Figure 1.

The WRC is a candidate BOC-interacting partner

(A) Network cluster analysis using STRING of the 125 high-confidence proteins identified in the BOC BioID screen. Physical subnetworks are shown with the lines indicating that the proteins are part of a physical complex and line thickness indicating the strength of data support. Disconnected nodes were hidden, i.e., only proteins forming a complex with at least one other protein found in the BioID screen are shown. Protein subunits of the WRC are colored in yellow.

(B) List of enriched network clusters (STRING), sorted by cluster strength. Cluster strength: Log10(observed/expected). This measure describes how large the enrichment effect is. It is the ratio between (i) the number of proteins in the network that are annotated with a term and (ii) the number of proteins that are expected to be annotated with this term in a random network of the same size. False discovery rate describes how significant the enrichment is. Shown are p values corrected for multiple testing within each category using the Benjamini–Hochberg procedure.

(C) The five components of the WRC.