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. 1980 Jun 15;188(3):769–773. doi: 10.1042/bj1880769

Sulphated glycosaminoglycans in regenerating rat liver.

M Edward, W F Long, H H Watson, F B Williamson
PMCID: PMC1161960  PMID: 7470034

Abstract

The total weight percentage glycosaminoglycan content of rat liber was found to increase by 50% in the first 30 h after partial hepatectomy. The content returned to near normal by the third day, but then increased again to a second maximum at 5-6 days, only to gradually decline to normal by the ninth day, when regeneration was nearly complete. This biphasic pattern was most marked in the chondroitin sulphate A/C component, with a 6-fold increase by the sixth day. Dermatan sulphate showed the same temporal trend, whereas heparan sulphate remained relatively unaltered. No such changes were detected in the livers of rats subjected to sham operation. The possible molecular mechanisms underlying the apparent link between cellular glycosaminoglycan content and proliferative tendency are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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