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. 1980 Feb 15;186(2):475–481. doi: 10.1042/bj1860475

5,6-epoxyretinoic acid is a physiological metabolite of retinoic acid in the rat.

A M McCormick, J L Napoli, S Yoshizawa, H F DeLuca
PMCID: PMC1161599  PMID: 7378063

Abstract

5,6-Epoxyretinoic acid was detected in small intestine, kidney, liver, testes and serum of vitamin A-deficient rats 3 h after a single physiological dose of [3H]retinoic acid. The maximum concentration of 5,6-epoxide in intestinal mucosa was observed 3 h after intrajugular administration of retinoic acid. However, at 7 h post administration, no 5,6-epoxyretinoic acid was detected in mucosa, demonstrating the rapid intestinal metabolism or excretion of this metabolite. No 5,6-epoxy[3H]retinoic acid was detected in mucosa, liver or serum of retinoic acid-repleted rats 3 h after administration of 2 micrograms of [3H]retinoic acid.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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