Skip to main content
NCBI home page
Biochemical Journal logoLink to Biochemical Journal
. 1980 Nov 15;192(2):607–612. doi: 10.1042/bj1920607

The role of glycogen synthase phosphatase in the glucocorticoid-induced deposition of glycogen in foetal rat liver.

F Vanstapel, F Doperé, W Stalmans
PMCID: PMC1162376  PMID: 6263259

Abstract

1. The mechanism that underlies the induction of glycogen synthesis in the foetal rat liver by glucocorticoids was reinvestigated in conditions where the accumulation of glycogen is either precociously induced with dexamethasone or inhibited by steroid deprivation. It appears that glucocorticoids act as the physiological trigger for glycogen synthesis by inducing both glycogen synthase (a known effect) and its activating enzyme, glycogen synthase phosphatase. 2. The activity of glycogen synthase phosphatase in adult liver stems from the interaction of two protein components [Doperé, Vanstapel & Stalmans (1980) Eur. J. Biochem. 104, 137--146]. Two independent experimental approaches indicate that the cytosolic 'S-component' is already well developed in the foetal liver before the onset of glycogen synthesis. The manifold glucocorticoid-dependent increase in synthase phosphatase activity during late gestation must be attributed to the specific development of the glycogen-bound 'G-component'.

Full text

PDF
607

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BALLARD F. J., OLIVER I. T. Glycogen metabolism in embryonic chick and neonatal rat liver. Biochim Biophys Acta. 1963 Jun 4;71:578–588. doi: 10.1016/0006-3002(63)91130-2. [DOI] [PubMed] [Google Scholar]
  2. Chan T. M., Exton J. H. A rapid method for the determination of glycogen content and radioactivity in small quantities of tissue or isolated hepatocytes. Anal Biochem. 1976 Mar;71(1):96–105. doi: 10.1016/0003-2697(76)90014-2. [DOI] [PubMed] [Google Scholar]
  3. Cohen A. Plasma corticosterone concentration in the foetal rat. Horm Metab Res. 1973 Jan;5(1):66–66. [PubMed] [Google Scholar]
  4. Cohen N. M., Turner R. C. Plasma insulin in the foetal rat. Biol Neonate. 1972;21(1):107–111. doi: 10.1159/000240500. [DOI] [PubMed] [Google Scholar]
  5. Devos P., Hers H. G. Glycogen metabolism in the liver of the foetal rat. Biochem J. 1974 May;140(2):331–340. doi: 10.1042/bj1400331. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Doperé F., Vanstapel F., Stalmans W. Glycogen-synthase phosphatase activity in rat liver. Two protein components and their requirement for the activation of different types of substrate. Eur J Biochem. 1980 Feb;104(1):137–146. doi: 10.1111/j.1432-1033.1980.tb04409.x. [DOI] [PubMed] [Google Scholar]
  7. Dupouy J. P., Coffigny H., Magre S. Maternal and foetal corticosterone levels during late pregnancy in rats. J Endocrinol. 1975 Jun;65(3):347–352. doi: 10.1677/joe.0.0650347. [DOI] [PubMed] [Google Scholar]
  8. Eisen H. J., Goldfine I. D., Glinsmann W. H. Regulation of hepatic glycogen synthesis during fetal development: roles of hydrocortisone, insulin, and insulin receptors. Proc Natl Acad Sci U S A. 1973 Dec;70(12):3454–3457. doi: 10.1073/pnas.70.12.3454. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Felix J. M., Sutter M. T., Sutter B. C., Jacquot R. Circulating insulin and tissular reactivity to insulin in the rat during the perinatal period. Horm Metab Res. 1971 Mar;3(2):71–75. doi: 10.1055/s-0028-1095030. [DOI] [PubMed] [Google Scholar]
  10. Girard J. R., Kervran A., Soufflet E., Assan R. Factors affecting the secretion of insulin and glucagon by the rat fetus. Diabetes. 1974 Apr;23(4):310–317. doi: 10.2337/diab.23.4.310. [DOI] [PubMed] [Google Scholar]
  11. Greengard O., Dewey H. K. The premature deposition or lysis of glycogen in livers of fetal rats injected with hydrocortisone or glucagon. Dev Biol. 1970 Mar;21(3):452–461. doi: 10.1016/0012-1606(70)90135-1. [DOI] [PubMed] [Google Scholar]
  12. Holt P. G., Oliver I. T. Plasma corticosterone concentrations in the perinatal rat. Biochem J. 1968 Jun;108(2):339–341. doi: 10.1042/bj1080339. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. JACQUOT R., KRETCHMER N. EFFECT OF FETAL DECAPITATION ON ENZYMES OF GLYCOGEN METABOLISM. J Biol Chem. 1964 May;239:1301–1304. [PubMed] [Google Scholar]
  14. JACQUOT R. [Research on the endocrine control of glycogen accumulation in the liver of the rat fetus. Part I. Experiences of decapitation of the fetus in utero]. J Physiol (Paris) 1959 Jul-Aug;51:655–691. [PubMed] [Google Scholar]
  15. Jost A., Picon L. Hormonal control of fetal development and metabolism. Adv Metab Disord. 1970;4:123–184. doi: 10.1016/b978-0-12-027304-1.50010-7. [DOI] [PubMed] [Google Scholar]
  16. Pines M., Bashan N., Moses S. W. Effect of hydrocortisone and glucagon on glycogen metabolism in the fetal rat liver. Biochim Biophys Acta. 1975 Dec 5;411(2):369–376. doi: 10.1016/0304-4165(75)90316-5. [DOI] [PubMed] [Google Scholar]
  17. Plas C., Jacquot R. Recherches sur la différenciation fonctionnelle du foie chez le foetus de rat. Activité UDPG-transglucosylasique et teneur en glycogène après administration d'hydrocortisone. C R Acad Sci Hebd Seances Acad Sci D. 1967 Jan 9;264(2):374–376. [PubMed] [Google Scholar]
  18. Plas C., Menuelle P., Moncany M. L., Fulchignoni-Lataud M. C. Time dependence of the glycogenic effect of insulin in cultured fetal hepatocytes. Diabetes. 1979 Aug;28(8):705–712. doi: 10.2337/diab.28.8.705. [DOI] [PubMed] [Google Scholar]
  19. Schwartz A. L., Rall T. W. Hormonal regulation of glycogen metabolism in neonatal rat liver. Biochem J. 1973 Aug;134(4):985–993. doi: 10.1042/bj1340985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Vanstapel F., Doperé F., Stalmans W. On the development of the two components of glycogen synthase phosphatase in foetal rat liver [proceedings]. Arch Int Physiol Biochim. 1979 Feb;87(1):218–219. [PubMed] [Google Scholar]
  21. Vanstapel F., Stalmans W. Glucocorticoid-dependent development of glycogen synthase phosphatase in foetal rat liver [proceedings]. Arch Int Physiol Biochim. 1978 Oct;86(4):966–967. [PubMed] [Google Scholar]
  22. Watts C., Gain E. R. Glycogen metabolism in the liver of the developing rat. Biochem J. 1976 Nov 15;160(2):263–270. doi: 10.1042/bj1600263. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Wishart G. J., Dutton G. J. Regulation of onset of development of UDP-glucuronosyltransferase activity towards o-aminophenol by glucocorticoids in late-foetal rat liver in utero. Biochem J. 1977 Dec 15;168(3):507–511. doi: 10.1042/bj1680507. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES