Skip to main content
PMC home page
Biochemical Journal logoLink to Biochemical Journal
. 1981 Mar 1;193(3):915–918. doi: 10.1042/bj1930915

Desmosines in human urine. Amounts in early development and in Marfan's syndrome.

Z Gunja-Smith, R J Boucek
PMCID: PMC1162685  PMID: 7305966

Abstract

Desmosines from 24 h human urine samples were isolated, characterized and quantified. The desmosines are in peptidyl form (1000--1500 molecular weight), and their amount is decreased by two-thirds between 7 and 25 years of age. Patients with Marfan's syndrome have significantly lower urinary amounts of desmosines than do comparable controls during the early development period.

Full text

PDF
915

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anwar R. A., Oda G. The biosynthesis of desmosine and isodesmosine. J Biol Chem. 1966 Oct 25;241(20):4638–4641. [PubMed] [Google Scholar]
  2. Boucek R. J., Noble N. L., Gunja-Smith Z., Simpson C. F. Considerations of aortic elastin chemistry in the genesis of the intimal plaque (broad-breasted white turkey). Exp Mol Pathol. 1979 Dec;31(3):400–412. doi: 10.1016/0014-4800(79)90040-6. [DOI] [PubMed] [Google Scholar]
  3. Bowers D. Pathogenesis of primary abnormalities of the mitral valve in Marfan's syndrome. Br Heart J. 1969 Nov;31(6):679–683. doi: 10.1136/hrt.31.6.679. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Byers P. H., Siegel R. C., Holbrook K. A., Narayanan A. S., Bornstein P., Hall J. G. X-linked cutis laxa: defective cross-link formation in collagen due to decreased lysyl oxidase activity. N Engl J Med. 1980 Jul 10;303(2):61–65. doi: 10.1056/NEJM198007103030201. [DOI] [PubMed] [Google Scholar]
  5. Cunningham L. W., Ford J. D., Segrest J. P. The isolation of identical hydroxylysyl glycosides from hydrolysates of soluble collagen and from human urine. J Biol Chem. 1967 May 25;242(10):2570–2571. [PubMed] [Google Scholar]
  6. Goldstein R. A., Starcher B. C. Urinary excretion of elastin peptides containing desmosin after intratracheal injection of elastase in hamsters. J Clin Invest. 1978 May;61(5):1286–1290. doi: 10.1172/JCI109045. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gross L., Epstein E. Z., Kugel M. A. Histology of the Coronary Arteries and their Branches in the Human Heart. Am J Pathol. 1934 Mar;10(2):253–274.7. [PMC free article] [PubMed] [Google Scholar]
  8. LEVENE C. I. The pathogenesis of atheroma of the coronary arteries. J Pathol Bacteriol. 1956 Jul;72(1):83–86. doi: 10.1002/path.1700720111. [DOI] [PubMed] [Google Scholar]
  9. Layman D. L., Narayanan A. S., Martin G. R. The production of lysyl oxidase by human fibroblasts in culture. Arch Biochem Biophys. 1972 Mar;149(1):97–101. doi: 10.1016/0003-9861(72)90302-5. [DOI] [PubMed] [Google Scholar]
  10. Lee I., Yau C., Rucker R. B. Arterial elastin synthesis in the young chick. Biochim Biophys Acta. 1976 Sep 6;442(3):432–436. doi: 10.1016/0005-2787(76)90316-6. [DOI] [PubMed] [Google Scholar]
  11. Looker T., Berry C. L. The growth and development of the rat aorta. II. Changes in nucleic acid and scleroprotein content. J Anat. 1972 Oct;113(Pt 1):17–34. [PMC free article] [PubMed] [Google Scholar]
  12. Mecham R. P., Foster J. A. A structural model for desmosine cross-linked peptides. Biochem J. 1978 Aug 1;173(2):617–625. doi: 10.1042/bj1730617. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Starcher B. C. Determination of the elastin content of tissues by measuring desmosine and isodesmosine. Anal Biochem. 1977 May 1;79(1-2):11–15. doi: 10.1016/0003-2697(77)90372-4. [DOI] [PubMed] [Google Scholar]
  14. THOMAS J., ELSDEN D. F., PARTRIDGE S. M. PARTIAL STRUCTURE OF TWO MAJOR DEGRADATION PRODUCTS FROM THE CROSS-LINKAGES IN ELASTIN. Nature. 1963 Nov 16;200:651–652. doi: 10.1038/200651a0. [DOI] [PubMed] [Google Scholar]
  15. Takebayashi S., Kubota I., Takagi T. Ultrastructural and histochemical studies of vascular lesions in Marfan's syndrome, with report of 4 autopsy cases. Acta Pathol Jpn. 1973 Nov;23(4):847–866. doi: 10.1111/j.1440-1827.1973.tb02780.x. [DOI] [PubMed] [Google Scholar]
  16. Weiss J. B., Steven F. S. Urinary peptides derived from the cross-linked regions of connective tissue proteins. Nature. 1968 Feb 17;217(5129):661–661. doi: 10.1038/217661a0. [DOI] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES