Skip to main content
NCBI home page
Biochemical Journal logoLink to Biochemical Journal
. 1979 Dec 15;184(3):701–704. doi: 10.1042/bj1840701

Prostaglandins and their precursors in tissues from rats fed on trans, trans-linoleate.

J E Kinsella, D H Hwang, P Yu, J Mai, J Shimp
PMCID: PMC1161857  PMID: 540059

Abstract

Feeding trans,trans-9,12-linoleate to rats as 50 and 100% of the dietary fat decreased the concentrations of n-6 fatty acids, i.e. 18:2, 20:3 and 20:4, in heart, kidney, lung, adipose tissue and platelets of rats. The concentrations of prostaglandin products prostaglandins E1, E2 and F2 alpha in serum were significantly decreased in rats receiving high concentrations of dietary trans, trans-linoleate.

Full text

PDF
701

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Carpenter D. L., Slover H. T. Lipid composition of selected margarines. J Am Oil Chem Soc. 1973 Sep;50(9):372–376. doi: 10.1007/BF02640843. [DOI] [PubMed] [Google Scholar]
  2. Clausen J., Srivastava K. C. The synthesis of prostaglandins in human platelets. Lipids. 1972 Apr;7(4):246–250. doi: 10.1007/BF02533221. [DOI] [PubMed] [Google Scholar]
  3. Dunham E. W., Balasingam M., Privett O. S., Nickell E. C. Effects of essential fatty acid deficiency on prostaglandin synthesis and fatty acid composition in rat renal medulla. Lipids. 1978 Dec;13(12):892–897. doi: 10.1007/BF02533845. [DOI] [PubMed] [Google Scholar]
  4. FOLCH J., LEES M., SLOANE STANLEY G. H. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957 May;226(1):497–509. [PubMed] [Google Scholar]
  5. Fleischman A. I., Justice D., Bierenbaum M. L., Stier A., Sullivan A. Beneficial effect of increased dietary linoleate upon in vivo platelet function in man. J Nutr. 1975 Oct;105(10):1286–1290. doi: 10.1093/jn/105.10.1286. [DOI] [PubMed] [Google Scholar]
  6. Gorman R. R. Modulation of human platelet function by prostacyclin and thromboxane A2. Fed Proc. 1979 Jan;38(1):83–88. [PubMed] [Google Scholar]
  7. Hornsta G. Degree and duration of prostaglandin E 1-induced inhibition of platelet aggregation in the rat. Eur J Pharmacol. 1971;15(3):343–349. doi: 10.1016/0014-2999(71)90101-4. [DOI] [PubMed] [Google Scholar]
  8. Hulan H. W., Kramer J. K. The effects of long-chain monoenes on prostaglandin E2 synthesis by rat skin. Lipids. 1977 Jul;12(7):604–609. doi: 10.1007/BF02533389. [DOI] [PubMed] [Google Scholar]
  9. Hwang D. H., Kinsella J. E. The effects of trans linoleic acid on the concentration of serum prostaglandin F2alpha and platelet aggregation. Prostaglandins Med. 1978 Aug;1(2):121–130. doi: 10.1016/0161-4630(78)90038-1. [DOI] [PubMed] [Google Scholar]
  10. Hwang D. H., Mathias M. M., Dupont J., Meyer D. L. Linoleate enrichment of diet and prostaglandin metabolism in rats. J Nutr. 1975 Aug;105(8):995–1002. doi: 10.1093/jn/105.8.995. [DOI] [PubMed] [Google Scholar]
  11. Iacono J. M., Binder R. A., Marshall M. W., Schoene N. W., Jencks J. A., Mackin J. F. Decreased susceptibility to thrombin and collagen platelet aggregation in man fed a low fat diet. Haemostasis. 1974;3(5-6):306–318. doi: 10.1159/000214069. [DOI] [PubMed] [Google Scholar]
  12. Kaa E. In vitro biosynthesis of prostaglandin E2 by kidney medulla of essential fatty acid deficient rats. Lipids. 1976 Sep;11(9):693–696. doi: 10.1007/BF02532889. [DOI] [PubMed] [Google Scholar]
