Abstract
Lysosomal enzyme secretion by the murine macrophage-like cell line, P388D1, was compared with that of normal peritoneal macrophages. Unlike macrophages, lysosomal hydrolase secretion by P388D1 cells occurred spontaneously in vitro and was not further stimulated by the presentation of inflammatory agents such as zymosan and asbestos.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Davies P., Allison A. C., Ackerman J., Butterfield A., Williams S. Asbestos induces selective release of lysosomal enzymes from mononuclear phagocytes. Nature. 1974 Oct 4;251(5474):423–425. doi: 10.1038/251423a0. [DOI] [PubMed] [Google Scholar]
- Dean R. T., Hylton W., Allison A. C. Induction of macrophage lysosomal enzyme secretion by agents acting at the plasma membrane. Exp Cell Biol. 1979;47(6):454–462. doi: 10.1159/000162963. [DOI] [PubMed] [Google Scholar]
- Dean R. T., Hylton W., Allison A. C. Lysosomal enzyme secretion by macrophages during intracellular storage of particles. Biochim Biophys Acta. 1979 Apr 18;584(1):57–65. doi: 10.1016/0304-4165(79)90235-6. [DOI] [PubMed] [Google Scholar]
- Gordon S., Todd J., Cohn Z. A. In vitro synthesis and secretion of lysozyme by mononuclear phagocytes. J Exp Med. 1974 May 1;139(5):1228–1248. doi: 10.1084/jem.139.5.1228. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hösli P., Vogt E. Cystic fibrosis: leakage of lysosomal enzymes and of alkaline phosphatase into the extracellular space. Biochem Biophys Res Commun. 1977 Dec 7;79(3):741–748. doi: 10.1016/0006-291x(77)91174-3. [DOI] [PubMed] [Google Scholar]
- Koren H. S., Handwerger B. S., Wunderlich J. R. Identification of macrophage-like characteristics in a cultured murine tumor line. J Immunol. 1975 Feb;114(2 Pt 2):894–897. [PubMed] [Google Scholar]
- Mørland B., Kaplan G. Properties of a murine monocytic tumor cell line J-774 in vitro. II. Enzyme activities. Exp Cell Res. 1978 Aug;115(1):63–72. doi: 10.1016/0014-4827(78)90402-0. [DOI] [PubMed] [Google Scholar]
- Ralph P., Nakoinz I. Direct toxic effects of immunopotentiators on monocytic, myelomonocytic, and histiocytic or macrophage tumor cells in culture. Cancer Res. 1977 Feb;37(2):546–550. [PubMed] [Google Scholar]
- Schorlemmer H. U., Davies P., Hylton W., Gugig M., Allison A. C. The selective release of lysosomal acid hydrolases from mouse peritoneal macrophages by stimuli of chronic inflammation. Br J Exp Pathol. 1977 Jun;58(3):315–326. [PMC free article] [PubMed] [Google Scholar]
- Snyderman R., Pike M. C., Fischer D. G., Koren H. S. Biologic and biochemical activities of continuous macrophage cell lines P388D1 and J774.1. J Immunol. 1977 Dec;119(6):2060–2066. [PubMed] [Google Scholar]