Abstract
In lactating rats fed on a cafeteria diet (chow plus palatable high-energy foods) the decreased glucose uptake and lipogenesis in vitro in acini correlated with the depressed mammary-gland lipogenesis in vivo. Insulin in vitro restored the rate of glucose uptake and its conversion to lipid to values approaching those for acini from rats fed on the chow diet alone.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Agius L., Robinson A. M., Girard J. R., Williamson D. H. Alterations in the rate of lipogenesis in vivo in maternal liver and adipose tissue on premature weaning of lactating rats: a possible regulatory role of prolactin. Biochem J. 1979 Jun 15;180(3):689–692. doi: 10.1042/bj1800689. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Beck-Nielsen H., Pedersen O., Sørensen N. S. Effects of diet on the cellular insulin binding and the insulin sensitivity in young healthy subjects. Diabetologia. 1978 Oct;15(4):289–296. doi: 10.1007/BF02573821. [DOI] [PubMed] [Google Scholar]
- Coniglio J. G., Bridges R. The effect of dietary fat on fatty acid synthesis in cell-free preparations of lactating mammary gland. Lipids. 1966 Jan;1(1):76–80. doi: 10.1007/BF02668127. [DOI] [PubMed] [Google Scholar]
- Farid M., Baldwin R. L., Yang Y. T., Osborne E., Grichting G. Effects of age, diet and lactation on lipogenesis in rat adipose, liver and mammary tissues. J Nutr. 1978 Mar;108(3):514–524. doi: 10.1093/jn/108.3.514. [DOI] [PubMed] [Google Scholar]
- GARTON G. A. THE COMPOSITION AND BIOSYNTHESIS OF MILK LIPIDS. J Lipid Res. 1963 Jul;4:237–254. [PubMed] [Google Scholar]
- HOHORST H. J., KREUTZ F. H., BUECHER T. [On the metabolite content and the metabolite concentration in the liver of the rat]. Biochem Z. 1959;332:18–46. [PubMed] [Google Scholar]
- Lavau M., Fried S. K., Susini C., Freychet P. Mechanism of insulin resistance in adipocytes of rats fed a high-fat diet. J Lipid Res. 1979 Jan;20(1):8–16. [PubMed] [Google Scholar]
- Robinson A. M., Girard J. R., Williamson D. H. Evidence for a role of insulin in the regulation of lipogenesis in lactating rat mammary gland. Measurements of lipogenesis in vivo and plasma hormone concentrations in response to starvation and refeeding. Biochem J. 1978 Oct 15;176(1):343–346. doi: 10.1042/bj1760343. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Robinson A. M., Williamson D. H. Comparison of glucose metabolism in the lactating mammary gland of the rat in vivo and in vitro. Effects of starvation, prolactin or insulin deficiency. Biochem J. 1977 Apr 15;164(1):153–159. doi: 10.1042/bj1640153. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Robinson A. M., Williamson D. H. Control of glucose metabolism in isolated acini of the lactating mammary gland of the rat. The ability of glycerol to mimic some of the effects of insulin. Biochem J. 1977 Dec 15;168(3):465–474. doi: 10.1042/bj1680465. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Romsos D. R., Muiruri K. L., Lin P. Y., Leveille G. A. Influence of dietary fat, fasting, and acute premature weaning on in vivo rates of fatty acid synthesis in lactating mice. Proc Soc Exp Biol Med. 1978 Nov;159(2):308–312. doi: 10.3181/00379727-159-40338. [DOI] [PubMed] [Google Scholar]
- Sclafani A., Springer D. Dietary obesity in adult rats: similarities to hypothalamic and human obesity syndromes. Physiol Behav. 1976 Sep;17(3):461–471. doi: 10.1016/0031-9384(76)90109-8. [DOI] [PubMed] [Google Scholar]
- Smith S., Gagné H. T., Pitelka D. R., Abraham S. The effect of dietary fat on lipogenesis in mammary gland and liver from lactating and virgin mice. Biochem J. 1969 Dec;115(4):807–815. doi: 10.1042/bj1150807. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stansbie D., Brownsey R. W., Crettaz M., Denton R. M. Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats. Biochem J. 1976 Nov 15;160(2):413–416. doi: 10.1042/bj1600413. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stansbie D., Denton R. M., Bridges B. J., Pask H. T., Randle P. J. Regulation of pyruvate dehydrogenase and pyruvate dehydrogenase phosphate phosphatase activity in rat epididymal fat-pads. Effects of starvation, alloxan-diabetes and high-fat diet. Biochem J. 1976 Jan 15;154(1):225–236. doi: 10.1042/bj1540225. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wigand J. P., Anderson J. H., Jr, Jennings S. S., Blackard W. G. Effect of dietary composition on insulin receptors in normal subjects. Am J Clin Nutr. 1979 Jan;32(1):6–9. doi: 10.1093/ajcn/32.1.6. [DOI] [PubMed] [Google Scholar]
- Wilde C. J., Kuhn N. J. Lactose synthesis in the rat, and the effects of litter size and malnutrition. Biochem J. 1979 Aug 15;182(2):287–294. doi: 10.1042/bj1820287. [DOI] [PMC free article] [PubMed] [Google Scholar]