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. 2024 Nov 21;78:102958. doi: 10.1016/j.eclinm.2024.102958

Burden of disease attributable to high body mass index: an analysis of data from the Global Burden of Disease Study 2021

Xiao-Dong Zhou a,bk, Qin-Fen Chen b,bk, Wah Yang c, Mauricio Zuluaga d, Giovanni Targher e,f, Christopher D Byrne g, Luca Valenti h,i, Fei Luo j, Christos S Katsouras k, Omar Thaher l, Anoop Misra m, Karim Ataya n, Rodolfo J Oviedo o, Alice Pik-Shan Kong p,q, Khalid Alswat r, Amedeo Lonardo s, Yu Jun Wong t,u, Adam Abu-Abeid v, Hazem Al Momani w, Arshad Ali x, Gabriel Alejandro Molina y, Olivia Szepietowski z, Nozim Adxamovich Jumaev aa, Mehmet Celal Kızılkaya ab, Octavio Viveiros ac, Carlos Jesus Toro-Huamanchumo ad,ae,af, Kenneth Yuh Yen Kok ag, Oral Ospanov ah, Syed Imran Abbas ai, Andrew Gerard Robertson aj, Yasser Fouad ak, Christos S Mantzoros al,bj, Huijie Zhang am, Nahum Méndez-Sánchez an, Silvia Sookoian ao,ap,aq, Wah-Kheong Chan ar, Sombat Treeprasertsuk as, Leon Adams at,au, Ponsiano Ocama av, John D Ryan aw, Nilanka Perera ax, Ala I Sharara ay, Said A Al-Busafi az, Christopher Kenneth Opio ba, Manuel Garcia bb, Michelle Ching Lim-Loo bc, Elena Ruiz-Úcar bd, Arun Prasad be, Anna Casajoana bf, Tamer N Abdelbaki bg, Ming-Hua Zheng bh,bi,
PMCID: PMC11617770  PMID: 39640937

Correction to Figure 4 Caption

In the original paper, the caption for Figure 4A mistakenly labels “DALYs” (Disability-Adjusted Life Years) when it should read “deaths.” This error was due to a typographical oversight. The corrected title is as follows: Figure 4: (A) Age-standardized death rates attributable to high BMI in 2021; (B) Age-standardized DALY rates attributable to high BMI in 2021.

Correction to Table 1

In the original paper, Table 1 contains misaligned age-standardized death values for causes of death compared to the Global Burden of Disease (GBD) study. This error was caused by a shift in data rows, resulting in incorrect automatic entries where values intended for Age-standardized DALYs (e.g., 0.36) were mistakenly populated in the Age-standardized death column. Consequently, values such as 0.36, 1.36, 2.36, 3.36, and so forth were incorrectly filled into the age-standardized death data. A corrected version of Table 1 is attached for reference, with all values realigned to accurately reflect the original GBD data.

Table 1.

Deaths and age-standardized death rates of high BMI in 1990 and 2021 and the temporal trend of age-standardized death rates from 1990 to 2021.

1990
2021
Relative change in age-standardized death rate, 1990–2021 (95% CI)
No. death cases (95% UI) Age-standardized death rates per 100,000 (95% UI) No. death cases (95% UI) Age-standardized death rates per 100,000 (95% UI)
Global 1,459,533 (723,043–2,287,052) 40.90 (19.87–64.16) 3,709,063 (1,847,840–5,658,334) 44.23 (22.01–67.64) 0.08 (0.01–0.15)
Sex
 Female 828,147 (407,103–1,302,480) 41.57 (20.18–65.25) 2,013,089 (979,000–3,076,045) 43.26 (21.08–66.05) 0.04 (−0.03 to 0.12)
 Male 631,386 (315,453–988,214) 39.03 (19.35–60.80) 1,695,974 (861,972–2,635,343) 44.90 (23.01–70.17) 0.15 (0.06–0.23)
SDI
 Low SDI 70,040 (42,195–110,220) 32.89 (20.11–51.01) 204,362 (114,078–318,520) 43.22 (24.93–66.40) 0.31 (0.14–0.50)
 Low-middle SDI 177,919 (100,108–281,095) 31.91 (18.22–49.61) 671,617 (349,426–1,011,204) 49.59 (26.29–74.99) 0.55 (0.35–0.74)
 Middle SDI 306,277 (185,062–452,734) 33.78 (20.37–50.30) 1,126,388 (581,131–1,700,642) 44.80 (23.60–67.57) 0.33 (0.10–0.46)
 High-middle SDI 430,095 (194,645–685,431) 48.62 (22.28–77.66) 904,396 (417,515–1,428,690) 46.71 (21.70–73.63) −0.04 (−0.12 to 0.05)
 High SDI 472,370 (199,898–767,235) 43.07 (18.21–69.90) 797,416 (368,146–1,253,107) 35.13 (16.59–54.47) −0.18 (−0.24 to −0.07)
Causes
 Cardiovascular diseases 863,066 (477,898–1,316,551) 24.43 (13.63–37.3) 1,904,239 (1,072,732–2,864,242) 22.77 (12.87–34.24) −0.07 (−0.14 to 0.02)
 Chronic respiratory diseases 38,041 (16,523–59,933) 1.00 (0.43–1.58) 62,363 (26,317–100,543) 0.74 (0.31–1.19) −0.26 (−0.35 to −0.14)
 Diabetes and kidney diseases 330,122 (170,826–489,762) 9.01 (4.53–13.57) 1,142,121 (602,169–1,666,047) 13.51 (7.14–19.81) 0.50 (0.39–0.64)
 Digestive diseases 21,103 (4725–35,436) 0.63 (0.14–1.06) 46,716 (10,268–79,844) 0.58 (0.13–0.98) −0.09 (−0.19 to 0.12)
 Neoplasms 137,353 (57,450–225,297) 3.66 (1.51–6.03) 356,738 (146,116–581,012) 4.18 (1.71–6.8) 0.14 (0.07–0.20)
 Neurological disorders 31,577 (−1617 to 142,814) 1.22 (−0.07 to 5.43) 139,439 (−21,838 to 580,290) 1.79 (−0.27 to 7.44) 0.47 (−0.47 to 2.67)
 Respiratory infections and tuberculosis 38,272 (8106–107,542) 0.94 (0.20–2.62) 57,447 (12,864–150,517) 0.67 (0.15–1.75) −0.29 (−0.40 to −0.08)
Regions
 Southeast Asia, East Asia, and Oceania 209,280 (133,212–314,962) 21.31 (13.51–31.76) 843,126 (434,145–1,321,468) 32.18 (16.72–50.06) 0.51 (0.03–0.87)
 Central Europe, Eastern Europe, and Central Asia 313,169 (127,541–516,522) 70.50 (28.19–116.6) 482,197 (206,766–766,422) 73.46 (31.57–116.87) 0.04 (−0.06 to 0.18)
 High-income 495,925 (211,655–800,301) 41.52 (17.71–67.04) 815,587 (370,336–1,288,209) 33.19 (15.69–51.55) −0.20 (−0.25 to −0.09)
 Latin America and Caribbean 121,529 (62,408–183,615) 58.07 (30.04–87.81) 390,581 (200,873–593,116) 63.83 (32.60–97.11) 0.10 (0.01–0.19)
 North Africa and Middle East 139,628 (80,646–204,715) 94.42 (54.85–138.13) 444,512 (248,383–651,458) 111.09 (62.99–165.05) 0.18 (0.05–0.30)
