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. 1980 Sep 15;190(3):533–536. doi: 10.1042/bj1900533

Demonstration of a geometric isomer of bilirubin-IX alpha in the serum of a hyperbilirubinaemic newborn infant and the mechanism of jaundice phototherapy.

S Onishi, K Isobe, S Itoh, N Kawade, S Sugiyama
PMCID: PMC1162129  PMID: 7470068

Abstract

Photobilirubin-IX alpha in the serum of a hyperbilirubinaemic newborn infant was demonstrated for the first time by reversed-phase high-pressure liquid chromatography. The concentrations increased significantly during phototherapy. Corresponding to these changes in the serum, biliary unconjugated bilirubin concentrations increased markedly but photobilirubin-IX alpha was not detected in the bile. Moreover, large amounts of 'unknown pigment' that are diazo-negative appeared in the bile during phototherapy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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