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. 1981 Jun 1;195(3):761–764. doi: 10.1042/bj1950761

Autocatalytic alkylation of the cytochrome P-450 prosthetic haem group by 1-aminobenzotriazole. Isolation of an NN-bridged benzyne-protoporphyrin IX adduct.

P R Ortiz de Montellano, J M Mathews
PMCID: PMC1162949  PMID: 7316983

Abstract

Destruction of hepatic cytochrome P-450 during catalytic processing of 1-amino-benzotriazole is accompanied by an equal loss of microsomal haem but not by loss of cytochrome b5, or stimulation of lipid peroxidation. An abnormal porphyrin, tentatively identified as an NN-bridged benzyne-protoporphyrin IX adduct, appears to be formed by the addition of catalytically generated benzyne to prosthetic haem.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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