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. 1980 Jun 15;188(3):757–761. doi: 10.1042/bj1880757

Altered lipolytic response to glucagon and adenosine deaminase in adipocytes from starved rats.

R C Honnor, E D Saggerson
PMCID: PMC1161958  PMID: 7470032

Abstract

1. Adipocytes isolated from epididymal adipose tissue of fed or 24 h-starved rats were incubated with a range of glucagon concentrations in the presence and absence of adenosine deaminase (4 munits/ml). 2. With adenosine deaminase present, the lipolytic response to low concentrations of glucagon (1-6 ng/ml) was considerably enhanced in cells from starved rats. 3. The effect of adenosine deaminase on basal lipolysis was altered after starvation. 4. D-3-Hydroxybutyrate (5 mM) decreased the sensitivity of lipolysis to glucagon. 5. The possible involvement of glucagon-stimulated lipolysis in the regulation of ketogenesis is briefly discussed.

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Selected References

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