submicrosomal distribution of uridine diphosphate glucuronyltransferase from rat liver. Biochem J. 1970 Apr;117(2):319–324. doi: 10.1042/bj1170319. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. O'Máille E. R., Richards T. G., Short A. H. Factors determining the maximal rate of organic anion secretion by the liver and further evidence on the hepatic site of action of the hormone secretin. J Physiol. 1966 Oct;186(2):424–438. doi: 10.1113/jphysiol.1966.sp008044. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. OMURA T., SATO R. THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE. J Biol Chem. 1964 Jul;239:2370–2378. [PubMed] [Google Scholar]
  18. Shima K., Kurokawa M., Sawazaki N., Tanaka R., Kumahara Y. Effect of secretin on plasma insulin and glucagon in man. Endocrinol Jpn. 1978 Oct;25(5):461–465. doi: 10.1507/endocrj1954.25.461. [DOI] [PubMed] [Google Scholar]
  19. Strasberg S. M., Siminovitch K. A., Ilson R. G. Bile production in fasted and fed primates. Ann Surg. 1974 Sep;180(3):356–363. doi: 10.1097/00000658-197409000-00017. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Wheeler H. O., Mancusi-Ungaro P. L. Role of bile ducts during secretin choleresis in dogs. Am J Physiol. 1966 May;210(5):1153–1159. doi: 10.1152/ajplegacy.1966.210.5.1153. [DOI] [PubMed] [Google Scholar]
  21. Wishart G. J. Functional heterogeneity of UDP-glucuronosyltransferase as indicated by its differential development and inducibility by glucocorticoids. Demonstration of two groups within the enzyme's activity towards twelve substrates. Biochem J. 1978 Aug 15;174(2):485–489. doi: 10.1042/bj1740485. [DOI] [PMC free article] [PubMed] [Google Scholar]

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