 South Asia 91,954 (46,062–155,163) 16.58 (8.74–27.79) 448,678 (214,705–698,248) 31.70 (15.44–49.7) 0.91 (0.56–1.33)
 Sub-Saharan Africa 88,048 (53,414–136,421) 45.76 (27.18–70.37) 284,382 (160,256–427,513) 67.34 (38.78–102.13) 0.47 (0.29–0.66)
 World Bank Regions 825,830 (405,994–1,298,931) 24.19 (11.59–37.98) 3,701,337 (1,843,736–5,646,169) 44.19 (21.98–67.58) 0.83 (0.72–0.97)
 WHO region 1,448,757 (717,769–2,270,841) 40.84 (19.84–64.08) 3,684,012 (1,835,234–5,618,806) 44.25 (22.01–67.65) 0.08 (0.01–0.15)
 European Union 300,328 (130,095–482,020) 50.23 (21.68–80.72) 419,910 (198,142–672,566) 37.28 (17.88–59.34) −0.26 (−0.32 to −0.15)
 League of Arab States 93,700 (54,474–138,019) 101.80 (58.54–149.61) 314,703 (177,705–467,749) 130.76 (75.14–195.39) 0.28 (0.11–0.45)
 Commonwealth 221,787 (107,464–356,741) 28.87 (14.05–46.35) 741,090 (356,775–1,136,519) 38.31 (18.41–59.14) 0.33 (0.20–0.48)
 OECD Countries 608,719 (263,354–978,455) 45.88 (19.90–73.72) 1,077,196 (511,582–1,688,391) 39.26 (19.08–60.51) −0.14 (−0.20 to −0.02)
 G20 1,045,845 (498,668–1,651,416) 38.33 (17.91–60.41) 2,508,139 (1,216,695–3,877,430) 38.98 (18.96–60.30) 0.02 (−0.05 to 0.09)
 African Union 151,517 (90,193–228,330) 60.15 (35.72–89.11) 491,144 (275,282–731,417) 86.48 (49.45–129.8) 0.44 (0.26–0.60)
 Four World Regions 1,453,713 (720,260–2,278,004) 40.82 (19.84–64.04) 3,698,546 (1,842,234–5,642,121) 44.19 (21.98–67.58) 0.08 (0.01–0.15)
 World Bank Income Levels 1,456,672 (721,695–2,282,563) 40.86 (19.86–64.11) 3,704,134 (1,845,217–5,650,715) 44.21 (21.99–67.61) 0.08 (0.01–0.15)
 Nordic Region 14,360 (5312–23,981) 37.09 (13.88–61.66) 16,769 (7097–27,654) 25.05 (10.77–41.28) −0.32 (−0.39 to −0.16)
 Organization of Islamic Cooperation 244,516 (137,488–372,008) 52.41 (29.85–78.55) 806,667 (439,001–1,198,877) 71.57 (39.42–107.21) 0.37 (0.24–0.49)
 Association of Southeast Asian Nations 53,733 (32,894–83,980) 21.96 (13.48–33.99) 222,760 (118,705–342,708) 35.86 (19.44–55.15) 0.63 (0.37–0.88)
 Gulf Cooperation Council 7520 (3992–11,670) 105.29 (56.86–163.13) 35,910 (20,177–51,894) 137.46 (76.71–201.14) 0.31 (0.07–0.63)
 Sahel Region 28,578 (16,831–44,670) 48.03 (28.28–74.92) 80,107 (44,088–123,263) 62.89 (34.89–96.41) 0.31 (0.10–0.56)
 Health System Grouping Levels 1,456,701 (721,713–2,282,604) 40.86 (19.86–64.11) 3,704,180 (1,845,244–5,650,779) 44.21 (22–67.61) 0.08 (0.01–0.15)

Abbreviations: BMI, high body mass index; CI, confidence interval; SDI, Socio-demographic Index; UI, uncertainty intervals.

Impact on Data Interpretation

These corrections ensure accurate representation of the data but do not change the overall conclusions of the paper.


Articles from eClinicalMedicine are provided here courtesy of Elsevier

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