  13. Kinsella J. E., McCarthy R. D. Biosynthesis of secretory lipids from [2-14C]acetate by bovine mammary cells in vitro. Biochim Biophys Acta. 1968 Dec 18;164(3):518–529. doi: 10.1016/0005-2760(68)90181-1. [DOI] [PubMed] [Google Scholar]
  14. Kinsella J. E., Shimp J. L., Mai J., Weihrauch J. Fatty acid content and composition of freshwater finfish. J Am Oil Chem Soc. 1977 Oct;54(10):424–429. doi: 10.1007/BF02671025. [DOI] [PubMed] [Google Scholar]
  15. Kummerow F. A. Current studies on relation of fat to health. J Am Oil Chem Soc. 1974 Jun;51(6):255–259. doi: 10.1007/BF02642631. [DOI] [PubMed] [Google Scholar]
  16. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  17. Mann G. V. Diet-Heart: end of an era. N Engl J Med. 1977 Sep 22;297(12):644–650. doi: 10.1056/NEJM197709222971206. [DOI] [PubMed] [Google Scholar]
  18. Marcus A. J. The role of lipids in platelet function: with particular reference to the arachidonic acid pathway. J Lipid Res. 1978 Sep;19(7):793–826. [PubMed] [Google Scholar]
  19. McGiff J. C. New developments in prostaglandin and thromboxane research: introduction. Fed Proc. 1979 Jan;38(1):64–65. [PubMed] [Google Scholar]
  20. Nugteren D. H. Inhibition of prostaglandin biosynthesis by 8cis, 12trans, 14cis-eicosatrienoic acid and 5cis, 8cis, 12trans, 14cis-eicosatetraenoic acid. Biochim Biophys Acta. 1970 Jun 9;210(1):171–176. doi: 10.1016/0005-2760(70)90072-x. [DOI] [PubMed] [Google Scholar]
  21. Pace-Asciak C. R., Rangaraj G. Distribution of prostaglandin biosynthetic pathways in organs and tissues of the fetal lamb. Biochim Biophys Acta. 1978 Mar 30;528(3):512–514. doi: 10.1016/0005-2760(78)90042-5. [DOI] [PubMed] [Google Scholar]
  22. Privett O. S., Phillips F., Shimasaki H., Nozawa T., Nickell E. C. Studies of effects of trans fatty acids in the diet on lipid metabolism in essential fatty acid deficient rats. Am J Clin Nutr. 1977 Jul;30(7):1009–1017. doi: 10.1093/ajcn/30.7.1009. [DOI] [PubMed] [Google Scholar]
  23. Raheja R. K., Kaur C., Singh A., Bhatia I. S. New colorimetric method for the quantitative estimation of phospholipids without acid digestion. J Lipid Res. 1973 Nov;14(6):695–697. [PubMed] [Google Scholar]
  24. Silver M. J., Smith J. B., Ingerman C., Kocsis J. J. Human blood prostaglandins: formation during clotting. Prostaglandins. 1972 Jun;1(6):429–436. doi: 10.1016/0090-6980(72)90011-1. [DOI] [PubMed] [Google Scholar]
  25. Sprecher H. Biosynthetic pathways of polyunsaturated fatty acids. Adv Exp Med Biol. 1977;83:35–50. doi: 10.1007/978-1-4684-3276-3_5. [DOI] [PubMed] [Google Scholar]
  26. Vergroesen A. J. Physiological effects of dietary linoleic acid. Nutr Rev. 1977 Jan;35(1):1–5. doi: 10.1111/j.1753-4887.1977.tb06475.x. [DOI] [PubMed] [Google Scholar]
  27. Weston P. G., Johnston P. V. Cerebral prostaglandin synthesis during the dietary and pathological stresses of essential fatty acid deficiency and experimental allergic encephalomyelitis. Lipids. 1978 Jun;13(6):408–414. doi: 10.1007/BF02533710. [DOI] [PubMed] [Google Scholar]
  28. van Evert W. C., Nugteren D. H., van Dorp D. A. Inhibition of prostaglandin biosynthesis by c-5,c-8,c-11-eicosatrienoic acid. Prostaglandins. 1978 Feb;15(2):267–272. doi: 10.1016/0090-6980(78)90165-x. [DOI] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES