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. 1979 Dec 15;184(3):705–707. doi: 10.1042/bj1840705

Postnatal development of uridine diphosphate glucuronyltransferase activity towards bilirubin and 2-aminophenol in human liver.

S Onishi, N Kawade, S Itoh, K Isobe, S Sugiyama
PMCID: PMC1161858  PMID: 120201

Abstract

UDP-glucuronyltransferase activities towards 2-aminophenol and bilirubin were studied in a total of 70 human subjects, including premature and full-term newborn babies, infants, children and adults. These two activities have been reported in rat to develop latefoetally and neonatally respectively, but in man they both develop neonatally. There is a linear relationship between the logarithm of each liver transferase activity and the logarithm of the number of days after birth during the first 3 months of life, after which each activity remains constant.

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Selected References

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  1. Arias I. M., Gartner L. M., Cohen M., Ezzer J. B., Levi A. J. Chronic nonhemolytic unconjugated hyperbilirubinemia with glucuronyl transferase deficiency. Clinical, biochemical, pharmacologic and genetic evidence for heterogeneity. Am J Med. 1969 Sep;47(3):395–409. doi: 10.1016/0002-9343(69)90224-1. [DOI] [PubMed] [Google Scholar]
  2. Black M., Billing B. H., Heirwegh K. P. Determination of bilirubin UDP-glucuronyl transferase activity in needle-biopsy specimens of human liver. Clin Chim Acta. 1970 Jul;29(1):27–35. doi: 10.1016/0009-8981(70)90216-0. [DOI] [PubMed] [Google Scholar]
  3. Bock K. W., Fröhling W., Remmer H., Rexer B. Effects of phenobarbital and 3-methylcholanthrene on substrate specificity of rat liver microsomal UDP-glucuronyltransferase. Biochim Biophys Acta. 1973 Nov 15;327(1):46–56. doi: 10.1016/0005-2744(73)90102-2. [DOI] [PubMed] [Google Scholar]
  4. Cornelius C. E., Arias I. M. Animal model of human disease. Crigler-Najjar Syndrome. Animal model: hereditary nonhemolytic unconjugated hyperbilirubinemia in Gunn rats. Am J Pathol. 1972 Nov;69(2):369–372. [PMC free article] [PubMed] [Google Scholar]
  5. Fevery J., Blanckaert N., Heirwegh K. P., Préaux A. M., Berthelot P. Unconjugated bilirubin and an increased proportion of bilirubin monoconjugates in the bile of patients with Gilbert's syndrome and Crigler-Najjar disease. J Clin Invest. 1977 Nov;60(5):970–979. doi: 10.1172/JCI108877. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Heirwegh K. P., Fevery J., Meuwissen J. A., De Groote J., Compernolle F., Desmet V., Van Roy F. P. Recent advances in the separation and analysis of diazo-positive bile pigments. Methods Biochem Anal. 1974;22:205–250. doi: 10.1002/9780470110423.ch5. [DOI] [PubMed] [Google Scholar]
  7. Heirwegh K. P., Meuwissen J. A., Fevery J. Critique of the assay and significance of bilirubin conjugation. Adv Clin Chem. 1973;16:239–288. doi: 10.1016/s0065-2423(08)60347-9. [DOI] [PubMed] [Google Scholar]
  8. Lucier G. W., McDaniel O. S. Steroid and non-steroid UDP glucuronyltransferase: glucuronidation of synthetic estrogens as steroids. J Steroid Biochem. 1977 Aug;8(8):867–872. doi: 10.1016/0022-4731(77)90096-6. [DOI] [PubMed] [Google Scholar]
  9. MILLER I., WEIL W. B., Jr SOME PROBLEMS IN EXPRESSING AND COMPARING BODY COMPOSITION DETERMINED BY DIRECT ANALYSIS. Ann N Y Acad Sci. 1963 Sep 26;110:153–160. doi: 10.1111/j.1749-6632.1963.tb17081.x. [DOI] [PubMed] [Google Scholar]
  10. Winsnes A. Studies on the activation in vitro of glucuronyltransferase. Biochim Biophys Acta. 1969 Nov 4;191(2):279–291. doi: 10.1016/0005-2744(69)90247-2. [DOI] [PubMed] [Google Scholar]
  11. Wishart G. J., Campbell M. T. Demonstration of two functionally heterogenous groups within the activities of UDP-glucuronosyltransferase towards a series of 4-alkyl-substituted phenols. Biochem J. 1979 Feb 15;178(2):443–447. doi: 10.1042/bj1780443. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Wishart G. J. Demonstration of functional heterogeneity of hepatic uridine diphosphate glucuronosyltransferase activities after administration of 3-methylcholanthrene and phenobarbital to rats. Biochem J. 1978 Aug 15;174(2):671–672. doi: 10.1042/bj1740671. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Wishart G. J. Functional heterogeneity of UDP-glucuronosyltransferase as indicated by its differential development and inducibility by glucocorticoids. Demonstration of two groups within the enzyme's activity towards twelve substrates. Biochem J. 1978 Aug 15;174(2):485–489. doi: 10.1042/bj1740485. [DOI] [PMC free article] [PubMed] [Google Scholar]

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