Skip to main content
Biochemical Journal logoLink to Biochemical Journal
. 1979 Oct 15;184(1):177–180. doi: 10.1042/bj1840177

A cartilage catabolic factor from synovium.

J T Dingle, J Saklatvala, R Hembry, J Tyler, H B Fell, R Jubb
PMCID: PMC1161690  PMID: 534517

Abstract

Porcine synovium in organ culture produces a factor that causes chondrocytes to degrade their matrix. A quantitative assay for the factor, for which the cartilage of bovine nasal septum is used, is described. Evidence is presented that the catabolic factor is a protein.

Full text

PDF
177

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barrett A. J. Chicken alpha2-proteinase inhibitor: a serum protein homologous with ovoinhibitor of egg white. Biochim Biophys Acta. 1974 Nov 5;371(1):52–62. doi: 10.1016/0005-2795(74)90154-8. [DOI] [PubMed] [Google Scholar]
  2. Dingle J. T. Heberden oration 1978. Recent studies on the control of joint damage: the contribution of the Strangeways Research Laboratory. Ann Rheum Dis. 1979 Jun;38(3):201–214. doi: 10.1136/ard.38.3.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dingle J. T., Horsfield P., Fell H. B., Barratt M. E. Breakdown of proteoglycan and collagen induced in pig articular cartilage in organ culture. Ann Rheum Dis. 1975 Aug;34(4):303–311. doi: 10.1136/ard.34.4.303. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Fell H. B., Jubb R. W. The effect of synovial tissue on the breakdown of articular cartilage in organ culture. Arthritis Rheum. 1977 Sep-Oct;20(7):1359–1371. doi: 10.1002/art.1780200710. [DOI] [PubMed] [Google Scholar]
  5. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  6. Vogt M., Dulbecco R. VIRUS-CELL INTERACTION WITH A TUMOR-PRODUCING VIRUS. Proc Natl Acad Sci U S A. 1960 Mar;46(3):365–370. doi: 10.1073/pnas.46.3.365. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES