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. 1980 Nov 15;192(2):733–740. doi: 10.1042/bj1920733

Synthesis of apoprotein B of very low density lipoprotein in embryonic-chick liver. Development of responsiveness of oestrogen.

S A Nadin-Davis, C B Lazier, F Capony, D L Williams
PMCID: PMC1162391  PMID: 7236235

Abstract

The influence of exogenous oestrogen on the rate of synthesis of the apoprotein B of very-low-density lipoprotein by embryonic chick liver has been examined at various stages of development. Significant synthesis of apoprotein B was found in the absence of hormone treatment as early as day 6 of egg incubation. This basal level of apoprotein B synthesis varied from 2.5--6% of total protein synthesis. Embryos at day 10 or earlier treated with oestradiol exhibited no increase in the basal level of apoprotein B synthesis. Embryos at day 11 responded to oestradiol slightly and, from days 12 to 20, oestrogen treatment raised the relative rate of apoprotein B synthesis significantly above basal values: the maximal rate was about 16% of total protein synthesis. The anti-oestrogen tamoxifen citrate abolished the hormone-induced increase in apoprotein B synthesis and was not itself oestrogenic. The basal level of apoprotein B production was not sensitive to tamoxifen citrate, either in relatively early or in later stages of development. The basal level of apoprotein B synthesis, therefore, is oestrogen-independent and under developmental control distinct from the hormone-sensitive synthesis. The ontogeny of oestrogen-responsiveness of apoprotein B production appears to parallel the acquisition of the hepatic oestrogen-receptor system [Lazier (1978) Biochem. J. 174, 143--152].

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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